Oral ondansetron versus domperidone for acute gastroenteritis in pediatric emergency departments: Multicenter double blind randomized controlled trial

The use of antiemetics for vomiting in acute gastroenteritis in children is still a matter of debate. We conducted a double-blind randomized trial to evaluate whether a single oral dose of ondansetron vs domperidone or placebo improves outcomes in children with gastroenteritis. After failure of initial oral rehydration administration, children aged 1-6 years admitted for gastroenteritis to the pediatric emergency departments of 15 hospitals in Italy were randomized to receive one oral dose of ondansetron (0.15 mg/kg) or domperidone (0.5 mg/kg) or placebo. The primary outcome was the percentage of children receiving nasogastric or intravenous rehydration. A p value of 0.014 was used to indicate statistical significance (and 98.6% CI were calculated) as a result of having carried out two interim analyses. 1,313 children were eligible for the first attempt with oral rehydration solution, which was successful for 832 (63.4%); 356 underwent randomization (the parents of 125 children did not give consent): 118 to placebo, 119 to domperidone, and 119 to ondansetron. Fourteen (11.8%) needed intravenous rehydration in the ondansetron group vs 30 (25.2%) and 34 (28.8%) in the domperidone and placebo groups, respectively. Ondansetron reduced the risk of intravenous rehydration by over 50%, both vs placebo (RR 0.41, 98.6% CI 0.20-0.83) and domperidone (RR 0.47, 98.6% CI 0.23-0.97). No differences for adverse events were seen among groups. In a context of emergency care, 6 out of 10 children aged 1-6 years with vomiting due to gastroenteritis and without severe dehydration can be managed effectively with administration of oral rehydration solution alone. In children who fail oral rehydration, a single oral dose of ondansetron reduces the need for intravenous rehydration and the percentage of children who continue to vomit, thereby facilitating the success of oral rehydration. Domperidone was not effective for the symptomatic treatment of vomiting during acute gastroenteritis

Parametric Formulation of the Floodable Length Curve: Application Case to Offshore Patrol Vessels

The residual buoyancy of vessels after damage has a fundamental role in their survivability and it is implemented through adequate ship internal subdivision. Traditionally the number and the position of transverse watertight bulkheads are selected for most ships early in the design phase by means of the \u201cfloodable length curve\u201d coupled with the concept of \u201cmargin line\u201d. However, for naval vessels, it is more and more common during the acquisition process to explore a wide domain of feasible ships, identified with the assistance of automated processes and assessed also in terms of capabilities, among which is survivability. The generation and the comparison of a considerable number of different ship configurations is very time consuming. Therefore recourse to a parametric expression of the floodable length curve is considered to be a very efficient approach and would thus enable characterisation of the ship, in terms of survivability performance. In this paper such an approach is presented, using an offshore patrol vessel (OPV) as the case study

Possible pitfalls in diagnosing celiac disease,Il rischio di andare alla deriva sull{'}iceberg della celiachia

No abstract availabl

Functional gastrointestinal disorders, lifestyle habits, and smartphone addiction in adolescents

We performed a cross-sectional study. In spring 2019, 1,594 students (mean age 12.87 years) completed a questionnaire on gastrointestinal symptoms, smartphone use, Quality of Life (QoL), dietary habits, and physical activity. Based on the Rome IV criteria, 30.9% of participants met the symptom-based criteria for FGIDs and 8.9% experienced ≥2 disorders simultaneously. Well-being was less frequently reported by children with FGIDs than others (29.0% vs. 48.2%; p < 0.001). Participants addicted to smartphones reported low than others well-being (18.0% vs. 25.8%; p < 0.001), they also showed higher prevalence of FGIDs [Odds Ratio (OR), 1.98; 95% Confidence Interval (CI), 1.47-2.68; p < 0.001]. Among dietary habits, skipping breakfast (OR, 1.50; 95% CI, 1.09-2.05; p = 0.01) and low fruit consumption (OR, 1.66; 95% CI, 1.172.36; p = 0.005) were more frequent in participants with FGIDs. FGIDs are common in pediatric populations. FGIDs have an impact on QoL. Some dietary habits and physical activity are associated with these disorders. Smartphone addiction was found to be associated with FGIDs

Functional gastrointestinal disorders and smartphone use in adolescents

Question: Are functional gastrointestinal disorders (FGIDs) common in Italy? If so, what are the associated risk factors? Finding: In this cross-sectional study of 1,594 adolescents, the prevalence of FGIDs was 30.9% and was mainly associated with smartphone addiction. Meaning: Smartphone use and dietary habits should be monitored in children with FGI

Il rischio di andare alla deriva sull’iceberg della celiachia.

A 12-year old child with failure-to-thrive had diagnosis of celiac disease at the age of 20 months, in spite of negative serologic markers and only slight histological modifications at the duodenal biopsy. After 10 years of gluten free diet his weight and height were ≤ 2 SD than the normal values for the age. He had also neurodevelopmental delay, dyslexia and visual disturbances. Markers of HLA susceptibility for celiac disease were absent. Investigations showed growth hormone deficiency and neuromuscular impairment due to mitochondrial encephaloneuromyopathy (cytochrome c-oxidase deficiency). Possible pitfalls in diagnosing celiac disease are discussed. Clinical history, serology, histology and gluten-dependency must be taken in account especially in doubtful clinical situations