744 research outputs found
Heat and extension at mid- and lower crustal levels of the Rio Grande rift
The process by which large amounts (50 to 200 percent) of crustal extension are produced was concisely described by W. Hamilton in 1982 and 1983. More recently, England, Sawyer, P. Morgan and others have moved toward quantifying models of lithospheric thinning by incorporating laboratory and theoretical data on rock rheology as a function of composition, temperature, and strain rate. Hamilton's description identifies three main crustal layers, each with a distinctive mechanical behavior; brittle fracturing and rotation in the upper crust, discontinuous ductile flow in the middle crust and laminar ductile flow in the lower crust. The temperature and composition dependent brittle-ductile transition essentially defines the diffuse boundary between upper and middle crust. It was concluded that the heat responsible for the highly ductile nature of the lower crust and the lensoidal and magma body structures at mid-crustal depths in the rift was infused into the crust by relatively modest ( 10 percent by mass) magmatic upwelling (feeder dikes) from Moho levels. Seismic velocity-versus-depth data, supported by gravity modeling and the fact that volumes of rift related volcanics are relatively modest ( 6000 cubic km) for the Rio Grande system, all imply velocities and densities too small to be consistent with a massive, composite, mafic intrusion in the lower crust
Perceptions of Common Task Training by Training Managers, Trainers, and Soldiers of a Field Artillery Battalion at Fort Sill, Oklahoma
Agricultural Educatio
Quantum Chemical Prediction of the 13C NMR Shifts in Alkyl and Chlorocorannulenes: Correction of Chlorine Effects
Prediction of the 13C NMR shifts of sym-pentachlorocorannulene and decachlorocorannulene provided impetus for the development of a correction scheme based on a regression of experimental and quantum chemical data. A training set of 15 compounds (18 carbon signals) comprising carbons atoms bearing 1–4 chlorine atoms leads to an estimated error per chlorine atom of about 10–12 ppm. Specifically, linear regression of the data obtained at B3LYP/cc-pVDZ leads to y = −3.77 + 13.11x, with R = 0.982. Ultimately, experiment and theory converge for sym-pentachlorocorannulene and decachlorocorannulene, the former by correction of the theory, the latter by collecting the proper experimental data
Inter-individual coordination in walking chimpanzees
Funding was provided to D.B.B. (St Andrews Undergraduate Research Assistantship Scheme), J.C. and G.K.K. (European Research Council, 609819 SOMICS), and M.K.S. (Swiss National Science Foundation, P2BEP3 175269).Humans, like many other animals, live in groups and coordinate actions with others in social settings.1 Such interpersonal coordination may emerge unconsciously and when the goal is not the coordination of movements, as when falling into the same rhythm when walking together.2 Although one of our closest living relatives, the chimpanzee (Pan troglodytes), shows the ability to succeed in complex joint action tasks where coordination is the goal,3 little is known about simpler forms of joint action. Here, we examine whether chimpanzees spontaneously synchronize their actions with conspecifics while walking together. We collected data on individual walking behavior of two groups of chimpanzees under semi-natural conditions. In addition, we assessed social relationships to investigate potential effects on the strength of coordination. When walking with a conspecific, individuals walked faster than when alone. The relative phase was symmetrically distributed around 0° with the highest frequencies around 0, indicating a tendency to coordinate actions. Further, coordination was stronger when walking with a partner compared with two individuals walking independently. Although the inter-limb entrainment was more pronounced between individuals of similar age as a proxy for height, it was not affected by the kinship or bonding status of the walkers or the behaviors they engaged in immediately after the walk. We conclude that chimpanzees adapt their individual behavior to temporally coordinate actions with others, which might provide a basis for engaging in other more complex forms of joint action. This spontaneous form of inter-individual coordination, often called entrainment, is thus shared with humans.Publisher PDFPeer reviewe
Constructions of generalized complex structures in dimension four
Four-manifold theory is employed to study the existence of (twisted)
generalized complex structures. It is shown that there exist (twisted)
generalized complex structures that have more than one type change loci. In an
example-driven fashion, (twisted) generalized complex structures are
constructed on a myriad of four-manifolds, both simply and non-simply
connected, which are neither complex nor symplectic
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Lithospheric processes
