LASER-BASED ACCELERATOR FOR INTERROGATION OF REMOTE CONTAINERS

A method and apparatus for generating high-energy beams of electrons or x-rays through laser wakefield acceleration to remotely examine containers is disclosed. By scanning the beam of electrons or x-rays across a container, an inspector can remotely determine whether the containers contain items of interest, such as special nuclear materials, without having to manually inspect the contents of the container. The invention can be compact enough to be portable, which provides for the flexibility to examine a variety of different containers under a variety of different conditions

Mechanism of Ubiquitin-Chain Formation by the Human Anaphase-Promoting Complex

SummaryThe anaphase-promoting complex (APC/C) orchestrates progression through mitosis by decorating cell-cycle regulators with ubiquitin chains. To nucleate chains, the APC/C links ubiquitin to a lysine in substrates, but to elongate chains it modifies lysine residues in attached ubiquitin moieties. The mechanism enabling the APC/C, and ubiquitin ligases in general, to switch from lysine residues in substrates to specific ones in ubiquitin remains poorly understood. Here, we determine the topology and the mechanism of assembly for the ubiquitin chains mediating functions of the human APC/C. We find that the APC/C triggers substrate degradation by assembling K11-linked ubiquitin chains, the efficient formation of which depends on a surface of ubiquitin, the TEK-box. Strikingly, homologous TEK-boxes are found in APC/C substrates, where they facilitate chain nucleation. We propose that recognition of similar motifs in substrates and ubiquitin enables the APC/C to assemble ubiquitin chains with the specificity and efficiency required for tight cell-cycle control

Compact and Low-Loss PCM-based Silicon Photonic MZIs for Photonic Neural Networks

We present an optimized Mach-Zehnder Interferometer (MZI) with phase change materials for photonic neural networks (PNNs). With 0.2 dB loss, -38 dB crosstalk, and length of 52 micrometer, the designed MZI significantly improves the scalability and accuracy of PNNs under loss and crosstalk.Comment: This paper is accepted at IEEE Photonics Conference (IPC) 202

Characterization and Optimization of Integrated Silicon-Photonic Neural Networks under Fabrication-Process Variations

Silicon-photonic neural networks (SPNNs) have emerged as promising successors to electronic artificial intelligence (AI) accelerators by offering orders of magnitude lower latency and higher energy efficiency. Nevertheless, the underlying silicon photonic devices in SPNNs are sensitive to inevitable fabrication-process variations (FPVs) stemming from optical lithography imperfections. Consequently, the inferencing accuracy in an SPNN can be highly impacted by FPVs -- e.g., can drop to below 10% -- the impact of which is yet to be fully studied. In this paper, we, for the first time, model and explore the impact of FPVs in the waveguide width and silicon-on-insulator (SOI) thickness in coherent SPNNs that use Mach-Zehnder Interferometers (MZIs). Leveraging such models, we propose a novel variation-aware, design-time optimization solution to improve MZI tolerance to different FPVs in SPNNs. Simulation results for two example SPNNs of different scales under realistic and correlated FPVs indicate that the optimized MZIs can improve the inferencing accuracy by up to 93.95% for the MNIST handwritten digit dataset -- considered as an example in this paper -- which corresponds to a <0.5% accuracy loss compared to the variation-free case. The proposed one-time optimization method imposes low area overhead, and hence is applicable even to resource-constrained design

Study of quasimonoenergetic electron bunch generation in self-modulated laser wakefield acceleration using TW or sub-TW ultrashort laser pulses

This work presents a study on laser wakefield electron acceleration in the self-modulated regime (SM-LWFA) using 50-fs laser pulses with energy on the mJ scale, at λ = 0.8 µm, impinging on a thin H2 gas jet. Particle-in-cell simulations were performed using laser peak powers ranging from sub-terawatt to a few terawatts and plasma densities varying from the relativistic self-focusing threshold up to values close to the critical density. The differences in the obtained acceleration processes are discussed. Results show that bunched electron beams with full charge on the nC scale and kinetic energy in the MeV range can be produced and configurations with peak density in the range 0.5–5 × 1020 atoms/cm3 generate electrons with maximum energies. In this range, some simulations generated quasimonoenergetic bunches with ∼0.5% of the total accelerated charge and we show that the beam characteristics, process dynamics, and operational parameters are close to those expected for the blowout regime. The configurations that led to quasimonoenergetic bunches from the sub-TW SM-LWFA regime allow the use of laser systems with repetition rates in the kHz range, which can be beneficial for practical applications

Loss of the PTCH1 tumor suppressor defines a new subset of plexiform fibromyxoma.

