Isocurvature fluctuations in the effective Newton's constant

We present a new isocurvature mode present in scalar-tensor theories of gravity that corresponds to a regular growing solution in which the energy of the relativistic degrees of freedom and the scalar field that regulates the gravitational strength compensate during the radiation dominated epoch on scales much larger than the Hubble radius. We study this isocurvature mode and its impact on anisotropies of the cosmic microwave background for the simplest scalar-tensor theory, i.e. the extended Jordan-Brans-Dicke gravity, in which the scalar field also drives the acceleration of the Universe. We use Planck data to constrain the amplitude of this isocurvature mode in the case of fixed correlation with the adiabatic mode and we show how this mode could be generated in a simple two field inflation model.Comment: Version updated to match published version. No changes in the result

Phantom scalar-tensor models and cosmological tensions

We study three different extended scalar-tensor theories of gravity by also allowing a negative sign for the kinetic term for the scalar field in the Jordan frame. Our scope is to understand how the observational constraints for these models cope with the volume of the parameter space in which the theory is healthy. Models with a negative kinetic term lead to decreasing effective gravitational constant with redshift and behave as an effective relativistic component with a negative energy density as opposite to their corresponding version with a standard kinetic term. As a consequence, we find that the extended branch with a negative sign for the kinetic term correspond in general to lower $H_0$ and $\sigma_8$ compared to $\Lambda$CDM. We find that in all the cases with a negative sign for the kinetic term studied here, cosmological observations constrain these models around GR and prefer a volume of the parameter space in which the theory is not healthy since the scalar field behave as a ghost also in the related Einstein frame. We show that also in the phantom branch early modify gravity with a quartic coupling can substantially reduce the $H_0$ tension fitting the combination of cosmic microwave background data from Planck, baryon acoustic oscillations from BOSS and eBOSS, and Supernovae from the Pantheon sample with calibration information by SH0ES.Comment: 33 pages, 11 figures, 6 table

Cosmological effects of the Galileon term in Scalar-Tensor Theories

We study the cosmological effects of a Galileon term in scalar-tensor theories of gravity. The subset of scalar-tensor theories considered are characterized by a non-minimal coupling $F(\sigma) R$, a kinetic term with arbitrary sign $Z (\partial \sigma)^2$ with $Z = \pm 1$, a potential $V(\sigma)$, and a Galileon term $G_3(\sigma, (\partial \sigma)^2) \square \sigma$. In addition to the modified dynamics, the Galileon term provides a screening mechanism to potentially reconcile the models with General Relativity predictions inside a Vainshtein radius. Thanks to the Galileon term, the stability conditions, namely ghost and Laplacian instabilities, in the branch with a negative kinetic term ($Z = -1$) are fulfilled for a large volume of the parameter space. Solving numerically the background evolution and linear perturbations, we derive the constraints on the cosmological parameters in presence of a Galileon term for different combination of the cosmic microwave background (CMB) data from Planck, baryon acoustic oscillations (BAO) measurements from BOSS, and supernovae from the Pantheon compilation. We find that the Galileon term alters the dynamics of all the studied cases. For a standard kinetic term ($Z = 1$), we find that Planck data and a compilation of BAO data constrain the Galileon term to small values that allow screening very inefficiently. For a negative kinetic term ($Z = -1$), a Galileon term and a non-zero potential lead to an efficient screening in a physically viable regime of the theory, with a value for the Hubble constant today which alleviates the tension between its CMB and local determinations. For a vanishing potential, the case with $Z=-1$ and the Galileon term driving the late acceleration of the Universe is ruled out by Planck data.Comment: 23 pages, 15 figures, 4 table

