Analytical Tools for Blockchain: Review, Taxonomy and Open Challenges

Bitcoin has introduced a new concept that could feasibly revolutionise the entire Internet as it exists, and positively impact on many types of industries including, but not limited to, banking, public sector and supply chain. This innovation is grounded on pseudo-anonymity and strives on its innovative decentralised architecture based on the blockchain technology. Blockchain is pushing forward a race of transaction-based applications with trust establishment without the need for a centralised authority, promoting accountability and transparency within the business process. However, a blockchain ledger (e.g., Bitcoin) tend to become very complex and specialised tools, collectively called “Blockchain Analytics”, are required to allow individuals, law enforcement agencies and service providers to search, explore and visualise it. Over the last years, several analytical tools have been developed with capabilities that allow, e.g., to map relationships, examine flow of transactions and filter crime instances as a way to enhance forensic investigations. This paper discusses the current state of blockchain analytical tools and presents a thematic taxonomy model based on their applications. It also examines open challenges for future development and research

Fighting Energy Poverty Using User-Driven Approaches in Mountainous Greece: Lessons Learnt from a Living Lab

The experience of operating an energy-related Living Lab (LL) in mountainous Greece is presented in this paper in an attempt to explore the dynamics of such initiatives to address energy vulnerability. The LL is situated in Metsovo, which is a typical mountainous town of Greece with increased vulnerability issues identified in previous studies. Since Greek mountainous societies have proved to be particularly exposed to energy poverty, the LL aimed to function as an exemplary case on how to tackle energy poverty issues in mountainous regions, mainly through reducing energy consumption and improving energy efficiency. The methodological context was based on a holistic LL approach consisting of various activities, such as conduction of energy cafés, questionnaire surveys, home visits from Energy Advisors, installation of monitoring equipment, ICT tools and processing, etc. In particular, the LL consisted of three independent rounds, each of which involved 50 households, with 30 of them being equipped with monitoring tools. Energy advisors repeatedly visited households to collect information (on heating expenses, behavioral aspects, etc.) and offer household-specific advice on potential energy savings measures. Overall, the LL operation proved to have benefited most participants (76%), especially households with monitoring equipment, as 85.5% of the last ones already applied energy-efficiency measures and 80% made further plans for future investments. Through the particular LL example, apart from the benefits delivered to the local society, useful information can be provided to policy-makers toward addressing more effectively energy vulnerability in mountainous societies

Enhanced cortical neural stem cell identity through short SMAD and WNT inhibition in human cerebral organoids facilitates emergence of outer radial glial cells

Cerebral organoids exhibit broad regional heterogeneity accompanied by limited cortical cellular diversity despite the tremendous upsurge in derivation methods, suggesting inadequate patterning of early neural stem cells (NSCs). Here we show that a short and early Dual SMAD and WNT inhibition course is necessary and sufficient to establish robust and lasting cortical organoid NSC identity, efficiently suppressing non-cortical NSC fates, while other widely used methods are inconsistent in their cortical NSC-specification capacity. Accordingly, this method selectively enriches for outer radial glia NSCs, which cyto-architecturally demarcate well-defined outer sub-ventricular-like regions propagating from superiorly radially organized, apical cortical rosette NSCs. Finally, this method culminates in the emergence of molecularly distinct deep and upper cortical layer neurons, and reliably uncovers cortex-specific microcephaly defects. Thus, a short SMAD and WNT inhibition is critical for establishing a rich cortical cell repertoire that enables mirroring of fundamental molecular and cyto-architectural features of cortical development and meaningful disease modelling