Methods for measuring fluoroscopic skin dose

This paper briefly reviews available technologies for measuring or estimating patient skin dose in the interventional fluoroscopic environment

Anniversary Paper: A sampling of novel technologies and the role of medical physicists in radiation oncology

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/135037/1/mp1006.pd

An application of Bayesian statistical methods to adaptive radiotherapy

In adaptive radiotherapy, measured patient-specific setup variations are used to modify the patient setup and treatment plan, potentially many times during the treatment course. To estimate the setup adjustments and re-plan the treatment, the measured data are usually processed using Kalman filtering or by computing running averages. We propose, as an alternative, the use of Bayesian statistical methods, which combine a population (prior) distribution of systematic and random setup errors with the measurements to determine a patient-specific (posterior) probability distribution. The posterior distribution can either be used directly in the re-planning of the treatment or in the generation of statistics needed for adjustments. Based on the assumption that day-to-day setup variations are independent and identically distributed Normal distributions, we can efficiently compute parameters of the posterior distribution from parameters of the prior distribution and statistics of the measurements. We illustrate a simple procedure to apply the method in practice to adaptive radiotherapy, allowing for multiple adjustments of treatment parameters during the course of treatment.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/48981/2/pmb5_16_013.pd

Lateglacial shifts in seasonality reconcile conflicting North Atlantic temperature signals

The accelerating flux of glacial meltwater to the oceans due to global warming is a potential trigger for future climate disturbance. Past disruption of Atlantic Ocean circulation, driven by melting of land-based ice, is linked in models to reduced ocean-atmosphere heat transfer and abrupt cooling during stadial events. The most recent stadial, the Younger Dryas (YD), is traditionally viewed as a severe cooling centered on the North Atlantic but with hemispheric influence. However, indications of summer warmth question whether YD cooling was truly year-round or restricted to winter. Here, we present a beryllium-10-dated glacier record from the north-east North Atlantic, coupled with 2-D glacier-climate modeling, to reconstruct Lateglacial summer air temperature patterns. Our record reveals that, contrary to the prevailing model, the last glacial advance in Scotland did not occur during the YD but predated the stadial, while the YD itself was characterized by warming-driven deglaciation. We argue that these apparently paradoxical findings can be reconciled with regional and global climate events by invoking enhanced North Atlantic seasonality—with anomalously cold winters but warming summers—as an intrinsic response to globally increased poleward heat fluxes

Occupational Radiation Protection in Interventional Radiology: A Joint Guideline of the Cardiovascular and Interventional Radiology Society of Europe and the Society of Interventional Radiology

No Abstract

Genome Sequence of a Lancefield Group C Streptococcus zooepidemicus Strain Causing Epidemic Nephritis: New Information about an Old Disease

Outbreaks of disease attributable to human error or natural causes can provide unique opportunities to gain new information about host-pathogen interactions and new leads for pathogenesis research. Poststreptococcal glomerulonephritis (PSGN), a sequela of infection with pathogenic streptococci, is a common cause of preventable kidney disease worldwide. Although PSGN usually occurs after infection with group A streptococci, organisms of Lancefield group C and G also can be responsible. Despite decades of study, the molecular pathogenesis of PSGN is poorly understood. As a first step toward gaining new information about PSGN pathogenesis, we sequenced the genome of Streptococcus equi subsp. zooepidemicus strain MGCS10565, a group C organism that caused a very large and unusually severe epidemic of nephritis in Brazil. The genome is a circular chromosome of 2,024,171 bp. The genome shares extensive gene content, including many virulence factors, with genetically related group A streptococci, but unexpectedly lacks prophages. The genome contains many apparently foreign genes interspersed around the chromosome, consistent with the presence of a full array of genes required for natural competence. An inordinately large family of genes encodes secreted extracellular collagen-like proteins with multiple integrin-binding motifs. The absence of a gene related to speB rules out the long-held belief that streptococcal pyrogenic exotoxin B or antibodies reacting with it singularly cause PSGN. Many proteins previously implicated in GAS PSGN, such as streptokinase, are either highly divergent in strain MGCS10565 or are not more closely related between these species than to orthologs present in other streptococci that do not commonly cause PSGN. Our analysis provides a comparative genomics framework for renewed appraisal of molecular events underlying APSGN pathogenesis