5 research outputs found
Structure of New Delhi metallo-β-lactamase 1 (NDM-1)
- Author
- Publication venue
- 'International Union of Crystallography (IUCr)'
- Publication date
- Field of study
Post-anaesthesia pulmonary complications after use of muscle relaxants (POPULAR): a multicentre, prospective observational study
- Author
- Abad Gurumeta Alfredo
- Abernethy Caroline
- Abigail Patrick
- Achaibar Kira
- Adam Emily
- Afshari Arash
- Agudelo Montoya María Elizabeth
- Akgün Fatma Nur
- Aletti Gabriele
- Alkış Neslihan
- Allan Ashley
- Allan Katie
- Allaouchiche Bernard
- Allcock Clare
- Almasy Emoke
- Amey Isobel
- Amigoni Maria
- Andersen Elin
- Andersson Peder
- Anipchenko Natalya
- Antunes Pedro
- Armstrong Earlene
- Aslam Tayyba
- Assunção José-Pedro
- Ausserer Julia
- Avvai Mary
- Awad Nahla
- Ayas Montero Begoña
- Ayuso Mercedes
- Azevedo Patricia
- Badarau Victoria
- Badescu Roxana
- Baiardo Redaelli Martina
- Baird Colin
- Baird Yolanda
- Baker Tim
- Balaji Packianathaswamy
- Balan Cristina
- Balandin Alina
- Balescu-Arion Carmen
- Baliuliene Vilda
- Baltasar Isabel Jorge
- Baluch Saif Nasr
- Bandrabur Daniela
- Bankewitz Carla
- Barber Katrina
- Barbera Francesco
- Barcraft-Barnes Helena
- Barletti Valentina
- Barnett Gill
- Baron Kirsty
- Barros Ana
- Barsan Victoria
- Bartlett Pauline
- Batistaki Chrysanthi
- Baumgarten Georg
- Baumüller Eva
- Baytaş Volkan
- Beauchamp Nigel
- Becerra Cayetano Isabel A.
- Bell Stephanie
- Bellandi Mattia
- Belletti Alessandro
- Belmonte Cuenca Julio
- Benitez-Cano Adela
- Beretta Luigi
- Berger Marc Moritz
- Bergmann Nicole
- Bergmark Kristina
- Bermudez Lopez Maria
- Bernotaite Monika
- Beurskens Charlotte
- Bidd Heena
- Bifulco Francesca
- Bignami Elena
- Bilic Aleksandar
- Bilskiene Diana
- Bischoff Petra
- Bishop Luke
- Bjønness Therese
- Blaylock Heather
- Blethyn Kate
- Blincoe Thomas
- Blobner Manfred
- Blobner Manfred
- Blobner Manfred
- Blokhin Ivan
- Blunt Nadia
- Boer Christa
- Bois Grégory
- Bonicolini Eleonora
- Booth Joanna
- Borecka-Kedzierska Miraslawa
- Borstnar Katarina
- Borys Michal
- Boselli Emmanuel
- Bouvet Lionel
- Bouwman Arthur
- Bowen Leonora
- Bowrey Sarah
- Boxall Leigh
- Bozić Teodora
- Bradley Tom
- Branco Teresa
- Brazzi Luca
- Brazzoni Marcella
- Brear Tracy
- Brogly Nicolas
- Brohi Farooq
- Broms Jacob
- Bubliauskas Andrius
- Bucolo Gea Erika
- Buerkle Hartmut
- Buggy Donal
- Buhre Wolfgang F.
- Bukauskas Tomas
- Butturini Francesco
- Byttner Anders
- Cabrera Díaz Itahísa
- Calderon Adriana
- Calhau Ricardo
- Callejo Angel
- Cammu Guy
- Campesato Manuela
- Camsooksai Julie
- Can Özlem Selvi
- Cantor Andreea
- Carise Elsa
- Carmona Cristina
- Carreteiro Joana
- Carrieri Cosima
- Carter Anna
- Casal Manuela
- Casanova Irene
- Cascella Marco
- Casero Luis M.
- Casiraghi Giuseppina Maria
- Castelo-Branco Laila
- Castro Arranz Carlos
- Cernea Daniela
- Cervantes Oriol
- Chandler Ben
- Charnock Robert
- Chatzimicali Aikaterini
- Chervjakov Igor
- Chinery Elaine
- Chishti Ahmad
- Chondhury Priyakam
- Christie Emily
- Christodoudiles George
- Ciardo Stefano
- Cimpeanu Luminata
- Cinnella Gilda
- Cirstea Emanuel
- Clark Sebastian
- Clayton Matthew
- Cocu Simona
- Collyer Thomas
- Colvin Carrie
- Cope Sean
- Copeta Filomena
- Copotoiu Sanda
- Correia de Barros Filinto
- Corso Ruggero Massimo
- Cortegiani Andrea
- Costa Gabriela
- Cowton Amanda
- Cox Nicola
- Craig James
- Cricca Valentina
- Cronin John
- Cunha Mariana
- Cuomo Arturo
- Curley Katherine
- Czuczwar Miroslaw
- Cîndea Iulia
- Dabrowska Dominika
- Damster Sandrine
- Danguy des Déserts Marc
- Daniliuc Aura
- Danninger Thomas
- Darwish Imad
- Dascalu Corina
- Davies Kirsty
- Davies Simon
- De Boer Hans D.
- De Flaviis Adelisa
- De Salut Mar Parc
- de Selincourt Gabrielle
- Deana Cristian
- Debaene Bertrand
- Debreceni Gabor
- Dedhia Jatin
- Delgado Garcia Isabel
- Della Rocca Giorgio
- Delroy-Buelles Ilana
- Desai Tejal
- Dhillon Parveen
- Di Giacinto Ida
- Di Mauro Piero
- Diaz Gomez Tamara V.
- Dimitrovski Aleksandar
- Dinic Vesna
- Divander Mona-Britt
- Dolinar Janez
- Domingues Susana
- Doolan James
- Downes Charlotte
- Dragoescu Alice
- Droc Gabriela
- Dum Elisabeth
- Dumitrescu Alexandra
- Duncan Louise
- Dzurňáková Paula
- Dîrzu Dan-Sebastian
- Eberl Susanne
- Edwards Jayne
- Edwards Mark
- Ekelund Kim
- Ekengren Patrik
- Elghouty Eyad
- Ellerkmann Richard
- Ellis Helen
- Elme Andreas
- Eriksson Lars I
- Eriksson Lars I
- Eriksson Lars I.
