Intellectual functioning in clinically confirmed fetal valproate syndrome

Background: An increased risk of impaired intelligence (IQ) has been documented in valproate-exposed children, but investigations have not previously focused on those with a clinical diagnosis of Fetal Valproate Syndrome (FVS). Methods: This cross sectional observational study recruited individuals with a diagnosis of FVS and completed standardized assessments of intellectual abilities making comparisons to a normative comparison group. Both mean difference (MD) and prevalence of scores below the lower average range were analyzed. Results: The mean full-scale IQ in 31 individuals with FVS (mean age 14.97; range 6–27 years) was 19 points lower (19.55, 95% CI −24.94 to 14.15), and IQ scores <70 were present in 26%. The mean differences for verbal comprehension (21.07, 95% CI −25.84 to −16.29), working memory (19.77, 95% CI −25.00 to −14.55) and processing speed (16.87, 95% CI −22.24 to −11.50) performances were poorer than expected with the mean differences over one standard deviation from the comparison group. Sixty one percent of cases demonstrated disproportionately lower verbal comprehension ability. There were no significant group differences for IQ in high vs. moderate dose valproate or mono vs. polytherapy. There were no differences in IQ between those with and those without a major congenital malformation. The requirement for educational intervention was high at 74%. Conclusion: Intellectual difficulties are a central feature of FVS and are more severe in their presentation in individuals with a diagnosis of valproate embryopathy. Individuals with FVS who present with the characteristic facial presentation should be considered at high risk of cognitive difficulties regardless of the dose of valproate exposure or the presence of a major congenital malformation

Malaria prophylaxis - the South African viewpoint

A consensus meeting was held under the auspices of the Department of National Health and Population Development in September 1991 in order to establish local, current consensus on malaria prophylaxis for the South African traveller within South Africa and neighbouring African countries. The meeting was attended by malaria experts and others interested in malaria. The consensus reached took into consideration not only the international literature, but also local clinical experience and viewpoints. As a result, it was decided that prevention of mosquito bites is the mainstay of malaria prophylaxis and that chemooprophylaxis should be individualised. Malaria may still be contracted despite good compliance with the recommended prophylactic regimen

Outflows at the Edges of an Active Region in a Coronal Hole: A Signature of Active Region Expansion?

Outflows of plasma at the edges of active regions surrounded by quiet Sun are now a common observation with the Hinode satellite. While there is observational evidence to suggest that the outflows are originating in the magnetic field surrounding the active regions, there is no conclusive evidence that reveals how they are driven. Motivated by observations of outflows at the periphery of a mature active region embedded in a coronal hole, we have used a three-dimensional simulation to emulate the active region's development in order to investigate the origin and driver of these outflows. We find outflows are accelerated from a site in the coronal hole magnetic field immediately surrounding the active region and are channelled along the coronal hole field as they rise through the atmosphere. The plasma is accelerated simply as a result of the active region expanding horizontally as it develops. Many of the characteristics of the outflows generated in the simulation are consistent with those of observed outflows: velocities up to 45 km per sec, properties akin to the coronal hole, proximity to the active region's draining loops, expansion with height, and projection over monopolar photospheric magnetic concentrations. Although the horizontal expansion occurs as a consequence of the active region's development in the simulation, expansion is also a general feature of established active regions. Hence, it is entirely possible and plausible that the expansion acceleration mechanism displayed in the simulation is occurring in active regions on the Sun and, in addition to reconnection, is driving the outflows observed at their edges.Comment: 19 pages, 9 figure

Surface critical behavior in fixed dimensions d<4d<4: Nonanalyticity of critical surface enhancement and massive field theory approach

The critical behavior of semi-infinite systems in fixed dimensions $d<4$ is investigated theoretically. The appropriate extension of Parisi's massive field theory approach is presented.Two-loop calculations and subsequent Pad\'e-Borel analyses of surface critical exponents of the special and ordinary phase transitions yield estimates in reasonable agreement with recent Monte Carlo results. This includes the crossover exponent $\Phi (d=3)$, for which we obtain the values $\Phi (n=1)\simeq 0.54$ and $\Phi (n=0)\simeq 0.52$, considerably lower than the previous $\epsilon$-expansion estimates.Comment: Latex with Revtex-Stylefiles, 4 page

Chiral exponents in O(N) x O(m) spin models at O(1/N^2)

The critical exponents corresponding to chirality are computed at O(1/N^2) in d-dimensions at the stable chiral fixed point of a scalar field theory with an O(N) x O(m) symmetry. Pade-Borel estimates for the exponents are given in three dimensions for the Landau-Ginzburg-Wilson model at m = 2.Comment: 8 latex page