This is the final report of a three-year, Laboratory Directed Research and Development (LDRD) project at the Los Alamos National Laboratory (LANL). The main objective was to improve understanding of the origin and evolution of the Earth`s lithosphere by studying selected processes, such as deformation and magmatic intrusion during crustal extension, formation and extraction of mantle melts, fluid transport of heat and mass, and surface processes that respond to deep-seated events. Additional objectives were to promote and develop innovative techniques and to support relevant educational endeavors. Seismic studies suggest that underplating of crust by mantle melts is an important crustal-growth mechanism, that low-angle faults can be seismogenic, and that shear deformation creates mantle anisotropy near plate boundaries. Results of geochemical work determined that magmas from oceanic intraplate islands are derived from a uniform depth in the upper mantle, whereas melts erupted at mid-ocean ridges are mixed from a range of depths. The authors have determined the extent and style of fluid infiltration and trace-element distribution in natural magmatic systems, and, finally, investigated {sup 21}Ne as a tool for dating of surficial materials
Murine norovirus infection does not cause major disruptions in the murine intestinal microbiota
BACKGROUND: Murine norovirus (MNV) is the most common gastrointestinal pathogen of research mice and can alter research outcomes in biomedical mouse models of inflammatory bowel disease (IBD). Despite indications that an altered microbiota is a risk factor for IBD, the response of the murine intestinal microbiota to MNV infection has not been examined. Microbiota disruption caused by MNV infection could introduce the confounding effects observed in research experiments. Therefore, this study investigated the effects of MNV infection on the intestinal microbiota of wild-type mice. RESULTS: The composition of the intestinal microbiota was assessed over time in both outbred Swiss Webster and inbred C57BL/6 mice following MNV infection. Mice were infected with both persistent and non-persistent MNV strains and tissue-associated or fecal-associated microbiota was analyzed by 16S rRNA-encoding gene pyrosequencing. Analysis of intestinal bacterial communities in infected mice at the phylum and family level showed no major differences to uninfected controls, both in tissue-associated samples and feces, and also over time following infection, demonstrating that the intestinal microbiota of wild-type mice is highly resistant to disruption following MNV infection. CONCLUSIONS: This is the first study to describe the intestinal microbiota following MNV infection and demonstrates that acute or persistent MNV infection is not associated with major disruptions of microbial communities in Swiss Webster and C57BL/6 mice
Murine norovirus infection does not cause major disruptions in the murine intestinal microbiota
Abstract
Background
Murine norovirus (MNV) is the most common gastrointestinal pathogen of research mice and can alter research outcomes in biomedical mouse models of inflammatory bowel disease (IBD). Despite indications that an altered microbiota is a risk factor for IBD, the response of the murine intestinal microbiota to MNV infection has not been examined. Microbiota disruption caused by MNV infection could introduce the confounding effects observed in research experiments. Therefore, this study investigated the effects of MNV infection on the intestinal microbiota of wild-type mice.
Results
The composition of the intestinal microbiota was assessed over time in both outbred Swiss Webster and inbred C57BL/6 mice following MNV infection. Mice were infected with both persistent and non-persistent MNV strains and tissue-associated or fecal-associated microbiota was analyzed by 16S rRNA-encoding gene pyrosequencing. Analysis of intestinal bacterial communities in infected mice at the phylum and family level showed no major differences to uninfected controls, both in tissue-associated samples and feces, and also over time following infection, demonstrating that the intestinal microbiota of wild-type mice is highly resistant to disruption following MNV infection.
Conclusions
This is the first study to describe the intestinal microbiota following MNV infection and demonstrates that acute or persistent MNV infection is not associated with major disruptions of microbial communities in Swiss Webster and C57BL/6 mice.http://deepblue.lib.umich.edu/bitstream/2027.42/112329/1/40168_2012_Article_7.pd
The chemistry of branched condensed phosphates.
Condensed phosphates may exist as linear, cyclic or branched structures. Due to their important role in nature, linear polyphosphates have been well studied. In contrast, branched phosphates (ultraphosphates) remain largely uncharacterised, because they were already described in 1950 as exceedingly unstable in the presence of water, epitomized in the antibranching-rule. This rule lacks experimental backup, since, to the best of our knowledge, no rational synthesis of defined ultraphosphates is known. Consequently, detailed studies of their chemical properties, reactivity and potential biological relevance remain elusive. Here, we introduce a general synthesis of monodisperse ultraphosphates. Hydrolysis half-lives up to days call the antibranching-rule into question. We provide evidence for the interaction of an enzyme with ultraphosphates and discover a rearrangement linearizing the branched structure. Moreover, ultraphosphate can phosphorylate nucleophiles such as amino acids and nucleosides with implications for prebiotic chemistry. Our results provide an entry point into the uncharted territory of branched condensed phosphates
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