391 research outputs found
I reinterventi nellâiperparatiroidismo
reinterventi in chirurgia paratiroidea rappresentano una sfida impegnativa per il chirurgo che deve valutare attentamente i dati operatori e istologici del primo intervento, usare una diagnostica accurata preoperatoria con ecografia e scintigrafia con sestamibi e avere ben presente lâanatomia e lâembriologia delle ghiandole paratiroidee. Elementi fondamentali per ottenere un successo chirurgico sono lâuso del dosaggio intraoperatorio del paratormone e una grande esperienza del chirurgo. Seguendo tali principi si arriva a ottenere una remissione del quadro iperparatiroideo nellâ85-90% per lâHPT I e nel 70% per lâHPT II e III.
Gli Autori presentano la loro casistica di 75 reinterventi dopo HPT I e di 85 reinterventi dopo HPT II e III, su una casistica totale di 2072 interventi di paratiroidectomia eseguiti fra gennaio 1975 e ottobre 2009
Examination of Alzheimer-Type Neurodegeneration in Mouse Trisomy 16 Neurons Maintained by Transplantation
Virtual anthropology: a preliminary test of macroscopic observation versus 3D surface scans and computed tomography (CT) scans.
Virtual anthropology (VA) is based on applying anthropological methods currently used to analyse bones to 3D models of human remains. While great advances have been made in this endeavour in the past decade, several interrogations concerning how reliable these models are and what their proper use should be remain unanswered. In this research, a fundamental assumption of VA has been investigated: if the way we perceive and apply an anthropological method is truly similar when looking at bones macroscopically and through various 3D media. In order to answer, 10 skulls of known age and sex were scanned using a computed tomography (CT) scanner and a 3D surface scanner. Two observers separately applied a defined staging method to eight suture sites on these skulls, first looking at the bone macroscopically, then at the 3D surface scan, and finally on the CT scan. Two rounds of observation were carried out by each observer. Intra- and inter-observer error were evaluated, and two sample t-tests used to evaluate if the different types of medium used yielded significantly different observations. The results show a high degree of inter-observer error, and that data obtained from 3D surface scans differ from macroscopic observation (confidence level 95%, P †0.05). CT scans, in these settings, yielded results comparable to those obtained through macroscopic observations. These results offer many possibilities for future research, including indications on the kind of anthropological methods and anatomical landmarks that might be reliably transferable to the virtual environment. All current methods used in traditional anthropology should be tested, and if they prove unreliable, new techniques to analyse bones from virtual models should be developed.Key pointsLarge discrepancies between observation on dry bones and computer-generated 3D models (surface scans or CT scans) could lead to the re-evaluation of the suitability of traditional anthropological methods for application on 3D models.This preliminary study evaluates whether macroscopic, 3D surface scans, and CT scans viewings generate different observations.The results indicate that the data are not always coherent across all three media of observation.Explanations include the aspect given to the bone by the 3D software, differences between handling bones in real life versus on a computer, and level of expertise of the observers
Maternal treatment with sodium butyrate reduces the development of autism-like traits in mice offspring
Les occupations du natoufien et du PPNB ancien à Qarassa (Suweida, Syrie du sud). Premiers résultats et perspectives
Peer Reviewe
Elovl5 is required for proper action potential conduction along peripheral myelinated fibers
Elovl5 elongates fatty acids with 18 carbon atoms and in cooperation with other enzymes guarantees the normal levels of very longâchain fatty acids, which are necessary for a proper membrane structure. Action potential conduction along myelinated axons depends on structural integrity of myelin, which is maintained by a correct amount of fatty acids and a proper interaction between fatty acids and myelin proteins. We hypothesized that in Elovl5 (â/â) mice, the lack of elongation of Elovl5 substrates might cause alterations of myelin structure. The analysis of myelin ultrastructure showed an enlarged periodicity with reduced Gâratio across all axonal diameters. We hypothesized that the structural alteration of myelin might affect the conduction of action potentials. The sciatic nerve conduction velocity was significantly reduced without change in the amplitude of the nerve compound potential, suggesting a myelin defect without a concomitant axonal degeneration. Since Elovl5 is important in attaining normal amounts of polyunsaturated fatty acids, which are the principal component of myelin, we performed a lipidomic analysis of peripheral nerves of Elovl5âdeficient mice. The results revealed an unbalance, with reduction of fatty acids longer than 18 carbon atoms relative to shorter ones. In addition, the ratio of saturated to unsaturated fatty acids was strongly increased. These findings point out the essential role of Elovl5 in the peripheral nervous system in supporting the normal structure of myelin, which is the key element for a proper conduction of electrical signals along myelinated nerves
SimulPast: un laboratorio virtual para el anĂĄlisis de las dinĂĄmicas histĂłricas:SimulPast: a virtual lab to analyse historical dynamics
Entanglements of faith: Discourses, practices of care and homeless people in an Italian City of Saints
This is the author accepted manuscript. The final version is available from SAGE via http://dx.doi.org/10.1177/0042098013514620This paper investigates how Catholic-inspired services for homeless people are delivered in Turin, Italy. The purpose is to critically interrogate particular faith-based organisationsâ moral discourses on homelessness, and to show how they are enacted through practices of care directed at the homeless subject. The paper contributes to the geographical literature on faith-based organisations addressing its shortcomings â namely the lack of critical and contextual focus on faith-based organisationsâ âlove for the poorâ. To address this point, the paper takes a vitalist perspective on the urban and introduces the notion of the âentanglements of faithâ, which allows an integrated and grounded perspective on faith-based organisationsâ interventions. The outcomes of the work suggest that these faith-based organisations propose standardised services that, producing particular assemblages and affective atmospheres, have deep emotional and relational effects on their recipients. Further lines of research are sketched in the conclusions
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