Planck 2018 results. XI. Polarized dust foregrounds

The study of polarized dust emission has become entwined with the analysis of the cosmic microwave background (CMB) polarization in the quest for the curl-like B-mode polarization from primordial gravitational waves and the low-multipole E-mode polarization associated with the reionization of the Universe. We used the new Planck PR3 maps to characterize Galactic dust emission at high latitudes as a foreground to the CMB polarization and use end-to-end simulations to compute uncertainties and assess the statistical significance of our measurements. We present Planck EE, BB, and TE power spectra of dust polarization at 353 GHz for a set of six nested high-Galactic-latitude sky regions covering from 24 to 71% of the sky

Fatal poisoning of four workers in a farm: Distribution of hydrogen sulfide and thiosulfate in 10 different biological matrices

We evaluate the distribution of sulfide and thiosulfate (TS) in biological samples of four dairy farmers died inside a pit connected to a manure lagoon. Autopsies were performed 4 days later. Toxicological analyses of sulfide and TS were made using an extractive alkylation technique combined with gas chromatography/mass spectrometry (GC/MS). Autopsies revealed: multiorgan congestion; pulmonary edema; manure inside distal airways of three of the four victims. Sulfide concentrations were cardiac blood: 0.5–3.0 μg/mL, femoral blood: 0.5–1.2 μg/mL, bile: <0.1–2.2 μg/mL; liver 2.8–8.3 μg/g, lung: 5.0–9.4 μg/g, brain: 2.7–13.9 μg/g, spleen: 3.3–6.3 μg/g, fat: <0.1–1.5 μg/g, muscle: 2.6–3.5 μg/g. TS concentrations were cardiac blood: 2.1–4.9 μg/mL, femoral blood: 2.1–2.3 μg/mL, bile: 2.5–4.4 μg/mL, urine: <0.5–1.8 μg/mL; liver <0.5–2.6, lung: 2.8–5.4 μg/g, brain: <0.5–1.9 μg/g, spleen: 1.2–2.9 μg/g, muscle: <0.5–5.6 μg/g. The cause of death was assessed to be acute poisoning by hydrogen sulfide (H2S) for all the victims. Manure inhalation contributed to the death of three subjects. The measurement of sulfide and TS concentrations in biological samples contributed to better understand the sequence of the events. Subjects 3 provided the highest concentration of sulfide in brain, thus, supporting the hypothesis of a rapid loss of consciousness and respiratory depression. One by one, the other farmers entered the pit in attempts to rescue the coworkers but collapsed. Despite the rapid death, subject 3 was the only one with TS detectable in urine. This could be due to differences in metabolism of H2S

Bronchoalveolar lavage causes decrease in PaO2, increase in (A-a) gradient value and bronchoconstriction in asthmatics.

7siAbstract The aims of this study were to (1) record the changes of (arterial oxygen partial pressure) PaO2, (arterial carbon dioxide partial pressure) PaCO2, (percentage saturation of haemoglobin with oxygen in arterial blood) SaO2 and alveolar-arterial (A-a) oxygen gradiant resulting from bronchoalveolar lavage (BAL) in asthmatic and normal subjects; (2) measure changes in forced expiratory volume in 1 s (FEV1), vital capacity forced (FVC) associated with BAL; and (3) assess possible predictive factors for the degree of hypoxaemia and impairment of spirometry resulting from BAL. Bronchoscopy and BAL (150 ml) were performed in 24 asthmatics and 15 healthy subjects. Serial arterial blood samples (radial artery) were obtained in all subjects: T1 and before T2 after local anaesthesia; T3 at end of bronchoscopy; T4 after BAL and 5 min, 15 min, 1 h, 2 h, 8 h and 24 h (T5-T10) after the procedure, FEV1 and FVC were measured immediately before and 5 min afer bronchoscopy. Baseline PaO2 was lower in asthmatics (10.2 +/- 0.8 kPa) than in healthy subjects (10.8 +/- 0.8). Both groups showed a significant decrease in PaO2, and a significant widening in (A-a) oxygen tension gradiant at T3-9, with respect to T1 (P < 0.05). PaO2 reached a significantly lower value in asthmatics (7.1 +/- 0.6 kPa) than in HS (7.7 +/- 0.5; P < 0.05). In asthmatics, FEV1, FVC and the ratio FEV1/FVC decreased significantly after BAL (P < 0.001). In healthy subjects, FEV1 and FVC decreased significantly (P < 0.001), whereas FEV1/FVC did not. The fall in FEV1 after BAL was significantly greater in asthmatics (32.4 +/- 10.0%) than in healthy subjects (17.7 +/- 4.6; P < 0.001). Severity of asthma, basline FEV1 or initial PaO2 did not predict the degree of hypoxaemia or the fall of FEV1. It is concluded that BAL causes more severe hypoxaemia and a greater decrease in FEV1 in asthmatics compared to healthy subjects, strongly supporting the recommendation of special caution and careful monitoring when BAL is undertaken in asthmatics.nonemixedSPANEVELLO A; MIGLIORI GB; SATTA A; SHARARA A; BALLARDINI L; IND PW; NERI M.Spanevello, Antonio; Migliori, Gb; Satta, A; Sharara, A; Ballardini, L; Ind, Pw; Neri, M

