Predicting Flock Vigilance from Simple Passerine Interactions: Modelling with Cellular Automata

Vigilance in flocks can be described and modelled as a plausible set of local interactions between neighbouring birds. Each bird in the modelled flock chooses to feed or to scan based solely on whether or not its neighbours are feeding or scanning. This simple model has the ability both to reproduce observations that have not been previously explained and to predict flock behaviours that might be confirmed with future field studies. Examples include simulations showing decreased vigilance with increased flock size (as observed in the field), greater time spent scanning when obstacles such as trees are present (as observed) and a coordinated feed/scan pattern (that is predicted to become increasingly coordinated when the birds look up from feeding more frequently). The numerical model also predicts that flock geometry influences vigilance. If two flocks are the same size, individuals in the one with the larger perimeter will spend more time scanning. This prediction could be tested with field studies and already has been observed empirically for two limiting cases: birds arranged in a line (high perimeters, high scan times) and birds in a circle (lower perimeters, lower scan times). As demonstrated by its multiple successes, cellular models of this type are a powerful new approach to understanding bird flock behaviours

OC449-09 Data Report : St. Thomas, USVI to Bermuda, December 1-10, 2008

Data collected during multiple surveys of hydrography, velocity, and biological quantities are presented from a 9-day cruise aboard the R/V Oceanus near the island of St. Thomas, USVI and a subsequent transit to Bermuda during December, 2008. This cruise (OC449-09) was undertaken primarily to field test a newly acquired towed-undulating body, the Scanfish. The Scanfish and a second towed body, the Video Plankton Recorder (VPR), were used to survey hydrographic, optical, and biological properties north and south of St. Thomas. Conductivity-Temperature-Depth (CTD) casts and plankton net-tows were made at locations along the survey transects for inter-comparison. The VPR was also used to profile conditions between St. Thomas and Bermuda during transit. An overview of the cruise is given along with descriptions of the data collection methods, processing steps taken, and data products available for distribution.Funding for this research was provided by the King Abdullah University of Science and Technology (KAUST) under a cooperative research agreement with Woods Hole Oceanographic Institution

Spatial variability in the flow of a valley glacier: Deformation of a large array of boreholes

Measurements of the deformation of a dense array of boreholes in Worthington Glacier, Alaska, show that the glacier moves with generally bed-parallel motion. Strain in the 200 m deep valley glacier is constant near the surface but follows a nonlinear vertical profile below a depth of about 120 m. By a depth of 180 m, the octahedral strain rate reaches 0.35 yr-1. The three-dimensional velocity field shows spatial complexity with significant deviations from plane strain, despite relatively simple valley geometry in the vicinity of the 6 x 106 m3 study volume. No evidence was found for time-varying deformation or movement along localized shear planes. Observations were made by repeatedly measuring the long-axis geometry of 31 closely spaced boreholes over a 70 day period, and three additional holes after 1 full year of deformation. The holes were spaced 15 to 30 m apart. Installation and measurement of such a large number of boreholes required the development of a semi-automated hot water drilling system that creates straight and vertical boreholes with uniform walls. The equipment and procedures enables borehole profiles to be measured without the use of hole casing. Inclinometry measurements collected in the holes were processed, analyzed for error, and visualized as a fully three-dimensional data set. the new methods offer unique insight into small-scale spatial and temporal variations in the pattern of flow in a valley glacier

Towards classical geometrodynamics from Group Field Theory hydrodynamics

We take the first steps towards identifying the hydrodynamics of group field theories (GFTs) and relating this hydrodynamic regime to classical geometrodynamics of continuum space. We apply to GFT mean field theory techniques borrowed from the theory of Bose condensates, alongside standard GFT and spin foam techniques. The mean field configuration we study is, in turn, obtained from loop quantum gravity coherent states. We work in the context of 2d and 3d GFT models, in euclidean signature, both ordinary and colored, as examples of a procedure that has a more general validity. We also extract the effective dynamics of the system around the mean field configurations, and discuss the role of GFT symmetries in going from microscopic to effective dynamics. In the process, we obtain additional insights on the GFT formalism itself.Comment: revtex4, 32 pages. Contribution submitted to the focus issue of the New Journal of Physics on "Classical and Quantum Analogues for Gravitational Phenomena and Related Effects", R. Schuetzhold, U. Leonhardt and C. Maia, Eds; v2: typos corrected, references updated, to match the published versio