- Ernst Thomas
- Errando Carlos Luis
- Esteves Simao
- Ewaldsson Callis
- Farid Nahla
- Featherstone James
- Febres Daniela
- Fedorov Sergey
- Feggeler Johanna
- Feijten Prisca
- Fellmann Tobias
- Fernando Aruna
- Fernández Castineira Adrian
- Fernández-Candil Juan
- Ferrando Carlos
- Ferreira Leonia
- Ferreira Patrick
- Feyling Anders
- Filipescu Daniela
- Fleischer Andreas
- Floris Leda
- Foerster Urs
- Fox Benjamin
- Franke Uwe
- Frasca Denis
- Frey Christian
- Frost Victoria
- Fullin Giorgio
- Fumagalli Jacopo
- Furneval Julie
- Fusari Maurizio
- Gallacher Stuart
- Galushka Svetlana
- Gambale Giorgio
- Gambino Irene
- Garcia-Perez Maria Luisa
- Garg Sanjeev
- Garlak Justyna
- Gavranović Zeljka
- Gavrilov Roman
- Gaynor James
- Gecaj-Gashi Agreta
- Georghiou Maria
- Gerjevic Bozena
- Gferer Gudrun
- Giarratano Antonino
- Gibson Andy
- Gievski Vanja
- Giles Julian
- Gillberg Lars
- Gilowska Katarzyna
- Gilsanz Rodriguez Fernando
- Gioia Antonio
- Giovannoni Cecilia
- Girotra Vandana
- Gkinas Dimitrios
- Gkiokas George
- Godoroja Daniela
- Goebel Ulrich
- Goel Vandana
- Gonzalez Matilde
- Goranović Tatjana
- Gornik-Wlaszczuk Ewa
- Gosavi Smita
- Gottfridsson Peter
- Gottschalk Andre
- Granell Manuel
- Granstrom Anna
- Grassetto Alberto
- Greenwood Anna
- Grigoras Ioana
- Grintescu Ioana
- Gritsan Alexey
- Gritsan Galina
- Grynyuk Andriy
- Guadagnin Giovanni Maria
- Guarnieri Marcello
- Guerrero Diez Maria
- Gunenc Ferim
- Gupta Pawan
- Guttenthaler Vera
- Günther Ulf
- Güçlü Çiğdem
- Hack Yvonne
- Hafisayena Ade
- Hagău Natalia
- Haldar Jagannath
- Hales Dawn
- Hales Dawn
- Hancı Volkan
- Hanna-Jumma Sameer
- Harazim Hana
- Harlet Pierre
- Harper Daniel
- Harris Benjamin
- Harvey Orla
- Hashimi Medita
- Hawkins Lesley
- Hayes Conrad
- Heaton James
- Heier Tom
- Helliwell Laurence
- Hemmes Sabrine
- Henderson Kate
- Hermanides Jeroen
- Hermanns Henning
- Herrera Hueso Berta
- Hestenes Siv
- Hettiarachchi Roshane M
- Highgate Judith
- Hodgson Keith
- Hoeft Andreas
- Hoeft Andreas
- Hoelbling Daniel
- Holland Jonathan
- Hollmann Markus
- Hollmann Markus
- Horhota Lucian
- Hormis Anil
- Hribar Renata
- Hua Alina
- Humphreys Sally
- Humphries Ryan
- Humplíková Simona
- Hunt Jane
- Hunter Jennifer
- Hunter Jennifer
- Hunter Jennifer M
- Husnain Ali
- Hussein Ahmed
- Hyams Benjamin
- Iannuccelli Fabrizio
- Ilett Katie
- Ilyas Carl
- Inan Turgay
- India Inmaculada
- Ionităv Victor
- Irwin Foo
- Jain Vipul
- Janez Benedik
- Jankovic Radmilo
- Jenkins Sarah
- Jenko Matej
- Jimenez Gomez Barbara
- Jimenez Raquel
- Joachim Suganthi
- Joelsson-Alm Eva
- John John
- Jonikaite Lina
- Jonsson Fagerlund Malin
- Jonsson Fagerlund Malin
- Jonsson Fagerlund Malin
- Jovic Miomir
- Junke Etienne
- Kabakov Borys
- Kadaoui Salah-Din
- Kanski Andrzej
- Karadağ Süheyla
- Karbonskiene Aurika
- Karjagin Juri
- Kasnik Darja
- Katanolli Fatos
- Katsika Eleni
- Kaufmann Kai
- Keane Helen
- Kelly Martin
- Kent Melanie
- Keraitiene Grazina
- Khudhur Ahmed
- Khuenl-Brady Karin
- Kidd Laurie
- King Siobhan
- Kirchgäßner Katharina
- Kirmeier Eva
- Kirmeier Eva
- Klancir Tino
- Klucniks Andris
- Knotzer Johann
- Knowlden Peter
- Koers Lena
- Kompan Janez
- Koneti Kiran Kumar
- Kooij Fabian
- Koolen Eric
- Koopman - van Gemert Anna Wilhelmina Margaretha Maria
- Kopp Kristen
- Korfiotis Dimitrios
- Korolkov Oleg
- Kosinová Martina
- Kotzinger Oskar
- Kovačević Marko
- Kranke Eva
- Kranke Peter
- Kraus Christiane
- Kraus Stephanie
- Kubitzek Christiane
- Kucharski Rafal
- Kucukguclu Semih
- Kudrashou Aliaksandr
- Kumar Vinayak
- Kummen Live
- Kunit Cornelia
- Kushakovsky Vlad
- Kuvaki Bahar
- Kuzmanovska Biljana
- Kyttari Aikaterina
- Köstenberger Markus
- Landoni Giovanni
- Lau Gary
- Lazarev Konstantin
- Leggett Samantha
- Legrottaglie Anna Maria
- Leonardi Silvia
- Leong Maria
- Lercher Helene
- Leuvrey Matthieu
- Leva Brigitte
- Levstek Meta
- Lewald Heidrun
- Lewald Heidrun
- Limb James
- Lindholm Espen
- Linton Fiona
- Liperi Corrado
- Lipski Fabian
- Lirk Philipp
- Lisi Alberto
- Lišková Katarina
- Lluch Oltra Aitana
- Loganathan Vinothan
- Lombardi F. Stefania
- Lopez Lopez Eloisa
- Lopez Rodríguez Maria
- Lorenzini Laura
- Lowicka Malgorzata
- Lugovoy Alexander
- Luippold Madeleine
- Lumb Andrew
- López Alvarez Alexo
- López Eliana
- Mac Gregor Mark Gordon
- Macas Andrius
- Machado Humberto
- Maciariello Maria
- Madeira Isabel
- Maitan Stefano
- Majewski Jacek
- Maldini Branka
- Malewski Georgia
- Manfredini Livia
- Marchand Bahareh
- Marcu Alexandra
- Margalef Jordi
- Margarson Michael
- Marinheiro Lucia
- Markić Ana
- Markovič Bozič Jasmina
- Marrazzo Francesco
- Martin Ayuso Maria
- Martin Jane
- Martinez Esther
- Martino Enrico Antonio
- Martinson Victoria
- Marusič-Gaser Katarina
- Mascarenhas Catia
- Mathis Cindy
- Matsota Paraskevi
- Mavrommati Eleni
- Mazul Sunko Branka
- Mccourt Killian
- Mcgill Neil
- Mckee Raymond
- Meier Sonja
- Meistelman Claude
- Meistelman Claude
- Meistelman Claude
- Melbourne Susan
- Melbybråthen Grethe
- Meli Andrea
- Melia Aiden
- Melotti Rita Maria
- Menga Maria Rosaria
- Mercer Pauline
- Merotra Susan
- Mescolini Silvia
- Metterlein Thomas
- Meço Başak Ceyda
- Michalov Martin
- Michlig Sam
- Midgley Susan
- Milić Morena
- Milojevic Milan
- Minto Gary
- Mirabella Lucia
- Mirea Liliana
- Mittelstädt Ludger
- Miñana Amanda
- Moeglen Aude
- Moise Alida
- Mokini Zhirajr
- Molin Anna
- Moltó Luis
- Monea Maria Concetta
- Montalto Francesca
- Montgomery Claire
- Montgomery Jane
- Montillo Gerardo
- Moore Faye
- Moore Sally
- Moreira Zelia
- Moreno Ricardo
- Moreno Tania
- Moret Enrique
- Moreton Sarah
- Morgan Marianne
- Moro Velasco Concepción
- Morri Davide
- Moull Alice
- Moura Fernando
- Mrozek Katarzyna
- Mráz Peter
- Mukhtar Karim
- Muniyappa Sudeshkumar
- Murray Heather
- Murthy Burra V. S.
