UTJECAJ SPOLA NA RAZVOJ ŽDREBADI LIPICANSKE PASMINE

The offspring’s development especially in the first months after foaling is crucial for further development. If favourable conditions of feeding, keeping and fancying as well as other important conditions are ensured, a homogenous growth and development of the offspring is obtained. Research was conducted on 44 male and 42 female Lipizzaner breed foals in the first six months after foaling. The measuring of the withers height, chest girth and cannon bone circumference were done seven days after foaling and at the age of six months. Measuring data were processed by the statistical program SPSS/PC (Nie et al., 1975). The processed data of the obtained measurings indicate homogeneity for both male and female foals. The male foals had a little higher values than the female in both measurings, but the differences between sexes were highly significant only in the cannon bone circumference. Correlations among obtained values were positive and ranged between low and very high, with correlation coefficients between r= 0.379 and r=0.843 for male and r=0.338 and r=0.723 for female foals. The differences between the obtained values were significant and highly significant and a little more marked in male foals.Razvoj podmlatka, naročito u prvim mjesecima nakon ždrijebljenja, odlučujući je i za kasniju razvijenost. Ukoliko se u fazi sisanja osiguraju povoljni uvjeti hranidbe, držanja i njege, kao i ostalih uvjeta bitnih za normalan rast i razvoj, dobiva se ujednačeni rast i razvoj podmlatka. Istraživanja su obavljena na 44 muške i 42 ženske ždrebadi lipicanske pasmine u prvih šest mjeseci nakon ždrijebljenja. Izvršena su mjerenja visine grebena, opsega prsa i opsega cjevanice sedam dana nakon ždrijebljenja i u dobi od šest mjeseci. Podaci mjerenja obrañeni su prema statističkom programu SPSS/PC (Nie i sur., 1975.). Obrañeni podaci dobivenih mjerenja ukazuju na ujednačenost, kako za mušku tako i za žensku ždrebad. Muška ždrebad imala su nešto veće vrijednosti nego ženska u oba mjerenja, no razlike izmeñu spolova bile su visoko signifikantne samo u opsegu cjevanice. Korelacijske povezanosti izmeñu dobivenih vrijednosti bile su pozitivne i kretale su se između slabe i vrlo jake, s korelacijskim koeficijentima izmeñu r=0,379 i r=0,843 za mušku te r=0,338 i r=0,723 za žensku ždrebad. Razlike između dobivenih vrijednosti bile su signifikantne i visoko signifikantne te nešto jače izražene kod muške ždrebadi

Influence of Microclimate in a Barn on Dairy Cows’ Welfare and Production

Microclimate in a barn has a major influence on cows’ health and welfare, as well as on milk production of dairy cows. Extreme values of air temperature and humidity can negatively influence barn conditions, having thus negative effect on cows kept in barns. The research aimed to investigate influence of basic microclimate parameters on a modern dairy farm located in Eastern Croatia. Research period referred to summer season, from 01 June – 31 August 2013. Measurements were carried out in three time intervals (00:00-08:00; 08:00-16:00; 16:00-00:00) for the following parameters: temperature (T), humidity (H) and temperature-humidity index (THI). The results showed that the values of T and THI were higher than optimal values recommended by the scientific literature. Differences between the daily interval for T, H and THI were statistically highly significant (p<0.0001). Furthermore, significant difference (p<0.0001; p<0.05) was determined for all investigated parameters between June and July, and June and August. However, between July and August there was no significant difference. Although measurements were performed on a modern dairy farm equipped with additional cooling by fans, it was not sufficient to create an optimal microclimate environment for dairy cows. Because of that, additional measures need to be undertaken during summer months (for example, installation of water sprinklers) to reduce the air temperature and temperature-humidity index, all with the purpose to increase comfort of dairy cows and to prevent decrease in milk production

