SUSTAINING AGRICULTURAL PRODUCTION IN A DEREGULATED ECONOMY

This paper reuiews the policy framework for Nlgelian agriculture and gauges Its Impact plior to and since the commencement of economic deregulation. It investigates the prospects, analyses tile constraints and ouUlnes a feasible strategy for sustaining ag~icultural growth In a deregulated enabling environment. The paper notes that In the period, 1970 to 1982, the deterioration In ag~icultural pe1jormance In Nlge1ia was the result not only of extemal shocks and erwironmental and/or edaphfc foctors, but of distorted policy pursuits which created clislncentiues for farming. Howeuer, following attemptS to deregulate the economy with the adopUon of the Structural Adjustment Pl:o!P·amme In 1986 and the consequent eff01t to get price lncenUues right for agriculture, there was some Improvement in ag~icultural performance. It Is noted that agricultural sector growth has recently been lwmpered by increased costs 01ising mainly from genera/deregulation. An lnuestlgatlon of the resource base and prospects shows that ag~kulture can contlibute more to g~·owth than In recent years. But success wlll require engendering a conducive enabling environment and Incentives, avaliC!bility of technology and Inputs as well as Infrastructure. This calls for an oction plan which glues the prluate and Informal sectors bigger roles In the execution of development prog~·ammes. In addition, the public section would need to refocus current policies and priolitles with more uigorous implementation of known successful approoches based on factor endowments for stimulating growth

Distribution of Enzymes (Rhodanese, 3-Mercaptopyruvate Sulphurtransferase, Arginase And Thiaminase) in Some Commonly Consumed Plant Tubers in Nigeria.

Four different enzymes (Rhodanese, 3-mercaptopyruvate sulphurtransferase (3-MST) , Arginase and thiaminase) activities were detected in crude plant extracts of nine randomly selected plant tubers which includes sweet potato (Ipomoea batatas), irish potato (Solanum tuberosum), white yam, yellow yam, bitter yam (Diascorea bulbifera), sweet yam (Diascorea esculentu), water yam (Diascorea alata), cocoyam and cassava (Manihot esculentu) . In each case, the enzymes exhibited high activities. The p value activity of 3-MST varies significantly in the various plant tuber. White yam showed the highest activity with a mean of 0.2 which varies significantly when compared to, red cocoyam with a mean of 0.005. Arginase was also seen to vary significantly in the different plant samples with Irish potato having the highest mean value of activity while cassava showed the lowest mean value. Thiaminase activity varied significantly in the plant tubers. Cassava stem had the highest mean value of thiaminase activity while bitter yam peel showed the lowest mean value of activity. These studies confirm the activities and nutritional values of these enzymes in the commonly consumed plant tubers. Keywords: Plant Tubers, Arginase, Rhodanese, 3-Mercaptopyruvate Sulphurtransferase,        Thiaminase, Activity

Vitamin D3 Receptor Activation Rescued Corticostriatal Neural Activity and Improved Motor-Cognitive Function in −D2R Parkinsonian Mice Model

