The change agent teaching model : Educating entrepreneurial leaders to help solve grand societal challenges

Higher education is increasingly expected to educate change agents who can help with solving grand societal challenges. Social and sustainable entrepreneurship (SSE) education and social and sustainable leadership (SSL) education provide promising directions to develop the education that prepares these students for their future roles. However, both educations are part of different research streams and have their respective pedagogical approaches. In this systematic literature review, we identify the differences and similarities between SSE and SSL education. We used the teaching model framework to map systematically the elements of the teaching and learning process. Our results show that the different streams share the aim of educating change agents in authentic, collaborative learning processes that are experiential in nature and challenge students to create value for others. However, SSE education focuses more on creating societal value, whereas SSL education captures the personal development of students. Based on the review, we present an overarching teaching model for educating change agents. Our teaching model can guide practitioners to design change agent education. It illustrates the urgency to change pedagogies fundamentally and how students, staff, and teaching infrastructures should be approached using such pedagogies to realize impactful change agent education

Privatisering onder de loep

Sinds de jaren twintig van de vorige eeuw is overheidsinterventie met openbaar vervoer manifest. Politieke stromingen, tijden van crisis maar ook van economische voorspoed, innovatie en de invloeden vanuit Europa dragen bij aan de wisselende koers die de Nederlandse politiek de afgelopen 50 jaar heeft gevaren. Ontwikkelingen als marktwerking (publiek vs. privaat}, (de}centralisering (rijk vs. regio} en liberalisering vs. regulering, zijn onlosmakelijk verbonden met de organisatie van openbaar vervoer in Nederland

Churg-Strauss Syndrome following PTU Treatment

Propylthiouracil (PTU) is a frequently prescribed drug in the treatment of hyperthyroidism. The use of PTU is, however, accompanied by numerous potentially serious side effects including vasculitis. PTU-related vasculitides can present as haematuria, pulmonary haemorrhage, or cutaneous lesion together with aspecific symptoms such as fever, myalgia, arthralgia, and fatigue. Cerebral involvement is seldom observed. We present a 49-year-old female with Graves' disease and asthma, who developed paresis of the proximal extremities, eosinophilia, pulmonary, and cutaneous lesions following treatment with PTU. A cerebral vasculitis consistent with Churg-Strauss syndrome (CSS) was suspected. Although cerebral involvement is seldom observed with PTU treatment, cerebral vasculitis should be considered in patients developing CNS symptoms

Weight bearing exercise can elicit similar peak muscle activation as medium–high intensity resistance exercise in elderly women

Purpose: To assess whether stepping-based weight bearing exercise (WBE) can elicit peak activation of upper leg muscles similar to resistance exercise (RE) at an intensity required to induce strength gains in elderly women. Methods: Muscular activation of several upper leg muscles was measured during RE and WBE in a cohort of 19 healthy elderly women (69.3 ± 3.4 years). WBE consisted of forward and lateral stepping with step heights of 10, 20 and 30 cm. Muscular activation was compared to 60% of one-repetition maximum (1-RM) of congruent RE. Results: Peak activation during WBE was higher than RE at 60% 1-RM during forward and lateral stepping in vastus lateralis starting at 20 cm (p = 0.049 and p = 0.001), and biceps femoris at 30 cm step height (p = 0.024 and p = 0.030). Gluteus maximus peak activation matched RE at 60% 1-RM at 20 and 30 cm step height regardless of step direction (p ≥ 0.077). Peak activation of the rectus femoris and gluteus medius matched RE activation at 60% 1-RM during lateral stepping at 30 cm (p = 0.355 and p = 0.243, respectively) but not during forward stepping. WBE did not induce similar activation as RE in the semitendinosus. Conclusion: In WBE, most upper leg muscles were recruited at an equal or higher intensity than in RE at 60% 1-RM. Lateral stepping at 30 cm step height showed the highest training potential of all WBE’s applied

Cooling of Active Components in Structurally Integrated Phased Arrays Antennas

This paper presents an innovative cooling solution for active phased array antennas, using a 3D printed liquid cooling device integrated in the structure’s PCB

Bench stepping with incremental heights improves muscle volume, strength and functional performance in older women

Aim: Task-specific exercises such as bench stepping can improve functional ability and reduce falling incidents in older adults. However, such exercises are often not optimized to improve muscle volume and force-velocity characteristics. This study determined the effects of a 12-week stepping program using incremental step heights (STEEP), on muscle volume, strength, power, functional ability and balance performance in older women. Methods: Forty-five community-dwelling women (69y ± 4) were randomly assigned to the STEEP group or a non-training CONTROL group. Training intensity was primarily determined by step height, while training volume remained equal. Thigh muscle volume (CT-scan), force-velocity characteristics of the knee extensors (Biodex dynamometer) and functional ability (Short Physical Performance Battery, timed stair ascent, 10-m walk test and countermovement jump height) were determined pre- and post-intervention. In addition, 3D trunk accelerations were recorded at the lower back to assess balance during the Short Physical Performance Battery balance tests. Results: Two-way ANOVA showed that the STEEP program increased thigh muscle volume, knee extensor isometric peak torque, dynamic peak power, unloaded rate of velocity development and improved performance on all functional tests to a greater extent than CONTROL (p <.05), except the countermovement jump. No improvements were found for peak velocity and balance performance (p >.05). Conclusion: Our results indicate that bench step training with incremental step heights simultaneously improves functional ability, thigh muscle volume and force-velocity characteristics of the knee extensors in older women

Chikungunya Virus nsP3 Blocks Stress Granule Assembly by Recruitment of G3BP into Cytoplasmic Foci

Chikungunya virus nonstructural protein nsP3 has an essential but unknown role in alphavirus replication and interacts with Ras-GAP SH3 domain-binding protein (G3BP). Here we describe the first known function of nsP3, to inhibit stress granule assembly by recruiting G3BP into cytoplasmic foci. A conserved SH3 domain-binding motif in nsP3 is essential for both nsP3-G3BP interactions and viral RNA replication. This study reveals a novel role for nsP3 as a regulator of the cellular stress respons

Cardiac magnetic resonance findings predicting mortality in patients with pulmonary arterial hypertension: a systematic review and meta-analysis

Objectives: To provide a comprehensive overview of all reported cardiac magnetic resonance (CMR) findings that predict clinical deterioration in pulmonary arterial hypertension (PAH). Methods: MEDLINE and EMBASE electronic databases were systematically searched for longitudinal studies published by April 2015 that reported associations between CMR findings and adverse clinical outcome in PAH. Studies were appraised using previously developed criteria for prognostic studies. Meta-analysis using random effect models was performed for CMR findings investigated by three or more studies. Results: Eight papers (539 patients) investigating 21 different CMR findings were included. Meta-analysis showed that right ventricular (RV) ejection fraction was the strongest predictor of mortality in PAH (pooled HR 1.23 [95 % CI 1.07–1.41], p = 0.003) per 5 % decrease. In addition, RV end-diastolic volume index (po

NATALIA: a satcom phased array in Ku-band

This article presents the prototype of an electronically steerable receive-only array antenna realised within the ESA-project NATALIA. This project is funded under contract number 18612/04/NL/US. The antenna is conceived for the reception of mobile satellite services in Ku-band and its design targets the market of automotive applications. The design of the prototype is based on an innovative polarisation agile phased array concept and exhibits an excellent RF-performance as well as a very compact envelope