Academic Study and the Phenomena of Dialogue

To what extent is the academic study of religion interested in Hindu-Christian dialogue, and to what extent can it handle the phenomena of dialogue within the limitations of its method

Development and synthetic applications of the asymmetric anionic amino-Cope rearrangement

The thermal and anionic amino-Cope rearrangement of suitably functionalised 3-amino-1,5-hexadienes could potentially constitute a powerful tool for the stereoselective synthesis of highly functionalised acyclic or cyclic systems. [Illustration omitted.] Incorporation of β-aminoalcohol auxiliaries into the diene enabled high diastereoselectivity to be obtained during the 1,2-addition of the allyl Grignard reagent to α,β-unsaturated imines. Asymmetric anionic amino-Cope rearrangement of the diastereoisomerically pure 3-amino-1,5-diene substrates furnished the target aldehyde in good yield and with high levels of asymmetric induction (up to 94% e.e.). The aldehyde obtained was used as a non-racemic starting material to synthesise small heterocycles, with high levels of diastereoselectivity in some cases, providing a high yielding route to some important chiral building blocks. The successful formation of both tetrahydropyrans and lactones without any apparent loss of chirality was achieved and provided a background for investigation into the synthesis of piperidines, which could lead to a plausible route to biologically significant aza-sugars. [Illustration omitted.

COST PROJECTIONS FOR POST-CLOSURE CUSTODIAL CARE OF THE BARNWELL RADIOACTIVE WASTE DISPOSAL FACILITY

This document evaluates the adequacy of the Barnwell Extended Care Fund in light of the risks identified and concludes that it is sufficiently funded to cover the costs and uncertainties associated with activities planned for post-closure care of the facility. The report concludes that the fund is currently sufficiently funded to cover some but not all of the costs that might be incurred in responding to unplanned events and consequences. The document reviews background information pertinent to the post- closure monitoring and maintenance of the Barnwell low-level radioactive waste disposal facility (the Barnwell facility) and describes financial responsibility for post-closure activities

Hormonal Contraception Use is Common Among Patients with Inflammatory Bowel Diseases and an Elevated Risk of Deep Vein Thrombosis:

Persons with inflammatory bowel disease (IBD) have an increased risk of venous thromboembolism (VTE). We sought to examine whether self-report of hormonal contraception (HC), as a proxy for exposure to estrogen-based contraception, was less common for women with multiple risk factors for VTE

Telomere length predicts for outcome to FCR chemotherapy in CLL

We have previously shown that dividing patients with CLL into those with telomeres inside the fusogenic range (TL-IFR) and outside the fusogenic range (TL-OFR) is powerful prognostic tool. Here, we used a high-throughput version of the assay (HT-STELA) to establish whether telomere length could predict for outcome to fludarabine, cyclophosphamide, rituximab (FCR)-based treatment using samples collected from two concurrent phase II studies, ARCTIC and ADMIRE (n = 260). In univariate analysis, patients with TL-IFR had reduced progression-free survival (PFS) (P < 0.0001; HR = 2.17) and shorter overall survival (OS) (P = 0.0002; HR = 2.44). Bifurcation of the IGHV-mutated and unmutated subsets according to telomere length revealed that patients with TL-IFR in each subset had shorter PFS (HR = 4.35 and HR = 1.48, respectively) and shorter OS (HR = 3.81 and HR = 2.18, respectively). In addition, the OS of the TL-OFR and TL-IFR subsets were not significantly altered by IGHV mutation status (P = 0.61; HR = 1.24 and P = 0.41; HR = 1.47, respectively). In multivariate modeling, telomere length was the dominant co-variable for PFS (P = 0.0002; HR = 1.85) and OS (P = 0.05; HR = 1.61). Taken together, our data suggest that HT-STELA is a powerful predictor of outcome to FCR-based treatment and could be used to inform the design of future risk-adapted clinical trials

Development of Soft-Hardware Platform for Training System Design of Electrotechnical Complexes and Electric Drives

