Gender and cycling: Gendering cycling subjects and forming bikes, practices and spaces as gendered objects

Jennifer Bonham, Carol Bacchi and Thomas Wanne

Triple‐negative breast carcinomas are a heterogeneous entity that differs between young and old patients

OBJECTIVE: To compare the frequency and immunohistochemical profiles of triple-negative breast carcinomas in younger and older women. METHODS AND RESULTS: We selected patients diagnosed with triple-negative breast carcinomas. The groups examined were women who were 35 years old or younger between 1997 and 2007 (n = 74) and, for comparison, women who were 60 years old or older (n = 19, consecutive cases). All formalin-fixed and paraffin-embedded tumor samples were reviewed and immunohistochemically stained for ER, PR, HER2, Ki-67 antigen, epidermal growth factor receptor, cytokeratin 5/6, p53, vimentin, CD117, and p63 using tissue microarrays blocks. Triple-negative breast carcinomas corresponded to 34.6% (74/213) of the carcinomas from the younger patients and 16.2% (19/117) of the carcinomas from the older patients (p = 0.002). No significant differences in the frequency of the basal phenotype were observed in the two patient groups based on CK5/6 and/or epidermal growth factor receptor expression (74.3% vs. 68.4%). However, triple-negative breast carcinomas in the older patients presented a higher frequency of CK5/6 expression compared to those of younger patients (42.1% vs. 9.6%; p = 0.005), whereas triplenegative breast carcinomas of younger patients had a higher expression level of epidermal growth factor receptor (71.6% vs. 47.3%). CONCLUSIONS: These results show that there were significant molecular differences between the triple-negative basal-like breast carcinomas that were diagnosed in younger women and those that were diagnosed in older women. These findings may provide a basis for describing the more aggressive phenotype of the triple-negative breast carcinomas observed in younger women

Fatores de influência no preço do milho no Brasil.

Introdução; Revisão Bibliográfica; O mercado da soja; Resultados e discussão; Conclusões

The turn to problematization: political implications of contrasting interpretive and poststructural adaptations

The purpose of this paper is to introduce and elaborate the varied meanings of problematization in contemporary policy theory. The primary focus is on the different meanings and uses of the term in interpretivism and in Foucault-influenced poststructuralism. The paper argues that interpretive/ argumentative adaptations direct attention primarily to how policy makers/workers develop problematizations (ways of understanding a problem) while Foucault-influenced poststructuralists critically scrutinize problematizations (the ways in which “problems” are produced and represented) in governmental policies and practices. It concludes that Foucault-influenced adaptations provide a more substantive critique of extant social arrangements than interpretive approaches, which tend to be reformist in design and inclination.Carol Bacch

Local political leadership and the modernisation of local government

Political leadership has been a key element of central government’s attempts to ‘modernise’ local government over the past decade, within a discourse that emphasised ‘strong’ and ‘visible’ leadership and the role of leaders and leadership in driving change within local authorities. In the context of such an approach, and also taking account of academic discourse, this article draws upon interviews with nearly thirty individuals in leadership positions in local authorities in England, Scotland and Wales to assess their experiences of leadership and their views of some aspects of the role and work of councils. It suggests that whilst there is broad convergence between the aspirations of government and the narratives that emerge from these leaders on some aspects of local political leadership, there are also differences, perhaps most notably over the relationship between changes to decision making structures and the loci of political power

Antigenic expression in human choroid plexus carcinoma : report of two cases

Neoplasias provenientes do epitélio de revestimento do plexo coróide são inco-muns, tendo sido descritos 6 padrões morfológicos. O padrão anaplásico, também denominado carcinoma do plexo coróide, é o de menor freqüência e pode dar metastases fora do SNC. A distinção histológica desses tumores, particularmente da variedade anaplásica, com outras neoplasias primárias e metastáticas no SNC pode ser difícil. O uso de técnicas imunocitoquimicas em parafina tem-se mostrado útil no esclarecimento das linhagens tumorais. Os papilomas do plexo coróide têm, no entanto, sido objeto de controvérsia, por sua complexa expressão antigênica. Usando a técnica de imunoperoxidase (sistema avidina-biotina-peroxidase) pesquisaram-se, em dois casos da variedade anaplásica, os seguintes marcadores: proteína glial fibrilar ácida (GFAP) com anticorpo monoclonal e policlonal; ceratinas de 40-50kDa, ceratinas de 60-70kDa (callus ceratina), enolase neuronal específica (NSE) e proteína S-100, com anticorpos monoclonais. Os dois tumores mostraram positividade para NSE, proteína S-100 e ceratina de 40-50kDa; uma das duas neoplasias mostrou diferenciação glial, revelando positividade para GFAP tanto com anticorpo monoclonal quanto policlonal.Primary neoplasms of choroid plexus are rare. Six morphological variants have been described: papillary, cystic, acinar, mucus-secreting, oncocytic, and anaplastic. The anaplastic variant, the so-called choroid plexus carcinoma, is the rarest of all and can metastasize. The differential diagnosis of the anaplastic variant of choroid plexus neoplasms with adenocarcinomas, melanomas and indifferentiated neoplasms can be troublesome chiefly in adults. The now large use of immunocytochemical techniques in tissue section has become a powerful tool in the analysis of cell lineages, tumoral and non-tumoral. Nevertheless, the choroid plexus neoplasms have shown a complex and a somewhat confusing pattern of antigenic expression. In two choroid plexus carcinomas (one localized in the right lateral ventricle from a boy of 1 year and 9 months old, and the other localized in the left lateral ventricle from a girl of 3 years old) the following antigens were searched (using the avidin-biotin-peroxydase complex): glial fibrillary acidic protein (GFAP) with monoclonal and polyclonal antibodies; cytokeratins of 40-50kDa, cytokeratins of 60-70kDA (callus cytokeratin), neuronal specific enolase (NSE) and S-100 protein with monoclonal antibodies. The two neoplasms showed immunoreactivity against NSE, S-100 protein and cytokeratin of 40-50kDA The neoplasm of the boy exhibited glial differentiation having immunoreactivity against GFAP with monoclonal and polyclonal antibodies