Non-perturbative calculations for the effective potential of the PTPT symmetric and non-Hermitian (−gϕ4)(-g\phi^{4}) field theoretic model

We investigate the effective potential of the $PT$ symmetric $(-g\phi^{4})$ field theory, perturbatively as well as non-perturbatively. For the perturbative calculations, we first use normal ordering to obtain the first order effective potential from which the predicted vacuum condensate vanishes exponentially as $G\to G^+$ in agreement with previous calculations. For the higher orders, we employed the invariance of the bare parameters under the change of the mass scale $t$ to fix the transformed form totally equivalent to the original theory. The form so obtained up to $G^3$ is new and shows that all the 1PI amplitudes are perurbative for both $G\ll 1$ and $G\gg 1$ regions. For the intermediate region, we modified the fractal self-similar resummation method to have a unique resummation formula for all $G$ values. This unique formula is necessary because the effective potential is the generating functional for all the 1PI amplitudes which can be obtained via $\partial^n E/\partial b^n$ and thus we can obtain an analytic calculation for the 1PI amplitudes. Again, the resummed from of the effective potential is new and interpolates the effective potential between the perturbative regions. Moreover, the resummed effective potential agrees in spirit of previous calculation concerning bound states.Comment: 20 page

Star-graph expansions for bond-diluted Potts models

We derive high-temperature series expansions for the free energy and the susceptibility of random-bond $q$-state Potts models on hypercubic lattices using a star-graph expansion technique. This method enables the exact calculation of quenched disorder averages for arbitrary uncorrelated coupling distributions. Moreover, we can keep the disorder strength $p$ as well as the dimension $d$ as symbolic parameters. By applying several series analysis techniques to the new series expansions, one can scan large regions of the $(p,d)$ parameter space for any value of $q$. For the bond-diluted 4-state Potts model in three dimensions, which exhibits a rather strong first-order phase transition in the undiluted case, we present results for the transition temperature and the effective critical exponent $\gamma$ as a function of $p$ as obtained from the analysis of susceptibility series up to order 18. A comparison with recent Monte Carlo data (Chatelain {\em et al.}, Phys. Rev. E64, 036120(2001)) shows signals for the softening to a second-order transition at finite disorder strength.Comment: 8 pages, 6 figure

Neutron matter with a model interaction

An infinite system of neutrons interacting by a model pair potential is considered. We investigate a case when this potential is sufficiently strong attractive, so that its scattering length tends to infinity. It appeared, that if the structure of the potential is simple enough, including no finite parameters, reliable evidences can be presented that such a system is completely unstable at any finite density. The incompressibility as a function of the density is negative, reaching zero value when the density tends to zero. If the potential contains a sufficiently strong repulsive core then the system possesses an equilibrium density. The main features of a theory describing such systems are considered.Comment: 8 pages, LaTeX. In press, Eur. Phys. J.

Spaces of finite element differential forms

We discuss the construction of finite element spaces of differential forms which satisfy the crucial assumptions of the finite element exterior calculus, namely that they can be assembled into subcomplexes of the de Rham complex which admit commuting projections. We present two families of spaces in the case of simplicial meshes, and two other families in the case of cubical meshes. We make use of the exterior calculus and the Koszul complex to define and understand the spaces. These tools allow us to treat a wide variety of situations, which are often treated separately, in a unified fashion.Comment: To appear in: Analysis and Numerics of Partial Differential Equations, U. Gianazza, F. Brezzi, P. Colli Franzone, and G. Gilardi, eds., Springer 2013. v2: a few minor typos corrected. v3: a few more typo correction

The 3-D O(4) universality class and the phase transition in two-flavor QCD

We determine the critical equation of state of the three-dimensional O(4) universality class. We first consider the small-field expansion of the effective potential (Helmholtz free energy). Then, we apply a systematic approximation scheme based on polynomial parametric representations that are valid in the whole critical regime, satisfy the correct analytic properties (Griffiths' analyticity), take into account the Goldstone singularities at the coexistence curve, and match the small-field expansion of the effective potential. From the approximate representations of the equation of state, we obtain estimates of several universal amplitude ratios. The three-dimensional O(4) universality class is expected to describe the finite-temperature chiral transition of quantum chromodynamics with two light flavors. Within this picture, the O(4) critical equation of state relates the reduced temperature, the quark masses, and the condensates around T_c in the limit of vanishing quark masses.Comment: 19 pages, 5 fig