- Mushambi Mary
- Männer Olja
- Nadolski Maria
- Nardelli Pasquale
- Nardin Giordano
- Navarro Perez Rosalia
- Naveiro Pan Andrea
- Negri Manuela
- Nesek Adam Visnja
- Neskovic Vojislava
- Neuwersch Stefan
- Neves Miriam
- Nguyen Ba Vinh
- Nicholas Caroline
- Nightingale Jeremy
- Norrie Kylie
- Novak-Jankovič Vesna
- Novillo Marta
- Nováková Andrea
- Numan Sandra
- Ní Eochagáin Aisling
- O'Reilly Rosalind
- Oduro-Dominah Louise
- Oldner Anders
- Oliveira Isabel
- Ologoiu Daniela
- Oloktsidou Eirini
- Orlando Alessandro
- Ovezov Alexey
- Ozbilgin Sule
- Paal Peter
- Padin Barreiro Lidia
- Palugniok Ryszard
- Papaioannou Alexandra
- Papapostolou Konstantinos
- Paranthaman Prabhakar
- Pardey Bracho Gilda F
- Parente Suzana
- Parfeni Alexandru
- Pasin Laura
- Passey Samuel
- Pastor Ernesto
- Patch Sarah
- Patil Andan
- Paunescu Alina
- Pehboeck Daniel
- Pereira Carla
- Pereira Manuela
- Perez Caballero Paula
- Perez Tejero Gisela
- Perez-Cerda Francisco
- Pesenti Antonio
- Petta Rocco
- Philippe Simon
- Pickering David
- Pico Veloso Jandro
- Pina Pedro
- Pinho-Oliveira Vitor
- Pinol Santiago
- Pinto Rita
- Pistidda Laura
- Pitterle Manuela
- Piwowarczyk Pawel
- Plotnikova Olga
- Pohl Holger
- Polakovičová Lucia
- Polderman Jorinde
- Pompei Livia
- Popescu Mihai
- Popovic Radmila
- Pota Vincenzo
- Potocnik Miriam
- Potreć Beata
- Potter Alison
- Pramod Nalwaya
- Prchalova Martina
- Preckel Benedikt
- Pugh Richard
- Pulletz Mark
- Pérez García Aníbal
- Pérez Soto Antonia
- Radoeshki Aleksandar
- Rafi Amir
- Ragazzi Riccardo
- Raineri Santi Maurizio
- Rajamanickam Tamiselvan
- Rajput Zahra
- Ramachandran Rajeskar
- Ramasamy Radhika
- Ramessur Suneil
- Rao Roshan
- Rasmussen Anders
- Rato André
- Razaque Usman
- Real Navacerrada Maria Isabel
- Reavley Caroline
- Reid James
- Reschreiter Henrik
- Rial Erick
- Ribeiro Sandy
- Rich Nathalie
- Richardson Lydia
- Rimaitis Kestutis
- Rimaitis Marius
- Ringvold Else-Marie
- Ripke Fabian
- Ristescu Irina
- Ritchie Keith
- Rodrigues Patrícia
- Rogers Emma
- Rogerson David
- Romagnoli Stefano
- Romero Esther
- Rondovic Goran
- Rose Bernd Oliver
- Roth Winfried
- Rotter Marie-Therese
- Rousseau Guy
- Rudjord Anders
- Rueffert Henrik
- Rundgren Malin
- Rupprecht Korbinian
- Rushton Andrew
- Russotto Vincenzo
- Rypulak Elżbieta
- Ryszka Maciej
- Ródenas Frederic
- Saby Sandrine
- Sagic Jelena
- Saleh Omar
- Sales Gabriele
- Sanchez Sanchez Yvan Enrique
- Sanghera Sumayer
- Santiveri Francisco Xavier
- Santos Sofia
- Sarno Stephen
- Saul Daniel
- Saunders David
- Savić Nenad
- Scalco Loïc
- Scanlon Deborah
- Schax Christoph
- Scheffer Gert Jan
- Schening Anna
- Schiavone Vincenzo
- Schmidt-Ehrenberg Florian
- Schmidt-Mutter Catherine
- Schopflin Christian
- Schreiber Jan-Uwe
- Schultz Marcus
- Schurig Marlen
- Schönberg Christina
- Scott Carmen
- Sebestian Siby
- Sehgal Selena
- Sem Victoria
- Semenas Egidijus
- Serafini Elena
- Serchan Paschalitsa
- Shields Martin
- Shobha Ramakrishnan
- Shosholcheva Mirjana
- Siamansour Tanja Saman
- Siddaiah Narendra
- Siddiqi Khalid
- Sinclair Rhona
- Singh Permendra
- Singh Rajendra
- Sinha Aneeta
- Sinha Ashok
- Skinner Amanda
- Smee Elizabeth
- Smith Neil
- Smith Thomas
- Smitz Carine
- Smole Daniel
- Smékalová Olga
- Sojčić Nataša
- Soler Pedrola Maria
- Somanath Sameer
- Sonksen Julian
- Sorella Maria Cristina
- Soro Marina
- Soto Carmen
- Spada Anna
- Spadaro Savino
- Spaeth Johannes
- Sparr Harald
- Spielmann Annika
- Spindler-Vesel Alenka
- Stamelos Matthaios
- Stancombe Lucia
- Stanculescu Andreea
- Standl Thomas
- Standley Tom
- Stanek Ondrej
- Stanisavljević Snezana
- Starczewska Malgorzata
- Steel Elizabeth
- Steen Julie
- Stefan Oana Mara
- Stera Caterina
- Stevens Markus
- Stoerckel Marlène
- Stošić Biljana
- Stroumpoulis Konstantinos
- Struck Rafael
- Stäuble Christiane
- Suarez de la Rica Alejandro
- Sultanpori Altaf
- Sundara Rajan Rajinikanth
- Suying Ong
- Svensén Christer
- Swan Louise
- Syrogianni Paulina
- Sysiak Justyna
- Szederjesi Janos
- Sá Couto Paula
- Sá Jacinta
- Sõrmus Alar
- Taddei Stefania
- Tan Hao Ern
- Tanou Virginia
- Tarabová Katarína
- Tardaguila Sancho Paula
- Tarroso Maria
- Tartaglione Marco
- Taylor Emma
- Tbaily Lee
- Telford Richard
- Terenzoni Massimo
- Theodoraki Kassiani
- Thornley Helen
- Tiganiuc Liviu
- Toim Hardo
- Tomescu Dana
- Tommasino Concezione
- Toni Jessica
- Toninelli Arturo
- Toretti Ilaria
- Townley Stephen
- Trepenaitis Darius
- Trethowan Brian
- Tsaousi Georgia
- Tsiftsi Aikaterini
- Tudor Andrada
- Turan Guldem
- Turhan Sanem Çakar
- Ulm Kurt
- Ulm Kurt
- Umc Radboud
- Unic-Stojanovic Dragana
- Unterbuchner Christoph
- Unzueta Carmen
- Uranjek Jasna
- Ursic Tomaz
- v Tiesenhausen Anna
- Vaida Simona
- Valldeperas Ferrer Silvia
- Valldeperas Hernandez Maria Inmaculada
- Valsamidis Dimitrios
- Van Beek Rienk
- van Dasselaar Nick
- van der Beek Tim
- Van Duivenvoorde Yoni
- van Klei Wilton A.
- Van Poorten Frans
- Van Zaane Bas
- Van Zundert Tom
- van Zyl Rebekka
- Vargas Munoz Ana Milena
- Varsani Nimu
- Vasconcelos Pedro
- Vassilakis George
- Vecchiatini Tommaso
- Vercauteren Marcel
- Verdouw Bas
- Verheyen Veerle
- Verri Marco
- Večeřa Lubomir
- Vicari Sottosanti Luigi Giancarlo
- Vico Manuel
- Vidal Mitjans Patricia
- Vilardi Anna
- Vissicchio Daniela
- Vitale Giovanni
- Vitković Bibiana
- Vizcaychipi Marcela Paola
- Voicu Alexandra
- Voje Minca
- Volfová Ivana
- Volta Carlo Alberto
- Von Lutterotti Theresia
- Vrecič-Slabe Simona
- Vukcevic Dejan
- Vukovic Rade
- Vullo P. Agostina
- Wade Andrew
- Wallberg Hanna
- Wallden Jakob
- Wallner Johann
- Walther Sturesson Louise
- Watson Davina
- Weber Stefan
- Wegiel Leskiewicz Anna
- Weller Debbie
- Wensing Carin
- Werkmann Markus
- Westberg Henrik
- Wikström Erik
- Willett Emma
- Williams Benedict
- Wilson Robin
- Wirth Steffen
- Wittmann Maria
- Wood Laura
- Wright Stella
- Zachoval Christian
- Zambon Massimo
- Zampieri Silvia
- Zampone Salvatore
- Zangrillo Alberto
- Zani Gianluca
- Zavackiene Asta
- Ziegleder Raphael
- Zonneveldt Harry
- Zsisku Lajos
- Zucker Tom-Philipp
- Zuleika Mehrun
- Zupančič Darja
- Åslin Bjorn
- Şanli Karip Ceren
- Štourač Petr
- Żukowski Maciej
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2019
- Field of study
Background Results from retrospective studies suggest that use of neuromuscular blocking agents during general
anaesthesia might be linked to postoperative pulmonary complications. We therefore aimed to assess whether the use
of neuromuscular blocking agents is associated with postoperative pulmonary complications.
