821 research outputs found
Emerging strategies for environmental decontamination of the nosocomial fungal pathogen Candida auris
Wireless sensor network based system for underground chemical plume tracking, A
A real-time subsurface chemical plume monitoring and tracking system is being developed that uses wireless-sensor networking to automatically extract data from underground chemical sensors. This system is aimed at tracking plumes caused by the release of toxic chemicals and biological agents into the environment as a result of accidental spills and improper disposal. Current practice involves manual collection of samples from monitoring wells followed by laboratory analysis, an expensive process taking days to weeks; such a delay reduces the effectiveness of mitigation techniques as well. Virtual Sensor Networks (VSN), a novel resource efficient approach for sensor networking being developed to track the migrating underground plumes, will be applicable to a broad class of problems. Laboratory based experiments and simulations are in progress to demonstrate the feasibility of the approach for large-scale plume tracking.This research is supported in part by Army Research Office and the National Science Foundation.1st place, ISTeC Student Research Poster Contest (April 7, 2008)
Towards Reforming Sri Lanka Railways: Insights from International Experience and Industry Expert Opinion
Growing of the automobile industry and the demand for personal car use and chronic financial deficits in the balance sheets of rail operators have significantly affected the rail industry deterioration since 1970. However, gradual rail reforms were carried out by many countries to eliminate financial and operational issues and to develop their rail transportation systems. Sri Lanka has more than 150 years of history in railway operations, yet it is still in a weak position in terms of the operational efficiency and the financial position. The main purpose of this paper is to explore the key issues and root causes for the operational and financial deficiencies of Sri Lanka Railways and identify the best reform model in the light of world rail reform experiences and rail industry experts’ opinion. A semi-structured questionnaire was employed to interview twelve railway industry experts. Content analysis, Analytical Hierarchy Process (AHP) Method, and Policy Delphi Method were the main analytical techniques employed in the study. The results of the analysis showed that the vertical separation of the ownership between rail service operation and rail infrastructure provision is suitable for Sri Lanka Railways and, given the existing operational and financial characteristics, the reform steps should mostly be designed as in the case of the German- Sweden hybrid model of rail reforms
A Tale of Two Cities: Data and Configuration Variances in Robust Deep Learning
Deep neural networks (DNNs), are widely used in many industries such as image
recognition, supply chain, medical diagnosis, and autonomous driving. However,
prior work has shown the high accuracy of a DNN model does not imply high
robustness (i.e., consistent performances on new and future datasets) because
the input data and external environment (e.g., software and model
configurations) for a deployed model are constantly changing. Hence, ensuring
the robustness of deep learning is not an option but a priority to enhance
business and consumer confidence. Previous studies mostly focus on the data
aspect of model variance. In this article, we systematically summarize DNN
robustness issues and formulate them in a holistic view through two important
aspects, i.e., data and software configuration variances in DNNs. We also
provide a predictive framework to generate representative variances
(counterexamples) by considering both data and configurations for robust
learning through the lens of search-based optimization
Fluconazole resistance in Candida albicans is induced by Pseudomonas aeruginosa quorum sensing
Microorganisms employ quorum sensing (QS) mechanisms to communicate with each other within microbial ecosystems. Emerging evidence suggests that intraspecies and interspecies QS plays an important role in antimicrobial resistance in microbial communities. However, the relationship between interkingdom QS and antimicrobial resistance is largely unknown. Here, we demonstrate that interkingdom QS interactions between a bacterium, Pseudomonas aeruginosa and a yeast, Candida albicans, induce the resistance of the latter to a widely used antifungal fluconazole. Phenotypic, transcriptomic, and proteomic analyses reveal that P. aeruginosa’s main QS molecule, N-(3-Oxododecanoyl)-L-homoserine lactone, induces candidal resistance to fluconazole by reversing the antifungal’s effect on the ergosterol biosynthesis pathway. Accessory resistance mechanisms including upregulation of C. albicans drug-efflux, regulation of oxidative stress response, and maintenance of cell membrane integrity, further confirm this phenomenon. These findings demonstrate that P. aeruginosa QS molecules may confer protection to neighboring yeasts against azoles, in turn strengthening their co-existence in hostile polymicrobial infection sites
Effects of tea extracts on the colonization behaviour of Candida species:attachment inhibition and biofilm enhancement
Purpose. We assessed the effects of four different types of tea extracts (green, oolong, black and pu-erh tea) on cellular surface properties (hydrophobicity and auto-aggregation) and the colonization attributes (attachment and biofilm formation) of four strains of Candida albicans and three strains of Candida krusei. Methodology. The cellular surface properties were determined using spectrophotometry. The colonization activities were quantified using colorimetric viability assays and visualized using scanning electron microscopy (SEM) and confocal laser scanning microscopy (CLSM). Results. The tea extracts, in general, reduced the hydrophobicity (by 8-66%) and auto-aggregation (by 20-65%), and inhibited the attachment of two C. krusei strains (by 41-88%). Tea extracts enhanced the biofilm formation of one C. albicans and two C. krusei strains (by 1.4-7.5-fold). The observed reduction in hydrophobicity strongly correlated with the reduction in attachment of the two C. krusei strains (
Blockchain and smart contracts : a solution for payment issues in construction supply chains
The construction industry has dynamic supply chains with multiple suppliers usually engaged in short-term relationships. Government legislation, novel types of payment agreements, conventional information technology solutions, and supply chain management best practices have endeavoured to solve payment-related financial issues in the construction industry, which are mainly caused by the complexities of the construction supply chain. Nevertheless, payment-related issues persist as one of the key challenges in the industry. Applications of blockchain technology–a trusted, distributed data storing mechanism–along with smart contracts are gaining focus as solutions for complex interorganisational processes. A smart contract is a self-executing script that codifies a set of rules or agreements between multiple parties and runs across the blockchain network. This paper identifies the suitability of blockchain and smart contract technologies in solving payment issues in the construction industry. An expert forum of construction industry stakeholders served as the primary data collection method through a structured questionnaire. The key finding of the paper is that blockchain and smart contract powered solutions can significantly mitigate the payment and related financial issues in the construction industry, including partial payments, nonpayments, cost of finance, long payment cycle, retention, and security of payments
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