Cellular/Molecular Dual Modulation of Endocannabinoid Transport and Fatty Acid Amide Hydrolase Protects against Excitotoxicity

The endocannabinoid system has been suggested to elicit signals that defend against several disease states including excitotoxic brain damage. Besides direct activation with CB 1 receptor agonists, cannabinergic signaling can be modulated through inhibition of endocannabinoid transport and fatty acid amide hydrolase (FAAH), two mechanisms of endocannabinoid inactivation. To test whether the transporter and FAAH can be targeted pharmacologically to modulate survival/repair responses, the transport inhibitor N-(4-hydroxyphenyl)-arachidonamide (AM404) and the FAAH inhibitor palmitylsulfonyl fluoride (AM374) were assessed for protection against excitotoxicity in vitro and in vivo. AM374 and AM404 both enhanced mitogen-activated protein kinase (MAPK) activation in cultured hippocampal slices. Interestingly, combining the distinct inhibitors produced additive effects on CB 1 signaling and associated neuroprotection. After an excitotoxic insult in the slices, infusing the AM374/AM404 combination protected against cytoskeletal damage and synaptic decline, and the protection was similar to that produced by the stable CB 1 agonist AM356 (R-methanandamide). AM374/ AM404 and the agonist also elicited cytoskeletal and synaptic protection in vivo when coinjected with excitotoxin into the dorsal hippocampus. Correspondingly, potentiating endocannabinoid responses with the AM374/AM404 combination prevented behavioral alterations and memory impairment that are characteristic of excitotoxic damage. The protective effects mediated by AM374/AM404 were (1) evident 7 d after insult, (2) correlated with the preservation of CB 1 -linked MAPK signaling, and (3) were blocked by a selective CB 1 antagonist. These results indicate that dual modulation of the endocannabinoid system with AM374/AM404 elicits neuroprotection through the CB 1 receptor. The transporter and FAAH are modulatory sites that may be exploited to enhance cannabinergic signaling for therapeutic purposes

Circulation in the vicinity of Mackenzie Canyon from a year-long mooring array

© The Author(s), 2020. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Lin, P., Pickart, R. S., Fissel, D., Ross, E., Kasper, J., Bahr, F., Torres, D. J., O'Brien, J., Borg, K., Melling, H., & Wiese, F. K. Circulation in the vicinity of Mackenzie Canyon from a year-long mooring array. Progress in Oceanography, 187, (2020): 102396, doi:10.1016/j.pocean.2020.102396.Data from a five-mooring array extending from the inner shelf to the continental slope in the vicinity of Mackenzie Canyon, Beaufort Sea are analyzed to elucidate the components of the boundary current system and their variability. The array, part of the Marine Arctic Ecosystem Study (MARES), was deployed from October 2016 to September 2017. Four distinct currents were identified: an eastward-directed flow adjacent to the coast; a westward-flowing, surface-intensified current centered on the outer-shelf; a bottom-intensified shelfbreak jet flowing to the east; and a recirculation at the base of the continental slope within the canyon. The shelf current transports −0.120.03 Sv in the mean and is primarily wind-driven. The response is modulated by the presence of ice, with little-to-no signal during periods of nearly-immobile ice cover and maximum response when there is partial ice cover. The shelfbreak jet transports 0.030.02 Sv in the mean, compared to 0.080.02 Sv measured upstream in the Alaskan Beaufort Sea over the same time period. The loss of transport is consistent with a previous energetics analysis and the lack of Pacific-origin summer water downstream. The recirculation in the canyon appears to be the result of local dynamics whereby a portion of the westward-flowing southern limb of the Beaufort Gyre is diverted up the canyon across isobaths. This interpretation is supported by the fact that the low-frequency variability of the recirculation is correlated with the wind-stress curl in the Canada Basin, which drives the Beaufort gyre.The authors are indebted to Fisheries and Oceans Canada for building the logistics for MARES into the at-sea missions of the Integrated Beaufort Observatory. We are grateful to the captain and crew of the CCGS Sir Wilfred Laurier for ably deploying and recovering the MARES array. Marshall Swartz assisted with the cruise preparation logistics. We thank the two anonymous reviewers for their input which helped improve the paper. This project was funded by the US Bureau of Ocean Energy Management (BOEM), on behalf of the National Ocean Partnership Program. The Canadian contribution was supported by the Environmental Studies Research Fund (ESRF Project 2014-02N). MARES publication 003