Methods We did a multicentre, prospective observational cohort study. Patients were recruited from 211 hospitals in
28 European countries. We included patients (aged ≥18 years) who received general anaesthesia for any in-hospital
procedure except cardiac surgery. Patient characteristics, surgical and anaesthetic details, and chart review at discharge
were prospectively collected over 2 weeks. Additionally, each patient underwent postoperative physical examination
within 3 days of surgery to check for adverse pulmonary events. The study outcome was the incidence of postoperative
pulmonary complications from the end of surgery up to postoperative day 28. Logistic regression analyses were
adjusted for surgical factors and patients’ preoperative physical status, providing adjusted odds ratios (ORadj) and
adjusted absolute risk reduction (ARRadj). This study is registered with ClinicalTrials.gov, number NCT01865513.
Findings Between June 16, 2014, and April 29, 2015, data from 22803 patients were collected. The use of neuromuscular
blocking agents was associated with an increased incidence of postoperative pulmonary complications in patients who
had undergone general anaesthesia (1658 [7·6%] of 21694); ORadj 1·86, 95% CI 1·53–2·26; ARRadj –4·4%, 95% CI
–5·5 to –3·2). Only 2·3% of high-risk surgical patients and those with adverse respiratory profiles were anaesthetised
without neuromuscular blocking agents. The use of neuromuscular monitoring (ORadj 1·31, 95% CI 1·15–1·49;
ARRadj –2·6%, 95% CI –3·9 to –1·4) and the administration of reversal agents (1·23, 1·07–1·41; –1·9%, –3·2 to –0·7)
were not associated with a decreased risk of postoperative pulmonary complications. Neither the choice of sugammadex
instead of neostigmine for reversal (ORadj 1·03, 95% CI 0·85–1·25; ARRadj –0·3%, 95% CI –2·4 to 1·5) nor extubation at
a train-of-four ratio of 0·9 or more (1·03, 0·82–1·31; –0·4%, –3·5 to 2·2) was associated with better pulmonary outcomes.
Interpretation We showed that the use of neuromuscular blocking drugs in general anaesthesia is associated with an
increased risk of postoperative pulmonary complications. Anaesthetists must balance the potential benefits of
neuromuscular blockade against the increased risk of postoperative pulmonary complications
Incidence of severe critical events in paediatric anaesthesia (APRICOT): a prospective multicentre observational study in 261 hospitals in Europe
- Author
- Aantaa Riku
- Abdel-Hafiz Mostafa
- Abdelaal Amr
- Abou-Samra Mark
- Absalom Anthony
- Acevedo Bambaren Ismael
- Adam Christian
- Adriaens Veronique
- Afshari Arash
- Ahmed Samira
- Alanoglu Zekeriyya
- Albarello Raffaella
- Albokrinov Andrew
- Alders David
- Alderson Peter
- Alexandri Bogdan
- Ali Eissa Eid Mohamed
- Alkis Neslihan
- Allen Claire
- Allison Celia
- Almenrader Nicole
- Amaral Rosa
- Amory Catherine
- Ancupans Agris
- Anders Kroken Bjørn
- Anders Nicola
- Angadi Pradeep
- Angeles Sanz M.
- Anselmi Irene
- Anselmi Luciano
- Antonio Idone Francesco
- Anuncia Escontrela Rodríguez Blanca
- Armoniene Inesa
- Artes David
- Aslami Hamid
- Astuto Marinella
- Audren Noémie
- Aurilio Caterina
- Ayyash Reema
- Babici Remus
- Badarau Victoria
- Badeti Rodica
- Baethge Sabine
- Bakken Boerke Wenche
- Balamat Stefania
- Bandrabur Daniela
- Banerjee Indrani
- Banus Ester
- Bapat Smita
- Baraggia Paolo
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- Lazaro Juan J
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- Steinmann Johannes
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- Stevens Markus F
- Stevic Marija
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- Stoegermüller Birgit
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- Strachan Dominic
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- Taylor Matthew
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- Thil Elke
- Thomas Alun
- Thomas Deborah
- Thomson Wendy
- Tielens Luc
- Tognon Costanza
- Tolasov Konstantin
- Toller Wolfgang
- Tomlinson William
- Tonise Virge
- Tore Altun Gülbin
- Trabkin Evelina
- Trante Irinel
- Trieschmann Uwe
- Trifan Oana
- Trikash Nikolay
- Tsiotou Adelais
- Turner Nigel M.
- Uhrig Lynn
- Ullensvang Kyrre
- Ulrici Johanna
- Umuroglu Tumay
- Underhill Helen
- Urbanec René
- Vaidyanath Chandra
- Vail Hannah
- Vaitoskaite Agne
- Vallejo Tarrat Andrea
- Valzan Silvia
- van de Riet Yvette
- Van de Velde Anne
- Van Deenen Denise
- Van Den Eynde Nancy
- van der Knijff - van Dortmont Anouk
- van der Marel Caroline
- van der Schatte Olivier Roelof
- Van Der Werff Désirée B. M.
- van der Zwan Tim
- van Doorn Thea
- Van Hecke Rachel
- Van Limmen Jurgen
- Van Mossevelde Veerle
- van Osch Rob
- Van Reeth Veronique
- van Stijn Mireille F M
- Vanpeteghem Caroline
- Varyvoda Mykhailo
- Vason Milo
- Velcev Ana
- Veldhuizen Marianne
- Verchere-Montmayeur Juliette
- Vermeulen Petronella M
- Vermeulen Petronella M
- Veyckemans Francis
- Veyckemans Francis
- Viacava Rosanna
- Viken Oddbjorn
- Vilo Sanna
- Virag Katalin
- Vittinghoff Maria
- Vittori Alessandro
- Vodianytskyi Sergii
- Voet Marieke
- Volger Hauke
- Volkers Martin
- Volpe Claudia
- Vons Mark Hendriks Kristy
- Vossen Carine
- Wai Carolynn
- Wappler Frank
- Wasiluk Malgorzata
- Watson Karen
- Weber Stefan
- Weinlichova Stanislava
- Weiss Katja
- Wellesley Hugo
- Wensing Renee T. M.