Morphological characteristics of the Đakovo Lippizaner

Praćenje razvitka tjelesnih mjera lipicanskog podmlatka ima posebnu važnost pri određivanju tjelesne i pripusne dozrelosti konja. Poznavanjem intenziteta rasta i razvitka uzgajivači svojim postupcima u uzgoju mogu donekle utjecati na rast i razvitak. Od posebne važnosti je pravilna hranidba, te način držanja i njega. Podaci iz matične evidencije ergele Đakovo obuhvatili su grla s punim rodovnikom što je omogućilo praćenje fenotipskih promjena po generacijama. Od morfoloških svojstava statistički su obrađene tjelesne mjere (visina grebena, opseg prsa i opseg cjevanice mjerene vrpcom) odraslih kobila i pastuha, te ždrebadi nakon oždrebljenja, zatim u dobi od šest, dvanaest, dvadeset četiri te trideset šest mjeseci. Muška grla su imala veću visinu grebena, kako pri oždrebljenju tako i u zreloj dobi od ženskih grla. Opseg prsa kod muških grla je veći pri oždrebljenju, dok je u zreloj dobi manji od ženskih. Veći opseg prsa ženskih grla u zreloj dobi proizlazi iz činjenice da su u toj životnoj dobi neka ženska grla uvrštena u istraživanje bila u poodmaklom mjesecu graviditeta. Dobivene vrijednosti opsega cjevanice nemaju značajnu razliku u odnosu na spol. Ergela Đakovo zauzima značajno mjesto u zaprežnom sportu kao što je vožnja u dvopregu i četveropregu. Uzgojni cilj je kako u ergeli tako i u privatnom uzgoju uzgojiti kvalitetna grla za vožnju u zaprezi i jahanje. U postizanju što većih okvira i koščatosti lipicanskog uzgoja konja u ergeli Đakovo koristili su se lipicanski pastusi iz Mađarske, Rumunjske, Austrije i Slovenije kao osvježivači krvi. Danas đakovački lipicanac spada u najkrupniji uzgoj ovoga konja. Osvježavanjem krvi već u prvoj generaciji potomaka utvrđen je veći tjelesni okvir i koščatost.Observing the development of physical measurement of Lippizaner offspring has a specific importance when determining physical and admission maturity of the horse. Knowing the growth and development intensity the breeders can slightly influence the growth and development with their treatments in breeding. Appropriate feeding, care are and of special significance data from the register of the Đakovo horse-farm include animal with full pedigree, that has enabled following the phenotype changes by generations. From morphological characteristics, statistically elaborated were physical measurements (withers height, chest girth, cannon-bone circumference measured by ribbon) of adult mares and stallions, and foals at foaling, at age of six, twelve, twenty four and thirty six months. Males had a higher withers height, both at foaling time and at mature age than females. The chest girth in males is larger at foaling time, while at mature age it is smaller than in females. A larger chest girth in females at mature age is the consequence of gravidity of some females that were included in the research. The obtained values of the cannon-bone circumference have no significant difference with respect to sex. The horse-farm Đakovo has a significant place in team sport, both in two-horse and four-horse teams. The breeding aim is to raise qualitaty animals for team sport and riding at both horse-farm and private breeding. To obtain larger frames and boniness in Lippizaner horses at the horse-farm Đakovo, stallions from Hungary, Romania, Austria and Slovenia were used to infuse new blood. Today the Đakovo Lippizaner is one of the largest when considered this horse breeding. A larger physical frame and boniness is established already in the first generation when refreshed by blood

Місто як екзистенційна пастка (на матеріалі сучасної поезії)

Осмислюється специфіка екзистенційно зумовленого сприймання урбаністичного простору в творчості сучасних українських поетів. Окреслюється своєрідне осмислення символів дороги, лабіринту, човна, мосту, що є елементами просторової символіки художнього світу. Стверджується, що урбаністичний простір сприймається сучасними митцями як екзистенцій на пастка, духовно мертвий простір “недоіснування”, вихід з якого потребує духовного зусилля. Ключові слова: хронотоп, топос, екзистенційний, ліричний герой, постмодернізм, символ.Осмысливается специфика экзистенциально преопределенного восприятия урбанистического пространства в творчестве современных украинских поэтов. Анализируется своеобразное осмысление символов дороги, лабиринта, лодки, моста, который является элементами пространственной символики художественного мира. Утверждается, что урбанистическое пространство воспринимается современными художниками как экзистенциальная ловушка, духовно мертвое пространство “недосуществования”, выход из которого требует в духовном усилии. Ключевые слова: хронотоп, топос, экзистенциальный, лирический герой, постмодернизм, символ.A specific is comprehended ekzistenciаl the predefined perception of urbanism space in creation of the modern Ukrainian poets. The original comprehension of symbols of road, labyrinth, boat, bridge which is the elements of spatial symbolism of the artistic world is outlined. It becomes firmly established that urbanism space is perceived modern artists as ekzistencial on trap, spiritually dead ground, an exit from which needs spiritual effort. Keywords: khronotop, topos, ekzistencial, lyric hero, postmodernizm, symbol