BackgroundPlexiform fibromyxoma (PF) is a rare gastric tumor often confused with gastrointestinal stromal tumor. These so-called "benign" tumors often present with upper GI bleeding and gastric outlet obstruction. It was recently demonstrated that approximately one-third of PF have activation of the GLI1 oncogene, a transcription factor in the hedgehog (Hh) pathway, via a MALAT1-GLI1 fusion protein or GLI1 up-regulation. Despite this discovery, the biology of most PFs remains unknown.MethodsNext generation sequencing (NGS) was performed on formalin-fixed paraffin-embedded (FFPE) samples of PF specimens collected from three institutions (UCSD, NCI and OHSU). Fresh frozen tissue from one tumor was utilized for in vitro assays, including quantitative RT-PCR and cell viability assays following drug treatment.ResultsEight patients with PF were identified and 5 patients' tumors were analyzed by NGS. An index case had a mono-allelic PTCH1 deletion of exons 15-24 and a second case, identified in a validation cohort, also had a PTCH1 gene loss associated with a suspected long-range chromosome 9 deletion. Building on the role of Hh signaling in PF, PTCH1, a tumor suppressor protein, functions upstream of GLI1. Loss of PTCH1 induces GLI1 activation and downstream gene transcription. Utilizing fresh tissue from the index PF case, RT-qPCR analysis demonstrated expression of Hh pathway components, SMO and GLI1, as well as GLI1 transcriptional targets, CCND1 and HHIP. In turn, short-term in vitro treatment with a Hh pathway inhibitor, sonidegib, resulted in dose-dependent cell killing.ConclusionsFor the first time, we report a novel association between PTCH1 inactivation and the development of plexiform fibromyxoma. Hh pathway inhibition with SMO antagonists may represent a target to study for treating a subset of plexiform fibromyxomas

Generation of ultrafast electron bunch trains via trapping into multiple periods of plasma wakefields

We demonstrate a novel approach to the generation of femtosecond electron bunch trains via laser-driven wakefield acceleration. We use two independent high-intensity laser pulses, a drive, and injector, each creating their own plasma wakes. The interaction of the laser pulses and their wakes results in a periodic injection of free electrons in the drive plasma wake via several mechanisms, including ponderomotive drift, wake-wake interference, and pre-acceleration of electrons directly by strong laser fields. Electron trains were generated with up to 4 quasi-monoenergetic bunches, each separated in time by a plasma period. The time profile of the generated trains is deduced from an analysis of beam loading and confirmed using 2D Particle-in-Cell simulations.Comment: 11 pages, 5 figures, accepted by Physics of Plasma

Laser-triggered ion acceleration and table top isotope production

We have observed deuterons accelerated to energies of about 2 MeV in the interaction of relativistically intense 10 TW, 400 fs laser pulse with a thin layer of deuterated polystyrene deposited on Mylar film. These high-energy deuterons were directed to the boron sample, where they produced ~105 atoms of positron active isotope 11C from the reaction 10B(d,n)11C. The activation results suggest that deuterons were accelerated from the front surface of the target

METHOD AND APPARATUS FOR HIGH ENERGY GENERATION AND FOR INDUCING NUCLEAR REACTIONS

A System is provided for generating high-energy particles and for inducing nuclear reactions. The System includes a laser and for emitting a laser beam, an irradiation target for receiving the laser beam and producing high-energy particles, and a Secondary target for receiving the high energy particles, thereby inducing a nuclear reaction. A method is also provided including producing a laser beam of high-intensity with an ultra-short pulse duration, irradiating the laser beam onto an irradiation target in order to ionize the irradiation target and produce a collimated beam of high energy particles, and colliding the collimated beam of high energy particles onto a Secondary target containing a nuclei, thereby inducing a nuclear reaction on the Secondary target