Computational wind engineering using finite element package ADINA

Thesis (M. Eng.)--Massachusetts Institute of Technology, Dept. of Civil and Environmental Engineering, 2008.Includes bibliographical references (leaves 61-64).Design of tall and long span structures is governed by the wind forces. Inadequate research in the field of wind dynamics has forced engineers to rely on design codes or wind tunnel tests for sufficient data. The present work uses a computational wind dynamics method to compare the coefficient of pressure (Cp) for the different aerodynamic shapes. ADINA, a finite element package, contains an inbuilt turbulence model which will be used to construct four different shapes for comparison. Results are verified with the experimental and simulation data. The effect of increase in the Reynolds number on the flow has been studied. Graphs for the pressure, velocity and turbulence energy distribution have been developed to assist the engineers in design.by Ankur Bajoria.M.Eng

Silent Narrative

In this article, I describe my public history project seeking to transform a street in Connaught Place, New Delhi, into a militarised Srinagar marketplace. Through this phenomenological project, I aim to make Hindu, middle- class, upper-middle-caste Indians realise that the Indian presence in the Kashmir Valley is a colonial, military occupation. Through this, I want them to reconsider India’s claims of being a secular, liberal-democracy. To contextualise my intervention, I briefly represent the mainstream Indian narrative on Kashmir, both in academia and the wider public space, in the first section of this article. Thus, by highlighting the ‘silences’ in the general understanding of Kashmir, I will demonstrate my project’s contribution to Kashmir’s historiography. KEYWORDS colonialism; exhibit; phenomenology; India-Occupied Kashmir; historiography; Museu

Uncomplicated Monochorionic Diamniotic Twins and the Timing of Delivery

Cleary-Goldman and d'Alton discuss the implications of a new study in PLoS Medicine examining the risk of fetal death in uncomplicated monochorionic diamnotic twin pregnancies

Assessing wire EDM as a novel approach for CFRP drilling: performance and thermal analysis across lay-up configurations

Conventional drilling of carbon fibre–reinforced plastic (CFRP) presents significant challenges due to the material’s abrasive nature and anisotropic properties, leading to tool wear, delamination, and surface damage. To address these challenges, this study pioneers the use of wire electrical discharge machining (WEDM) to evaluate the drilling performance of thick CFRP lay-up configurations mainly unidirectional and multidirectional, marking the first application of WEDM for CFRP drilling. The study evaluates material removal rate (MRR), delamination factor (DF), and surface damage while employing an analytical solution to estimate surface temperature and heat conduction in the laminates. An eight-full factorial experimental design was employed, involving variations in ignition current (3 A and 5 A) and pulse-off time (4 µs and 8 µs). The findings revealed that the multidirectional lay-up achieved an MRR of 2.85 mm3/min, significantly outperforming the unidirectional lay-up’s MRR of 0.95 mm3/min, representing a 300% increase at 5 A and 4 µs. However, the increase in discharge energy led to surface damage such as delamination, frayed fibres, and irregular circularity, especially evident in the unidirectional lay-up. For delamination, the multidirectional lay-up had the highest top DF of 1.4 at 5 A and 6 µs, while the unidirectional lay-up achieved the peak bottom DF of 1.24 at the same levels. While none of the parameters significantly affected the responses, the current exhibited the highest contribution ratios. Analytical predictions of the thermal distribution indicated a 45-µm delamination length at the laminate surface and depth, aligning closely with experimental predictions of 30–50 µm

Genetic, environmental and stochastic factors in monozygotic twin discordance with a focus on epigenetic differences

PMCID: PMC3566971This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited

Prophylactic Activity of Orally Administered FliD-Reactive Monoclonal SIgA Against Campylobacter Infection

This work is licensed under a Creative Commons Attribution 4.0 International License.Campylobacter infection is one of the most common causes of bacterial gastroenteritis worldwide and a major global health threat due to the rapid development of antibiotic resistance. Currently, there are no vaccines approved to prevent campylobacteriosis, and rehydration is the main form of therapy. Secretory immunoglobulin A (SIgA) is the main antibody class found in mucous secretions, including human milk, and serves as the first line of defense for the gastrointestinal epithelium against enteric pathogens. In this study, we describe the prophylactic activity of orally delivered recombinant SIgA generated from two human monoclonal antibodies (CAA1 and CCG4) isolated for their reactivity against the flagellar-capping protein FliD, which is essential for bacteria motility and highly conserved across Campylobacter species associated with severe enteritis. In an immunocompetent weaned mouse model, a single oral administration of FliD-reactive SIgA CAA1 or CCG4 at 2 h before infection significantly enhances Campylobacter clearance at early stages post-infection, reducing the levels of inflammation markers associated with epithelial damage and polymorphonuclear (PMN) cells infiltration in the cecum lamina propria. Our data indicate that the prophylactic activity of CAA1 and CCG4 is not only dependent on the specificity to FliD but also on the use of the SIgA format, as the immunoglobulin G (IgG) versions of the same antibodies did not confer a comparable protective effect. Our work emphasizes the potential of FliD as a target for the development of vaccines and supports the concept that orally administered FliD-reactive SIgA can be developed to prevent or mitigate the severity of Campylobacter infections as well as the development of post-infection syndromes.Bill & Melinda Gates foundation (grant: OPP1170883