Doença de arranhadela do gato em adolescente - uma apresentação atípica

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Contribution of sociodemographic, clinical, and psychological variables to quality of life in women with cervical cancer in the follow-up phase

This study evaluates the contribution of sociodemographic, clinical, and psychological variables to quality of life (QoL) of women with cervical cancer in the follow-up phase. This cross-sectional study, conducted at the Portuguese Oncology Institute of Lisbon, included 200 women with cervical cancer during follow-up. Patients were assessed on QoL (EORTC QLQ-C30), body image and specific symptoms (EORTC QLQ-CX24), psychological morbidity (HADS), social support (SSSS), emotional expression (CECS), and spirituality (SpREUK). Education and social support contributed positively to QoL, whereas body image and symptoms contributed negatively. Body image played a moderating role in the relationship between depression and QoL, but not between anxiety and QoL. Spirituality and emotional expression did not moderate the relationship between anxiety/depression and QoL. Health professionals should reference and monitor women with cervical cancer, providing support at the diagnosis and follow-up phase since physical and psychological symptoms, resulting from the disease, remain after the end of treatment and contribute negatively to their QoL. Interventions should focus on these particular outcomes to promote patients' QoL.(undefined

Síndrome da dor regional complexa – relato de dois casos clínicos

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Identification of a novel deletion in SURF1 gene: Heterogeneity in Leigh syndrome with COX deficiency

Leigh syndrome (LS) is a rare, progressive neurodegenerative mitochondrial disorder of infancy. It is a genetically heterogeneous disease. The mutations in SURF1 gene are the most frequently known cause. Here two cases of LS likely caused by SURF1 gene variants are reported: a 39-year-old male patient with a novel homozygous deletion (c.-11_13del), and a case of a 6-year-old boy with the same deletion and a nonsense mutation (c.868dupT), both in heterozygosity. Blue native PAGE showed absence of assembled complex IV. This is the first report of a variant that may abolish the SURF1 gene initiation codon in two LS patients.info:eu-repo/semantics/publishedVersio

THE ROLE OF CHOLINESTERASES IN ALZHEIMER’S DISEASE: SCREENING OF TARGET COMPOUNDS

Background: Alzheimer's disease (AD) is the most common form of dementia and causes a progressive and irreversible neurodegeneration. The loss of cholinergic neurons leads to the progressive reduction of acetylcholine (ACh) in the brain and resulting cognitive impairment in AD. ACh is hydrolyzed by both acetylcholinesterase (AChE) and butirylcholinesterase (BuChE). It was found that in the course of the disease, levels of AChE in the central nervous system (CNS) decrease, inversely to BuChE levels, so both enzymes represent legitimate therapeutic targets for ameliorating the cholinergic deficit characteristic of AD. Objective: Screen a library of new isoquinoline, indolinone and benzoazepinone derivatives for their ability to inhibit AChE and BuChE activities, using galantamine and rivastigmine as standards. Methods: The enzyme activities and inhibition studies were carried out using spectrophotometric techniques, based on the Ellman’s method, with acetylthiocholine (ATCI) and butirylthiocholine (BTCI) as substrates, for AChE and BuChE, respectively. The data were complemented with modeling to analyze the structure-activity relationship. Results: Our results show that the tested compounds are competitive inhibitors for AChEs and BuChEs, as the benchmarks galantamine and rivastigmine. The isoquinoline and indolinone derivative compounds showed strong anti-cholinesterases activities, with IC50 values ranging from 0.4 to 400 micromolar. Conclusions: The results presented are promising and provide a pathway for the design of new AChE and BuChE inhibitors

