Constructing compact 8-manifolds with holonomy Spin(7) from Calabi-Yau orbifolds

Compact Riemannian 7- and 8-manifolds with holonomy G(2) arid Spin(7) were first constructed by the author in 1994-5, by resolving orbifolds T-7/Gamma and T-8/Gamma. This paper describes a new construction of compact 8-manifolds with holonomy Spin(7). We start with a Calabi-Yau 4-orbifold Y with isolated singularities of a special kind. We divide by an antiholomorphic involution a of Y to get a real 8-orbifold Z = Y/. Then we resolve tire singularities of Z to get a compact 8-manifold M, which has metrics with holonomy Spin(7). Manifolds constructed in this way typically have large fourth Betti number b(4)(M).</sigma

Caspase-8 functions as a key mediator of inflammation and pro-IL-1β processing via both canonical and non-canonical pathways.

Caspase-8 is an apical component of cell death pathways. Activated caspase-8 can drive classical caspase-dependent apoptosis and actively inhibits cell death mediated by RIPK3-driven necroptosis. Genetic deletion of Casp8 results in embryonic lethality as a result of uncontrolled necroptosis. This lethality can be rescued by simultaneous deletion of Ripk3. Recently, caspase-8 has been additionally connected to inflammatory pathways within the cell. In particular, caspase-8 has been shown to be crucially involved in the induction of pro-IL-1β synthesis and processing via both non-canonical and canonical pathways. In this review, we bring together current knowledge regarding the role of caspase-8 in cellular inflammation with a particular emphasis on the interplay between caspase-8 and the classical and non-canonical inflammasomes.The authors received financial support of the Wellcome Trust (TPM; WT085090MA) and the Biotechnology and Biological Sciences Research Council (CEB; BB/K006436/1).This is the accepted manuscript. The final version is available from Wiley at http://onlinelibrary.wiley.com/doi/10.1111/imr.12284/abstract

Closed trajectories of a particle model on null curves in anti-de Sitter 3-space

We study the existence of closed trajectories of a particle model on null curves in anti-de Sitter 3-space defined by a functional which is linear in the curvature of the particle path. Explicit expressions for the trajectories are found and the existence of infinitely many closed trajectories is proved.Comment: 12 pages, 1 figur

Modified Debye-Huckel Electron Shielding and Penetration Factor

Screened potential, modified by non standard electron cloud distributions responsible for the shielding effect on fusion of reacting nuclei in astrophysical plasmas, is derived. The case of clouds with depleted tails in space coordinates is discussed. The modified screened potential is obtained both from statistical mechanics arguments based on fluctuations of the inverse of the Debye-Huckel radius and from the solution of a Bernoulli equation used in generalized statistical mechanics. Plots and tables useful in evaluating penetration probability at any energy are provided.Comment: 9 pages, 3 figures, 3 table

The use of polymeric meshes for Pelvic Organ Prolapse: current concepts, challenges and future perspectives

Pelvic organ prolapse (POP) is one of the most common chronic disorders in women, impacting the quality of life of millions of them worldwide. More than 100 surgical procedures have been developed over the decades to treat POP. However, the failure of conservative strategies and the number of patients with recurrence risk have increased the need for further adjuvant treatments. Since their introduction, surgical synthetic meshes have dramatically transformed POP repair showing superior anatomic outcomes in comparison to traditional approaches. Although significant progress has been attained, among the meshes in clinical use, there is no single mesh appropriate for every surgery. Furthermore, due to the risk of complications including acute and chronic infection, mesh shrinkage, and erosion of the tissue, the benefits of the use of meshes have recently been questioned. The aim of this work is to review the evolution of POP surgery, analyzing the current challenges, and detailing the key factors pertinent to the design of new mesh systems. Starting with a description of the pelvic floor anatomy, the article then presents the traditional treatments used in pelvic organ disorders. Next, the development of synthetic meshes is described with an insight into how their function is dependent on both mesh design variables (i.e., material, structure, and functional treatment) and surgical applications. These are then linked to common mesh‐related complications, and an indication of current research aiming to address these issues

Variability in H9N2 haemagglutinin receptor-binding preference and the pH of fusion

H9N2 avian influenza viruses are primarily a disease of poultry; however, they occasionally infect humans and are considered a potential pandemic threat. Little work has been performed to assess the intrinsic biochemical properties related to zoonotic potential of H9N2 viruses. The objective of this study, therefore, was to investigate H9N2 haemagglutinins (HAs) using two well-known correlates for human adaption: receptor-binding avidity and pH of fusion. Receptor binding was characterized using bio-layer interferometry to measure virus binding to human and avian-like receptor analogues and the pH of fusion was assayed by syncytium formation in virus-infected cells at different pHs. We characterized contemporary H9N2 viruses of the zoonotic G1 lineage, as well as representative viruses of the zoonotic BJ94 lineage. We found that most contemporary H9N2 viruses show a preference for sulphated avian-like receptor analogues. However, the ‘Eastern’ G1 H9N2 viruses displayed a consistent preference in binding to a human-like receptor analogue. We demonstrate that the presence of leucine at position 226 of the HA receptor-binding site correlated poorly with the ability to bind a human-like sialic acid receptor. H9N2 HAs also display variability in their pH of fusion, ranging between pH 5.4 and 5.85 which is similar to that of the first wave of human H1N1pdm09 viruses but lower than the pH of fusion seen in zoonotic H5N1 and H7N9 viruses. Our results suggest possible molecular mechanisms that may underlie the relatively high prevalence of human zoonotic infection by particular H9N2 virus lineages

TWO DIFFERENT TYPES OF PHOTOCHEMISTRY IN PHYCOERYTHROCYANIN α-SUBUNIT

The photochemical activities of phycoerythrocyanin α-subunits from Mastigocladus laminosus separated by isoelectric focusing were tested by irradiating at 500, 550, 577 and 600 nm. Two types of photoreversible photochromic responses have been characterized by absorption and absorption difference spectroscopy. Type I is the well-known absorption shift from 571 to 506 nm. Type II is a new response characterized by a line-broadening of the 570 nm absorption

Willmore minimizers with prescribed isoperimetric ratio

Motivated by a simple model for elastic cell membranes, we minimize the Willmore functional among two-dimensional spheres embedded in R^3 with prescribed isoperimetric ratio