- Weyland Andreas
- Whiteside Jeanette
- Whiteside Jonathan
- Whyte Emma
- Wieczorek Pawel
- Wiefelspütz Christina
- Wilkins Andrew
- Wilson Catharine
- Wilson Graham
- Wilson-Smith Elaine
- Wodey Eric
- Wojciechowski Dariusz
- Wolfe Barry Juliet
- Wolfler Andrea
- Woodward Tom
- Wossner Stephanie
- Wright Dave
- Wyffels Piet
- Yagudaev Irena
- Yamamoto Tomohiro
- Yildirim Guclu Cigdem
- Zadra Nicola
- Zaghet Brigitte
- Zalewska Dorota
- Zammit Simone
- Zanaboni Clelia
- Zang Aurélien
- Zangl Gregor
- Zani Gianluca
- Zederer Nicole
- Zeitlin Deborah
- Zeitlin Yelena
- Zettl Angelika
- Ziegler Bernhard
- Zielinska Marzena
- Zielinska Marzena
- Zoppellari Roberto
- Zundane Anda
- Zunser Igor
- Zurawska Magdalena
- Žurek Jirí
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2017
- Field of study
Background Little is known about the incidence of severe critical events in children undergoing general anaesthesia in Europe. We aimed to identify the incidence, nature, and outcome of severe critical events in children undergoing anaesthesia, and the associated potential risk factors. Methods The APRICOT study was a prospective observational multicentre cohort study of children from birth to 15 years of age undergoing elective or urgent anaesthesia for diagnostic or surgical procedures. Children were eligible for inclusion during a 2-week period determined prospectively by each centre. There were 261 participating centres across 33 European countries. The primary endpoint was the occurence of perioperative severe critical events requiring immediate intervention. A severe critical event was defined as the occurrence of respiratory, cardiac, allergic, or neurological complications requiring immediate intervention and that led (or could have led) to major disability or death. This study is registered with ClinicalTrials.gov, number NCT01878760. Findings Between April 1, 2014, and Jan 31, 2015, 31â127 anaesthetic procedures in 30â874 children with a mean age of 6·35 years (SD 4·50) were included. The incidence of perioperative severe critical events was 5·2% (95% CI 5·0â5·5) with an incidence of respiratory critical events of 3·1% (2·9â3·3). Cardiovascular instability occurred in 1·9% (1·7â2·1), with an immediate poor outcome in 5·4% (3·7â7·5) of these cases. The all-cause 30-day in-hospital mortality rate was 10 in 10â000. This was independent of type of anaesthesia. Age (relative risk 0·88, 95% CI 0·86â0·90; p<0·0001), medical history, and physical condition (1·60, 1·40â1·82; p<0·0001) were the major risk factors for a serious critical event. Multivariate analysis revealed evidence for the beneficial effect of years of experience of the most senior anaesthesia team member (0·99, 0·981â0·997; p<0·0048 for respiratory critical events, and 0·98, 0·97â0·99; p=0·0039 for cardiovascular critical events), rather than the type of health institution or providers. Interpretation This study highlights a relatively high rate of severe critical events during the anaesthesia management of children for surgical or diagnostic procedures in Europe, and a large variability in the practice of paediatric anaesthesia. These findings are substantial enough to warrant attention from national, regional, and specialist societies to target education of anaesthesiologists and their teams and implement strategies for quality improvement in paediatric anaesthesia. Funding European Society of Anaesthesiology
Incidence of severe critical events in paediatric anaesthesia (APRICOT): a prospective multicentre observational study in 261 hospitals in Europe
- Author
- Aantaa Riku
- Abdel-Hafiz Mostafa
- Abdelaal Amr
- Abou-Samra Mark
- Absalom Anthony
- Acevedo Bambaren Ismael
- Adam Christian
- Adriaens Veronique
- Afshari Arash
- Ahmed Samira
- Alanoglu Zekeriyya
- Albarello Raffaella
- Albokrinov Andrew
- Alders David
- Alderson Peter
- Alexandri Bogdan
- Ali Eissa Eid Mohamed
- Alkis Neslihan
- Allen Claire
- Allison Celia
- Almenrader Nicole
- Amaral Rosa
- Amory Catherine
- Ancupans Agris
- Anders Kroken Bjørn
- Anders Nicola
- Angadi Pradeep
- Angeles Sanz M.
- Anselmi Irene
- Anselmi Luciano
- Antonio Idone Francesco
- Anuncia Escontrela Rodríguez Blanca
- Armoniene Inesa
- Artes David
- Aslami Hamid
- Astuto Marinella
- Audren Noémie
- Aurilio Caterina
- Ayyash Reema
- Babici Remus
- Badarau Victoria
- Badeti Rodica
- Baethge Sabine
- Bakken Boerke Wenche
- Balamat Stefania
- Bandrabur Daniela
- Banerjee Indrani
- Banus Ester
- Bapat Smita
- Baraggia Paolo
- Barak Yuri
- Baranowski Artur
- Barber Nicola
- Barbera Cinzia
- Barbunc Danut
- Bari Francoise
- Baris Sibel
- Barlow Victoria
- Barr Katharine
- Bartholomew Karen
- Bartkowska-Sniatkowska Alicja
- Barzdina Arta
- Basiewicz Ewa
- Basov Mikhail
- Bassett Mike
- Batoz Hélène
- Bauer Annette
- Bauer Martin
- Bauer Michael
- Baujard Catherine
- Bauwman Arthur
- Beate Solas Anne
- Becke Karin
- Becke Karin
- Begec Zekine
- Bekavac Ivan
- Bell Graham
- Bell Sarah J.
- Benito Pilar
- Berger Jelena
- Berghmans Johan
- Bergland Unni
- Bergsma Margot
- Bermede Onat
- Bernotiene Aurelija
- Berton Jerome
- Bevilacqua Michela
- Bew Stephanie
- Bird Victoria
- Birliba Mihaela-Petronela
- Biskupova Vera
- Bloomfield Tom
- Blythe Elizabeth
- Boda Krisztina
- Boda Krisztina B.
- Boegli Yann
- Bollinger Matthias
- Book Malte
- Bordes Maryline
- Bortone Luciano
- Boryshkevych Ivanna
- Bourdaud Nathalie
- Boyd Matthew
- Boyle David
- Bracci Paolo
- Brackhahn Michael
- Bradbury Carol L.
- Breschan Christian
- Brezac Gilles
- Briggs Sandra
- Brotatsch Philipp
- Browning Mike
- Budic Ivana
- Buhre Wolfgang
- Busche René
- Busi Ilaria
- Bussolin Leonardo
- Butkovic Diana
- Butler Patrick
- Byers Gordon
- Börjesson Glenda
- Bøttger Morten
- Cabanova Barbora
- Cagney Brid
- Cakar Turhan K. Sanem
- Calderini Edoardo
- Calvao Santos Carolina
- Camporesi Anna
- Camus Blandine
- Capusan Alin
- Carachi Peter
- Carre Anne-Charlotte
- Cartal Marielle
- Casaer Sari
- Castellheim Albert
- Casutt Mattias
- Catalina Ionescu Gabriela
- Cavalier Alison
- Cecini Mariateresa
- Cento Valeria
- Cerati Giorgia
- Cerne Uros
- Cerutti Elisabetta
- Cettler Maciej
- Ceuca Daniela
- Ceyda Meco Basak
- Chapotte Catherine
- Chazelet Chantal
- Checinska Magdalena
- Checuti Sarah
- Chee Lew-Chin
- Childs Sophie
- Chirichiello Luca
- Chizhov Dmitri
- Chlopin Mikhail
- Chloropoulou Pelagia
- Christian Nilsson Jens
- Chrysi Mpratzou
- Cigdem Tütüncü Ayse
- Cillis Annagrazia
- Cimpeanu Luminita
- Cindea Iulia
- Ciobanu Tudor
- Clausen Nicola G.
- Clement Maria Gabriella Elena
- Cloherty Marianne
- Cnudde Steven
- Cohen Marc
- Colbus Laurent
- Coppens Marc
- Corouge Julien
- Cortegiani Andrea
- Coucke Patricia
- Crawford Michael
- Cristina Mondardini Maria
- Cuciuc Veaceslav
- Cucui-Cozma Cosmina
- Cullen Julia
- Cullen Pauline
- Cumming Craig
- D'Alessandro Sandra
- Dadure Christophe
- Dahmani Souhayl
- Dalton Andrew
- Dalton Mark
- Damps Maria
- Darwin Leanne
- Daugelavicius Vidunas
- Davidescu Irina
- Davidson Sarah
- Davies Jack
- Davies Kay
- Davin Isabelle
- Davison Rachel
- Day Alexandra
- De Abreu Leidy
- de Graaff Jurgen C.
- De Groote Françoise
- De Hert Stefan
- De Josemaria Belen
- de la Brière Francois
- De La Cruz Benito Fausto
- De Lorenzo Brita
- De Melo Eric
- De Pooter Françoise
- De Smet Karen
- De Villé Andrée
- Debrabant Lise
- Dei Giudici Luigi
- Dekens Jacky
- Dekker Elsa
- del Río Cristina
- Delcuze Axelle
- Desjeux Luc
- Diacono Jacques
- Dickinson Matthew
- Didier Anne
- Diers Anja
- Dirckx Maaike
- Disma Nicola
- Disma Nicola
- Divák Jan
- Diwan Rishi
- Dix Philippa
- Djapic Dajana
- Dockiene Ilona
- Dogger Jaap
- Dolci Mirko
- Dolinaj Vladimir
- Domingas Patuleia M.
- Domínguez Fernando
- Dons-Sinke Ilse
- Dorman Teresa
- Draskovic Biljana
- Druot Emilie
- Duflo Frédéric
- Dumitru Rusu Florin
- Dupont Hervé
- Eberl Susanne
- Ecoffey Claude
- Ehm Birgit
- Eich Christoph Bernhard
- Eisner Christoph
- Eissa Ayman
- Elena Malos Anca
- Elizabeth Biercamp Claire
- Ellekvist Marguerite B.
