Caracterização de produtores de leite orgânico e em transição agroecológica do Distrito Federal e Regiões Integradas do entorno - Brasil.

Foi elaborada uma pesquisa de campo utilizando o instrumento de diagnóstico rápido participativo-DRP, desenvolvido para colher informações relacionadas a produção de leite orgânico e em transição agroecológica a fim de caracterizar unidades familiares na região do Distrito Federal e integrada do entorno (DF-RIDE), Brasil. Com estas ações foi possível mapear os produtores na atividade, como também identificar gargalos da produção a partir dos índices estimados, e relacioná-los com a importância da conservação das pastagens por meio de parâmetros econômicos e técnicos das unidades produtivas da região enfatizando e relacionando-as com o manejo de pastagens agroecológicas nesses sistemas de produção. O instrumento utilizado auxiliou o produtor de leite a melhor observar suas atividades técnicas e econômicas, promovendo melhorias na gestão da propriedade. Foi possível ainda construir de forma participativa, métodos alternativos para melhorar o manejo de pastagens. Abstract: Was elaborate field research using the instrument of participatory rapid diagnosis-DRP, developed to gather information related to organic milk production and agroecological transition and characterize family units in the Federal District and surroundings integrated region (DF-RIDE), Brazil. With these actions was possible to map producers in activity, as well as identify bottlenecks of production from the estimated indices, and relates them with the importance of the pastures conservation, through economic and technical parameters of the productive units in the region emphasizing and relating it to the management of pastures in agroecological production systems. The instrument used assisted the milk producer to better observe their technical and economic activities, promoting improvements in the management of the property. It was still possible to build in a participative manner, alternative methods to improve pasture management

Patient-reported outcomes and patient-reported outcome measures in interstitial lung disease: Where to go from here?

Patient-reported outcome measures (PROMs), tools to assess patient self-report of health status, are now increasingly used in research, care and policymaking. While there are two well-developed disease-specific PROMs for interstitial lung diseases (ILD) and idiopathic pulmonary fibrosis (IPF), many unmet and urgent needs remain. In December 2019, 64 international ILD experts convened in Erice, Italy to deliberate on many topics, including PROMs in ILD. This review summarises the history of PROMs in ILD, shortcomings of the existing tools, challenges of development, validation and implementation of their use in clinical trials, and the discussion held during the meeting. Development of disease-specific PROMs for ILD including IPF with robust methodology and validation in concordance with guidance from regulatory authorities have increased user confidence in PROMs. Minimal clinically important difference for bidirectional changes may need to be developed. Cross-cultural validation and linguistic adaptations are necessary in addition to robust psychometric properties for effective PROM use in multinational clinical trials. PROM burden of use should be reduced through appropriate use of digital technologies and computerised adaptive testing. Active patient engagement in all stages from development, testing, choosing and implementation of PROMs can help improve probability of success and further growth

First experimental evidence of one-dimensional plasma modes in superconducting thin wires

We have studied niobium superconducting thin wires deposited onto a SrTiO$_{3}$ substrate. By measuring the reflection coefficient of the wires, resonances are observed in the superconducting state in the 130 MHz to 4 GHz range. They are interpreted as standing wave resonances of one-dimensional plasma modes propagating along the superconducting wire. The experimental dispersion law, $\omega$ versus $q$, presents a linear dependence over the entire wave vector range. The modes are softened as the temperature increases close the superconducting transition temperature. Very good agreement are observed between our data and the dispersion relation predicted by Kulik and Mooij and Sch\"on.Comment: Submitted to Physical review Letter

A Real-Life Multicenter National Study on Nintedanib in Severe Idiopathic Pulmonary Fibrosis