The article presents the results of the development of software and hardware platform as the equipment for the training of children and youth work skills with robotics, allowing in the future to apply this knowledge in practice, implementing automation system for home use. We consider the problems of existing solutions. The main difference is the integration of the proposed fees and extensions into a single set by connecting the connectors and the ability to connect third-party components from different manufacturers, without limiting users. As well as a simplified method using a visual object-oriented programming allows you to immediately engage in the work. Prepared lessons and tasks in the game style simplifies the information and allows you to understand how you can apply one or another technical solution

An evaluation of hydrologic and riparian resources in Saguaro National Park, Tucson, Arizona

Cooperation Agreement No. CA 8000 -2 -9001 Work Order No. 8039 -2 -9001Within Saguaro National Park only Rincon Mountain District contains significant riparian areas. The geologic framework of the Tanque Verde Ridge and Rincon Valley exerts strong control on the hydrology of these riparian systems. Pantano fault constitutes a line of hydrogeologic separation between the occurrence and utilization of groundwater in the Rincon Valley and the main Tucson basin. No known, comparable fault isolates the upper Tanque Verde Creek alluvium from downstream pumping effects. However, east of the confluence with Agua Caliente Wash, the highly permeable alluvial materials are much thinner, and serve to dampen such downstream effects. Therefore, the ground water reservoirs supporting the riparian areas within Rincon Mountain District are not directly connected to the Tucson basin aquifer. In what is described herein as upper basin areas, high gradient tributary streams to Tanque Verde Creek and Rincon Creek have discontinuous bodies of shallow alluvium interspersed with bedrock channel. Alluvium has accumulated behind small faults or resistant bedrock ledges and contains shallow ground water basins that support small pockets of riparian or xeroriparian vegetation. The ground water in these small basins is sustained by seeps or springs, and by runoff from precipitation and is not likely to be connected to a regional ground water system. In what we have characterized as middle basin areas, the stream gradients are less than 25m/km. In these low gradient reaches, the alluvial floodplain sediments are continuous, though not thick, as ledges of more resistant bedrock formations appear in the stream channel. These low gradient reaches contain larger volumes of ground water than the high gradient basins and support more robust riparian vegetation. The ground water in the low gradient reaches is believed to be connected to the regional ground water system. Such a low gradient reach exists in a tributary to Tanque Verde Creek about 1.4 km east of Wentworth Road and extends about 1.6 km into the Park. A similar low gradient reach occurs along Rincon Creek in the Expansion Area, and at the mouths of Chiminea and Madrona Creeks.This title from the Hydrology & Water Resources Technical Reports collection is made available by the Department of Hydrology & Atmospheric Sciences and the University Libraries, University of Arizona. If you have questions about titles in this collection, please contact [email protected]

Licensing an assured isolation facility for low-level radioactive waste. Volume 2: Recommendations on the content and review of an application

This report provides a detailed set of proposed criteria and guidance for the preparation of a license application for an assured isolation facility (AIF). The report is intended to provide a detailed planning basis upon which a prospective applicant may begin pre-licensing discussions with the Nuclear Regulatory Commission and initiate development of a license application. The report may also be useful to the NRC or to state regulatory agencies that may be asked to review such an application. Volume 1 of this report provides background information, and describes the licensing approach and methodology. Volume 2 identifies specific information that is recommended for inclusion in a license application

Licensing an assured isolation facility for low-level radioactive waste. Volume 1: Licensing strategy and issues

This report provides a detailed set of proposed criteria and guidance for the preparation of a license application for an assured isolation facility (AIF). The report is intended to provide a detailed planning basis upon which a prospective applicant may begin pre-licensing discussions with the Nuclear Regulatory Commission and initiate development of a license application. The report may also be useful to the NRC or to state regulatory agencies that may be asked to review such an application. Volume 1 of this report provides background information, and describes the licensing approach and methodology. Volume 2 identifies specific information that is recommended for inclusion in a license application