Background: fourth generation antipsychotics have been implicated in the blockade of calcium signalling through inhibition of dopamine receptive sites on dopaminergic D2 Receptor (D2R). As a result of the abnormal calcium signalling associated with D2R inhibition, changes occur in the motor and memory neural axis leading to the observed behavioural deficits after prolonged haloperidol. Thus, Vitamin D3 receptor (VD3R), a calcium controlling receptor in the striatum can be targeted to relief the neurological symptoms associated with haloperidol (−D2R) induced PD. Aim: This study sets to investigate the role of VD3R activation in vitro and in vivo after haloperidolinduced Dopaminergic (D2R) blockade. In addition, we examined the associated neural activity and behavioural changes in parkinsonian and VDRA intervention mice. Methods: Dopaminergic D2R inhibition was investigated in vitro using Melanocytes isolated from the scale of a Tilapia. In four separate set ups, the cells were cultured in calcium free Ringer’s solution as follows; 300 μM haloperidol, 100 μM VD3, 100 mM calcium chloride and a combination of 300 μM haloperidol and 100 μM VD3. Subsequently, dopaminergic vesicle accumulation and calcium signalling were observed in bright field microscopy using blue and green fluorescence probes. In the second phase, PD was induced in adult BALB/c mice (−D2; n = 8) after 14 days of intraperitoneal haloperidol treatment (10 mg/Kg). A set of n = 4 mice were untreated (−D2) while the other group (n = 4) received 100 mg/Kg of VD3 for 7 days (−D2/+VDR). The control groups (n = 4 each) were treated with normal saline (NS) and VD3 (+VDR) for 14 days. At the end of the treatment phase, the animals were assessed in Rotarod, parallel bar-, cylinder-, Y-Maze-, one trial place recognition- and novel object recognition-(NOR) tests. Neural activity was measured using chronic electrode implants placed in the M1 (motor cortex), CPu (striatum), CA1 (hippocampus) and PFC (prefrontal cortex). Neural activity was compared with the outcomes of behavioural tests for memory and motor functions and data was expressed as mean ± SEM (analysed using ANOVA with Tukey post-hoc test, significant level was set at 0.05). Results/Discussion: in vitro outcomes show that VDR increase calcium signalling and reverses the effect of haloperidol; specifically by reducing dopaminergic vesicle accumulation in the cell body. Similarly, in vivo neural recordings suggest an increase in calcium hyperpolarization currents in the CPu and PFC of intervention mice (−D2/+VDR) when compared with the parkinsonian mice (−D2). These animals (−D2/+VDR) also recorded an improvement in spatial working memory and motor function versus the Parkinsonian mice (−D2). These outcomes suggest the role of CPu-PFC corticostriatal outputs in the motor-cognitive decline seen in parkinsonian mice. Similarly, VDRA reduced the neural deficits through restoration of calcium currents (burst activities) in the intervention mice (−D2/+VDR). Conclusion: VDRA treatment reduced the motor-cognitive defects observed in haloperidol induced PD. Our findings suggest the role of VDRA in restoration of calcium currents associated with PFC and CPu corticostriatal outputs seen as burst frequencies in in vivo neural recording

GENDER-RELATED ALTERATIONS IN FREE FATTY ACIDS AND OXIDATIVE STRESS IN HYPERTENSION CO-MORBIDLY OCCURRING WITH TYPE 2 DIABETES MELLITUS

Increase in plasma free fatty acids (FFAs) concentrations may cause cellular damage via the induction of oxidative stress. The aim of this present study was to investigate FFAs and oxidative stress in hypertension co-morbidly occurring with Type 2 Diabetes Mellitus (T2DM). Age and sex matched control subjects (n=150) and patients (n=470) [hypertensive nondiabetics (HND, n=179), normotensive diabetics (ND, n=132), hypertensive diabetics (HD, n=159)] presenting at the Medical Out-Patient Clinic of the State Hospital, Abeokuta, Nigeria were recruited. Fasting plasma glucose, creatinine, urea, FFAs, thiobarbituric acid reactive substances (TBARS) were determined spectrophotometrically. The presence of either or both diseases resulted in significant increase (p<0.05) in the plasma FFAs and oxidative stress marker-TBARS in different compartments (plasma, erythrocytes andlipoproteins) for both male and female patients when compared with their control counterparts. The increase in FFAs was more marked in comorbidity female when compared with other female patients. There was significant (p<0.05) difference in gender FFAs concentrations. In both controls and patients, FFAs in plasma are significantly (p<0.05) higher in male when compared with their female counterparts. This research revealed biochemical variations in hypertension co-morbidly occurring with T2DMcharacterised by gender-related elevation in FFAs and enhanced oxidative stress. Plasma FFAs might be a good biomarker predicting the occurrence and development of hypertension and/or T2DM. &nbsp

