Stress-Induced Cocaine Seeking Requires a Beta-2 Adrenergic Receptor-Regulated Pathway from the Ventral Bed Nucleus of the Stria Terminalis That Regulates CRF Actions in the Ventral Tegmental Area

The ventral bed nucleus of the stria terminalis (vBNST) has been implicated in stress-induced cocaine use. Here we demonstrate that, in the vBNST, corticotropin releasing factor (CRF) is expressed in neurons that innervate the ventral tegmental area (VTA), a site where the CRF receptor antagonist antalarmin prevents the reinstatement of cocaine seeking by a stressor, intermittent footshock, following intravenous self-administration in rats. The vBNST receives dense noradrenergic innervation and expresses β adrenergic receptors (ARs). Footshock-induced reinstatement was prevented by bilateral intra-vBNST injection of the β-2 AR antagonist, ICI-118,551, but not the β-1 AR antagonist, betaxolol. Moreover, bilateral intra-vBNST injection of the β-2 AR agonist, clenbuterol, but not the β-1 agonist, dobutamine, reinstated cocaine seeking, suggesting that activation of vBNST β-2 AR is both necessary for stress-induced reinstatement and sufficient to induce cocaine seeking. The contribution of a β-2 AR-regulated vBNST-to-VTA pathway that releases CRF was investigated using a disconnection approach. Injection of ICI-118,551 into the vBNST in one hemisphere and antalarmin into the VTA of the contralateral hemisphere prevented footshock-induced reinstatement, whereas ipsilateral manipulations failed to attenuate stress-induced cocaine seeking, suggesting that β-2 AR regulate vBNST efferents that release CRF into the VTA, activating CRF receptors, and promoting cocaine use. Last, reinstatement by clenbuterol delivered bilaterally into the vBNST was prevented by bilateral vBNST pretreatment with antalarmin, indicating that β-2 AR-mediated actions in the vBNST also require local CRF receptor activation. Understanding the processes through which stress induces cocaine seeking should guide the development of new treatments for addiction

Making use of geometrical invariants in black hole collisions

We consider curvature invariants in the context of black hole collision simulations. In particular, we propose a simple and elegant combination of the Weyl invariants I and J, the {\sl speciality index} ${\cal S}$. In the context of black hole perturbations $\cal S$ provides a measure of the size of the distortions from an ideal Kerr black hole spacetime. Explicit calculations in well-known examples of axisymmetric black hole collisions demonstrate that this quantity may serve as a useful tool for predicting in which cases perturbative dynamics provide an accurate estimate of the radiation waveform and energy. This makes ${\cal S}$ particularly suited to studying the transition from nonlinear to linear dynamics and for invariant interpretation of numerical results.Comment: 4 pages, 3 eps figures, Revte

Pade approximation of the S-matrix as a way of locating quantum resonances and bound states

It is shown that the spectral points (bound states and resonances) generated by a central potential of a single-channel problem, can be found using rational parametrization of the S-matrix. To achieve this, one only needs values of the S-matrix along the real positive energy axis. No calculations of the S-matrix at complex energies or a complex rotation are necessary. The proposed method is therefore universal in that it is applicable to any potential (local, non-local, discontinuous, etc.) provided that there is a way of obtaining the S-matrix (or scattering phase-shifts) at real collision energies. Besides this, combined with any method that extracts the phase-shifts from the scattering data, the proposed rational parametrization technique would be able to do the spectral analysis using the experimental data.Comment: 20 pages, 6 figure

Lithium and carbon isotopic fractionations between the alteration assemblages of Nakhla and Lafayette

Nakhla and Lafayette delta 7Li values for samples and extracts (4.1-14.2�) are consistent with brine evaporation. Relatively 13C-poor siderite in Lafayette suggests more than one carbon source was sampled

Chains of large gaps between primes

Let $p_n$ denote the $n$-th prime, and for any $k \geq 1$ and sufficiently large $X$, define the quantity $$G_k(X) := \max_{p_{n+k} \leq X} \min( p_{n+1}-p_n, \dots, p_{n+k}-p_{n+k-1} ),$$ which measures the occurrence of chains of $k$ consecutive large gaps of primes. Recently, with Green and Konyagin, the authors showed that $$G_1(X) \gg \frac{\log X \log \log X\log\log\log\log X}{\log \log \log X}$$ for sufficiently large $X$. In this note, we combine the arguments in that paper with the Maier matrix method to show that $$G_k(X) \gg \frac{1}{k^2} \frac{\log X \log \log X\log\log\log\log X}{\log \log \log X}$$ for any fixed $k$ and sufficiently large $X$. The implied constant is effective and independent of $k$.Comment: 16 pages, no figure

Chiral exponents in O(N) x O(m) spin models at O(1/N^2)

The critical exponents corresponding to chirality are computed at O(1/N^2) in d-dimensions at the stable chiral fixed point of a scalar field theory with an O(N) x O(m) symmetry. Pade-Borel estimates for the exponents are given in three dimensions for the Landau-Ginzburg-Wilson model at m = 2.Comment: 8 latex page

Gradual diffusion and punctuated phase space density enhancements of highly relativistic electrons: Van Allen Probes observations

Abstract The dual-spacecraft Van Allen Probes mission has provided a new window into mega electron volt (MeV) particle dynamics in the Earth\u27s radiation belts. Observations (up to E ~10 MeV) show clearly the behavior of the outer electron radiation belt at different timescales: months-long periods of gradual inward radial diffusive transport and weak loss being punctuated by dramatic flux changes driven by strong solar wind transient events. We present analysis of multi-MeV electron flux and phase space density (PSD) changes during March 2013 in the context of the first year of Van Allen Probes operation. This March period demonstrates the classic signatures both of inward radial diffusive energization and abrupt localized acceleration deep within the outer Van Allen zone (L ~4.0 ± 0.5). This reveals graphically that both competing mechanisms of multi-MeV electron energization are at play in the radiation belts, often acting almost concurrently or at least in rapid succession. Key Points Clear observations to higher energy than ever before Precise detection of where and how acceleration takes place Provides new eyes on megaelectron Volt