213 research outputs found
Plausibility functions and exact frequentist inference
In the frequentist program, inferential methods with exact control on error
rates are a primary focus. The standard approach, however, is to rely on
asymptotic approximations, which may not be suitable. This paper presents a
general framework for the construction of exact frequentist procedures based on
plausibility functions. It is shown that the plausibility function-based tests
and confidence regions have the desired frequentist properties in finite
samples---no large-sample justification needed. An extension of the proposed
method is also given for problems involving nuisance parameters. Examples
demonstrate that the plausibility function-based method is both exact and
efficient in a wide variety of problems.Comment: 21 pages, 5 figures, 3 table
Religious diversity, empathy, and God images : perspectives from the psychology of religion shaping a study among adolescents in the UK
Major religious traditions agree in advocating and promoting love of neighbour as well as love of God. Love of neighbour is reflected in altruistic behaviour and empathy stands as a key motivational factor underpinning altruism. This study employs the empathy scale from the Junior Eysenck Impulsiveness Questionnaire to assess the association between empathy and God images among a sample of 5993 religiously diverse adolescents (13–15 years old) attending state maintained schools in England, Northern Ireland, Scotland, Wales, and London. The key psychological theory being tested by these data concerns the linkage between God images and individual differences in empathy. The data demonstrate that religious identity (e.g. Christian, Muslim) and religious attendance are less important than the God images which young people hold. The image of God as a God of mercy is associated with higher empathy scores, while the image of God as a God of justice is associated with lower empathy scores
The Infrared Behaviour of the Pure Yang-Mills Green Functions
We review the infrared properties of the pure Yang-Mills correlators and
discuss recent results concerning the two classes of low-momentum solutions for
them reported in literature; i.e. decoupling and scaling solutions. We will
mainly focuss on the Landau gauge and pay special attention to the results
inferred from the analysis of the Dyson-Schwinger equations of the theory and
from "{\it quenched}" lattice QCD. The results obtained from properly
interplaying both approaches are strongly emphasized.Comment: Final version to be published in FBS (54 pgs., 11 figs., 4 tabs
Accessing directly the properties of fundamental scalars in the confinement and Higgs phase
The properties of elementary particles are encoded in their respective
propagators and interaction vertices. For a SU(2) gauge theory coupled to a
doublet of fundamental complex scalars these propagators are determined in both
the Higgs phase and the confinement phase and compared to the Yang-Mills case,
using lattice gauge theory. Since the propagators are gauge-dependent, this is
done in the Landau limit of 't Hooft gauge, permitting to also determine the
ghost propagator. It is found that neither the gauge boson nor the scalar
differ qualitatively in the different cases. In particular, the gauge boson
acquires a screening mass, and the scalar's screening mass is larger than the
renormalized mass. Only the ghost propagator shows a significant change.
Furthermore, indications are found that the consequences of the residual
non-perturbative gauge freedom due to Gribov copies could be different in the
confinement and the Higgs phase.Comment: 11 pages, 6 figures, 1 table; v2: one minor error corrected; v3: one
appendix on systematic uncertainties added and some minor changes, version to
appear in EPJ
Spectral quark model and low-energy hadron phenomenology
We propose a spectral quark model which can be applied to low energy hadronic
physics. The approach is based on a generalization of the Lehmann
representation of the quark propagator. We work at the one-quark-loop level.
Electromagnetic and chiral invariance are ensured with help of the gauge
technique which provides particular solutions to the Ward-Takahashi identities.
General conditions on the quark spectral function follow from natural physical
requirements. In particular, the function is normalized, its all positive
moments must vanish, while the physical observables depend on negative moments
and the so-called log-moments. As a consequence, the model is made finite,
dispersion relations hold, chiral anomalies are preserved, and the twist
expansion is free from logarithmic scaling violations, as requested of a
low-energy model. We study a variety of processes and show that the framework
is very simple and practical. Finally, incorporating the idea of vector-meson
dominance, we present an explicit construction of the quark spectral function
which satisfies all the requirements. The corresponding momentum representation
of the resulting quark propagator exhibits only cuts on the physical axis, with
no poles present anywhere in the complex momentum space. The momentum-dependent
quark mass compares very well to recent lattice calculations. A large number of
predictions and relations can be deduced from our approach for such quantities
as the pion light-cone wave function, non-local quark condensate, pion
transition form factor, pion valence parton distribution function, etc.Comment: revtex, 24 pages, 3 figure
Low Energy Chiral Lagrangian in Curved Space-Time from the Spectral Quark Model
We analyze the recently proposed Spectral Quark Model in the light of Chiral
Perturbation Theory in curved space-time. In particular, we calculate the
chiral coefficients , as well as the coefficients ,
, and , appearing when the model is coupled to gravity. The
analysis is carried for the SU(3) case. We analyze the pattern of chiral
symmetry breaking as well as elaborate on the fulfillment of anomalies.
Matching the model results to resonance meson exchange yields the relation
between the masses of the scalar, tensor and vector mesons,
. Finally, the
large- limit suggests the dual relations in the vector and scalar
channels, and .Comment: 18 pages, no figure
Autologous haematopoietic stem cell transplantation as a first-line disease-modifying therapy in patients with ‘aggressive’ multiple sclerosis
Background:
Autologous haematopoietic stem cell transplantation (AHSCT) is an effective treatment for patients with multiple sclerosis (MS) who have highly active disease, despite the use of standard disease-modifying therapies (DMTs). However, the optimal time for offering AHSCT to patients with ‘aggressive’ MS is yet to be established.
Objectives:
The objective was to explore the safety and efficacy of AHSCT as a first-line DMT in patients with ‘aggressive’ MS.
Methods:
All patients with ‘aggressive’ MS who received AHSCT as a first-line DMT in five European and North American centres were retrospectively evaluated.
Results:
Twenty patients were identified. The median interval between diagnosis and AHSCT was 5 (1–20) months. All had multiple poor prognostic markers with a median pre-transplant Expanded Disability Status Scale (EDSS) score of 5.0 (1.5–9.5). After a median follow-up of 30 (12–118) months, the median EDSS score improved to 2.0 (0–6.5, p < 0.0001). No patient had further relapses. Three had residual magnetic resonance imaging (MRI) disease activities in the first 6 months post-transplant, but no further new or enhancing lesions were observed in subsequent scans.
Conclusion:
AHSCT is safe and effective as a first-line DMT in inducing rapid and sustained remission in patients with ‘aggressive’ MS
Dragon-kings: mechanisms, statistical methods and empirical evidence
This introductory article presents the special Discussion and Debate volume
"From black swans to dragon-kings, is there life beyond power laws?" published
in Eur. Phys. J. Special Topics in May 2012. We summarize and put in
perspective the contributions into three main themes: (i) mechanisms for
dragon-kings, (ii) detection of dragon-kings and statistical tests and (iii)
empirical evidence in a large variety of natural and social systems. Overall,
we are pleased to witness significant advances both in the introduction and
clarification of underlying mechanisms and in the development of novel
efficient tests that demonstrate clear evidence for the presence of
dragon-kings in many systems. However, this positive view should be balanced by
the fact that this remains a very delicate and difficult field, if only due to
the scarcity of data as well as the extraordinary important implications with
respect to hazard assessment, risk control and predictability.Comment: 20 page
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