Carta de Adolf Bach a Antonio Tovar Llorente. Bonn (Alemania), 16 de agosto de 1955

[ES] Carta de Adolf Bach, profesor de la Universidad de Bonn (Alemania), a Antonio Tovar Llorente agradeciéndole que haya intercedido ante el Ministro de Educación para que le concedan la Encomienda con Placa de la Orden Civil de Alfonso X el Sabio en abril, con motivo del V Congreso de Ciencias Onomásticas de Salamanca

Modulation in vitro of H-ras oncogene expression by trans-splicing

In man, activated N-, K- and H-ras oncogenes have been found in around 30% of the solid tumours tested. An exon known as IDX, which has been described previously and is located between exon 3 and exon 4A of the c-H-ras pre-mRNA, allows an alternative splicing process that results in the synthesis of the mRNA of a putative protein named p19. It has been suggested that this alternative pathway is less tumorigenic than that which results in the activation of p21. We have used the mammalian trans-splicing mechanism as a tool with which to modulate this particular pre-mRNA processing to produce mRNA similar to that of mature p19 RNA. The E4A exon of the activated H-ras gene was found to be a good target for external trans-splicing. We reprogrammed the rat carnitine octanoyltransferase exon 2 to specifically invade the terminal region of H-ras. Assays performed with this reprogrammed trans-exon showed that the trans-splicing product was obtained in competition with cis-splicing of the D intron of the H-ras gene, and was associated with concomitant down-modulation of D intron cis-splicing. We also found that the exon 4A of the human c-H-ras gene underwent successive trans-splicing rounds with an external exon.This work was supported by the Asociación Española contra el Cáncer, La Marató de TV3 and Fundación Ramón Areces. S Guil was a recipient of a BEFI fellowship. We also thank Martí Cullell for revising this manuscript.Peer Reviewe

Karlo Čeh, kontrabas : drugi dio diplomskog ispita

Drugi dio diplomskog ispita Karla Čeha (kontrabas), studenta Muzičke akademije Sveučilišta u Zagrebu. Ispit je održan na Muzičkoj akademiji u Koncertnoj dvorani "Blagoje Bersa" 26. 6. 2023. Klavirska pratnja: Tibor Naglić, v. umj. sur. Mentor: nasl. izv. prof. art. Nikša Bobetko. Program: 1. Adolf Mišek: Sonata No. 2; 2. Johann Sebastian Bach: Viola da Gamba Sonata No. 1; 3. Josip Novosel: Romanca