High scale impact in alignment and decoupling in two-Higgs doublet models

The two-Higgs doublet model (2HDM) provides an excellent benchmark to study physics beyond the Standard Model (SM). In this work we discuss how the behaviour of the model at high energy scales causes it to have a scalar with properties very similar to those of the SM -- which means the 2HDM can be seen to naturally favor a decoupling or alignment limit. For a type II 2HDM, we show that requiring the model to be theoretically valid up to a scale of 1 TeV, by studying the renormalization group equations (RGE) of the parameters of the model, causes a significant reduction in the allowed magnitude of the quartic couplings. This, combined with $B$-physics bounds, forces the model to be naturally decoupled. As a consequence, any non-decoupling limits in type II, like the wrong-sign scenario, are excluded. On the contrary, even with the very constraining limits for the Higgs couplings from the LHC, the type I model can deviate substantially from alignment. An RGE analysis similar to that made for type II shows, however, that requiring a single scalar to be heavier than about 500 GeV would be sufficient for the model to be decoupled. Finally, we show that not only a 2HDM where the lightest of the CP-even scalars is the 125 GeV one does not require new physics to be stable up to the Planck scale but this is also true when the heavy CP-even Higgs is the 125 GeV and the theory has no decoupling limit for the type I model.Comment: 28 pages, 19 figure

Fundamentos econômicos da formação do preço internacional de açucar e dos preços domésticos de açucar e etanol.

O objetivo deste estudo foi investigar os fatores que afetam o comportamento do etanol no mercado interno e os preços do açúcar nos mercados doméstico e internacional. Três ordens de fatores explicativos são considerados para o preço internacional: (a) índice geral de preços das commodities CRB Spot, (b) macro-fatores (taxa de câmbio, juros, liquidez) (c) fatores idiossincráticos relacionados ao mercado mundial de açúcar. Os fatores explicativos para os preços brasileiros de açúcar e etanol são: (a) preço internacional do açúcar, (b) macro fatores nacionais e internacionais (c) fatores idiossincráticos (clima, produtividade). O preço internacional é previsto principalmente pelo índice CRB e preços do petróleo. Relacionado ao mercado interno, o preço do açúcar foi previsto pelos preços internacionais e taxa de câmbio do real. Os erros de previsão permaneceram na faixa de 20%. No caso dos preços de etanol, os preços internacionais e domésticos do açúcar foram os principais preditores, embora os erros tenham atingido 40%. Como o etanol é commodity menos negociadas no exterior, seus preços são mais sensíveis a fatores idiossincráticos. No entanto, permanece a conclusão geral de que o comportamento dos preços do açúcar e etanol no mercado brasileiro é bastante coerente com o mercado global de commodities

Produtividade da agricultura: resultados para o Brasil e estados selecionados.

Este trabalho analisa a produtividade da agricultura nos anos recentes, em especial no período de 2000 a 2012. O artigo estima indicadores de produtividade não apenas para o Brasil, mas também para uma seleção de estados. Estes foram escolhidos pela sua relevância na produção nacional de grãos e carnes. Para isso, foram escolhidos os estados da Bahia, Minas Gerais, São Paulo, Paraná, Rio Grande do Sul, Mato Grosso e Goiás. Utilizou-se o conceito de produtividade total dos fatores (PTF) porque ele oferece uma definição mais abrangente de produtividade do que medidas que comparam o produto a apenas um insumo, como trabalho ou terra. Esta última forma de mensuração da produtividade é chamada produtividade parcial. A PTF considera, em sua definição, a reunião de todos os produtos das lavouras e da pecuária e os relaciona com todos os insumos usados na produção

Politics versus Policies: Fourth Wave Feminist Critiques of Higher Education’s Response to Sexual Violence

This article uses the lens of fourth wave feminism to examine media accounts of institutional and student responses in two cases of sexual violence at institutions of higher education. Competing discourses reveal a disconnect between what institutions say they do and students’ actual experiences of the institutional handling of sexual violence cases. When policies, actions, and values are not fully aligned, institutions of higher education are unable to respond to societal and institutional injustices. Hence, recommendations for better alignment between institutional values and actions are proposed