Improved overall survival in dendritic cell vaccination-induced immunoreactive subgroup of advanced melanoma patients

BACKGROUND: We present our experience of therapeutic vaccination using dendritic cells (DC) pulsed with autologous tumor antigens in patients with advanced melanoma. METHODS: Twenty-one pretreated advanced melanoma patients were vaccinated with autologous DC pulsed with 100 μg/ml of autologous-tumor-lysate (ATL) or – homogenate (ATH) and 50 μg/ml of keyhole limpet hemocyanin (KLH). The first 8 patients were treated subcutaneously or intradermally with immature-DC (iDC) (range 4.5 – 82 × 10(6)) and the remaining 13 intradermally with in vitro matured DC (mDC) (range 1.2–26 × 10(6)). Subcutaneous interleukin-2 (3 × 10(6 )IU) was administered from days 3 to 7 of each treatment cycle. RESULTS: Three of the 8 iDC patients obtained stabilizations (SD), each of 6 months' duration. The 13 mDC patients showed 1 complete response (8 months), 1 partial response (3 months), 2 mixed responses (6 and 12 months) and 3 SD (9, 7+, and 3+ months). Overall responses (OR) were observed in 4/21 (19%) patients, or 4/13 (30.7%) considering mDC treatment only. 10/21 (47.6%) patients showed non progressive disease (NPD), with 7/13 (53.8%) cases of NPD for mDC-treated patients. No major toxicities were observed. The positive delayed-type hypersensitivity (DTH) test to ATL/ATH and/or KLH correlated with increased overall survival (OS). Median OS was 24 months (range 3 – 45) for the 10 DTH-positive (1 iDC and 9 mDC) and 5 months (range 3–14) for the 11 DTH-negative patients (P < 0.001). The in vitro evaluation of gamma IFN-secreting T-cells in 10 patients showed good correlation with both DTH (75%) and clinical outcome (70%). CONCLUSION: Vaccination using DC pulsed with ATL/ATH and KLH in advanced melanoma patients is well tolerated and can induce a clinical response, especially when mDC are used. Successful immunization, verified by positive DTH, leads to longer survival

Planck 2018 results VIII. Gravitational lensing

We present measurements of the cosmic microwave background (CMB) lensing potential using the final Planck 2018 temperature and polarization data. Using polarization maps filtered to account for the noise anisotropy, we increase the significance of the detection of lensing in the polarization maps from 5σ to 9σ. Combined with temperature, lensing is detected at 40σ. We present an extensive set of tests of the robustness of the lensing-potential power spectrum, and construct a minimum-variance estimator likelihood over lensing multipoles 8 ≤ L ≤ 400 (extending the range to lower L compared to 2015), which we use to constrain cosmological parameters. We find good consistency between lensing constraints and the results from the Planck CMB power spectra within the ΛCDM model. Combined with baryon density and other weak priors, the lensing analysis alone constrains σ8Ωm0.25 = 0.589 ± 0.020 (1σ errors)