Dyeing of protein fabrics exploring locally available weed plants

In the present study weed plants i.e. Lantana camara, Solanum nigrum, Eupatorium adenophorum, Tridax procumbens, Parthenium histerophorus, Sida acuta, Ipomea cairica, Rumex nepalensis, Eclipta prostrate, Girardinia diversifolia, Erigeron bellidioides, Bidens pilosa and Athatoda vasica available in hilly as well as Tarai regions of Uttarakhand were collected, dried and powdered. The powdered dye materialswere extracted in distilled water. Subsequently dyeing of wool and silk fabrics was carried out. It was found that various plants like E. adenophorum, R. nepalensis and B. pilosa gave acceptable colour on silk and wool fabric. Therefore some weed plants can be used for textile dyeing which will provide a scope for management of weed plants as well as safety of other useful indigenous plant

Formulation Optimization of Hydrodynamically Balanced Oral Controlled Release Bioadhesive Tablets of Tramadol Hydrochloride

The directly compressible floating-bioadhesive tablets of tramadol were formulated using varying amounts Carbopol 971P (CP) and hydroxy-propylmethyl cellulose (HPMC), along with other requisite excipients. In vitro drug release profile, floatational characteristics and ex vivo bioadhesive strength using texture analyzer were determined, and systematically optimized using a 32 central composite design (CCD). The studies indicated successful formulation of gastroretentive compressed matrices with excellent controlled release, mucoadhesion and hydrodynamic balance. Comparison of the dissolution profiles of the optimized formulation, with optimal composition of CP:HPMC :: 80.0:125.0, with that of the marketed controlled release formulation other indicated analogy of drug release performance with each other. Validation of optimization study using eight confirmatory experimental runs indicated very high degree of prognostic ability of CCD with mean ± SEM of −0.06% ± 0.37. Further, the study successfully unravels the effect of the polymers on the selected response variables

Biochemical assessment of nutritional status in Indian mustard

The present investigation was carried out to evaluate the nutritional potential of five different Indian mustard genotypes. Fatty acid composition was determined in the oil, whereas seed meal was analyzed for limiting amino acids (tryptophan and methionine), protein content, glucosinolate content and antioxidant potential (DPPH free radical scavenging activity, total antioxidant activity and iron chelating activity). The monounsaturated fatty acids (MUFA) were found to be maximum in RH 0749 (58.70 %) followed by RH (OE) 0801 (48.91 %), JM 6011 (47.03 %), EC 597328 and EC 597340 (45.77 %). Polyunsaturated fatty acids (PUFA) were observed maximum in EC 597340 (47.45 %).Glucosinolate content ranged from 42.80 (EC 597328) to 79.79 ?mole/g defatted seed meal (EC 597340). The methanolic seed meal extract exhibited a concentration dependent elimination of DPPH free radicals. All the five genotypes showed about 50 % inhibition in 3.0 mg of dry seed meal. The highest total antioxidant activity (20.41mg/g) and metal ion chelating activity (32.58 %) was observed in RH 0749. Protein content varied from 33.57 [RH (OE) 0801] to 38.01 % (RH 0749). Maximum methionine and tryptophan content were recorded in RH 0749 (0.99 and 1.01 g/100g protein, respectively). Thus, RH 0749 was observed as a potent variety in terms of total antioxidant activity, metal ion chelating activity, protein content, methionine and tryptophan content

Evaluation and diversity analysis in Indian mustard [Brassica juncea (L.) Czern & Coss.] germplasm accessions on the basis of principal component analysis

Principal component analysis was carried out with 20 morphological traits (including quantitative as well as qualitative) among 96 germplasm lines of Indian mustard [Brassica juncea (L.) Czern & Coss.]. Principal factor analysis led to the identification of eight principal components (PCs) which explained about 70.41% variability. The first principal component (PC1) explained 16.21% of the total variation. The remaining PC’s explained progressively lesser and lesser of the total variation. Varimax Rotation enabled loading of similar type of variables on a common principal factor (PF) permitting to designate them as yield factor, maturity factor and oil factor etc. Based on PF scores and cluster mean values the germplasm accessions viz., RC2, RC32 and RC51 (cluster I), RC95 and RC96 (cluster X) were found superior for seed yield/plant and yield related factors like primary and secondary branches/plant; while the accessions RC34, RC185 and RC195 (cluster III) and RC53 (cluster VIII) were found superior for oil content. These accessions may further be utilized in breeding programmes for evolving mustard varieties having high seed yield and oil content. Hierarchical cluster analysis resulted into ten clusters containing two to 26 accessions. The results of cluster and principal factor analyses were in confirmation of each other

