On SS-Noetherian modules and SS-strong Mori modules

In this paper, we study some properties of $S$-Noetherian modules and $S$-strong Mori modules. Among other things, we prove the Hilbert basis theorem for $S$-Noetherian modules and $S$-strong Mori modules.Comment: 15 page

On SS-nn-absorbing ideals

Let $R$ be a commutative ring with identity, $S$ a multiplicative subset of $R$ and $I$ an ideal of $R$ disjoint from $S$. In this paper, we introduce the notion of an $S$-$n$-absorbing ideal which is a generalization of both the $S$-prime ideals and $n$-absorbing ideals. Moreover, we investigate the basic properties, quotient extension, existence and amalgamation of $S$-$n$-absorbing ideals.Comment: 18page

The first generation of a BAC-based physical map of Brassica rapa

<p>Abstract</p> <p>Background</p> <p>The genus <it>Brassica </it>includes the most extensively cultivated vegetable crops worldwide. Investigation of the <it>Brassica </it>genome presents excellent challenges to study plant genome evolution and divergence of gene function associated with polyploidy and genome hybridization. A physical map of the <it>B. rapa </it>genome is a fundamental tool for analysis of <it>Brassica </it>"A" genome structure. Integration of a physical map with an existing genetic map by linking genetic markers and BAC clones in the sequencing pipeline provides a crucial resource for the ongoing genome sequencing effort and assembly of whole genome sequences.</p> <p>Results</p> <p>A genome-wide physical map of the <it>B. rapa </it>genome was constructed by the capillary electrophoresis-based fingerprinting of 67,468 Bacterial Artificial Chromosome (BAC) clones using the five restriction enzyme SNaPshot technique. The clones were assembled into contigs by means of FPC v8.5.3. After contig validation and manual editing, the resulting contig assembly consists of 1,428 contigs and is estimated to span 717 Mb in physical length. This map provides 242 anchored contigs on 10 linkage groups to be served as seed points from which to continue bidirectional chromosome extension for genome sequencing.</p> <p>Conclusion</p> <p>The map reported here is the first physical map for <it>Brassica </it>"A" genome based on the High Information Content Fingerprinting (HICF) technique. This physical map will serve as a fundamental genomic resource for accelerating genome sequencing, assembly of BAC sequences, and comparative genomics between <it>Brassica </it>genomes. The current build of the <it>B. rapa </it>physical map is available at the <it>B. rapa </it>Genome Project website for the user community.</p

Impact on Soil Physical Properties Related to a High Mechanization Level in the Row Thinning of a Korean Pine Stand

In ground-based harvesting, machine traffic can cause soil physical disturbances including excessive compaction, the displacement of the soil surface and topsoil, and rutting. These impacts can indirectly hamper seedling survival and tree growth because of reduced soil permeability and root growth. However, the extent of soil disturbance in mechanized row thinning by harvester and forwarder systems in South Korea is unclear. Therefore, our objectives were to determine the impacts of two types of harvesters, soil textures, and extraction methods on soil compaction and rutting in a Korean Pine stand. The results showed that the machine passes affected soil disturbances. The soil bulk density inside the tracks (at 0&ndash;10 and 10&ndash;20 cm soil depths) after harvester passes (wheeled vs. tracked) increased by 17 and 27% and 30 and 20%, respectively. The largest impact was recorded for the forwarding track and significant differences were observed between the track and reference locations. Furthermore, the rutting depth in the forwarding trails was significantly higher than in the harvester trails. Thus, the application of a brush mat on harvester and forwarder trails may reduce machine-induced soil compaction. These results provide useful information to help forest engineers and field managers design environmentally sound ground-based harvesting operations

Impact on Soil Physical Properties Related to a High Mechanization Level in the Row Thinning of a Korean Pine Stand

In ground-based harvesting, machine traffic can cause soil physical disturbances including excessive compaction, the displacement of the soil surface and topsoil, and rutting. These impacts can indirectly hamper seedling survival and tree growth because of reduced soil permeability and root growth. However, the extent of soil disturbance in mechanized row thinning by harvester and forwarder systems in South Korea is unclear. Therefore, our objectives were to determine the impacts of two types of harvesters, soil textures, and extraction methods on soil compaction and rutting in a Korean Pine stand. The results showed that the machine passes affected soil disturbances. The soil bulk density inside the tracks (at 0–10 and 10–20 cm soil depths) after harvester passes (wheeled vs. tracked) increased by 17 and 27% and 30 and 20%, respectively. The largest impact was recorded for the forwarding track and significant differences were observed between the track and reference locations. Furthermore, the rutting depth in the forwarding trails was significantly higher than in the harvester trails. Thus, the application of a brush mat on harvester and forwarder trails may reduce machine-induced soil compaction. These results provide useful information to help forest engineers and field managers design environmentally sound ground-based harvesting operations

