11 research outputs found
Shiro Oni Studio, Japan
Get PDFPoster created by students in the 2017 IWU Freeman Asia Internship Program
Chase Bandolik Abroad
No full textBlog created by Chase Bandolik for the 2017 Freeman Asian Internship Progra
Development of novel targeted therapy strategies for the treatment of chemotherapy-resistant ovarian cancer with special focus on histone deacetylase inhibitors
No full textLow Field NMR Determination of pKa Values for Hydrophilic Drugs for Students in Medicinal Chemistry
No full textFor an interdisciplinary approach on different topics of medicinal and analytical chemistry, we applied a known experimental pKa value determination method on the field of the bench top nuclear magnetic resonance (NMR) spectrometry of some known biologically active pyridine-based drugs, i.e., pyridoxine hydrochloride, isoniazid, and nicotine amide. The chemical shifts of the aromatic ring protons in the 1H NMR spectrum change depending on the protonation status. The data were analyzed on dependence of the chemical shifts by different pH (pD) environments and then the pKa values were calculated. The pKa values obtained were in agreement with the literature data for the compounds, searched by the students on web programs available at our university. The importance of the pKa values in protein-ligand interactions and distribution etc. of drugs was brought up to the students’ attention. In addition, by the use of a free web application for pKa values prediction, students calculated the predicted modeled pKa value. The experimental and in-silico approaches enhance the tool box for undergraduate students in medicinal chemistry
Class I-Histone Deacetylase (HDAC) Inhibition is Superior to pan-HDAC Inhibition in Modulating Cisplatin Potency in High Grade Serous Ovarian Cancer Cell Lines
No full textSynergistic induction of apoptosis in resistant head and neck carcinoma and leukemia by alkoxyamide-based histone deacetylase inhibitors
No full textHydroxamic Acids Immobilized on Resins (HAIRs):Synthesis of Dual-Targeting HDAC Inhibitors and HDAC Degraders (PROTACs)
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Hydroxamic Acids Immobilized on Resins (HAIRs): Synthesis of Dual‐Targeting HDAC Inhibitors and HDAC Degraders (PROTACs)
No full textEntinostat, a selective HDAC1/2 inhibitor, potentiates the effects of olaparib in homologous recombination proficient ovarian cancer
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