El tema de la interpretación de la Ley en Alf Ross ejemplificado en dos fallos argentinos

Fil: Nino, Carlos Santiago. Universidad de Buenos Aires. Facultad de Derecho. Cátedra Filosofía del Derecho. Buenos Aires, ArgentinaFil: Bacqué, Jorge Antonio. Universidad de Buenos Aires. Facultad de Derecho. Buenos Aires, ArgentinaEsta obra fue reeditada y publicada en Lecciones y Ensayos, Nro. Extraordinario - 60 años de Lecciones y Ensayos, 2016 Bacqué, Jorge Antonio y Nino, Carlos Santiago, El tema de la interpretación de la ley..

El tema de la interpretación de la Ley en Alf Ross ejemplificado en dos fallos argentinos

Fil: Bacqué, Jorge Antonio. Universidad de Buenos Aires. Facultad de Derecho. Cátedra Filosofía del Derecho. Buenos Aires, ArgentinaFil: Nino, Carlos Santiago. Universidad de Buenos Aires. Facultad de Derecho.Cátedra Filosofía del Derecho. Buenos Aires, ArgentinaFil: Bacqué, Jorge Antonio. Universidad de Buenos Aires. Facultad de Derecho. Cátedra Introducción al Derecho. Buenos Aires, Argentin

El tema de la interpretación de la ley Alf Ross ejemplificado en dos fallos argentinos

Fil: Bacqué, Jorge Antonio. Universidad de Buenos Aires. Facultad de Derecho. Cátedra Filosofía del Derecho. Buenos Aires, ArgentinaFil: Nino, Carlos Santiago. Universidad de Buenos Aires. Cátedra Filosofía del Derecho. Buenos Aires, ArgentinaFil: Bacqué, Jorge Antonio. Universidad de Buenos Aires. Facultad de Derecho. Cátedra Introducción al Derecho. Buenos Aires, ArgentinaOriginalmente publicada en Lecciones y Ensayos, N° 36, 1967, esta obra fue reeditada y publicada en el presente con motivo del aniversario N° 60 de la revista

Identification of CRF66_BF, a New HIV-1 Circulating Recombinant Form of South American Origin

Circulating recombinant forms (CRFs) are important components of the HIV-1 pandemic. Among 110 reported in the literature, 17 are BF1 intersubtype recombinant, most of which are of South American origin. Among these, all 5 identified in the Southern Cone and neighboring countries, except Brazil, derive from a common recombinant ancestor related to CRF12_BF, which circulates widely in Argentina, as deduced from coincident breakpoints and clustering in phylogenetic trees. In a HIV-1 molecular epidemiological study in Spain, we identified a phylogenetic cluster of 20 samples from 3 separate regions which were of F1 subsubtype, related to the Brazilian strain, in protease-reverse transcriptase (Pr-RT) and of subtype B in integrase. Remarkably, 14 individuals from this cluster (designated BF9) were Paraguayans and only 4 were native Spaniards. HIV-1 transmission was predominantly heterosexual, except for a subcluster of 6 individuals, 5 of which were men who have sex with men. Ten additional database sequences, from Argentina (n = 4), Spain (n = 3), Paraguay (n = 1), Brazil (n = 1), and Italy (n = 1), branched within the BF9 cluster. To determine whether it represents a new CRF, near full-length genome (NFLG) sequences were obtained for 6 viruses from 3 Spanish regions. Bootscan analyses showed a coincident BF1 recombinant structure, with 5 breakpoints, located in p17 gag , integrase, gp120, gp41-rev overlap, and nef, which was identical to that of two BF1 recombinant viruses from Paraguay previously sequenced in NFLGs. Interestingly, none of the breakpoints coincided with those of CRF12_BF. In a maximum likelihood phylogenetic tree, all 8 NFLG sequences grouped in a strongly supported clade segregating from previously identified CRFs and from the CRF12_BF "family" clade. These results allow us to identify a new HIV-1 CRF, designated CRF66_BF. Through a Bayesian coalescent analysis, the most recent common ancestor of CRF66_BF was estimated around 1984 in South America, either in Paraguay or Argentina. Among Pr-RT sequences obtained by us from HIV-1-infected Paraguayans living in Spain, 14 (20.9%) of 67 were of CRF66_BF, suggesting that CRF66_BF may be one of the major HIV-1 genetic forms circulating in Paraguay. CRF66_BF is the first reported non-Brazilian South American HIV-1 CRF_BF unrelated to CRF12_BF.This work was funded through Acción Estratégica en Salud Intramural (AESI), Instituto de Salud Carlos III, projects PI16CIII/00033 and PI19CIII/00042; Red de Investigación en SIDA (RIS), Instituto de Salud Carlos III, Subdirección General de Evaluación y Fondo Europeo de Desarrollo Regional (FEDER), Plan Nacional I+D+I, project RD16ISCIII/0002/0004; and scientific agreements with Consellería de Sanidade, Government of Galicia (MVI 1004/16) and Osakidetza-Servicio Vasco de Salud, Government of Basque Country (MVI 1001/16).S