Plasma Concentrations of Tranexamic Acid in Postpartum Women After Oral Administration.

OBJECTIVE: To evaluate the pharmacokinetics of tranexamic acid after oral administration to postpartum women. METHODS: We conducted a single-center pharmacokinetic study at Teaching Hospital-Jaffna, Sri Lanka, on 12 healthy postpartum women who delivered vaginally. After oral administration of 2 g of immediate-release tranexamic acid 1 hour after delivery, pharmacokinetic parameters were measured on plasma samples at 0, 0.5, 1, 1.5, 2, 2.5, 3, 3.5, 4, 5, 6, 8, 10, and 12 hours. Plasma tranexamic acid concentrations were determined by high-performance liquid chromatography. The outcome measures were maximum observed plasma concentration, time to maximum plasma concentration, time to reach effective plasma concentration, time period effective serum concentration lasted, area under the curve for drug concentration, and half-life of tranexamic acid. RESULTS: The mean maximum observed plasma concentration was 10.06 micrograms/mL (range 8.56-12.22 micrograms/mL). The mean time to maximum plasma concentration was 2.92 hours (range 2.5-3.5 hours). Mean time taken to reach the effective plasma concentration of 5 micrograms/mL and the mean time this concentration lasted were 0.87 hours and 6.73 hours, respectively. Duration for which plasma tranexamic acid concentration remained greater than 5 micrograms/mL was 5.86 hours. Half-life was 1.65 hours. Area under the curve for drug concentration was 49.16 micrograms.h/mL (range 43.75-52.69 micrograms.h/mL). CONCLUSION: Clinically effective plasma concentrations of tranexamic acid in postpartum women may be achieved within 1 hour of oral administration. Given the promising pharmacokinetic properties, we recommend additional studies with larger sample sizes to investigate the potential of oral tranexamic acid for the treatment or prophylaxis of postpartum hemorrhage

Fuzzy Hypergraphs

Graph theory has found many application area in science, engineering, and mathematics. In order to expand the application base, the notion of a graph was generalized to that of a hypergraph, that is, a set X of vertices together with a collection of subsets of X. In this chapter, we fuzzify the notation of a hypergraph and state some possible applications. In this article, we apply the concept of bipolar fuzzy sets to hypergraphs and investigate some basic theorems and some properties of bipolar fuzzy hypergraphs. Some basic concepts of bipolar fuzzy set are defined. It is shown that any bipolar fuzzy graph can be expressed as the bipolar fuzzy intersection graphs of some bipolar fuzzy sets

Some recent observations on small-scale fishery In the vicinity of Madras

Madras zone is one of the important fishing centres on the east coast of India. To understand the fish landings from different gears in Madras, three landing centres, viz., Kasimedu, Triplicane and Nochikuppam were selected. Kasimedu is about 8 km north of Triplicane and Nochikuppam is about 2 km south of Triplicane. The major catch components from the demersal trawls of this area arc silver bellies, threadfin breams, sciaenids, lizardfish, prawns, squids and cuttlefish. These groups are landed in a meagre quantity by the traditional gears, thus maintaining compatability between mechanised and non-mechanised gears in the exploitation of fishery resources off Madras

Effects of Wall Cooling on Hypersonic Boundary Layer Receptivity Over a Cone

Effects of wall cooling on the receptivity process induced by the interaction of slow acoustic disturbances in the free-stream are numerically investigated for a boundary layer flow over a 5-degrees straight cone. The free-stream Mach number is 6.0 and the Reynolds number is 7.8x10(exp 6)/ft. Both the steady and unsteady solutions are obtained by solving the full Navier-Stokes equations using 5th-order accurate weighted essentially non-oscillatory (WENO) scheme for space discretization and using 3rd-order total variation diminishing (T VD) Runge-K utta scheme for time integration. Computations are performed for a cone with nose radius of 0.001 inch for adiabatic wall temperature (T(sub aw)), 0.75*T(sub aw), 0.5*T(sub aw), 0.40*T(sub aw), 0.30*T(sub aw), and 0.20*T(sub aw). Once the mean flow field is computed, disturbances are introduced at the upstream end of the computational domain. Generation of instability waves from leading edge region and receptivity of boundary layer to slow acoustic waves are investigated. Computations showed that wall cooling has strong stabilization effect on the first mode disturbances as was observed in the experiments. T ransition location moved to upstream when wall cooling was applied It is also found that the boundary layer is much more receptive to fast acoustic wave (by almost a factor of 50). When simulations performed using the same forcing frequency growth of the second mode disturbances are delayed with wall cooling and they attained values two times higher than that of adiabatic case. In 0.20*T(sub aw) case the transition Reynolds number is doubled compared to adiabatic conditions. The receptivity coefficient for adiabatic wall case (804 R) is 1.5225 and for highly cooled cones (241, and 161 R); they are in the order of 10(exp -3)

Effects of Nose Bluntness on Stability of Hypersonic Boundary Layers over Blunt Cone

Receptivity and stability of hypersonic boundary layers are numerically investigated for boundary layer flows over a 5-degree straight cone at a free-stream Mach number of 6.0. To compute the shock and the interaction of shock with the instability waves, we solve the Navier-Stokes equations in axisymmetric coordinates. The governing equations are solved using the 5th-order accurate weighted essentially non-oscillatory (WENO) scheme for space discretization and using third-order total-variation-diminishing (TVD) Runge-Kutta scheme for time integration. After the mean flow field is computed, disturbances are introduced at the upstream end of the computational domain. Generation of instability waves from leading edge region and receptivity of boundary layer to slow acoustic waves are investigated. Computations are performed for a cone with nose radii of 0.001, 0.05 and 0.10 inches that give Reynolds numbers based on the nose radii ranging from 650 to 130,000. The linear stability results showed that the bluntness has a strong stabilizing effect on the stability of axisymmetric boundary layers. The transition Reynolds number for a cone with the nose Reynolds number of 65,000 is increased by a factor of 1.82 compared to that for a sharp cone. The receptivity coefficient for a sharp cone is about 4.23 and it is very small, approx.10(exp -3), for large bluntness

चेन्नई मात्स्यिकी पोताश्रय में बैग जाल द्वारा बोई (मल्लेट) मुजिल सेफेलस का भारी अवतरण

कृपया पूरा लेखा पढ

रजत कोंगर सर्पमीन के वायूआशय का चेन्नई से निर्यात

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'Thoorivala' and its multi use

Thoorivalai' seems to be profitable as the man power used is less and catch landed is high. They get a large quantity of fish with a minimum of 600 kg to a maximum of 800 kg. The fishermen using this type of fishing at Kadathukkuppam (Tanjore Dt.) got a maximum of 700 kg fish by putting 9 hauls and engaging 10 persons a unit during July, 1988

Heavy landing of Upeneus taeniopterus along Chennai coast

During the period from 20-06-2005 to 28- 06-2005, there was unusually heavy landing of goatfish by trawlers at Chennai Fisheries Harbour. In June 2005 alone 388 tonnes of goatfish were landed from depths of 60-80m with a catch rate of 5.4 kg per hour

Export of silver conger eel's air bladder from Chennai

Muraenesox cinereus Silver conger eel is the only species of Muraenesocidae family, observed in the landings at Chennai Fisheries Harbour. M.cinereus are mainly landed by multiday trawlers. The catch was high during June-October with peak in June. Washed, dried air bladders are exported along with skin, fins, gill rakers, bones and teeth of elasmobranchs to Singapore and HongKong, and are used in the manufacture of soup and medicine