Risk classification at diagnosis predicts post-HCT outcomes in intermediate-, adverse-risk, and KMT2A-rearranged AML

Little is known about whether risk classification at diagnosis predicts post-hematopoietic cell transplantation (HCT) outcomes in patients with acute myeloid leukemia (AML). We evaluated 8709 patients with AML from the CIBMTR database, and after selection and manual curation of the cytogenetics data, 3779 patients in first complete remission were included in the final analysis: 2384 with intermediate-risk, 969 with adverse-risk, and 426 with KMT2A-rearranged disease. An adjusted multivariable analysis detected an increased risk of relapse for patients with KMT2A-rearranged or adverse-risk AML as compared to those with intermediate-risk disease (hazards ratio [HR], 1.27; P 5.01; HR, 1.71; P,.001, respectively). Leukemia-free survival was similar for patients with KMT2A rearrangement or adverse risk (HR, 1.26; P 5.002, and HR, 1.47; P,.001), as was overall survival (HR, 1.32; P,.001, and HR, 1.45; P,.001). No differences in outcome were detected when patients were stratified by KMT2A fusion partner. This study is the largest conducted to date on post-HCT outcomes in AML, with manually curated cytogenetics used for risk stratification. Our work demonstrates that risk classification at diagnosis remains predictive of post-HCT outcomes in AML. It also highlights the critical need to develop novel treatment strategies for patients with KMT2A-rearranged and adverse-risk disease

Study the relationship of erythropoietin and chronic obstructive pulmonary disease

Rationale: It has long been known that COPD causes polycythemia secondary to erythrocytosis caused by hypoxia present in advanced cases of COPD. However, it was shown in several studies that some COPD patients had anemia rather than erythrocytosis. Revealing the changes which occur in erythropoiesis in response to COPD was the aim of the current study. Methods: 41 COPD patients of different groups according to the inclusion and exclusion criteria and ten healthy control subjects age and sex matched were enrolled in the study. For all, history taking and full Clinical exam were performed, also ABGs, PFT (spirometry), routine labs (CBC, liver and renal function) and determination of EPO should be performed on human serum by ELISA. Results: Showed that the erythropoietin level was 15.24 ± 2.6 in stage 1, 22.61 ± 5.68 in stage 2, 33.59 ± 4, in stage 3, then 17.9 ± 3.3 in stage 4. Also the total percentage of anemia in COPD patients was 46.3% (19/41), in comparison to 51.3% (21/41) non anemic and 2.4% (1/41) polycythemic. And that the percentage of anemia was 27.3% in stage 1, followed by 38.0% in stage 2, 100% in stage 3 then dropped to 58.33% in stage 4 with emergence of polycythemia in 8.33% of cases. Conclusion: Although COPD was thought to cause polycythemia, the current study showed that almost half of patients have anemia, and polycythemia occurred only in the advanced stages. It also appeared that response to erythropoietin in COPD is probably blunted especially with increased severity of the condition. This might be considered as a contributing factor in the development of anemia in COPD which is considered as anemia of chronic disease

DIFFUSION ÉLASTIQUE DE PARTICULES α AUTOUR DE LA BARRIÈRE COULOMBIENNE ET DENSITÉ DE MATIÈRE DES NOYAUX MOYENS ET LOURDS

La diffusion élastique de particules α près de 180° a été mesurée autour de la barrière coulombienne sur les noyaux suivants : 110,112,114,116Cd 112,114,116,118,120,122,124Sn, 122,124,126,128,130Te, 144,148,150,152Sm, 204,206,208Pb. L'analyse à l'aide du modèle optique montre que la distance α-noyau R0,2 où le potentiel réel est 0,2 MeV est définie sans ambiguïté et à ± 0,03 fm près. En termes de distribution de matière, ceci permet de déterminer pour chaque noyau la valeur du rayon où la densité est 6 × 10-4 nucléon/fm3.Elastic scattering of α particles near 180° was measured around the Coulomb barrier on the following nuclei : 110,112,114,116Cd 112,114,116,118,120,122,124Sn, 122,124,126,128,130Te, 144,148,150,152Sm, 204,206,208Pb. An optical model analysis showed that the α-nucleus distance R0.2 where the nuclear potential is 0.2 MeV is determined without ambiguity and within ± 0.03 fm. In terms of nuclear matter density, this allows an unambiguous determination of the radius where the density is 6 × 10-4 nucleon/fm3

Effects of some insecticides on the division of a Spodoptera littoralis cell line and on the replication of Sl baculovirus (NPV)

Quatre insecticides chimiques (Chloropyrifos, Fenitrothion, Cypermethrin, Carbaryl) appartenant à 3 groupes de pesticides ont été utilisés sur des cellules de #S. littoralis$in vitro. Le Chloropyrifos induit une augmentation de 25$ NPV est augmentée avec augmentation du titre montrant un effet synergique comme celui observé in vivo. Le modèle pourrait permettre de mieux comprendre l'impact des insecticides et leur mode d'action. (Résumé d'auteur

Late Ordovician (Katian) spores in Sweden: oldest land plant remains from Baltica

A palynological study of the Ordovician–Silurian boundary (Katian–Rhuddanian) succession in the Röstaånga-1 drillcore, southern Sweden, has been performed. The lithology is dominated by mudstone and graptolitic shale, with subordinate limestone, formed in the deeper marine halo of southernBaltica. The palynological assemblages are dominated by marine microfossils, mainly chitinozoans and acritarchs. Sparse but well-preserved cryptospores, including Tetrahedraletes medinensis, Tetrahedraletes grayii and Pseudodyadospora sp., were encountered in the Lindegård Formation (late Katian–early Hirnantian), with the oldest record just above the first appearance of the graptolite species Dicellograptus complanatus. This represents the earliest record of early land plant spores from Sweden and possibly also from Baltica and implies that land plants had migrated to the palaeocontinent Baltica by at least the Late Ordovician

Parity-preserving and magnetic field–resilient superconductivity in InSb nanowires with Sn shells

International audienceWe study bottom-up grown semiconductor indium antimonide nanowires that are coated with shells of tin. The shells are uniform in thickness. The interface between Sn and InSb is abrupt and without interdiffusion. Devices for transport are prepared by in-situ shadowing of nanowires using nearby nanowires as well as flakes, resulting in etch-free junctions. Tin is found to induce a hard superconducting gap in the range 600-700 micro-eV. Superconductivity persists up to 4 T in magnetic field. A tin island exhibits the coveted two-electron charging effect, a hallmark of charge parity stability. The findings open avenues for superconducting and topological quantum circuits based on new superconductor-semiconductor combinations