Background: Two therapeutic options are currently available for patients with mild-to-moderate idiopathic pulmonary fibrosis (IPF): pirfenidone and nintedanib. To date, there is still insufficient data on the efficacy of these 2 agents in patients with more severe disease. Objectives: This national, multicenter, retrospective real-life study was intended to determine the impact of nintedanib on the treatment of patients with severe IPF. Methods: All patients included had severe IPF and had to have at least 6 months of follow-up before and at least 6 months of follow-up after starting nintedanib. The aim of the study was to compare the decline in lung function before and after treatment. Patient survival after 6 months of therapy with nintedanib was assessed. Results: Forty-one patients with a forced vital capacity (FVC) 6450% and/or a diffusing capacity of the lung for carbon monoxide (DLCO) 6435% predicted at the start of nintedanib treatment were enrolled. At the 6-month follow-up, the decline of DLCO (both absolute and % predicted) was significantly reduced compared to the pretreatment period (absolute DLCO at the -6-month, T0, and +6-month time points (5.48, 4.50, and 5.03 mmol/min/kPa, respectively, p = 0.03; DLCO% predicted was 32.73, 26.54, and 29.23%, respectively, p = 0.04). No significant beneficial effect was observed in the other functional parameters analyzed. The 1-year survival in this population was 79%, calculated from month 6 of therapy with nintedanib. Conclusions: This nationwide multicenter experience in patients with severe IPF shows that nintedanib slows down the rate of decline of absolute and % predicted DLCO but does not have significant impact on FVC or other lung parameters

Patient-reported outcomes and patient-reported outcome measures in interstitial lung disease: where to go from here?

Patient-reported outcome measures (PROMs), tools to assess patient self-report of health status, are now increasingly used in research, care and policymaking. While there are two well-developed disease-specific PROMs for interstitial lung diseases (ILD) and idiopathic pulmonary fibrosis (IPF), many unmet and urgent needs remain. In December 2019, 64 international ILD experts convened in Erice, Italy to deliberate on many topics, including PROMs in ILD. This review summarises the history of PROMs in ILD, shortcomings of the existing tools, challenges of development, validation and implementation of their use in clinical trials, and the discussion held during the meeting. Development of disease-specific PROMs for ILD including IPF with robust methodology and validation in concordance with guidance from regulatory authorities have increased user confidence in PROMs. Minimal clinically important difference for bidirectional changes may need to be developed. Cross-cultural validation and linguistic adaptations are necessary in addition to robust psychometric properties for effective PROM use in multinational clinical trials. PROM burden of use should be reduced through appropriate use of digital technologies and computerised adaptive testing. Active patient engagement in all stages from development, testing, choosing and implementation of PROMs can help improve probability of success and further growth

Análise sociométrica da rede de relacionamento das bibliotecas que constituem o Consórcio das Universidades Federais do Sul-Sudeste de Minas Gerais

O objetivo deste trabalho foi identificar a estrutura da rede de relacionamentos das Bibliotecas que constituem o Consórcio das Universidades Federais do Sul-Sudeste de Minas Gerais e verificar quais instituições se mostram mais centrais na estrutura de relacionamentos. Para isto, foi adotada a metodologia de estudo de caso, considerando abordagens qualitativas (aspectos relacionais) e quantitativas (indicadores estruturais), com auxílio dos softwares Ucinet® e Netdraw®, para a elaboração das matrizes sociométricas, proporcionando análises de centralidade de cada ator na rede, a presença de laços fracos/fortes e a existência de buracos estruturais na rede. Como resultado de pesquisa, foi evidenciada grande centralidade da UFJF e UFV, o que representa uma posição favorável para a busca e trocas de informações com melhores condições para gerar inovação na rede

Diagnostic accuracy of a clinical diagnosis of idiopathic pulmonary fibrosis: An international case-cohort study

We conducted an international study of idiopathic pulmonary fibrosis (IPF) diagnosis among a large group of physicians and compared their diagnostic performance to a panel of IPF experts. A total of 1141 respiratory physicians and 34 IPF experts participated. Participants evaluated 60 cases of interstitial lung disease (ILD) without interdisciplinary consultation. Diagnostic agreement was measured using the weighted kappa coefficient (\u3baw). Prognostic discrimination between IPF and other ILDs was used to validate diagnostic accuracy for first-choice diagnoses of IPF and were compared using the Cindex. A total of 404 physicians completed the study. Agreement for IPF diagnosis was higher among expert physicians (\u3baw=0.65, IQR 0.53-0.72, p20 years of experience (C-index=0.72, IQR 0.0-0.73, p=0.229) and non-university hospital physicians with more than 20 years of experience, attending weekly MDT meetings (C-index=0.72, IQR 0.70-0.72, p=0.052), did not differ significantly (p=0.229 and p=0.052 respectively) from the expert panel (C-index=0.74 IQR 0.72-0.75). Experienced respiratory physicians at university-based institutions diagnose IPF with similar prognostic accuracy to IPF experts. Regular MDT meeting attendance improves the prognostic accuracy of experienced non-university practitioners to levels achieved by IPF experts