Thorax Flexibility can be Increased by Standing Pole Exercise

Background: Discussion has been continued about the stability of the spine, and relationship with physical flexibility and exercise function. We have continued physical rehabilitation for various subjects, and proposed clinical application for pole exercise. In this study, we investigated the efficacy of standing pole exercise. Study protocol: The subjects were 9 healthy adults, 26.9 ± 5.9 years old. Method included standing pole exercise and 2 tests before and after the exercise. The exercise has 6 movements, including lateral bending, axis rotation, wave motion, backward spiral, forward spiral and warp and rounding. The pole was 160 cm in length, 610 g in weight. Two tests were percentage vital capacity (%VC) and weight bearing index (WBI), which showed significant differences between before and after the exercise (p<0.01). Discussion and conclusion: Theoretical mode of spinal stability has relationship with inner/outer core stability, flexibility, expandability, curved angles in spinal alignment, and so on. In current study, standing pole exercise would be effective for increased %VC and WBI, which may be from increased flexibility and expandability. These data would be basal data for clinical application and research development in the future

Pole Exercise Causes Body Changes in Physical Flexibility and Exercise Function

Background: Theoretical mode of spinal stability and core stability has been introduced previously, which has proceeded to rehabilitative approaches. We have focused on physical flexibility and exercise function, and firstly devised an original pole exercise in sitting position that can be done simply and cost-effectively. Subjects and Methods: The subjects 11 healthy young adults, 27.0 ± 5.6 years old. Methods included the intervention of pole exercise with Exercise of the thorax, lower thoracic vertebrae and pelvis, upper thoracic vertebrae and pelvis. Before and after the exercise, we investigated examinations. Tests of physical flexibility were Wing Test, Thomas Test, Shoulder Extension Test, straight leg raise (SLR), Body warp prone position, Heel Buttock Distance (HBD) and Finger Floor Distance (FFD). Tests of exercise functions were Back Muscle Strength (BMS), Weight Bearing Index (WBI), Functional Reach Test (FRT) and closed eye leg standing time. Results: The data of 7 flexibility tests and 4 exercise function tests revealed the significant differences between before and after the pole exercise (p<0.05). These tests would cover detail aspects of several human abilities in physiotherapy. Discussion and Conclusion: In current study, pole exercise seems to be clinically simple and easy method to perform. These results suggested that pole exercise including 6 movements would have clinical efficacy as to physical flexibility and exercise function in short period. Currently obtained data could become fundamental data for clinical application and research development in the future

Thymidine phosphorylase and dihydropyrimidine dehydrogenase are predictive factors of therapeutic efficacy of capecitabine monotherapy for breast cancerpreliminary results

Capecitabine monotherapy was administered for 25 patients with advanced or recurrent breast cancer, and the clinical therapeutic efficacy and its relationship to expression of 5-fluorouracil-related enzymes (i.e., thymidine phosphorylase (TP), thymidylate synthase (TS) and dihydropyrimidine dehydrogenase (DPD)) were investigated. The expressions of TP, TS and DPD were determined by immunohistochemical staining techniques and rated using a scoring system of 1～4. The expression score for TP/DPD showed a statistically significant correlation with the clinical response, whereas the expression score for TP/TS also showed a correlation but it was not statistically significant. The number of patients was small, but the results revealed the potential of application of the TP/DPD expression score as a factor for predicting the efficacy of the drug in individual patients

The Oxidative Esterification of Propionaldehyde to Methyl Propionate in the Liquid-Phase Using a Heterogeneous Palladium Catalyst

