Gulf Stream path and thermocline structure near 74°W and 68°W

The SYNoptic Ocean Prediction (SYNOP) experiment had the goal of providing a physical understanding of energetic mesoscale eddy processes in the Gulf Stream. In the SYNOP Inlet Array off Cape Hatteras and in the Central Array near 68°W moored observations were collected from October 1987 through August 1990. The Inlet Array measured the surface path and bottom currents where the Gulf Stream leaves the continental margin to enter the deep water regime. The cross-stream slope of the thermocline steepened linearly with path curvature, consistent with gradient wind balance. Structures are illustrated in the mapped fields consistent with baroclinic instability wherein troughs steepen and rings form

Gulf Stream flow field and events near 68°W

The SYNoptic Ocean Prediction (SYNOP) experiment was designed to provide an accurate understanding of the energetic mesoscale processes in the Gulf Stream. The Central Array measured velocity and temperature throughout the water column, with horizontal extent large enough nearly to span the meander envelope and Eulerian mean structure of the jet at 68°W. Two extended case studies of meander propagation through the array demonstrate the development and intensification of deep cyclonic and anticyclonic flows beneath the Gulf Stream

Refined histopathological predictors of BRCA1 and BRCA2 mutation status: A large-scale analysis of breast cancer characteristics from the BCAC, CIMBA, and ENIGMA consortia

Introduction: The distribution of histopathological features of invasive breast tumors in BRCA1 or BRCA2 germline mutation carriers differs from that of individuals with no known mutation. Histopathological features thus have utility for mutation prediction, including statistical modeling to assess pathogenicity of BRCA1 or BRCA2 variants of uncertain clinical significance. We analyzed large pathology datasets accrued by the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA) and the Breast Cancer Association Consortium (BCAC) to reassess histopathological predictors of BRCA1 and BRCA2 mutation status, and provide robust likelihood ratio (LR) estimates for statistical modeling. Methods: Selection criteria for study/center inclusion were estrogen receptor (ER) status or grade data available for invasive breast cancer diagnosed younger than 70 years. The dataset included 4,477 BRCA1 mutation carriers, 2,565 BRCA2 mutation carriers, and 47,565 BCAC breast cancer cases. Country-stratified estimates of the

Male breast cancer in BRCA1 and BRCA2 mutation carriers: pathology data from the Consortium of Investigators of Modifiers of BRCA1/2

Molecular tumour pathology - and tumour geneticsMTG1 - Moleculaire genetica en pathologie van borstkanke

Physics and technology of the Next Linear Collider: a report submitted to Snowmass '96

We present the current expectations for the design and physics program of an e+e- linear collider of center of mass energy 500 GeV -- 1 TeV. We review the experiments that would be carried out at this facility and demonstrate its key role in exploring physics beyond the Standard Model over the full range of theoretical possibilities. We then show the feasibility of constructing this machine, by reviewing the current status of linear collider technology and by presenting a precis of our `zeroth-order' design