- Ellerkmann Richard
- Ellwood James
- Engel Nicole
- Engelhardt Thomas
- Eniko Kovacs
- Ephraim Erik
- Erb Christian
- Erb Thomas
- Errass Loreen
- Fairgrieve Ross
- Faliszewski Isabella
- Farinelli Ivano
- Farquharson Pamela
- Feliu Montserrat
- Fiedler Fritz
- Fischer Thomas
- Fisher Haran
- Flewin Lisa
- Foster Brian
- Franco Teresa
- Fredrik Lund Ole
- Frelich Michal
- Frey Denise
- Fritzsche Katrin
- Funk Wolfgang
- Gabilondo Garcia Gustavo
- Gaebler Ralf
- Gagey Anne-Charlotte
- Gaidelyte Lina
- Galinescu Irena
- Galvin Deborah
- Gande Richard
- Gandhi Monica
- Garces Antonio
- García Irene
- Garrigue Delphine
- Garrioch Sweyn
- Gatt David
- Gaynor James
- Geary Tim
- Geil Dominik
- Genco Daniele
- Gerin Marc
- Gerling Volker
- Germann Reinhard
- Gernoth Christian
- Gestautaite Dalia
- Ghent Robert
- Gillberg Lars
- Gillet Patricia
- Giuseppe Picardo Sergio
- Glasgow Russell
- Glazunov Anton
- Godsiff Leisha
- Goebel Ulrich
- Gomes Cristina
- Goncharenko Galyna
- Gonçalves Marta
- Gooch Ingrid
- Gordeeva Elena
- Grau Catharina
- Grazzini Maurizia
- Grein Elodie
- Grindheim Guro
- Grundmann Ulrich
- Grynyuk Andry
- Guarracino Fabio
- Guddo Annamaria
- Guedes Isabel
- Guericke Holger
- Guerin Christilynn
- Guido Locatelli Bruno
- Guillier Marion
- Gurita Adriana
- Gurita Adriana
- Guskov Igor
- Gutierrez Valcarcel Andrea
- Gutierrez Ignacio
- Gutmann Anton
- Guzman Ines
- Gymoese Berthelsen Kasper
- Habre Walid
- Habre Walid
- Hammerschlag Jacinda
- Hamonic Yann
- Hannie J.
- Hansen Tom G.
- Hansen Tom G.
- Hanula Miloslav
- Happo Johanna
- Harden Alison
- Hare Alison
- Harlet Pierre
- Harmen Herrema Idse
- Harris Sarah
- Harrison Richard
- Hasani Antigona
- Hashimi Medita
- Hatipoglu Zehra
- Hawksworth Chris
- Hayem Catherine
- Hearn Robert
- Hedlund Lars
- Hein Maximilian
- Helena Gaitan M.
- Heli Litvic Dubravka
- Helm Emma
- Heyse Björn
- Himpe Dirk
- Hinz José
- Hivey Sarah
- Hizal Ayse
- Hobbs Amy
- Hochhold Christoph
- Hodgetts Vanessa
- Hoeft Andreas
- Hoehne Claudia
- Hofmann Ulrich
- Hogea Cristiana
- Holy Rolf
- Homer Rachel
- Hopman Geranne A. J.
- Horhota Lucian
- Huber Matthias
- Hullatt Laurence
- Hunter Catherine
- Hurni Thomas
- Hussain Nageena
- Hussey Joseph
- Hutchinson Adel
- Huygens Christel
- Hölzle Martin
- Ilie Luminita
- Ilksen Toprak Huseyin
- Ilmoja Mari-Liis
- Ingeborg Madsen Birgitte
- Ioannou Ioannis
- Iordanidou Despoina
- Ireland Nicholas
- Irwin Janice
- Isohanni Mika
- Isselhorst Carsten
- Ivani Giorgio
- Ivanov Alexander
- Ivascu Constantin
- Izzo Francesca
- Jack Ewan
- Jacomet Alfred
- Jacqmarcq Olivier
- Jamil Yosry
- jan Scheffer Gert
- Janjevic Dusanka
- Jeng Min Law Savio
- Jerome Kevin
- Jetzek-Zader Martin
- Jiménez Anabel
- Joao Susano Maria
- Johansen Mathias
- John Robert
- Johnston Graham
- Jokinen Johanna
- Jones Gareth
- Joukes Ellen
- Julien-Marsollier Florence
- Jureckova Lucie
- Juzwa Magdalena
- Jöhr Martin
- Jöhr Martin
- Kachko Ludmyla
- Kahn David
- Kalagac Fabris Lada
- Kalliardou Evagelia
- Kappen Teus H.
- Karadeniz Meltem Savran
- Karjagin Juri
- Katz Jacob
- Kaufmann Nils
- Kazak Bengisun Zuleyha
- Keilhauer Julia
- Kelgeri Nivedita
- Kemal Arslantas Mustafa
- Kendigelen Pinar
- Kerovec Soric Ivana
- Kesic-Valpotic Gordana
- Khaffaf Ranj
- Khotcholava Magda
- Khrapak Maksym
- Kienbaum Peter
- Kikas Reet
- Kindermann Petra
- King Stephanie
- Kirilov Dmitry
- Kirton Christine
- Kiviluoma Kai
- Klimscha Walter
- Kloessing Jan
- Klymenko Tetyana
- Knauss Kristina
- Knezevic Mirjana
- Kochkin Vladimir
- Koessler Herbert
- Konecny Regina
- Kopycinska Renata
- Kortgen Andreas
- Kotecha Ami
- Kotzeva Svetlana
- Kranke Peter
- Krikstaponiene Jolita
- Kroess Ruth
- Kuehhirt Thomas
- Kuppers Beate
- Kusnirikova Zuzana
- Kyselova Iryna
- Ladak Nadia
- Laffargue Anne
- Lagarde Sylvaine
- Lako Sandra
- Lalot Michaël
- Lambelin Veronique
- Lambotte Patricia
- Lang Colin
- Lapi Maria
- Larcher Claire
- Laschat Michael
- Lauweryns Julie
- Lazarev Vladimir
- Lazaro Juan J.
- Le Freche Hélène
- Leal Teresa
- Lechat Jean-Paul
- Leclercq Mickeal
- Lee Clover-Ann
- Lee Corina
- Lee Juliette
- Legrand Aurélien
- Lehousse Thierry
- Lejus Corinne
- Lesmes Carlos
- Leva Brigitte
- Leva Brigitte
- Levinzon Michael
- Levitchi Roxana
- Levy David
- León Carsi Irene
- Lhubat Elizabeth
- Lindenskov Pal H. H.
- Lipczynski Dariusz
- Liyanage Ganga
- Locke Christie
- Lofino Giuseppe
- Lomas Bernadette
- Longobardo Annalisa
- Lonsdale Hannah
- Love David
- Loveniers Birgit
- Lucia Pinciroli Rosa
- Ludot Hugues
- Lugovoy Alexander
- Lukosiene Laura
- Luntzer Robert
- Lyly Anniina
- Lynch Johanne
- López Galera Sílvia
- Machado Elvira
- Machotta Andreas
- Mackiewicz Tomasz
- Mackova Iveta
- Mader Thomas
- Magasich Natalia
- Magner Claire
- Mahadewsing Ravin
- Majid Saleem Mohammed
- Makin Andrew
- Malarkkan Nalini
- Malisiova Anna
- Mameli Leila
- Mandras Ana
- Manen Berga Ferran
- Manevich Yair
- Maniora Maud
- Manner Tuula
- Marchesini Laura
- Marchetti Giuliano
- Marco Valls Joan
- Marcucci Carine
- Marcus Ritchie
- Maretic Hrvoje
- Maria Gago Martinez Andrea
- Maria Nistor Alina
- Marie Drage Inger
- Marie Anais
- Marjanovic Vesna
- Marthe Ballovarre Kari
- Martikainen Kati
- Martinez Maldonado Ever
- Martínez Ruiz Alberto
- Mascarenhas Catia
- Masip Nuria
- Mauch Jacqueline
- Maupain Olivier
- Maurizio Raineri Santi
- Mausser Gerlinde
- Mawer Rebecca
- Mayell Antonia
- McClintock Joanna
- McKee Lesley
- Megens A. M.
