7,979 research outputs found
PAMELA's cosmic positron from decaying LSP in SO(10) SUSY GUT
We propose two viable scenarios explaining the recent observations on cosmic
positron excess. In both scenarios, the present relic density in the Universe
is assumed to be still supported by thermally produced WIMP or LSP (\chi). One
of the scenarios is based on two dark matter (DM) components (\chi,X) scenario,
and the other is on SO(10) SUSY GUT. In the two DM components scenario,
extremely small amount of non-thermally produced meta-stable DM component
[O(10^{-10}) < n_X /n_\chi] explains the cosmic positron excess. In the SO(10)
model, extremely small R-parity violation for LSP decay to e^\pm is naturally
achieved with a non-zero VEV of the superpartner of one right-handed neutrino
(\tilde{\nu}^c) and a global symmetry.Comment: 6 pages, Talks presented in PASCOS, SUSY, and COSMO/CosPA in 201
Adhesion Induced DNA Naturation
DNA adsorption and naturation is modeled via two interacting flexible
homopolymers coupled to a solid surface. DNA denatures if the entropy gain for
unbinding the two strands overcomes the loss of binding energy. When adsorbed
to a surface, the entropy gain is smaller than in the bulk, leading to a
stronger binding and, upon neglecting self-avoidance, absence of a denatured
phase. Now consider conditions where the binding potentials are too weak for
naturation, and the surface potential too weak to adsorb single strands. In a
variational approach it is shown that their combined action may lead to a
naturated adsorbed phase. Conditions for the absence of naturation and
adsorption are derived too. The phase diagram is constructed qualitatively.Comment: 4 pages, 1 figur
DNA end resection by Dna2–Sgs1–RPA and its stimulation by Top3–Rmi1 and Mre11–Rad50–Xrs2
The repair of DNA double-strand breaks (DSBs) by homologous recombination requires processing of broken ends. For repair to start, the DSB must first be resected to generate a 3′-single-stranded DNA (ssDNA) overhang, which becomes a substrate for the DNA strand exchange protein, Rad51 (ref. 1). Genetic studies have implicated a multitude of proteins in the process, including helicases, nucleases and topoisomerases. Here we biochemically reconstitute elements of the resection process and reveal that it requires the nuclease Dna2, the RecQ-family helicase Sgs1 and the ssDNA-binding protein replication protein-A (RPA). We establish that Dna2, Sgs1 and RPA constitute a minimal protein complex capable of DNA resection in vitro. Sgs1 helicase unwinds the DNA to produce an intermediate that is digested by Dna2, and RPA stimulates DNA unwinding by Sgs1 in a species-specific manner. Interestingly, RPA is also required both to direct Dna2 nucleolytic activity to the 5′-terminated strand of the DNA break and to inhibit 3′ to 5′ degradation by Dna2, actions that generate and protect the 3′-ssDNA overhang, respectively. In addition to this core machinery, we establish that both the topoisomerase 3 (Top3) and Rmi1 complex and the Mre11–Rad50–Xrs2 complex (MRX) have important roles as stimulatory components. Stimulation of end resection by the Top3–Rmi1 heterodimer and the MRX proteins is by complex formation with Sgs1 (refs 5, 6), which unexpectedly stimulates DNA unwinding. We suggest that Top3–Rmi1 and MRX are important for recruitment of the Sgs1–Dna2 complex to DSBs. Our experiments provide a mechanistic framework for understanding the initial steps of recombinational DNA repair in eukaryotes
Effects of 3D-printed polycaprolactone/��-tricalcium phosphate membranes on guided bone regeneration
This study was conducted to compare 3D-printed polycaprolactone (PCL) and polycaprolactone/��-tricalcium phosphate (PCL/��-TCP) membranes with a conventional commercial collagen membrane in terms of their abilities to facilitate guided bone regeneration (GBR). Fabricated membranes were tested for dry and wet mechanical properties. Fibroblasts and preosteoblasts were seeded into the membranes and rates and patterns of proliferation were analyzed using a kit-8 assay and by scanning electron microscopy. Osteogenic differentiation was verified by alizarin red S and alkaline phosphatase (ALP) staining. An in vivo experiment was performed using an alveolar bone defect beagle model, in which defects in three dogs were covered with different membranes. CT and histological analyses at eight weeks after surgery revealed that 3D-printed PCL/��-TCP membranes were more effective than 3D-printed PCL, and substantially better than conventional collagen membranes in terms of biocompatibility and bone regeneration and, thus, at facilitating GBR. ? 2017 by the authors. Licensee MDPI, Basel, Switzerland.118Ysciescopu
Weak localization and electron-electron interactions in Indium-doped ZnO nanowires
Single crystal ZnO nanowires doped with indium are synthesized via the
laser-assisted chemical vapor deposition method. The conductivity of the
nanowires is measured at low temperatures in magnetic fields both perpendicular
and parallel to the wire axes. A quantitative fit of our data is obtained,
consistent with the theory of a quasi-one-dimensional metallic system with
quantum corrections due to weak localization and electron-electron
interactions. The anisotropy of the magneto-conductivity agrees with theory.