Volume-Level Calibrations for Partially-filled Liquid Process and Storage Vessels: Metering for Complex Geometries

Process vessels utilized for liquids and liquid-phase processes are important in the chemical process industries as they are employed for a number of purposes which include use as reservoirs, surge tanks, transportation tankers and as reactors. It is therefore often desired to have real-time data about the liquid volume and level especially for partially-filled vessels. While obtaining volume-level data for filled tanks for common geometries are simple tasks, this is not so for partially-filled vessels with complex geometries. This paper therefore sets out to develop a useful theoretical tool which can assist process engineers with the task of calibrating process tanks for these complex yet widely-used geometries. The paper presents a mathematical analysis of these geometries and develops equations and charts which could be used to estimate tank volumes from given depth of liquid for any geometry of partially-filled process vessel. The paper also develops a useful methodology which can assist in the design and sizing of process vessels using the developed charts. The paper is unique in that it utilized a normalization technique in the mathematical analyses of the partially-filled process vessels. Fractional volume and fractional depth were introduced as key variables in addition to dimensionless geometric parameters

The WOMAN trial: clinical and contextual factors surrounding the deaths of 483 women following post-partum haemorrhage in developing countries.

BACKGROUND: Post-partum haemorrhage (PPH) is a leading cause of maternal death worldwide. The WOMAN trial assessed the effects of tranexamic acid (TXA) on death and surgical morbidity in women with PPH. The trial recorded 483 maternal deaths. We report the circumstances of the women who died. METHODS: The WOMAN trial recruited 20,060 women with a clinical diagnosis of PPH after a vaginal birth or caesarean section. We randomly allocated women to receive TXA or placebo. When a woman died, we asked participating clinicians to report the cause of death and to provide a short narrative of the events surrounding the death. We collated and edited for clarity the narrative data. RESULTS: Case fatality rates were 3.0% in Africa and 1.7% in Asia. Nearly three quarters of deaths were within 3 h of delivery and 91% of these deaths were from bleeding. Women who delivered outside a participating hospital (12%) were three times more likely to die (OR = 3.12, 95%CI 2.55-3.81) than those who delivered in hospital. Blood was often unavailable due to shortages or because relatives could not afford to buy it. Clinicians highlighted late presentation, maternal anaemia and poor infrastructure as key contributory factors. CONCLUSIONS: Although TXA use reduces bleeding deaths by almost one third, mortality rates similar to those in high income countries will not be achieved without tackling late presentation, maternal anaemia, availability of blood for transfusion and poor infrastructure

Change management: The case of the elite sport performance team

The effective and efficient implementation of change is often required for both successful performance and management survival across a host of contemporary domains. However, although of major theoretical and practical significance, research to date has overlooked the application of change management (hereafter CM) knowledge to the elite sport performance team environment. Considering that the success of ‘off-field’ sports businesses are largely dependent on the performances of their ‘on-field’ team, this article explores the application of current CM theorizing to this specific setting and the challenges facing its utility. Accordingly, we identify the need and importance of developing theory specific to this area, with practical application in both sport and business, through examination of current knowledge and identification of the domain's unique, dynamic and contested properties. Markers of successful change are then suggested to guide initial enquiry before the article concludes with proposed lines of research which may act to provide a valid and comprehensive theoretical account of CM to optimize the research and practice of those working in the field

Culture change in elite sport performance teams: Examining and advancing effectiveness in the new era

Reflecting the importance of optimizing culture for elite teams, Fletcher and Arnold (2011) recently suggested the need for expertise in culture change. Acknowledging the dearth of literature on the specific process, however, the potential effectiveness of practitioners in this area is unknown. The present paper examines the activity's precise demands and the validity of understanding in sport psychology and organizational research to support its delivery. Recognizing that sport psychologists are being increasingly utilized by elite team management, initial evidence-based guidelines are presented. Finally, to stimulate the development of ecologically valid, practically meaningful knowledge, the paper identifies a number of future research directions