БЮДЖЕТНО-ПОДАТКОВА ПОЛІТИКА: ТЕОРІЯ ТА ПРАКТИКА ЗАСТОСУВАННЯ В УКРАЇНІ

The article is devoted to defining  theoretical principles, tools, and mechanisms of fiscal policy; compliance of Ukrainian fiscal policy with existing theoretical principles and practice in this area of government  regulation in developed countries.The main stages in the evolution of Keynesian strategies of macro regulation are highlighted.We analyzed current phase, which is defined as a phase of fiscal consolidation that started at the theoretical level with discussions on what is more effective: a policy based on stringent rules and laws or policy based on circumstances. It is emphasized that practical importance of theoretical discussions was increased with side effects, that have arisen during the economic policies to overcome the global financial crisis of 2008-2009. Overview of the basic measures stimulating fiscal policy pursued by developed countries to overcome the financial crisis of 2008-2009 is provided. It is determined that the leading countries adhere to common tactic of stimulating fiscal policy and concluded that despite some modifications, fiscal policy is based on the basic postulates of Keynesian theory of macroeconomic regulation and experience of anti-crisis policy of recent years proves its efficiency in modern conditions of information and network economy. The content of Ukrainian fiscal policy in modern terms is revealed. Factors that are crucial for fiscal policy are systematized. It was found that in recent years a contractionary policy was implemented, due to the need for fiscal consolidation, and despite the economic downturn, rising unemployment, reduced total expenditures.The following features of fiscal policy are determined: reaction is not systematic, but rather pointed; discretionary fiscal policy mechanism prevails; there is a discrepancy between the versions of the fiscal policy and the phases of the economic cycle, due to both objective factors such as the existence of military conflict and the lack of necessary funds and government implementation of quasi-fiscal operations, and focus on the action of purely economic factors to improve economic situation in the country.Статья посвящена определению теоретических основ, инструментов, механизмов бюджетно-налоговой политики и соответствия мер бюджетно-налоговой политики Украины существующим теоретическим положениям и практике проведения данного направления государственного регулирования экономики в развитых странах. Выделено основные этапы эволюции кейнсианской стратегии макрорегулирования. Обобщенно основные меры стимулирующей бюджетно-налоговой политики, которую проводили развитые страны для преодоления последствий финансово-экономического кризиса 2008-2009 гг. Раскрыто содержание бюджетно-налоговой политики Украины в современных условиях, систематизировано факторы, которые являются определяющими для её проведения.Стаття присвячена визначенню теоретичних засад, інструментів, механізмів бюджетно-податкової політики та відповідності  заходів бюджетно-податкової політики України існуючим теоретичним положенням і практиці проведення даного напряму державного регулювання економіки у розвинутих країнах. Виділено основні етапи еволюції кейнсіанської стратегії макрорегулювання. Узагальнено основні заходи стимулюючої бюджетно-податкової політики, яку проводили розвинуті країни для подолання наслідків фінансово-економічної кризи  2008-2009 рр. Розкрито зміст бюджетно-податкової політики України в сучасних умовах, систематизовано фактори, що є визначальними для проведення бюджетно-податкової політики

