Research on optimization-based design

Research on optimization-based design is discussed. Illustrative examples are given for cases involving continuous optimization with discrete variables and optimization with tolerances. Approximation of computationally expensive and noisy functions, electromechanical actuator/control system design using decomposition and application of knowledge-based systems and optimization for the design of a valve anti-cavitation device are among the topics covered

Execution of Multidisciplinary Design Optimization Approaches on Common Test Problems

A class of synthetic problems for testing multidisciplinary design optimization (MDO) approaches is presented. These test problems are easy to reproduce because all functions are given as closed-form mathematical expressions. They are constructed in such a way that the optimal value of all variables and the objective is unity. The test problems involve three disciplines and allow the user to specify the number of design variables, state variables, coupling functions, design constraints, controlling design constraints, and the strength of coupling. Several MDO approaches were executed on two sample synthetic test problems. These approaches included single-level optimization approaches, collaborative optimization approaches, and concurrent subspace optimization approaches. Execution results are presented, and the robustness and efficiency of these approaches an evaluated for these sample problems

A family of octamer-specific proteins present during mouse embryogenesis: Evidence for germline-specific expression of an Oct factor.

We have analysed various adult organs and different developmental stages of mouse embryos for the presence of octamer-binding proteins. A variety of new octamer-binding proteins were identified in addition to the previously described Oct1 and Oct2. Oct1 is ubiquitously present in murine tissues, in agreement with cell culture data. Although Oct2 has been described as a B-cell-specific protein, similar complexes were also found with extracts from brain, kidney, embryo and sperm. In embryo and brain at least two other proteins, Oct3 and Oct7, are present. A new microextraction procedure allowed the detection of two maternally expressed octamer-binding proteins, Oct4 and Oct5. Both proteins are present in unfertilized oocytes and embryonic stem cells, the latter containing an additional protein, Oct6. Whereas Oct4 was not found in sperm or testis, it is expressed in male and female primordial germ cells. Therefore Oct4 expression is specific for the female germline at later stages of germ cell development. Our results indicate that a family of octamer-binding proteins is present during mouse development and is differentially expressed during early embryogenesis. Protease clipping experiments of Oct4 and Oct1 suggest that both proteins contain similar DNA-binding domains

Octamer binding proteins confer transcriptional activity in early mouse embryogenesis.

Oct4 and Oct5 are two mouse maternally expressed proteins binding to the octamer motif. Both are found in unfertilized oocytes and embryonic stem cells, whereas Oct4 is also found in primordial germ cells. In this study, the activity of the octamer motif was analysed in two embryonic stem cell lines containing Oct4 and Oct5, the teratocarcinoma-derived cell line F9 and the blastocyst-derived cell line D3. It is known that oligomerization of the octamer motif creates a powerful B-cell specific enhancer. As shown here, this oligomerized transcriptional element is also a very strong enhancer in F9 and D3 embryonic stem cells. After differentiation of the stem cells, both enhancer activity and the amount of the octamer binding proteins decrease. An intact octamer stimulates heterologous promoters in embryonic stem cells, whereas mutations in the octamer motif abolish transcriptional stimulation and binding of the octamer factors. The use of transgenic embryos demonstrates transcriptional activation in the inner cell mass but not in the trophoblast of blastocysts. The results indicate that Oct4 and Oct5 are active early in mouse development

Monetary Policy, Regulation and Volatile Markets

Turmoil in financial markets causes reflection. Is monetary policy conducted in the most efficient way? Are regulatory and supervisory arrangements adequate when market volatility increases and financial institutions come under stress? In the present SUERF Study, we have collected the reflections by an outstanding group of top officials, researchers and observers. The editors are proud to be able to present their joint insights to SUERF readers. The papers were presented at the 27th SUERF Colloquium in Munich in June 2008: New trends in asset management: Exploring the implications.Financial markets, volatility, regulatory and supervisory arrangements, LATW, bubbles, monetary policy, asset prices, interest rate policy, LTCM, Basel II, MiFID, subprime, CDOs

Torn Between Two Plates: Exhumation of the Cer Massif (Internal Dinarides) as a Far‐Field Effect of Carpathian Slab Rollback Inferred From 40 Ar/ 39 Ar Dating and Cross Section Balancing

