Etude du passage membranaire de solutions huileuses du [60] fullerène administrées par voie orale (action sur le stress oxydatif dans un model expérimental d intoxication par le CCI4 chez le rat)

L'objectif de cette thèse a été d'étudier les effets d'une solution huileuse de [60]fullerène sur le stress oxydatif dans un modèle expérimental chez le rat. Les résultats obtenus montrent que ce fullerène peut être absorbé par voie digestive et que ces effets sont remarquables, même à des doses de l'ordre de quelques milligrammes par kilogramme de poids corporel.The objective of this thesis was to study the effects of an oily solution of [60]fullerene on oxidative stress in an experimental model in rats. The results obtained show that the fullerene can be absorbed through the digestive tract and that these effects are notable, even at doses of the order of several milligrams per kilogram of body weightCHATENAY M.-PARIS 11-BU Pharma. (920192101) / SudocSudocFranceF

An ultrasensitive LC–MS/MS method with liquid phase extraction to determine paclitaxel in both cell culture medium and lysate promising quantification of drug nanocarriers release in vitro

International audienc

The prolongation of the lifespan of rats by repeated oral administration of [60]fullerene

International audienc

The prolongation of the lifespan of rats by repeated oral administration of [60]fullerene

International audienc

The prolongation of the lifespan of rats by repeated oral administration of [60]fullerene

International audienc

The prolongation of the lifespan of rats by repeated oral administration of [60]fullerene

International audienc

The prolongation of the lifespan of rats by repeated oral administration of [60]fullerene

International audienc

Biocompatible titanate nanotubes with high loading capacity of genistein: cytotoxicity study and anti-migratory effect on U87-MG cancer cell lines

International audienceTitanate nanotubes (Ti-Nts) have proved to be a potential candidate for drug delivery due to their large surface change and higher cellular uptake as a direct consequence of their tubular shape. Ti-Nts were assessed for their safety, their kinetics of cellular uptake on U87-MG cell line and for genistein loading efficiency. No cytotoxic effect was observed under higher empty Ti-Nts concentrations up to 100 mu g mL(-1). The multiwalled tubular morphology was found to be an important parameter promoting high drug loading. The Ti-Nts could achieve higher genistein drug-loading content (25.2%) and entrapment efficiency (51.2%) leading to a controlled drug release as well as a higher cellular uptake of genistein-loaded- Ti-Nts which induces higher cytotoxicity and significant anti-migratory effect on U87-MG human glioblastoma astrocytoma, promising efficient antitumor activity

Phytochemical analysis and in vitro and in vivo evaluation of biological activities of artichoke (Cynara scolymus L.) floral stems: Towards the valorization of food by-products

International audienc