The two quantum corrections are of approximately equal magnitude with
respective temperature dependences of T^-1/3 and T^-1/2. The alternative model
of quasi-two-dimensional surface conductivity is excluded by the absence of
oscillations in the magneto-conductivity in parallel magnetic fields.Comment: 13 pages, Corrected forma
Unitarity constraints on the stabilized Randall-Sundrum scenario
Recently proposed stabilization mechanism of the Randall-Sundrum metric gives
rise to a scalar radion, which couples universally to matter with a weak
interaction ( TeV) scale. Demanding that gauge boson scattering as
described by the effective low enerrgy theory be unitary upto a given scale
leads to significant constraints on the mass of such a radion.Comment: 10 page Latex 2e file including 4 postscript figures. Accepted in
Journal of Physics
The Effective Lagrangian in the Randall-Sundrum Model and Electroweak Physics
We consider the two-brane Randall-Sundrum (RS) model with bulk gauge fields.
We carefully match the bulk theory to a 4D low-energy effective Lagrangian. In
addition to the four-fermion operators induced by KK exchange we find that
large negative S and T parameters are induced in the effective theory. This is
a tree-level effect and is a consequence of the shapes of the W and Z wave
functions in the bulk. Such effects are generic in extra dimensional theories
where the standard model (SM) gauge bosons have non-uniform wave functions
along the extra dimension. The corrections to precision electroweak observables
in the RS model are mostly dominated by S. We fit the parameters of the RS
model to the experimental data and find somewhat stronger bounds than
previously obtained; however, the standard model bound on the Higgs mass from
precision measurements can only be slightly relaxed in this theory.Comment: 16 pages, LaTeX, 1 figure included, uses JHEP.cls, extended
introduction, added reference
Interplay of Mre11 Nuclease with Dna2 plus Sgs1 in Rad51-Dependent Recombinational Repair
The Mre11/Rad50/Xrs2 complex initiates IR repair by binding to the end of a double-strand break, resulting in 5′ to 3′ exonuclease degradation creating a single-stranded 3′ overhang competent for strand invasion into the unbroken chromosome. The nuclease(s) involved are not well understood. Mre11 encodes a nuclease, but it has 3′ to 5′, rather than 5′ to 3′ activity. Furthermore, mutations that inactivate only the nuclease activity of Mre11 but not its other repair functions, mre11-D56N and mre11-H125N, are resistant to IR. This suggests that another nuclease can catalyze 5′ to 3′ degradation. One candidate nuclease that has not been tested to date because it is encoded by an essential gene is the Dna2 helicase/nuclease. We recently reported the ability to suppress the lethality of a dna2Δ with a pif1Δ. The dna2Δ pif1Δ mutant is IR-resistant. We have determined that dna2Δ pif1Δ mre11-D56N and dna2Δ pif1Δ mre11-H125N strains are equally as sensitive to IR as mre11Δ strains, suggesting that in the absence of Dna2, Mre11 nuclease carries out repair. The dna2Δ pif1Δ mre11-D56N triple mutant is complemented by plasmids expressing Mre11, Dna2 or dna2K1080E, a mutant with defective helicase and functional nuclease, demonstrating that the nuclease of Dna2 compensates for the absence of Mre11 nuclease in IR repair, presumably in 5′ to 3′ degradation at DSB ends. We further show that sgs1Δ mre11-H125N, but not sgs1Δ, is very sensitive to IR, implicating the Sgs1 helicase in the Dna2-mediated pathway
A Note on Vectorial AdS/CFT Duality for Spin- Boundary Theory
The vectorial holographic correspondences between higher-spin theories in
AdS and free vector models on the boundary are extended to the cases where
the latter is described by free massless spin- field. The dual higher-spin
theory in the bulk does not include gravity and can only be defined on rigid
AdS background with boundary. We discuss various properties of these
rather special higher-spin theories and calculate their one-loop free energies.
We show that the result is proportional to the same quantity for spin-
doubleton treated as if it is a AdS field. Finally, we consider even more
special case where the boundary theory itself is given by an infinite tower of
massless higher-spin fields.Comment: 27 pages, version to appear in JHE
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