44,717 research outputs found
Fiber Orientation Estimation Guided by a Deep Network
Diffusion magnetic resonance imaging (dMRI) is currently the only tool for
noninvasively imaging the brain's white matter tracts. The fiber orientation
(FO) is a key feature computed from dMRI for fiber tract reconstruction.
Because the number of FOs in a voxel is usually small, dictionary-based sparse
reconstruction has been used to estimate FOs with a relatively small number of
diffusion gradients. However, accurate FO estimation in regions with complex FO
configurations in the presence of noise can still be challenging. In this work
we explore the use of a deep network for FO estimation in a dictionary-based
framework and propose an algorithm named Fiber Orientation Reconstruction
guided by a Deep Network (FORDN). FORDN consists of two steps. First, we use a
smaller dictionary encoding coarse basis FOs to represent the diffusion
signals. To estimate the mixture fractions of the dictionary atoms (and thus
coarse FOs), a deep network is designed specifically for solving the sparse
reconstruction problem. Here, the smaller dictionary is used to reduce the
computational cost of training. Second, the coarse FOs inform the final FO
estimation, where a larger dictionary encoding dense basis FOs is used and a
weighted l1-norm regularized least squares problem is solved to encourage FOs
that are consistent with the network output. FORDN was evaluated and compared
with state-of-the-art algorithms that estimate FOs using sparse reconstruction
on simulated and real dMRI data, and the results demonstrate the benefit of
using a deep network for FO estimation.Comment: A shorter version is accepted by MICCAI 201
The imperial war museum’s social interpretation project
This report represents the output from research undertaken by University of Salford and MTM
London as part of the joint Digital R&D Fund for Arts and Culture, operated by Nesta, Arts
Council England and the AHRC. University of Salford and MTM London received funding from
the programme to act as researchers on the Social Interpretation (SI) project, which was led by
the Imperial War Museum (IWM) and their technical partners, The Centre for Digital
Humanities, University College London, Knowledge Integration, and Gooii. The project was
carried out between October 2011 and October 2012
Process transparency on construction sites : examples from construction companies in Brazil
Process transparency is the core concept in Visual Management (VM), which is one of the founding blocks of the Toyota Production System. This paper presents the
preliminary results of a collaborative research conducted between Brazil and the UK, as part of a research effort focused on the application of Visual Management in
construction. How process transparency is realized on construction sites is the main research question of the paper. The use of this concept and the implementation of the
transparency theory were investigated through multiple case studies, carried out in nine different construction companies. The findings are explained through six theoretical transparency increasing approaches. The affecting parameters in the application of, the management’s perception of and several methods in process
transparency in construction were identified. Further work, especially exploring the functions of process transparency on construction sites and reflecting the worker perception of the issue, is necessary to elaborate the process transparency concept
Black Hole Entropy and the Dimensional Continuation of the Gauss-Bonnet Theorem
The Euclidean black hole has topology . It is
shown that -in Einstein's theory- the deficit angle of a cusp at any point in
and the area of the are canonical conjugates. The
black hole entropy emerges as the Euler class of a small disk centered at the
horizon multiplied by the area of the there.These results are
obtained through dimensional continuation of the Gauss-Bonnet theorem. The
extension to the most general action yielding second order field equations for
the metric in any spacetime dimension is given.Comment: 7 pages, RevTe
Multi-lepton signals from the top-prime quark at the LHC
We analyze the collider signatures of models with a vector-like top-prime
quark and a massive color-octet boson. The top-prime quark mixes with the top
quark in the Standard Model, leading to richer final states than ones that are
investigated by experimental collaborations. We discuss the multi-lepton final
states, and show that they can provide increased sensitivity to models with a
top-prime quark and gluon-prime. Searches for new physics in high multiplicity
events are an important component of the LHC program and complementary to
analyses that have been performed.Comment: 7 pages, 4 figures, 2 table
Collider Phenomenology with Split-UED
We investigate the collider implications of Split Universal Extra Dimensions.
The non-vanishing fermion mass in the bulk, which is consistent with the
KK-parity, largely modifies the phenomenology of Minimal Universal Exta
Dimensions. We scrutinize the behavior of couplings and study the discovery
reach of the Tevatron and the LHC for level-2 Kaluza-Klein modes in the
dilepton channel, which would indicates the presence of the extra dimensions.
