Provider and Customer Response to the Service Environment: a Field Experiment

This research extends service theory by examining the relationship between providers and customers in an actual retail setting. Findings indicate that employee evaluations of the service environment improve in the presence of a pleasant, congruent ambient scent; providers are also more courteous and customers more friendly. Most importantly, provider mood states act as moderators of the relationships between the service environment and employee attitude as well as customer perceptions of employee behavior. Implications for managers include careful consideration of whether it is desirable to introduce ambient scent, and how to reduce the impact of negative employee mood states

Anthrofest 2016

The University of Pennsylvania anthropology annual undergraduate research conference known as ANTHROFEST brings together undergraduates involved in research across all concentrations in anthropology, as well as faculty and the broader undergraduate and graduate community. Each year, select students present and discuss their original research to the community at Penn. The conference is open to the public

90Y-clivatuzumab tetraxetan with or without low-dose gemcitabine: A phase Ib study in patients with metastatic pancreatic cancer after two or more prior therapies

AbstractBackgroundFor patients with metastatic pancreatic adenocarcinoma, there are no approved or established treatments beyond the 2nd line. A Phase Ib study of fractionated radioimmunotherapy was undertaken in this setting, administering 90Y-clivatuzumab tetraxetan (yttrium-90-radiolabelled humanised antibody targeting pancreatic adenocarcinoma mucin) with or without low radiosensitising doses of gemcitabine.MethodsFifty-eight patients with three (2–7) median prior treatments were treated on Arm A (N=29, 90Y-clivatuzumab tetraxetan, weekly 6.5mCi/m2doses×3, plus gemcitabine, weekly 200mg/m2 doses×4 starting 1week earlier) or Arm B (N=29, 90Y-clivatuzumab tetraxetan alone, weekly 6.5mCi/m2doses×3), repeating cycles after 4-week delays. Safety was the primary endpoint; efficacy was also evaluated.ResultsCytopaenias (predominantly transient thrombocytopenia) were the only significant toxicities. Fifty-three patients (27 Arm A, 26 Arm B, 91% overall) completed ⩾1 full treatment cycles, with 23 (12 Arm A, 11 Arm B; 40%) receiving multiple cycles, including seven (6 Arm A, 1 Arm B; 12%) given 3–9 cycles. Two patients in Arm A had partial responses by RECIST criteria. Kaplan–Meier overall survival (OS) appeared improved in Arm A versus B (hazard ratio [HR] 0.55, 95% CI: 0.29–0.86; P=0.017, log-rank) and the median OS for Arm A versus Arm B increased to 7.9 versus 3.4months with multiple cycles (HR 0.32, P=0.004), including three patients in Arm A surviving >1year.ConclusionsClinical studies of 90Y-clivatuzumab tetraxetan combined with low-dose gemcitabine appear feasible in metastatic pancreatic cancer patients beyond 2nd line and a Phase III trial of this combination is now underway in this setting

Early Treatment with Fumagillin, an Inhibitor of Methionine Aminopeptidase-2, Prevents Pulmonary Hypertension in Monocrotaline-Injured Rats

Pulmonary Hypertension (PH) is a pathophysiologic condition characterized by hypoxemia and right ventricular strain. Proliferation of fibroblasts, smooth muscle cells, and endothelial cells is central to the pathology of PH in animal models and in humans. Methionine aminopeptidase-2 (MetAP2) regulates proliferation in a variety of cell types including endothelial cells, smooth muscle cells, and fibroblasts. MetAP2 is inhibited irreversibly by the angiogenesis inhibitor fumagillin. We have previously found that inhibition of MetAP2 with fumagillin in bleomycin-injured mice decreased pulmonary fibrosis by selectively decreasing the proliferation of lung myofibroblasts. In this study, we investigated the role of fumagillin as a potential therapy in experimental PH. In vivo, treatment of rats with fumagillin early after monocrotaline injury prevented PH and right ventricular remodeling by decreasing the thickness of the medial layer of the pulmonary arteries. Treatment with fumagillin beginning two weeks after monocrotaline injury did not prevent PH but was associated with decreased right ventricular mass and decreased cardiomyocyte hypertrophy, suggesting a direct effect of fumagillin on right ventricular remodeling. Incubation of rat pulmonary artery smooth muscle cells (RPASMC) with fumagillin and MetAP2-targeting siRNA inhibited proliferation of RPASMC in vitro. Platelet-derived growth factor, a growth factor that is important in the pathogenesis of PH and stimulates proliferation of fibroblasts and smooth muscle cells, strongly increased expression of MetP2. By immunohistochemistry, we found that MetAP2 was expressed in the lesions of human pulmonary arterial hypertension. We propose that fumagillin may be an effective adjunctive therapy for treating PH in patients

Online Service Benefits’ Impact on Relationship Strength, Quality, & Continuation Intention

Many service providers now use social media, both as a way to interact efficiently with their customers, and as a means of gathering customer data needed to better manage customer relationships. Thus, social media can both provide service and assist in developing better future service. In the present research, we examine in detail whether and how social media perform the first of these tasks by examining its use as a tool for online service benefit provision. Then, we consider how benefits customers receive from maintaining relationships with service providers via social media impact outcomes, including reported relationship strength, customer loyalty, commitment, and intention to continue with the service. We also consider how customer choices regarding characteristics of the relationship itself (duration and frequency of interaction) may impact its effectiveness at driving these outcomes. The results of this study will contribute to theory by examining how existing relationship theory applies to relationships between online firms and their customers. We observe how moving a relationship online changes the impacts observed in more traditional environments. We also consider moderators (duration and frequency of interaction) that we do not believe have been considered previously in online settings. Finally, we offer managerial implications related to design of online services

Effectively "Flipping" an Experiential Course

This session reports how a “flipping the classroom” grant engaged undergraduate students using their preferred modes of communication and also provided them with opportunities for more “hands-on” activities leading to more effective learning. The course, a new elective created to combine three different experiential electives for efficiency, involved considerable rather varied material; the grant allowed the class to use class time for learning activities that normally have to take place outside of class. This included various forms of interactive learning, both individual and in teams, as well as meeting with the instructor as needed. Students then performed learning activities that normally take place during class time on their own time and schedule (including lectures recorded in Camtasia and posted on KSUTube for viewing). Students reported this was very effective because they could review lecture segments as needed. An excellent outcome was a student team winning an international competition.</p

Grocery Shopping before, during and after the Pandemic: A Qualitative Study.

This research compares grocery shopping attitudes and behaviors before and during the COVID‐19 pandemic, particularly online/offline shopping modes. Prior to COVID‐19, more consumers shopped in person, even if it was not preferred; consumers who preferred to shop online were found to have greater need for control. During the pandemic, more consumers adopted online grocery shopping, and differences in need for control disappeared. Qualitative research suggests that need for control was superseded by lower‐order needs related to food/safety. There is also a growing consumer desire to grocery shop in person, so postpandemic, this is anticipated to increase relative to online shopping.</p