Effects of Cu/Zn Superoxide Dismutase (sod1) Genotype and Genetic Background on Growth, Reproduction and Defense in Biomphalaria glabrata

Resistance of the snail Biomphalaria glabrata to the trematode Schistosoma mansoni is correlated with allelic variation at copper-zinc superoxide dismutase (sod1). We tested whether there is a fitness cost associated with carrying the most resistant allele in three outbred laboratory populations of snails. These three populations were derived from the same base population, but differed in average resistance. Under controlled laboratory conditions we found no cost of carrying the most resistant allele in terms of fecundity, and a possible advantage in terms of growth and mortality. These results suggest that it might be possible to drive resistant alleles of sod1 into natural populations of the snail vector for the purpose of controlling transmission of S. mansoni. However, we did observe a strong effect of genetic background on the association between sod1 genotype and resistance. sod1 genotype explained substantial variance in resistance among individuals in the most resistant genetic background, but had little effect in the least resistant genetic background. Thus, epistatic interactions with other loci may be as important a consideration as costs of resistance in the use of sod1 for vector manipulation

Lazy Incremental Learning of Control Knowledge for Efficiently Obtaining Quality Plans

General-purpose generative planners use domain-independent search heuristics to generate solutions for problems in a variety of domains. However, in some situations these heuristics force the planner to perform inefficiently or obtain solutions of poor quality. Learning from experience can help to identify the particular situations for which the domain-independent heuristics need to be overridden. Most of the past learning approaches are fully deductive and eagerly acquire correct control knowledge from a necessarily complete domain theory and a few examples to focus their scope

Measurement of hadron and lepton-pair production at 161 GeV<root s<172 GeV at LEP

Contains fulltext : 26256.pdf (publisher's version ) (Open Access

A Measurement of Pi-Polarization at Lep

Contains fulltext : 26223.pdf (publisher's version ) (Open Access