Quality of life in caregivers of patients with multiple myeloma

Objectives: This study aimed to assess the relationship between sociodemographic, clinical, and psychological variables with quality of life (QoL) and the moderating role of caregivers' age and caregiving duration in caregivers of patients with Multiple Myeloma.Method: The sample included 118 caregivers who completed questionnaires that assessed psychological morbidity, satisfaction with social support, coping, burden, unmet needs, and QoL.Results: High psychological morbidity, burden and information, financial and emotional unmet needs were associated with lower QoL, while higher satisfaction with social support and more effective use of coping strategies were associated with better QoL. Women caregivers reported more satisfaction with social support and those who did not choose to care reported greater financial unmet needs and more use of coping strategies. The relationship between caregivers' psychological morbidity/social support and QoL was mediated by emotional needs and double mediated by coping and burden. The caregivers' age moderated the relationship between psychological morbidity/social support and emotional needs.Conclusion: Interventions to support the caregiver's emotional needs to promote their QoL are needed. These should be particularly tailored for older caregivers reporting greater psychological morbidity and younger caregivers less satisfied with their social support, as they have a negative indirect impact on their QoL.Portuguese Associations of Portuguese Association against Leukemia and the PortugueseAssociation of Leukemias and Lymphoma

In silico, NMR and pharmacological evaluation of an hydroxyoxindole cholinesterase inhibitor

From a screening study of various potential inhibitors for cholinesterases (ChEs), compound (rac)-1 (4-((3-hydroxy-2-oxo-3-phenylindolin-1-yl) methyl) piperidin-1-ium chloride) showed an IC50 of 18 μM for butyrylcholinesterase (BuChE). Herein we present a toxicological and pharmacological evaluation of (rac)-1 to determine its potential for use as an alternative ChE inhibitor for the treatment of Alzheimer’s disease. The strategy adopted included in vivo and ex vivo studies with mouse models, Molecular Modelling and Saturation Transfer Difference (STD) NMR studies. Preliminary molecular docking studies were conducted with both (R) and (S)-1 with acetylcholinesterase (AChE) and BuChE, prior to advancing to the mouse model, and indeed favorable interactions were observed, with (R)-1 showing the best binding with AChE and (S)-1 with BuChE. STD-NMR studies were used to successfully validate these results. Toxicological studies were also conducted using the Artemia salina model, with donepezil as reference. It was found that in the in vivo mouse studies that (rac)-1 presented a slightly better inhibition of AChE (0.096 µmol.min−1.mg−1) than donepezil (0.112 µmol.min−1.mg−1) and the same level of inhibition for BuChE as donepezil (0.014 µmol.min−1.mg−1)

Attachment style and body image as mediators between marital adjustment and sexual satisfaction in women with cervical cancer

The majority of cervical cancer survivors face persisting sexual debilitating problems over time. The impairment in sexual function and satisfaction are not limited to physical dimensions. The goals of this study were to assess if marital adjustment and body image mediated the relationship between attachment style, sexual functioning, and sexual satisfaction. Methods This study used a cross-sectional design. The sample included 113 sexually active women that completed the EORTC QLQ C30 and EORTC QLQ CX24, the Index of Sexual Satisfaction, the Experiences in Close Relationships Scale, and the Revised Dyadic Adjustment Scale. Results Using structural equation modeling to describe the relationship between variables, an excellent fitted model was found: X2 (5) = 6.309 (p = 0.277); X2/df = 1262; GFI = 0.982; CFI = 0.986; SRMR = 0.0475; RMSEA = 0.048; P (RMSEA<0.05) = 0.429. Sexual/vaginal functioning and avoidance had a direct effect on sexual satisfaction. Marital adjustment was a partial mediator in the relation between avoidance and sexual satisfaction. Avoidance and anxious attachment had an indirect effect on sexual satisfaction mediated by marital adjustment. Body image was a partial mediator in the relationship between marital adjustment and sexual satisfaction. Conclusions The results showed that vaginal/sexual functioning, attachment style, marital adjustment, and body image were important predictors of sexual satisfaction. Psychoeducational programs to help patients deal with the impairment of sexual/vaginal functioning, as well as emotional support programs for couples to strengthen their marital relationship, need to be implemented, i.e., the couple’s intimacy and women’s body image, that have a clear impact on sexual satisfaction