Piterjiyumda human papilloma virus, p53 gen mutasyonu :_PCR ve immünohistokimyasal çalışma

TEZ3790Tez (Uzmanlık) -- Çukurova Üniversitesi, Adana, 2002.Kaynakça (s. 43-46) var.vii, 47 s. : rnk. res. ; 30 cm.…Bu çalışma Ç.Ü. Bilimsel Araştırma Projeleri Birimi Tarafından Desteklenmiştir. Proje No: TF 2000 U. 3

A Rare Diagnosis in the Neck During Childhood: Congenital Chondrolipoma

Chondrolipomas are mesenchymal tumors that found as mature cartilage tissue in a fat tissue. A 2-year-old boy was seen with a complaint of a mass of the neck. On physical examination of the child, there was a one-centimeter mass above the sternocleidomastoid muscle on the lateral neck. Pathological examination of this mass after excision was reported as chondrolipoma. Chondrolipomas are seen mostly in the breast and in the adult. They are rare tumors of the head and neck area and seen mostly the in oral cavity here. This is the first case of chondrolipoma with this age and localization combination in the literature. Chondrolipoma should therefore also be considered in the differential diagnosis of congenital masses located at lateral cervical area

Localized Secondary Amyloidosis of the Prostate

Amyloidosis is an that is characterized the deposition of an abnormal proteinaceous material in extracellular tissue. Amyloidosis may be localized or systemic. Only about 6-9% all cases of amyloidosis are localized to a single organ system, and prostate is one of the rarest sites of involvement. Herein we report a localized secondary amylodosis of the prostate in a 73-year-old man. Amyloidosis is characterized by deposition of an abnormal proteinaceous material in extracellular tissue. It’s etiology is uncertain (1). Amyloidosis of the prostate is very rare. In recent years, with the increase in the number of prostate biopsies to exclude the malignancy, the number of the primary or secondary amyloidosis cases increased (2). Deposition of the amyloid can be localized or systemic (3). Herein we report a localized secondary amylodosis of the prostate in a 73-year-old man who underwent to transrectal ultrasound (TRUS) guided biopsy of prostate for suspected prostate cance

Magnetic resonance imaging findings of extraskeletal mesenchymal chondrosarcoma of wrist: a case report

Extraskeletal mesenchymal chondrosarcomas (EMC) are high grade malignant tumors that rarely involves wrist. Published reports about them are mostly based on conventional radiography, tomography and conventional magnetic resonance imaging (MRI) findings. We did not recognize any report of dynamic-contrast enhanced MRI so far. Herein, we present dynamic contrast enhanced and Diffusion Weighted MRI findings of a case with extraskeletal mesenchymal chondrosarcoma of the wrist. In conclusion, EMC might show peripheral enhancement at early arterial phase and restricted diffusion on MRI. The knowledge of the imaging spectrum of the EMC might help us suggesting the diagnosis

Clinical and histopathological characteristics and differential diagnosis of chordomas

Purpose: Chordomas are rare malignant bone tumours occuring in the midline of axial skeleton. We aimed to assess these tumors which has been diagnosed in our center in terms of clinical and pathologic characteristics, and differantial diagnosis difficulties. Material and Methods: We retrospectively evaluated cinical and histopathologic characteristics of 10 chordoma patients diagnosed at pathology department of Baskent University Adana Teaching and Resarch Hospital between 2009 and 2014. Results: The patients were consisted of men (n= 9) and women (n= 1) with the age of 61.3 (38-84) years old. The localization of chordomas were the sacrococcygeal region at eight patients (80%), lumbar vertebrae at one patient ( 10%) and clivus at one patient (10%). The mean diameter was 4.68 (2.5-7.5) cm. Histopathologically, majority of cases were "conventional chordoma" while one of them was "chondroid chordoma". Surgical excision was performed for all patients, only one case has recieved radiotherapy, and chemotherapy was given after surgery for one patient. Local recurrence was detected in three patients and distant metastasis (lung) was found in a patient and he died in a short time. Conclusion: Because that chordomas are rare clinical bone tumours which can be treated efficiently by appropriate surgical excision, clinical and histopathological characteristics and differential diagnosis should be well known

Comparison of the inhibitory effect of different doses of subconjunctival bevacizumab application in an experimental model of corneal neovascularization

AIM: To evaluate the inhibitory effect of subconjunctival bevacizumab as single- and multiple-dose application, and compare their effects on corneal neovascularization in a rat model. METHODS: Thirty adult Sprague-Dawley rats were used in this experimental study. The central cornea of the rats was cauterized chemically. The rats were randomly enrolled into three groups. All groups received subconjunctival injections. In Group 1 (control group, n=10), 0.05 mL 0.9% NaCl solution was injected on the first day. In Group 2 (single-dose group, n=10), 0.05 mL bevacizumab (1.25 mg) was injected on the first day. In Group 3 (multiple-dose group, n=10), four doses of 0.05 mL bevacizumab (1.25 mg) were injected on the first, third, fifth and seventh day. Slit-lamp examination of all rats was performed at the third and ninth day. Digital images of the corneas were taken and analyzed using image analysis software to calculate corneal neovascularization area. All rats were sacrificed on the tenth day. In corneal sections, the number of blood vessels, state of inflammation and collagen formation was evaluated histopathologically. RESULTS: In Group 3, corneal edema grades were significantly lower than Group 1 and Group 2 (P=0.02, and P=0.035, respectively). The mean percentage of neovascularized corneal area in Group 3 was significantly lower than Group 2 (P=0.005). On histopathological examination, Group 2 and Group 3 showed significantly less number of blood vessels than Group 1 (P=0.005, and P=0.001, respectively). Additionally, Group 3 showed significantly less number of blood vessels compared to Group 2 (P=0.019). Inflammation and edema grades were significantly lower in Group 3 compared to Group 1 (P=0.001). CONCLUSION: Subconjunctival bevacizumab injection is effective in inhibition of newly formed corneal neovascularization. The multiple-dose bevacizumab treatment seems to be more effective compared to single-dose treatment

A Rare Cause of the Rare Condition: Paratesticular Fibrous Pseudotumor

Benign fibrous proliferations of the spermatic cord are uncommon and mostly arise from the paratesticular region. Although benign, they often clinically mimic malignancy and usually remain undiagnosed preoperatively. Here, we report a case of fibrous pseudotumor arising from the right spermatic cord encountered in a 26-year-old male who presented with a palpable right inguinal mass