Diagnostic accuracy of Xpert MTB/RIF Ultra for tuberculous meningitis in HIV-infected adults: a prospective cohort study.

BACKGROUND: WHO recommends Xpert MTB/RIF as initial diagnostic testing for tuberculous meningitis. However, diagnosis remains difficult, with Xpert sensitivity of about 50-70% and culture sensitivity of about 60%. We evaluated the diagnostic performance of the new Xpert MTB/RIF Ultra (Xpert Ultra) for tuberculous meningitis. METHODS: We prospectively obtained diagnostic cerebrospinal fluid (CSF) specimens during screening for a trial on the treatment of HIV-associated cryptococcal meningitis in Mbarara, Uganda. HIV-infected adults with suspected meningitis (eg, headache, nuchal rigidity, altered mental status) were screened consecutively at Mbarara Regional Referral Hospital. We centrifuged CSF, resuspended the pellet in 2 mL of CSF, and tested 0·5 mL with mycobacteria growth indicator tube culture, 1 mL with Xpert, and cryopreserved 0·5 mL, later tested with Xpert Ultra. We assessed diagnostic performance against uniform clinical case definition or a composite reference standard of any positive CSF tuberculous test. FINDINGS: From Feb 27, 2015, to Nov 7, 2016, we prospectively evaluated 129 HIV-infected adults with suspected meningitis for tuberculosis. 23 participants were classified as probable or definite tuberculous meningitis by uniform case definition, excluding Xpert Ultra results. Xpert Ultra sensitivity was 70% (95% CI 47-87; 16 of 23 cases) for probable or definite tuberculous meningitis compared with 43% (23-66; 10/23) for Xpert and 43% (23-66; 10/23) for culture. With composite standard, we detected tuberculous meningitis in 22 (17%) of 129 participants. Xpert Ultra had 95% sensitivity (95% CI 77-99; 21 of 22 cases) for tuberculous meningitis, which was higher than either Xpert (45% [24-68]; 10/22; p=0·0010) or culture (45% [24-68]; 10/22; p=0·0034). Of 21 participants positive by Xpert Ultra, 13 were positive by culture, Xpert, or both, and eight were only positive by Xpert Ultra. Of those eight, three were categorised as probable tuberculous meningitis, three as possible tuberculous meningitis, and two as not tuberculous meningitis. Testing 6 mL or more of CSF was associated with more frequent detection of tuberculosis than with less than 6 mL (26% vs 7%; p=0·014). INTERPRETATION: Xpert Ultra detected significantly more tuberculous meningitis than did either Xpert or culture. WHO now recommends the use of Xpert Ultra as the initial diagnostic test for suspected tuberculous meningitis. FUNDING: National Institute of Neurologic Diseases and Stroke, Fogarty International Center, National Institute of Allergy and Infectious Disease, UK Medical Research Council/DfID/Wellcome Trust Global Health Trials, Doris Duke Charitable Foundation

Measuring the Polarization of Boosted Hadronic Tops

We propose a new technique for measuring the polarization of hadronically decaying boosted top quarks. In particular, we apply a subjet-based technique to events where the decay products of the top are clustered within a single jet. The technique requires neither b-tagging nor W-reconstruction, and does not rely on assumptions about either the top production mechanism or the sources of missing energy in the event. We include results for various new physics scenarios made with different Monte Carlo generators to demonstrate the robustness of the technique.Comment: v2: version accepted for publication in JHE