The optimization of the oxidative esterification of propionaldehyde to methyl propionate using a supported palladium catalyst in methanol under heavy-metal-free and pressurized-oxygen conditions, which we recently reported in a previous paper, were carried out together with a study of the reaction route, the nature of the catalytic active sites, and the effect of the support. In our previous paper, we reported significantly improved activity for oxidative esterification using commercially available 5%Pd/Al2O3 at 1.5 MPa of O2 gas and 333 K and emphasized that the doping of 5%Pd/Al2O3 with lead was not needed for the reaction system, but we could not improve the activity that was reported when using 5%Pd/γ-Al2O3 doped with 5% Pb (a 93.2% conversion of propionaldehyde, 76.8% selectivity for methyl propionate and a 71.6% yield of methyl propionate) at 0.3 MPa of O2 gas and 353 K, as reported by another laboratory. In the present study, however, we exceeded those values and obtained a 98.3% conversion of propionaldehyde, 75.3% selectivity for methyl propionate and a 74.0% yield of methyl propionate using 5%Pd/γ-Al2O3 undoped with Pb at 1.5 MPa of O2 gas and 333 K. It should be noted that, in the preparation of the present 5%Pd/γ-Al2O3, Pd was doped onto Al2O3 that had been previously treated with aqueous NaOH. Another active alumina support,η-Al2O3, prepared from boehmite, afforded activity that was substantially lower than that of γ-Al2O3 and depended on the calcination temperature of boehmite to η-Al2O3. When using various concentrations of CH3OH in the aqueous reaction solution, the oxidative esterification proceeded through the formation of propionic acid. To determine why the Al2O3 support afforded better activity than the active carbon support, Pd/Al2O3 and Pd/C catalysts were examined by XAFS (X-ray absorption fine structure). XAFS revealed that Pd on Al2O3 shows a better redox nature than Pd on C, which resulted in activity on Pd/Al2O3 that was better than that on Pd/C

Thirty percent of ductal carcinoma in situ of the breast in Japan is extremely low-grade ER(+)/HER2(-) type without comedo necrosis

Background Overdiagnosis in mammography (MMG) is a problem. Combination of MMG and ultrasonography for breast cancer screening may increase overdiagnosis. Most cases of overdiagnosis are low-grade ductal carcinoma in situ (LGD), but no reports have focused on them. Materials and methods We immunostained 169 ductal carcinoma in situ (DCIS) cases for ER, PgR, HER2 and Ki67 and classified them into 4 subtypes : ER(+)/ HER2(-), ER(+)/HER2(+), ER(-)/HER2(-) and ER(-)/HER2(+). The Ki67 index was used to evaluate the grade of malignancy and examined for correlations with each ER/HER2 subtype and the nuclear grade (NG), with/without comedo necrosis. Results The Ki67 index correlated significantly with NG, both with/without comedo necrosis, and reliably evaluated the grade of malignancy. The index for ER(+)/HER2(-) (n=117, 69.2%) was 7.45±7.10, which was significantly lower than for each of the other types. The index was 5.71±6.94 for ER(+)/HER2(-) without comedo necrosis (n=52, 30.8%), which was significantly lower than with comedo necrosis. This was considered LGD, characterized by absence of microcalcification in MMG and either presence of a solid mass or cystic lesion or absence of hypoechoic areas in ultrasound. Conclusion In Japan, ER(+)/HER2(-) without comedo necrosis accounts for about 30% of DCIS and is LGD. This may be being overdiagnosed

The ASTRO-H X-ray Observatory

The joint JAXA/NASA ASTRO-H mission is the sixth in a series of highly successful X-ray missions initiated by the Institute of Space and Astronautical Science (ISAS). ASTRO-H will investigate the physics of the high-energy universe via a suite of four instruments, covering a very wide energy range, from 0.3 keV to 600 keV. These instruments include a high-resolution, high-throughput spectrometer sensitive over 0.3-2 keV with high spectral resolution of Delta E < 7 eV, enabled by a micro-calorimeter array located in the focal plane of thin-foil X-ray optics; hard X-ray imaging spectrometers covering 5-80 keV, located in the focal plane of multilayer-coated, focusing hard X-ray mirrors; a wide-field imaging spectrometer sensitive over 0.4-12 keV, with an X-ray CCD camera in the focal plane of a soft X-ray telescope; and a non-focusing Compton-camera type soft gamma-ray detector, sensitive in the 40-600 keV band. The simultaneous broad bandpass, coupled with high spectral resolution, will enable the pursuit of a wide variety of important science themes.Comment: 22 pages, 17 figures, Proceedings of the SPIE Astronomical Instrumentation "Space Telescopes and Instrumentation 2012: Ultraviolet to Gamma Ray