Abstract Extension across the southern Pannonian Basin and the internal Dinarides is characterized by Oligo‐Miocene metamorphic core complexes (MCCs) exhumed along mylonitic low‐angle extensional shear zones. Cer MCC at the transition between Dinarides and Pannonian Basin occupies a structural position within the distal‐most Adriatic thrust sheet and originates from two different tectonic processes: Late Cretaceous‐Paleogene nappe‐stacking during a continent‐continent collision with Adria in a lower plate position, and exhumation related to Miocene extension driven by the Carpathian slab‐rollback. Structural data and a balanced cross section across the Cer massif show linking of the exhuming shear zone to a breakaway fault, which reactivated the early Late Cretaceous most internal nappe contact. Paleozoic greenschist‐to amphibolite‐grade lithologies surround a polyphase intrusion composed of I‐ and S‐type granites and were exhumed along a shear zone characterized by top‐N transport. Thermobarometric analyses indicate an intrusion depth of 7–8 km of the Oligocene I‐type granite; cooling below ∼500°C occurred at 25.4 ± 0.6 Ma (1σ) yielded by 40 Ar/ 39 Ar dating of hornblende. Biotite and white mica from this intrusion as well as from the mylonitic shear zone yield 40 Ar/ 39 Ar cooling ages of 17–18 Ma independent of the used techniques (in situ laser ablation, single‐grain total fusion, single‐grain step heating, and multi‐grain step heating). White mica from the S‐type granite yield an 40 Ar/ 39 Ar cooling age of 16.7 ± 0.1 Ma (1σ). Associated dikes intruding the shear zone were also affected by N‐S extension resulting in the exhumation of the MCC, which was triggered by the opening of the Pannonian back‐arc basin in response to the Carpathian slab‐rollback.Plain Language Summary Horizontal stretching of continental plates induces thinning of the crustal upper part, melting of rocks, the sinking of the land surface, and formation of large basins. One of the world's best‐studied basins formed by such a process is the Central European Pannonian Basin. This basin is surrounded by the mountain belts of the Alps, Carpathians, and Dinarides. We have studied rocks between the Pannonian Basin and the southerly adjacent Dinaride Mountains, where rocks deposited in the basin are found right next to rocks that were initially about 7–8 km deep in the crust. These rocks are separated by a shear zone, along which they were brought to the surface. We have dated the activity of the shear zone by measuring concentrations of radioactive isotopes and their decay products contained in deformed minerals. The shear zone was active at a time when the Pannonian Basin started to open due to tectonic processes further NE underneath the Carpathian mountain chain. We also found evidence that the shear zone, which brought metamorphic rocks upwards was formerly one that brought rocks downwards into the crust during an earlier phase of mountain building, predating basin formation.Key Points Activity along the shear zone exhuming Cer metamorphic core complex in the internal Dinarides was dated by 40 Ar/ 39 Ar geochronology to ∼17 Ma Exhumation was facilitated by extensional reactivation of Late Cretaceous‐Paleogene nappe contacts resulting from Adria‐Europe collision Extensional reactivation of the thrusts is interpreted as a far‐field effect of Oligo‐Miocene Carpathian slab rollbac

Sub-kelvin temperature management in ion traps for optical clocks

The uncertainty of the ac Stark shift due to thermal radiation represents a major contribution to the systematic uncertainty budget of state-of-the-art optical atomic clocks. In the case of optical clocks based on trapped ions, the thermal behavior of the rf-driven ion trap must be precisely known. This determination is even more difficult when scalable linear ion traps are used. Such traps enable a more advanced control of multiple ions and have become a platform for new applications in quantum metrology, simulation and computation. Nevertheless, their complex structure makes it more difficult to precisely determine its temperature in operation and thus the related systematic uncertainty. We present here scalable linear ion traps for optical clocks, which exhibit very low temperature rise under operation. We use a finite-element model refined with experimental measurements to determine the thermal distribution in the ion trap and the temperature at the position of the ions. The trap temperature is investigated at different rf-drive frequencies and amplitudes with an infrared camera and integrated temperature sensors. We show that for typical trapping parameters for $\mathrm{In}^{+}$, $\mathrm{Al}^{+}$, $\mathrm{Lu}^{+}$, $\mathrm{Ca}^{+}$, $\mathrm{Sr}^{+}$ or $\mathrm{Yb}^{+}$ ions, the temperature rise at the position of the ions resulting from rf heating of the trap stays below 700 mK and can be controlled with an uncertainty on the order of a few 100 mK maximum.Comment: 18 page

Cardiac index monitoring by pulse contour analysis and thermodilution after pediatric cardiac surgery

ObjectivesTo validate a new device (PiCCO system; Pulsion Medical Systems, Munich, Germany), we compared cardiac index derived from transpulmonary thermodilution and from pulse contour analysis in pediatric patients after surgery for congenital heart disease. We performed a prospective clinical study in a pediatric cardiac intensive care unit of a university hospital.MethodsTwenty-four patients who had had cardiac surgery for congenital heart disease (median age 4.2 years, range 1.4-15.2 years) were investigated in the first 24 hours after admission to the intensive care unit. A 3F thermodilution catheter was inserted in the femoral artery. Intracardiac shunts were excluded by echocardiography intraoperatively or postoperatively. Cardiac index derived from pulse contour analysis was documented in each patient 1, 4, 8, 12, 16, 20, and 24 hours after admission to the intensive care unit. Subsequently, a set of three measurements of thermodilution cardiac indices derived by injections into a central venous line was performed and calculated by the PiCCO system.ResultsThe mean bias between cardiac indices derived by thermodilution and those derived by pulse contour analysis over all data points was 0.05 (SD 0.4) L · min · m−2 (95% confidence interval 0.01-0.10). A strong correlation between thermodilution and contour analysis cardiac indices was calculated (Pearson correlation coefficient r = 0.93; coefficient of determination r2 = 0.86).ConclusionsPulse contour analysis is a suitable method to monitor cardiac index over a wide range of indices after surgery for congenital heart disease in pediatric patients. Pulse contour analysis allows online monitoring of cardiac index. The PiCCO device can be recalibrated with the integrated transpulmonary thermodilution within a short time frame

Quantum beat spectroscopy of repulsive Bose polarons

The physics of impurities in a bosonic quantum environment is a paradigmatic and challenging many-body problem that remains to be understood in its full complexity. Here, this problem is investigated for impurities with strong repulsive interactions based on Ramsey interferometry in a quantum degenerate gas of 39K atoms. We observe an oscillatory signal that is consistent with a quantum beat between two co-existing coherent quasiparticle states: the attractive and repulsive polarons. The interferometric signal allows us to extract the polaron energies for a wide range of interaction strengths, complimenting earlier spectroscopic measurements. We furthermore identify several dynamical regimes towards the formation of the Bose polaron in good agreement with theory. Our results improve the understanding of quantum impurities interacting strongly with a bosonic environment, and demonstrate how quasiparticles as well as short-lived non-equilibrium many-body states can be probed using Ramsey interferometry