FORMULATION AND EVALUATION OF LAMOTRIGINE BASED SELF-NANO EMULSIFYING DRUG DELIVERY SYSTEM

Self-nanoemulsionof Lamotrigine (LMT), an anti-epileptic agent, having poor solubilty was formulated to improve the solubility and permeation. Co surfactant like Ethyl Oleate, Caprylate, Eucalyptus oil, Caprylic, Corn oil, Capmule, Fish oil, Coconut oil whereas PEG 400 and Propylene glycol to form the oil phase was selected as the oil. Seven trials were done using combination of sufactants/co-surfactants with oil phase . Trial H containing Caprylate as oil phase at Smix1:1(Tween20/PEG400, 1:1) proportion and trial I, the oil phase [Caprylate] composition was changed from Smix 1:1 to Smix (Tween20/PEG400, 1:2) formulated as SNEDDs and phase diagram shows 1:1 system is suitable for formulation . Aqueous dilution test shows that it is found for 3 hour gradually turbid on staying. Since it immediately dissolve the drug as a result of solubilisation effect of surfactant present in formulation. Stability study was carried out at 25o C/ 75 Rh. In this method no change in consistency, Colour or appearance has been observed. In vitro drug release was found to be identical in the formulations stored before after placed on stability. It appeared that the formulation of the selected batches kept on the stability test was found to be stable. In accelerated stability evaluation showed that Self nano-emulsion follows 1st order kinetic and found to be stabl

Birth Preparedness and Complication Readiness among Pregnant Women in Rural Area of District Sonipat, Haryana, India: A Cross Sectional Community Based Study

Introduction: Birth Preparedness and Complication Readiness (BPCR) is an important intervention included by WHO as essential elements of antenatalcare package. It is often delivered to pregnant women through their active participation by health care provider during antenatal care or initiated/followed up through visits to the homes of pregnant women by community health workers. Objectives: To determine the knowledge and practice regarding BPCR and to identify factors associated with it among rural pregnant women. Method: Cross-sectional study was conducted in rural field practice area of Community Medicine Department of a medical teaching institutes. A total of 210 pregnant women who were in the second and third trimesters of pregnancy were selected by simple random sampling and interviewed for data collection. Results: Mean age of study subjects was 24.14 + 3.88 years.The highest number of women was in the age group of 20-29 years (84.8%). More than half (57.6%) mothers had observed at least two or more components of BPCR. Maximum number of females had identified facility for delivery (63.8%) followed by transportation (60.9%). Identification of potential blood donor by mothers was low (14.3%). Bleeding was most commonly identified danger symptom in all three phases of child bearing. Knowledge regarding danger signs was significantly associated with birth preparedness. Conclusion: In the present study, practice of all components of BPCR by mothers was very low. Bleeding was the most commonly identified danger symptom during all three phases i.e., pregnancy, child birth and after birth.Knowledge regarding other danger signs was highly inadequate

Improved microwave induced syntheses and reactions of 2-aryl-3-(3-aryl-3oxo-propen-1-yl)-indoles with thiourea and hydrazine derivatives

159-162The potential of domestic microwave oven has been utilized to accelerate the reactions of 2-aryl-3-(3aryl- 3-oxo-propen-1-yl)-indoles (III) with hydrazine hydrate/phenyl hydrazine and thiourea, to obtain 2aryl- 3-[3-aryl-pyrazol-5-yl]-indoles <span style="font-size:11.0pt; font-family:" calibri","sans-serif";mso-ascii-theme-font:minor-latin;mso-fareast-font-family:="" "times="" new="" roman";mso-fareast-theme-font:minor-fareast;mso-hansi-theme-font:="" minor-latin;mso-bidi-font-family:arial;mso-ansi-language:en-us;mso-fareast-language:="" en-us;mso-bidi-language:ar-sa"="">(IV) <span style="font-size:11.0pt; font-family:" calibri","sans-serif";mso-ascii-theme-font:minor-latin;mso-fareast-font-family:="" "times="" new="" roman";mso-fareast-theme-font:minor-fareast;mso-hansi-theme-font:="" minor-latin;mso-bidi-font-family:"times="" roman";mso-ansi-language:en-us;="" mso-fareast-language:en-us;mso-bidi-language:ar-sa"="">and 2-aryl-3-[4-aryl-5, 6-dihydro-2(1H)-thioxopyrimidine-6yl]- indole (V). The former indolyl chalcones (III) have been synthesized by the condensation of 2-aryl-1H- indole-3-carboxaldehyde (I) and fluorinated acetophenones (II) in the presence of sodium hydroxide in open borosil glass vessels under microwave irradiation, using ethanol as energy transfer medium. The results obtained demonstrate the versatility of the process as considerable reaction rate enhancement has been observed bringing down the reaction time from hours to seconds, along with improved yields. All synthesized compounds have been characterized on the basis of elemental analyses, IR, 1H NMR, 19F NMR and mass spectral studies.</span