Gravitational Search Algorithm for NURBS Curve Fitting

By providing great flexibility non-uniform rational B-spline (NURBS) curves and surfaces are reason of preferability on areas like computer aided design, medical imaging and computer graphics. Knots, control points and weights provide this flexibility. Computation of these parameters makes the problem as a non-linear combinational optimization problem on a process of reverse engineering. The ability of solving these problems using meta-heuristics instead of conventional methods attracts researchers. In this paper, NURBS curve estimation is carried out by a novel optimization method namely gravitational search algorithm. Both knots and knots together weights simultaneous optimization process is implemented by using research agents. The high performance of the proposed method on NURBS curve fitting is showed by obtained results

Programmed Death Ligand 1 (Pd-L1) Expression in Malignant Mesenchymal Tumors

Scopu

Genotyping of echinococcus granulosus isolates by sequencing of mitochondrial cytochrome c oxidase subunit 1 (cox1) gene in Aydin [Aydın’da echinococcus granulosus İzolatlarının mitokondriyal sitokrom c oksidaz alt Ünite 1 geni (cox1) dizi analizi ile genotiplendirilmesi]

PubMed ID: 29933737Cyst hydatid (CH) is a zoonotic infection that is characterized by the development of metacestode form of Echinococcus granulosus primarily in liver of humans and ruminants. With a worldwide distribution, the infection is still considered as an important parasitic disease that threatens the public health in Turkey as in the other developing countries. Morphological and biological features of parasite fail to discriminate isolates for typing so molecular methods should be used for this purpose. Recently, a total of eleven genotypes of E.granulosus (G1-10 and lion strain) have been identified and these genotypes are highly correlated with host specificity of the parasite. The aim of this study, was to determine the genotypes of E.granulosus isolates from human samples in Aydın. Cyst fluids from CH operated cases in Adnan Menderes University Faculty of Medicine, Training and Research Hospital were used in the present study. Samples were washed with phosphate buffered saline (PBS) and stored in 70% ethanol at -20ºC. Mitochondrial cytochrome C oxidase subunit 1 (cox1) gene was amplified partially by polymerase chain reaction (PCR). The PCR products were sequenced initially, compared to other database in Genbank and evolutionary distances were estimated with references. The genotypes of E.granulosus isolates were determined according to the closest or exact matches to the references. A total of 20 E.granulosus isolates were genotyped in the present study, most of them (15 isolates, 75%) were identified as Genotype 1 (G1), that is defined as sheep genotype and the remaining isolates were defined as pig/camel genotype G6/7 (five isolates, 25%). A possible explanation to our results May be related to the geographical position of Turkey. The identification of G6/7 in addition to sheep genotype G1 indicated that pigs and camels in this area have role in the transmission and distribution of E.granulosus to humans. There is still limited information about the molecular epidemiology of E.granulosus in Turkey. This study reveals the first data about the genotype distribution of E.granulosus in our city, therefore the findings May help to design control program for the disease with a combination of epidemiological data. © 2018 Ankara Microbiology Society. All rights reserved

Developing of health perception and psychosocial skills in disadventaged students: A school based interventional study from çanakkale [Dezavantajlı öğrencilerde sağlık algısının ve psikososyal becerilerin geliştirilmesi: Okul tabanlı bir müdahale çalışması]

AIM: The aim of this study was to develop health perception and psychosocial skills in disadvantaged students in a primary school. METHOD: This interventional study was conducted in a primary school between May 2012 and June 2012 in Kepez, Canakkale within the context of “Consultancy Application in Primary Schools”as the first step of “From Local to Cambridge and NASA: Development of Canakkale Values and Promotional Awareness in Disadvantaged Students” (TR22.11.SK01.0111) project. Fifteen students with different disadvantages at the 5th,6th,7th,and 8th grades in the second semester were included in the study. Training studies were performed to develop psychosocial skills and health perception of students. These studies were performed at the school library twice a week for three weeks. In this study, socio-demographic, health perception evaluation and psychosocial skill evaluation forms were used as material. Study data were analyzed using by SPSS, 15.00 version. RESULTS: Most students (66.6%) were female. Statistically significant difference was defined in psychosocial skill developments of students between the median values measured three weeks apart (p<0.001). When examined responses of students to the health perception scale, it was observed that favorable attitudes of students were increased, whereas unfavorable attitudes were decreased in the measurements during the training. CONCLUSION: Students with disadvantages gained physical, psychological and social skills (being interactive; sharing, communicating, enterprising) features of leadership and social supporting as well as the development of health perception. Two students, who successfully completed these training activities in our study group, were chosen to the project camp. One of these two students, who successfully completed the activities in the project camp and past the final exam was accepted by science trip in the United Kingdom. In conclusion, professional group trainings at early ages may be helpful for developing characteristics of health perception, psychosocial skills, enterprising in disadvantaged students. © 2015, TAF Preventive Medicine Bulletin. ALL RIGHTS RESERVED