- Meijer Patrick
- Melero Alicia
- Meneghini Luisa
- Merella Federica
- Mesbah Ahmed
- Messerer Brigitte
- Metrangolo Salvatore
- Meybohm Patrick
- Meyer-Treschan Tanja
- Michelon Stefania
- Micici Slobodan
- Mielke Golo
- Mierzewska-Schmidt Magdalena
- Mifsud Mark
- Mifsud Stephanie
- Migeon Anne
- Mihaela Gheorghe Ligia
- Mihaela Dubau
- Milde Alexander
- Milojevic Irina
- Minardi Carmelo
- Mircetic Maja
- Mitchell John
- Miulescu Magdalena
- Mixa Vladimir
- Mocioiu Gabriel
- Molies Dolors
- Monclus Enric
- Moncreiff Michael
- Moniz Antonio
- Monrigal Jean
- Montague James
- Montferrer Núria
- Montobbio Giovanni
- Moors Xavier
- Moraru-Draghici Lucia
- Morawk-Wintersperger Ulrike
- Morgan Judith
- Morton Neil
- Morton Neil S.
- Moscaliuc Melania
- Moscatello Djurdjica
- Mossetti Valeria
- Muir Vimty
- Munar Francisca
- Munteanu Valentin
- Muro Cristina
- Najafi Nadia
- Nakhjavani Solmaz
- Nasser Leila
- Nastran Andraz
- Navaro Montserrat
- Nechaev Vladislav
- Neckebroek Martine
- Neiger Franz
- Nekrasov Konstantin
- Neri Simona
- Neumann Claudia
- Nicoleta Daraban
- Nolte Claire
- Noriega Bryant
- Nouette-Gaulain Karine
- Ntavlis Merkourios
- Numan Sandra C.
- Nuño Rosario
- O'Donahue Lizanne
- O'Hare Brendan
- Oberhauser Markus
- Ochsenreiter Miriam
- Oeding Joachim
- Olaru Valentin
- Oller Duque Lara
- Olmos Mendez Alberto
- Olteanu Dana
- Oppenrieder Karin
- Orliaguet Gilles
- Oshan Vimmi
- Ostreikov Ivan
- Ottolina Davide
- Ovezov Alexey
- Ozcengiz Dilek
- Ozer Yetkin
- Paal Peter
- Paiu Corneliu
- Paliokaite Evelina
- Pamies Carmen
- Pandurov Marina
- Parashchanka Aliaksandra
- Parasuraman Tamaraichelvi
- Pasini Lorena
- Passariello Leandro
- Patel Pradip
- Patel Shivali
- Pattar Alexander
- Paul Mission Jean
- Pauling Mark
- Pavlenko Vitaliy
- Pavlickova Jana
- Pearson Karen
- Pedro Pina António
- Pedrotti Dino
- Pegg Rachel
- Peiris Kawshala
- Peled Elia
- Pellegrini Michel
- Pereira Ricardo
- Perelló Marina
- Perera Remel
- Peresbota Daliana
- Perez Garcia Anibal
- Perez- Ferrer Antonio
- Perova-Sharonova Valentina
- Perry Nicole
- Peter Laura
- Petrescu Luxita
- Petrovic Sladjana
- Phaff Steen Nick
- Phillips Trudie
- Pick Darina
- Picker Olaf
- Pilla Clotaire
- Pino Gema
- Pirat Philippe
- Pirc Dejan
- Pirotte Thierry
- Pistidda Laura
- Pitino Sofia
- Plant Nina
- Platzer Manuela
- Plichon Benoit
- Plumb James
- Poduskov Evgeny
- Podvin Alexandre
- Poelaert Jan
- Popescu Barbura
- Popic Rok
- Popov Alexander
- Popovic Ljiljana
- Powell Alex
- Prat Mar
- Pratt Thomas
- Pregardien Caroline
- Preussler Niels-Peter
- Pribul Vicky
- Prysiazhniuk Dmytro
- Pryzmont Miroslaw
- Punt Kees
- Punzo Cinzia
- Puric Selena
- Pé d'Arca Sandra
- Quintel Michael
- Qureshi Arif
- Raber Manfred
- Rad Mandana
- Raffoflandreur Celine
- Raistrick Christopher
- Rajamani Balaji
- Ramminger Axel
- Ravi Radha
- Rawlinson Ellen
- Razlevice Ilona
- Reali Simone
- Rebac Vlatka
- Reikvam Tore
- Reindl Doris
- Reinert Jennifer
- Reinoso Barbero Francisco
- Retka Wlodzimierz
- Ribo Laura
- Richart Pierre
- Riche Jean-Claude
- Ricol Lainez Laura
- Riggenbach Christine
- Rizzo Giuliana
- Robert Philippe
- Roberts Steve
- Rodrigues Sara
- Rogerson David
- Roofthooft Eva
- Roos Torbjörn
- Rosada-Kurasinska Jowita
- Ross Mark
- Rossetti Francesca
- Rosu Lilica
- Roth Benjamin
- Roth Jens
- Roth Winfried
- Roulleau Philippe
- Roxo Helena
- Rubio Paloma
- Rudewicz Iwona
- Rudio Olga
- Rushman Sarah
- Russell Susan
- Russell William
- Russo Sebastian G.
- Rustemeyer Lydia
- Rutherford John
- Rutherford William
- Rémond Charlotte
- Sa Angela
- Sabau Lucie
- Sabourdin Nada
- Sage Frederic
- Saha Rita
- Salgado Helena
- Salici Fabiana
- Salota Vishal
- Salvo Ida
- Samani Amee
- Sammartino Maria
- Sanchez Torres Cristel
- Sandström Kerstin
- Sanko Elena
- Sanna Andrea
- Sansone Pasquale
- Santos Maria
- Saour Anne-Charlotte
- Saviciene Nijole
- Savu Anca
- Sawicki Piotr
- Sbaraglia Fabio
- Scalisi Rita
- Schaefer Maximilian S.
- Schellino Maria Maddalena
- Schierlinger Bettina
- Schindler Ehrenfried
- Schink Cornel
- Schmain Dmitri
- Schmucker Erika
- Schoeler Michael
- Scholten Harm
- Schorer Clemens
- Schousboe Birgitte M. B.
- Schouten Anton N. J.
- Schramm Michael
- Schwarzkopf Konrad
- Sciascia Angela
- Scordo Lucia
- Scott-Warren Victoria
- Seabra Manuel
- Seidel-Ahyai Natascha
- Semjen François
- Serrano Silvia
- Seyhan Ozkan Tulay
- Sharman Sarah-Jane
- Shaw Neil
- Sheinkin Olga
- Shepherd Elizabeth
- Short Judith
- Sidlovskaite-Baltake Dominika
- Sieben Anne
- Siemek-Mitela Jadzia
- Sileo Rosanna
- Simhi Eliahu
- Simic Dusica
- Simic Irena
- Simin Jovana
- Simitzes Helena
- Simon Dominique
- Simpson Joanna
- Simurina Tatjana
- Sinclair John
- Singh Piyush
- Sinner Barbara
- Sirghie Rodica
- Sivrikoz Nuket
- Skaaden Lene
- Skacel Monika
- Sketcher Jonathan
- Sklyar Vitaliy
- Skordou Natalia
- Slater Patricia
- Slavkovic Bojana
- Smith Carolyn
- Smith Fiona
- Smith Natalie
- Smitz Carine
- Snoek Aarjan
- Sobczyk Jaek
- Sodhi Puja
- Sola Ruiz Eva
- Sola Chrystelle
- Sonzogni Valter
- Soskova Tereza
- Spahr-Schopfer Isabelle
- Spanjer Vera
- Spanjersberg Rob
- Sponheim Sjur
- Staals Lonneke
- Stack Charles
- Staiti Giuseppe
- Standl Thomas
- Starita Giusi
- Stasevski Vladyslav
- Steel Simon
- Stefan Violeta
- Steiner Maria
- Steinmann Johannes
- Stevanovic Vesna
- Stevens France
- Stevens Markus F.