Hitomi (ASTRO-H) X-ray Astronomy Satellite

The Hitomi (ASTRO-H) mission is the sixth Japanese x-ray astronomy satellite developed by a large international collaboration, including Japan, USA, Canada, and Europe. The mission aimed to provide the highest energy resolution ever achieved at E  >  2  keV, using a microcalorimeter instrument, and to cover a wide energy range spanning four decades in energy from soft x-rays to gamma rays. After a successful launch on February 17, 2016, the spacecraft lost its function on March 26, 2016, but the commissioning phase for about a month provided valuable information on the onboard instruments and the spacecraft system, including astrophysical results obtained from first light observations. The paper describes the Hitomi (ASTRO-H) mission, its capabilities, the initial operation, and the instruments/spacecraft performances confirmed during the commissioning operations for about a month

Equalization of the Occlusal State by Wearing a Mouthguard Contributes to Improving Postural Control Function

The aim of this study was to clarify the effect on the postural control function of equalizing the occlusal contact state by wearing a mouthguard. Method: Participants included 23 untrained adults, 11 gymnasts, and 10 weightlifters. Custom mouthguards were fabricated and adjusted so that all teeth were in even contact with light clenching. The standing postural control function was evaluated by the displacement of the center of foot pressure (COP) measured using a gravity center fluctuation meter. Measurement conditions were with and without a mouthguard. Statistical analyses were performed on the differences in COP displacement among participant groups and between mouthguard conditions and the difference in the reduction rate of COP displacement when wearing a mouthguard among participant groups. Results: COP significantly decreased in the order of untrained adults to weightlifters to gymnasts, irrespective of the mouthguard condition. The reduction rate in COP displacement after wearing a mouthguard was greatest in gymnasts. Conclusions: The effect of the mouthguard on postural control function was more pronounced in gymnasts than in untrained adults and weightlifters, and this study suggests that equalization of the occlusal state by wearing a mouthguard contributes to improving postural control function

Targeted elimination of mutated mitochondrial DNA by a multi-functional conjugate capable of sequence-specific adenine alkylation

ミトコンドリアの変異DNAを減らす化合物の開発. 京都大学プレスリリース. 2021-08-27.Deleting DNA to treat mitochondrial diseases. 京都大学プレスリリース. 2021-08-27.Mutations in mitochondrial DNA (mtDNA) cause mitochondrial diseases, characterized by abnormal mitochondrial function. Although eliminating mutated mtDNA has potential to cure mitochondrial diseases, no chemical-based drugs in clinical trials are capable of selective modulation of mtDNA mutations. Here, we construct a class of compounds encompassing pyrrole-imidazole polyamides (PIPs), mitochondria-penetrating peptide, and chlorambucil, an adenine-specific DNA-alkylating reagent. The sequence-selective DNA binding of PIPs allows chlorambucil to alkylate mutant adenine more efficiently than other sites in mtDNA. In vitro DNA alkylation assay shows that our compound 8950A-Chb(Cl/OH) targeting a nonpathogenic point mutation in HeLa S3 cells (m.8950G>A) can specifically alkylate the mutant adenine. Furthermore, the compound reduces the mtDNA possessing the target mutation in cultured HeLa S3 cells. The programmability of PIPs to target different sequences could allow this class of compounds to be developed as designer drugs targeting pathogenic mutations associated with mitochondrial diseases in future studies