Doxorubicin Regulates Autophagy Signals via Accumulation of Cytosolic Ca2+ in Human Cardiac Progenitor Cells

Doxorubicin (DOXO) is widely used to treat solid tumors. However, its clinical use is limited by side effects including serious cardiotoxicity due to cardiomyocyte damage. Resident cardiac progenitor cells (hCPCs) act as key regulators of homeostasis in myocardial cells. However, little is known about the function of hCPCs in DOXO-induced cardiotoxicity. In this study, we found that DOXO-mediated hCPC toxicity is closely related to calcium-related autophagy signaling and was significantly attenuated by blocking mTOR signaling in human hCPCs. DOXO induced hCPC apoptosis with reduction of SMP30 (regucalcin) and autophagosome marker LC3, as well as remarkable induction of the autophagy-related markers, Beclin-1, APG7, and P62/SQSTM1 and induction of calcium-related molecules, CaM (Calmodulin) and CaMKII (Calmodulin kinase II). The results of an LC3 puncta assay further indicated that DOXO reduced autophagosome formation via accumulation of cytosolic Ca2+. Additionally, DOXO significantly induced mTOR expression in hCPCs, and inhibition of mTOR signaling by rapamycin, a specific inhibitor, rescued DOXO-mediated autophagosome depletion in hCPCs with significant reduction of DOXO-mediated cytosolic Ca2+ accumulation in hCPCs, and restored SMP30 and mTOR expression. Thus, DOXO-mediated hCPC toxicity is linked to Ca2+-related autophagy signaling, and inhibition of mTOR signaling may provide a cardio-protective effect against DOXO-mediated hCPC toxicity

Whole genome and global gene expression analyses of the model mushroom Flammulina velutipes reveal a high capacity for lignocellulose degradation.

Flammulina velutipes is a fungus with health and medicinal benefits that has been used for consumption and cultivation in East Asia. F. velutipes is also known to degrade lignocellulose and produce ethanol. The overlapping interests of mushroom production and wood bioconversion make F. velutipes an attractive new model for fungal wood related studies. Here, we present the complete sequence of the F. velutipes genome. This is the first sequenced genome for a commercially produced edible mushroom that also degrades wood. The 35.6-Mb genome contained 12,218 predicted protein-encoding genes and 287 tRNA genes assembled into 11 scaffolds corresponding with the 11 chromosomes of strain KACC42780. The 88.4-kb mitochondrial genome contained 35 genes. Well-developed wood degrading machinery with strong potential for lignin degradation (69 auxiliary activities, formerly FOLymes) and carbohydrate degradation (392 CAZymes), along with 58 alcohol dehydrogenase genes were highly expressed in the mycelium, demonstrating the potential application of this organism to bioethanol production. Thus, the newly uncovered wood degrading capacity and sequential nature of this process in F. velutipes, offer interesting possibilities for more detailed studies on either lignin or (hemi-) cellulose degradation in complex wood substrates. The mutual interest in wood degradation by the mushroom industry and (ligno-)cellulose biomass related industries further increase the significance of F. velutipes as a new model

Therapeutic Cell Protective Role of Histochrome under Oxidative Stress in Human Cardiac Progenitor Cells

Cardiac progenitor cells (CPCs) are resident stem cells present in a small portion of ischemic hearts and function in repairing the damaged heart tissue. Intense oxidative stress impairs cell metabolism thereby decreasing cell viability. Protecting CPCs from undergoing cellular apoptosis during oxidative stress is crucial in optimizing CPC-based therapy. Histochrome (sodium salt of echinochrome A&mdash;a common sea urchin pigment) is an antioxidant drug that has been clinically used as a pharmacologic agent for ischemia/reperfusion injury in Russia. However, the mechanistic effect of histochrome on CPCs has never been reported. We investigated the protective effect of histochrome pretreatment on human CPCs (hCPCs) against hydrogen peroxide (H2O2)-induced oxidative stress. Annexin V/7-aminoactinomycin D (7-AAD) assay revealed that histochrome-treated CPCs showed significant protective effects against H2O2-induced cell death. The anti-apoptotic proteins B-cell lymphoma 2 (Bcl-2) and Bcl-xL were significantly upregulated, whereas the pro-apoptotic proteins BCL2-associated X (Bax), H2O2-induced cleaved caspase-3, and the DNA damage marker, phosphorylated histone (&gamma;H2A.X) foci, were significantly downregulated upon histochrome treatment of hCPCs in vitro. Further, prolonged incubation with histochrome alleviated the replicative cellular senescence of hCPCs. In conclusion, we report the protective effect of histochrome against oxidative stress and present the use of a potent and bio-safe cell priming agent as a potential therapeutic strategy in patient-derived hCPCs to treat heart disease