- Stevic Marija
- Steward Heather
- Stoegermüller Birgit
- Stoia Paolo
- Strachan Dominic
- Stranjanac Vladimir
- Straume Zane
- Stuck Tus Ivana
- Stupnik Spela
- Sulen Nina
- Supthut Hauke
- Surkov Denis
- Sutherland Paul
- Suvejan Mirela
- Svircevic Vesna
- Sweeney Lorraine
- Tabacaru Radu
- Takala Annika
- Takil Arzu
- Talalaj Mariola
- Talbot Laura
- Tarabikin Alex
- Taright Hanna
- Taylor Christopher
- Taylor Matthew
- Taylor Matthew
- Teodora Nastase Alina
- Teresa Rocha Maria
- Tesoro Simonetta
- Thadsad Muthu
- Thil Elke
- Thomas Alun
- Thomas Deborah
- Thomson Wendy
- Tielens Luc
- Tognon Costanza
- Tolasov Konstantin
- Toller Wolfgang
- Tomlinson William
- Tonise Virge
- Tore Altun Gülbin
- Trabkin Evelina
- Trante Irinel
- Trieschmann Uwe
- Trifan Oana
- Trikash Nikolay
- Tsiotou Adelais
- Turner Nigel M.
- Uhrig Lynn
- Ullensvang Kyrre
- Ulrici Johanna
- Umuroglu Tumay
- Underhill Helen
- Urbanec René
- Vaidyanath Chandra
- Vail Hannah
- Vaitoskaite Agne
- Vallejo Tarrat Andrea
- Valzan Silvia
- van de Riet Yvette
- Van de Velde Anne
- Van Deenen Denise
- Van Den Eynde Nancy
- van der Knijff - van Dortmont Anouk
- van der Marel Caroline
- van der Schatte Olivier Roelof
- Van Der Werff Désirée B. M.
- van der Zwan Tim
- van Doorn Thea
- Van Hecke Rachel
- Van Limmen Jurgen
- Van Mossevelde Veerle
- van Osch Rob
- Van Reeth Veronique
- van Stijn Mireille F. M.
- Vanpeteghem Caroline
- Varyvoda Mykhailo
- Vason Milo
- Velcev Ana
- Veldhuizen Marianne
- Verchere-Montmayeur Juliette
- Vermeulen Petronella M.
- Vermeulen Petronella M.
- Veyckemans Francis
- Veyckemans Francis
- Viacava Rosanna
- Viken Oddbjorn
- Vilo Sanna
- Virag Katalin
- Vittinghoff Maria
- Vittori Alessandro
- Vodianytskyi Sergii
- Voet Marieke
- Volger Hauke
- Volkers Martin
- Volpe Claudia
- Vons Mark Hendriks Kristy
- Vossen Carine
- Wai Carolynn
- Wappler Frank
- Wasiluk Malgorzata
- Watson Karen
- Weber Stefan
- Weinlichova Stanislava
- Weiss Katja
- Wellesley Hugo
- Wensing Renee T. M.
- Weyland Andreas
- Whiteside Jeanette
- Whiteside Jonathan
- Whyte Emma
- Wieczorek Pawel
- Wiefelspütz Christina
- Wilkins Andrew
- Wilson Catharine
- Wilson Graham
- Wilson-Smith Elaine
- Wodey Eric
- Wojciechowski Dariusz
- Wolfe Barry Juliet
- Wolfler Andrea
- Woodward Tom
- Wossner Stephanie
- Wright Dave
- Wyffels Piet
- Yagudaev Irena
- Yamamoto Tomohiro
- Yildirim Guclu Cigdem
- Zadra Nicola
- Zaghet Brigitte
- Zalewska Dorota
- Zammit Simone
- Zanaboni Clelia
- Zang Aurélien
- Zangl Gregor
- Zani Gianluca
- Zederer Nicole
- Zeitlin Deborah
- Zeitlin Yelena
- Zettl Angelika
- Ziegler Bernhard
- Zielinska Marzena
- Zielinska Marzena
- Zoppellari Roberto
- Zundane Anda
- Zunser Igor
- Zurawska Magdalena
- Žurek Jirí
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2017
- Field of study
Background Little is known about the incidence of severe critical events in children undergoing general anaesthesia in Europe. We aimed to identify the incidence, nature, and outcome of severe critical events in children undergoing anaesthesia, and the associated potential risk factors. Methods The APRICOT study was a prospective observational multicentre cohort study of children from birth to 15 years of age undergoing elective or urgent anaesthesia for diagnostic or surgical procedures. Children were eligible for inclusion during a 2-week period determined prospectively by each centre. There were 261 participating centres across 33 European countries. The primary endpoint was the occurence of perioperative severe critical events requiring immediate intervention. A severe critical event was defined as the occurrence of respiratory, cardiac, allergic, or neurological complications requiring immediate intervention and that led (or could have led) to major disability or death. This study is registered with ClinicalTrials.gov, number NCT01878760. Findings Between April 1, 2014, and Jan 31, 2015, 31 127 anaesthetic procedures in 30 874 children with a mean age of 6.35 years (SD 4.50) were included. The incidence of perioperative severe critical events was 5.2% (95% CI 5.0-5.5) with an incidence of respiratory critical events of 3.1% (2.9-3.3). Cardiovascular instability occurred in 1.9% (1.7-2.1), with an immediate poor outcome in 5.4% (3.7-7.5) of these cases. The all-cause 30-day in-hospital mortality rate was 10 in 10 000. This was independent of type of anaesthesia. Age (relative risk 0.88, 95% CI 0.86-0.90; p<0.0001), medical history, and physical condition (1.60, 1.40-1.82; p<0.0001) were the major risk factors for a serious critical event. Multivariate analysis revealed evidence for the beneficial effect of years of experience of the most senior anaesthesia team member (0.99, 0.981-0.997; p<0.0048 for respiratory critical events, and 0.98, 0.97-0.99; p=0.0039 for cardiovascular critical events), rather than the type of health institution or providers. Interpretation This study highlights a relatively high rate of severe critical events during the anaesthesia management of children for surgical or diagnostic procedures in Europe, and a large variability in the practice of paediatric anaesthesia. These findings are substantial enough to warrant attention from national, regional, and specialist societies to target education of anaesthesiologists and their teams and implement strategies for quality improvement in paediatric anaesthesia
Post-anaesthesia pulmonary complications after use of muscle relaxants (POPULAR): a multicentre, prospective observational study
- Author
- Abad Gurumeta Alfredo
- Abernethy Caroline
- Abigail Patrick
- Achaibar Kira
- Adam Emily
- Afshari Arash
- Agudelo Montoya María Elizabeth
- Akgün Fatma Nur
- Aletti Gabriele
- Alkış Neslihan
- Allan Ashley
- Allan Katie
- Allaouchiche Bernard
- Allcock Clare
- Almasy Emoke
- Amey Isobel
- Amigoni Maria
- Andersen Elin
- Andersson Peder
- Anipchenko Natalya
- Antunes Pedro
- Armstrong Earlene
- Aslam Tayyba
- Assunção José-Pedro
- Ausserer Julia
- Avvai Mary
- Awad Nahla
- Ayas Montero Begoña
- Ayuso Mercedes
- Azevedo Patricia
- Badarau Victoria
- Badescu Roxana
- Baiardo Redaelli Martina
- Baird Colin
- Baird Yolanda
- Baker Tim
- Balaji Packianathaswamy
- Balan Cristina
- Balandin Alina
- Balescu-Arion Carmen
- Baliuliene Vilda
- Baltasar Isabel Jorge
- Baluch Saif Nasr
- Bandrabur Daniela
- Bankewitz Carla
- Barber Katrina
- Barbera Francesco
- Barcraft-Barnes Helena
- Barletti Valentina
- Barnett Gill
- Baron Kirsty
- Barros Ana
- Barsan Victoria
- Bartlett Pauline
- Batistaki Chrysanthi
- Baumgarten Georg
- Baumüller Eva
- Baytaş Volkan
- Beauchamp Nigel
- Becerra Cayetano Isabel A.
- Bell Stephanie
- Bellandi Mattia
- Belletti Alessandro
- Belmonte Cuenca Julio
- Benitez-Cano Adela
- Beretta Luigi
- Berger Marc Moritz
- Bergmann Nicole
- Bergmark Kristina
- Bermudez Lopez Maria
- Bernotaite Monika
- Beurskens Charlotte
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- Bignami Elena
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