Collage Vol. I

JUDY COCHRAN: Editorial MICHAEL TANGEMAN: Haikus 2-5 ELISE ALBRECHT, CURTIS PLOWGIAN: French Calligrams 6 JASON VARDEN: Waiting 7 ALEXANDER GREEN: Photo 8 EDUARDO JARAMILLO: Formas violentas 9-11 GABRIELE DILLMANN: Photo 12 MICHAEL GOLDSBERG: Funf fur Ashley 13 MEGAN CARLSON: Fur Jared (German) 14 MAGGIE GLOVER: For Jared 14-15 CHRIS FAUR: Painting 16 LINDSEY ESHELMAN: Stuhl (The Chair) 17 HALLE THOMPSON, GWENN DOBOS: Les Bouches 18 JILL BOO: Lacheln (A Smile) 19 ALEXANDER GREEN: Photo 20 JULIA GRAWEMEYER: Villanelle 21, Expressions francaises (French Figures) 22-23, Pour me rappeler (So that I\u27d remember) 24 MICHEL CLIQUET: Photo 25 CHARLES O\u27KEEFE: Photos 26-28 LINE LERYCKE: Photos 29-32 MICHEL CLIQUET: Pierre docile (Docile Stone) 29-32 LOGAN FAVIA: Ataraxia 33 AVRITA SINGH: Absence 34 RACHEL GROTHEER: Compassion 35, Ligne (Line) 36, Nuit, douce nuit (Night, gentle night) 37, Rouge (Red) 38, Bonjour Bleu (Hello Blue) 39, Ligne courbe (Curved Line) 40 AMELIA DUNLAP: Compassion 41-42 KYLE SIMPSON: Separation 43 ALEXANDER GREEN: Photo 44 GWENN DOBOS: Ataraxia 45 SARAH SLOTKIN: Separation 46 CURTIS PLOWGIAN: Absence 47 ELISA VER MERRIS: Photo 48, Attachement (Attachment) 49 JENNIFER JOHNSON: Attachement (Attachment)50 ANNA KELLY: Compassion 51 RICHARD BANAHAN: Photo 52, Mon grand-pere et moit (My grandfather and me) 53 MEREDITH KATZ: Separation 54 BRENDA HEATER: Compassion 55 ZACHARY WALSH: Ataraxia 56 MICHEL CLIQUET: Photos 57-5

Collage Vol. II

JUDY COCHRAN: Editorial, 4-5 ROBERTA CHAPMEN: Photo, 6 ANITRA CHUGHTAI (Translations): Haikus, 7 CHARLES O\u27KEEFE: Photo, 8 MARK VANDERLINDE-ABERNATHY, ALYSSA LANDRY (Translator): Memories of a Spider (Les souvenirs d\u27une araignee), 9 MARK VANDERLINE-ABERNATHY, AMY NORSKOG (Translator): Tomato Fields (Champ de tomates), 10 SARAH BISHOP, HEFEDH ZANINA (Translator): Dear John (Cher John), 11 RYAN BUTZ (Translator): Basho\u27s Haiku, Issa\u27s Haiku, 12-13 JENNIFER HUMBERT, FADOUA EL BOUAMRAOUI (Translator): Pressed Lips (Levres Serrees), 15 ADELE REEVES (Translator): Contemporary song by Mr. Children, 16-17 BRODY PAGEL, GRACE DUGAR (Translator): The Lizard King (Le Roi Lezard), 18 JIMMY PIPKIN (Translator): In Love with You, 19 MOLLY ROSCOE: Saturday Night at Rusty\u27s (Samedi Soir a Rusty\u27s), 20 CHARLES O\u27KEEFE: Photo, 21 MATT MESSMER (Translator): Waseda University School Song, 22-23 TIMOTHY COOPER: Wenn du grosh bist… (When you\u27re Tall…), 24 DAVID HARMAN: Der Dunkle Stern (The Dark Star), 25 ANN TOWNSEND, JUDY COCHRAN (Translator): From a Window (D\u27une Fenetre), 26-27 SARA CAHILL: El sauce lloron (The Weeping Willow), 28-32 CHARLES O\u27KEEFE: Photo, 30 JENNIFER HUMBERT, MATT BISHOP: Past, Present (passe, present), 33 CAROL GENEYA KAPLAN, FADOUA EL BOUAMRAOUI (Translator): Une Autre Femme (Another Woman), 34-35 CHARLES O\u27KEEFE: Photo, 36 ANN TOWNSEND, JUDY COCHRAN (Translator): The Mowers (Les Faucheurs), 37 PRISCILLA PATON: Photo, 38 GONZALO TUESTA: La Grande Dame De Paris (The Great Lady of Paris), 39 SARAH PILLERDORF (Translator): Japanese Cartoons by Tezuka Osamu, 41-45 DANIELLE GERKEN: Schuhe der Heimat (Boots of Home), 47 CURTIS PLOWGIAN: Le peste de la langue francaise, 48-52 PRISCILLA PATON: Photo, 50 ZANE HOUSEHOLDER: Vive la Republique! (Film), 54 JENNIFER ZIMMER: EL tenis y las frustraciones (Tennis and Frustrations), La tumba de Ben (Ben\u27s Grave), 56-57 AUTUMN LOTZE: Times Square in the rain, 58-59 CHARLES O\u27KEEFE: Photo, 60 STEPHEN M. JULKA: Colors of the Earth, 61 THOMAS BRESSOUD: Java, 62 ERIC NELSON: World, 63 SARAH CLAPP (Translator): At a long day\u27s end (Natsume Soseki), A friend has come and is now leaving, Eating persimmons (Masaoka Shiki), 64 CHARLES O\u27KEEFE: Photo, 65 JOHN BURZYNSKI, MEGAN FETTER (Translator): Home is where the heart is, 66 RICHARD BANAHAN: Photo, 67 KIM FREEMAN: Baltimore, 68 JACOB RIDRIGUEZ-NOBLE: Home (Heimat), 69 SUZANNE KENNEDY: Oft verberge ich mich (Oft I hide myself), 70 RICHARD BANAHAN: Photo, 7

Caspase-11 promotes allergic airway inflammation

Activated caspase-1 and caspase-11 induce inflammatory cell death in a process termed pyroptosis. Here we show that Prostaglandin E2 (PGE2) inhibits caspase-11-dependent pyroptosis in murine and human macrophages. PGE2 suppreses caspase-11 expression in murine and human macrophages and in the airways of mice with allergic inflammation. Remarkably, caspase-11-deficient mice are strongly resistant to developing experimental allergic airway inflammation, where PGE2 is known to be protective. Expression of caspase-11 is elevated in the lung of wild type mice with allergic airway inflammation. Blocking PGE2 production with indomethacin enhances, whereas the prostaglandin E1 analog misoprostol inhibits lung caspase-11 expression. Finally, alveolar macrophages from asthma patients exhibit increased expression of caspase-4, a human homologue of caspase-11. Our findings identify PGE2 as a negative regulator of caspase-11-driven pyroptosis and implicate caspase-4/11 as a critical contributor to allergic airway inflammation, with implications for pathophysiology of asthm