Finishing the euchromatic sequence of the human genome

The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead

A controladoria e o capital intelectual: um estudo empírico sobre sua gestão The controllership and the intellectual capital: an empirical study on its management

Este estudo objetivou investigar a adequação do Sistema de Informações Contábeis Gerenciais de grandes empresas brasileiras à gestão do Capital Intelectual. Assumiu-se a Controladoria como a área na empresa mais adequada para identificar, avaliar e mensurar esses elementos e para disponibilizar as informações necessárias à gestão das empresas no atingimento de sua missão. A pesquisa do tipo exploratória está baseada em uma amostra composta por 30 gestores de grandes empresas brasileiras. A análise dos dados, tratados por meio do método qualitativo (Análise de Conteúdo), permitiu verificar que a grande maioria dos gestores realiza investimentos em elementos do Capital Intelectual e que atribuíram indicadores para avaliar esses investimentos, mas não de forma integrada que permita a quantificação correta dos valores investidos e a avaliação do retorno desses investimentos. Por outro lado, os gestores mostraram-se receptivos a aplicar um modelo de gestão para tal fim e consideraram a Controladoria como a área mais adequada para gerenciar esse modelo.<br>The purpose of this essay is to investigate through the Controlling Departments how the Management Information Systems in large Brazilian companies treat investments on Intellectual capital elements. It has been assumed that the Controlling Department is the companies' most adequate area to identify, evaluate and measure such elements, and to provide the managerial information required for the accomplishment of each company's mission. The exploratory research is based on a sample of 30 managers of large Brazilian companies. The qualitative analysis of the data collected (Contents Analysis) lead us to the conclusion that the great majority of managers invest on detecting Intellectual Capital elements and have tools to evaluate such investment, but not in an integrated manner that permits to correctly quantify the invested amounts and to evaluate the return on the investment. On the other hand, managers have been receptive to adopt a managerial model for that purpose, if available, and have considered the Controlling Department as the most adequate area to manage such model