BREEDING VALUES OF LIPIZZANER STALLIONS FOR SOME BODY MEASUREMENTS

U uzgoju i selekciji lipicanske pasmine konja se u ocjeni genetske vrijednosti pastuha također poklanja pažnja tjelesnom okviru, koji treba odgdvoriti poželjnom tipu za dotičnu pasminu. Budući da je vrijeme testiranja pastuha relativno dugo, uključivanje informacije o potomstvu može doprinijeti skraćenju trajanja ispitivanja i bržem donošenju selekcijskih odluka. Cilj ispitivanja je bio procjena uzgojne vrijednosti lipicanskih pastuha za visinu grebena i obujam prsa u uvjetima uzgoia u Centru za uzgoj i selekciju konja u Đakovu, u Hrvatskoj. Podaci se odnose na 305 ždrebadi, potomaka 12 pastuha. Genetske i fonotipske varijance ocijenjene su REML procedurom. Heritabilitet za visinu grebena i opseg prsa iznosio je 0,26 odnosno 0,25. Uzgojne vrijednosti za ove tijelesne mjere ocijenjene su BLUP metodom i to s modelom koji je uključivao godinu rođenja, redosljed ždrebljenja i spol ždrebadi kao fiksne, a očeve kao slučajne efekte. Ocjene uzgojnih vrijednosti varilale su od 0,614 do -0,246 za visinu grebena i od 0,215 do -0,232 za obujam prsa. U radu je također diskutirano o redosljedu pastuha glede ocjena uzgojnih vrijednosti i mogućnostima korištenja ovakvih informacija u uzgojno selekcijskom radu.Breeding and selection of the Lipizzaner horses are based on estimating of the body conformations, which should correspond to the desirable type of the breed in question. Some information about the stallion s offspring can reduce the testing time and speed up the decision-making concerning the selection. The purpose of this study was to estimate the breeding values of the Lipizzaner stallions for height at whiters and chest girth under the breeding conditions in the Centre for horse breeding and selection in Đakovo, Croatia. The data were obtained on 305 foals sired by 12 stallions. The genetic and the phenotypic variances were estimated by means of the restricted maximum likelihood (REML procedure). The heritability for height at whiters and chest girth was 0.26 and 0.25 respectively. The breeding values for body measurements were estimated by BLUP method. The model included the year of birth, the foaling number and the sex as fixed effects, and sires as random effects. The estimates concerning breeding values ranged from 0,611 to -0.264 form height at whiters and from 0.215 to -0.232 for the chest girth. This paper also discusses the rank of stallions concerning the estimation of the breeding values and possibility to use such issues of information in breeding and selection

Morphological characteristics of the Đakovo Lippizaner

Praćenje razvitka tjelesnih mjera lipicanskog podmlatka ima posebnu važnost pri određivanju tjelesne i pripusne dozrelosti konja. Poznavanjem intenziteta rasta i razvitka uzgajivači svojim postupcima u uzgoju mogu donekle utjecati na rast i razvitak. Od posebne važnosti je pravilna hranidba, te način držanja i njega. Podaci iz matične evidencije ergele Đakovo obuhvatili su grla s punim rodovnikom što je omogućilo praćenje fenotipskih promjena po generacijama. Od morfoloških svojstava statistički su obrađene tjelesne mjere (visina grebena, opseg prsa i opseg cjevanice mjerene vrpcom) odraslih kobila i pastuha, te ždrebadi nakon oždrebljenja, zatim u dobi od šest, dvanaest, dvadeset četiri te trideset šest mjeseci. Muška grla su imala veću visinu grebena, kako pri oždrebljenju tako i u zreloj dobi od ženskih grla. Opseg prsa kod muških grla je veći pri oždrebljenju, dok je u zreloj dobi manji od ženskih. Veći opseg prsa ženskih grla u zreloj dobi proizlazi iz činjenice da su u toj životnoj dobi neka ženska grla uvrštena u istraživanje bila u poodmaklom mjesecu graviditeta. Dobivene vrijednosti opsega cjevanice nemaju značajnu razliku u odnosu na spol. Ergela Đakovo zauzima značajno mjesto u zaprežnom sportu kao što je vožnja u dvopregu i četveropregu. Uzgojni cilj je kako u ergeli tako i u privatnom uzgoju uzgojiti kvalitetna grla za vožnju u zaprezi i jahanje. U postizanju što većih okvira i koščatosti lipicanskog uzgoja konja u ergeli Đakovo koristili su se lipicanski pastusi iz Mađarske, Rumunjske, Austrije i Slovenije kao osvježivači krvi. Danas đakovački lipicanac spada u najkrupniji uzgoj ovoga konja. Osvježavanjem krvi već u prvoj generaciji potomaka utvrđen je veći tjelesni okvir i koščatost.Observing the development of physical measurement of Lippizaner offspring has a specific importance when determining physical and admission maturity of the horse. Knowing the growth and development intensity the breeders can slightly influence the growth and development with their treatments in breeding. Appropriate feeding, care are and of special significance data from the register of the Đakovo horse-farm include animal with full pedigree, that has enabled following the phenotype changes by generations. From morphological characteristics, statistically elaborated were physical measurements (withers height, chest girth, cannon-bone circumference measured by ribbon) of adult mares and stallions, and foals at foaling, at age of six, twelve, twenty four and thirty six months. Males had a higher withers height, both at foaling time and at mature age than females. The chest girth in males is larger at foaling time, while at mature age it is smaller than in females. A larger chest girth in females at mature age is the consequence of gravidity of some females that were included in the research. The obtained values of the cannon-bone circumference have no significant difference with respect to sex. The horse-farm Đakovo has a significant place in team sport, both in two-horse and four-horse teams. The breeding aim is to raise qualitaty animals for team sport and riding at both horse-farm and private breeding. To obtain larger frames and boniness in Lippizaner horses at the horse-farm Đakovo, stallions from Hungary, Romania, Austria and Slovenia were used to infuse new blood. Today the Đakovo Lippizaner is one of the largest when considered this horse breeding. A larger physical frame and boniness is established already in the first generation when refreshed by blood

