Strickly finite-range potential for light and heavy nuclei

Strictly finite-range (SFR) potentials are exactly zero beyond their finite range. Single-particle energies and densities, as well as S-matrix pole trajectories, are studied in a few SFR potentials suited for the description of neutrons interacting with light and heavy nuclei. The SFR potentials considered are the standard cutoff Woods-Saxon (CWS) potentials and two potentials approaching zero smoothly: the SV potential introduced by Salamon and Vertse [Phys. Rev. C 77, 037302 (2008)] and the SS potential of Sahu and Sahu [Int. J. Mod. Phys. E 21, 1250067 (2012)]. The parameters  of these latter potentials were set so that the potentials may be similar to the CWS shape. The range of the SV and SS potentials scales with the cube root of the mass number of the core like the nuclear radius itself. For light nuclei a single term of the SV potential (with a single parameter) is enough for a good description of the neutron-nucleus interaction. The trajectories are compared with a benchmark for which the starting points (belonging to potential depth zero) can be determined independently. Even the CWS potential is found to conform to this benchmark if the range is identified with the cutoff radius. For the CWS potentials some trajectories show irregular shapes, while for the SV and SS potentials all trajectories behave regularly.Fil: Salamon, P.. MTA Institute for Nuclear Research; HungríaFil: Lovas, R. G.. MTA Institute for Nuclear Research; HungríaFil: Id Betan, Rodolfo Mohamed. Universidad Nacional de Rosario. Facultad de Ciencias Exactas, Ingeniería y Agrimensura; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Rosario. Instituto de Física de Rosario (i); ArgentinaFil: Vertse, T.. MTA Institute for Nuclear Research; Hungría. University of Debrecen. Faculty of Informatics; HungríaFil: Balkay, L.. University of Debrecen. Medical and Health Science Center. Institute of Nuclear Medicine; Hungrí

Arte e moda : algumas conexões possíveis

Orientação: Carla Beatriz Franco Ruschman

FDG, [ F]FLT, [ F]FAZA, and C-Methionine Are Suitable Tracers for the Diagnosis and Follow-Up of the Efficacy of Chemotherapy by miniPET in Both Multidrug Resistant and Sensitive Human Gynecologic Tumor Xenografts

Expression of multidrug pumps including P-glycoprotein (MDR1, ABCB1) in the plasma membrane of tumor cells often results in decreased intracellular accumulation of anticancer drugs causing serious impediment to successful chemotherapy. It has been shown earlier that combined treatment with UIC2 anti-Pgp monoclonal antibody (mAb) and cyclosporine A (CSA) is an effective way of blocking Pgp function. In the present work we investigated the suitability of four PET tumor diagnostic radiotracers including 2-[F-18] fluoro-2-deoxy-D-glucose ((18)FDG), C-11-methionine, 3 '-deoxy-3 '-[F-18] fluorothymidine (F-18-FLT), and [F-18] fluoroazomycin-arabinofuranoside ((18)FAZA) for in vivo follow-up of the efficacy of chemotherapy in both Pgp positive (Pgp(+)) and negative (Pgp(-)) human tumor xenograft pairs raised in CB-17 SCID mice. Pgp(+) and Pgp(-) A2780AD/A2780 human ovarian carcinoma and KB-V1/KB-3-1 human epidermoid adenocarcinoma tumor xenografts were used to study the effect of the treatment with an anticancer drug doxorubicin combined with UIC2 and CSA. The combined treatment resulted in a significant decrease of both the tumor size and the accumulation of the tumor diagnostic tracers in the Pgp(+) tumors. Our results demonstrate that (18)FDG, F-18-FLT, (18)FAZA, and C-11-methionine are suitable PET tracers for the diagnosis and in vivo follow-up of the efficacy of tumor chemotherapy in both Pgp(+) and Pgp(-) human tumor xenografts by miniPET