Observation of large event rates for dilepton resonances can result from a
nontrivial fermion mass profile along the extra dimensions, which, in turn, may
corroborate extra dimensional explanation for the observation of the positron
excess in cosmic rays.Comment: 23 pages, 15 figure
Heavy Quarkonium in a weakly-coupled quark-gluon plasma below the melting temperature
We calculate the heavy quarkonium energy levels and decay widths in a
quark-gluon plasma, whose temperature T and screening mass m_D satisfy the
hierarchy m alpha_s >> T >> m alpha_s^2 >> m_D (m being the heavy-quark mass),
at order m alpha_s^5. We first sequentially integrate out the scales m, m
alpha_s and T, and, next, we carry out the calculations in the resulting
effective theory using techniques of integration by regions. A collinear region
is identified, which contributes at this order. We also discuss the
implications of our results concerning heavy quarkonium suppression in heavy
ion collisions.Comment: 25 pages, 2 figure
Analysis of chromosome positions in the interphase nucleus of Chinese hamster cells by laser-UV-microirradiation experiments
Unsynchronized cells of an essentially diploid strain of female Chinese hamster cells derived from lung tissue (CHL) were laser-UV-microirradiated (=257 nm) in the nucleus either at its central part or at its periphery. After 7–9 h postincubation with 0.5 mM caffeine, chromosome preparations were made in situ. Twenty-one and 29 metaphase spreads, respectively, with partial chromosome shattering (PCS) obtained after micro-irradiation at these two nuclear sites, were Q-banded and analyzed in detail. A positive correlation was observed between the frequency of damage of chromosomes and both their DNA content and length at metaphase. No significant difference was observed between the frequencies of damage obtained for individual chromosomes at either site of microirradiation. The frequency of joint damage of homologous chromosomes was low as compared to nonhomologous ones. Considerable variation was noted in different cells in the combinations of jointly shattered chromosomes. Evidence which justifies an interpretation of these data in terms of an interphase arrangement of chromosome territories is discussed. Our data strongly argue against somatic pairing as a regular event, and suggest a considerable variability of chromosome positions in different nuclei. However, present data do not exclude the possibility of certain non-random chromosomal arrangements in CHL-nuclei. The interphase chromosome distribution revealed by these experiments is compared with centromere-centromere, centromere-center and angle analyses of metaphase spreads and the relationship between interphase and metaphase arrangements of chromosomes is discussed
Norovirus Infection and Disease in an Ecuadorian Birth Cohort: Association of Certain Norovirus Genotypes With Host FUT2 Secretor Status.
BACKGROUND: Although norovirus is the most common cause of gastroenteritis, there are few data on the community incidence of infection/disease or the patterns of acquired immunity or innate resistance to norovirus. METHODS: We followed a community-based birth cohort of 194 children in Ecuador with the aim to estimate (1) the incidence of norovirus gastroenteritis from birth to age 3 years, (2) the protective effect of norovirus infection against subsequent infection/disease, and (3) the association of infection and disease with FUT2 secretor status. RESULTS: Over the 3-year period, we detected a mean of 2.26 diarrheal episodes per child (range, 0-12 episodes). Norovirus was detected in 260 samples (18%) but was not found more frequently in diarrheal samples (79 of 438 [18%]), compared with diarrhea-free samples (181 of 1016 [18%]; P = .919). A total of 66% of children had at least 1 norovirus infection during the first 3 years of life, and 40% of children had 2 infections. Previous norovirus infections were not associated with the risk of subsequent infection. All genogroup II, genotype 4 (GII.4) infections were among secretor-positive children (P < .001), but higher rates of non-GII.4 infections were found in secretor-negative children (relative risk, 0.56; P = .029). CONCLUSIONS: GII.4 infections were uniquely detected in secretor-positive children, while non-GII.4 infections were more often found in secretor-negative children
Inert gas clearance from tissue by co-currently and counter-currently arranged microvessels
To elucidate the clearance of dissolved inert gas from tissues, we have developed numerical models of gas transport in a cylindrical block of tissue supplied by one or two capillaries. With two capillaries, attention is given to the effects of co-current and counter-current flow on tissue gas clearance. Clearance by counter-current flow is compared with clearance by a single capillary or by two co-currently arranged capillaries. Effects of the blood velocity, solubility, and diffusivity of the gas in the tissue are investigated using parameters with physiological values. It is found that under the conditions investigated, almost identical clearances are achieved by a single capillary as by a co-current pair when the total flow per tissue volume in each unit is the same (i.e., flow velocity in the single capillary is twice that in each co-current vessel). For both co-current and counter-current arrangements, approximate linear relations exist between the tissue gas clearance rate and tissue blood perfusion rate. However, the counter-current arrangement of capillaries results in less-efficient clearance of the inert gas from tissues. Furthermore, this difference in efficiency increases at higher blood flow rates. At a given blood flow, the simple conduction-capacitance model, which has been used to estimate tissue blood perfusion rate from inert gas clearance, underestimates gas clearance rates predicted by the numerical models for single vessel or for two vessels with co-current flow. This difference is accounted for in discussion, which also considers the choice of parameters and possible effects of microvascular architecture on the interpretation of tissue inert gas clearance
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