Apolipoprotein E4 has extensive conformational heterogeneity in lipid-free and lipid-bound forms

The ε4-allele variant of apolipoprotein E (ApoE4) is the strongest genetic risk factor for Alzheimer\u27s disease, although it only differs from its neutral counterpart ApoE3 by a single amino acid substitution. While ApoE4 influences the formation of plaques and neurofibrillary tangles, the structural determinants of pathogenicity remain undetermined due to limited structural information. Previous studies have led to conflicting models of the C-terminal region positioning with respect to the N-terminal domain across isoforms largely because the data are potentially confounded by the presence of heterogeneous oligomers. Here, we apply a combination of single-molecule spectroscopy and molecular dynamics simulations to construct an atomically detailed model of monomeric ApoE4 and probe the effect of lipid association. Importantly, our approach overcomes previous limitations by allowing us to work at picomolar concentrations where only the monomer is present. Our data reveal that ApoE4 is far more disordered and extended than previously thought and retains significant conformational heterogeneity after binding lipids. Comparing the proximity of the N- and C-terminal domains across the three major isoforms (ApoE4, ApoE3, and ApoE2) suggests that all maintain heterogeneous conformations in their monomeric form, with ApoE2 adopting a slightly more compact ensemble. Overall, these data provide a foundation for understanding how ApoE4 differs from nonpathogenic and protective variants of the protein

Challenges in QCD matter physics --The scientific programme of the Compressed Baryonic Matter experiment at FAIR

Substantial experimental and theoretical efforts worldwide are devoted to explore the phase diagram of strongly interacting matter. At LHC and top RHIC energies, QCD matter is studied at very high temperatures and nearly vanishing net-baryon densities. There is evidence that a Quark-Gluon-Plasma (QGP) was created at experiments at RHIC and LHC. The transition from the QGP back to the hadron gas is found to be a smooth cross over. For larger net-baryon densities and lower temperatures, it is expected that the QCD phase diagram exhibits a rich structure, such as a first-order phase transition between hadronic and partonic matter which terminates in a critical point, or exotic phases like quarkyonic matter. The discovery of these landmarks would be a breakthrough in our understanding of the strong interaction and is therefore in the focus of various high-energy heavy-ion research programs. The Compressed Baryonic Matter (CBM) experiment at FAIR will play a unique role in the exploration of the QCD phase diagram in the region of high net-baryon densities, because it is designed to run at unprecedented interaction rates. High-rate operation is the key prerequisite for high-precision measurements of multi-differential observables and of rare diagnostic probes which are sensitive to the dense phase of the nuclear fireball. The goal of the CBM experiment at SIS100 (sNN= 2.7--4.9 GeV) is to discover fundamental properties of QCD matter: the phase structure at large baryon-chemical potentials (μB&gt; 500 MeV), effects of chiral symmetry, and the equation of state at high density as it is expected to occur in the core of neutron stars. In this article, we review the motivation for and the physics programme of CBM, including activities before the start of data taking in 2024, in the context of the worldwide efforts to explore high-density QCD matter

Synthesis of Fluorine-18 Functionalized Nanoparticles for use as in vivo Molecular Imaging Agents

Nanoparticles containing fluorine-18 were prepared from block copolymers made by ring opening metathesis polymerization (ROMP). Using the fast initiating ruthenium metathesis catalyst (H_2IMes)(pyr)_2(Cl)_2Ru=CHPh, low polydispersity amphiphilic block copolymers were prepared from a cinnamoyl-containing hydrophobic norbornene monomer and a mesyl-terminated PEG-containing hydrophilic norbornene monomer. Self-assembly into micelles and subsequent cross-linking of the micelle cores by light-activated dimerization of the cinnamoyl groups yielded stable nanoparticles. Incorporation of fluorine-18 was achieved by nucleophilic displacement of the mesylates by the radioactive fluoride ion with 31% incorporation of radioactivity. The resulting positron-emitting nanoparticles are to be used as in vivo molecular imaging agents for use in tumor imaging