Study of helicopterroll control effectiveness criteria

A study of helicopter roll control effectiveness based on closed-loop task performance measurement and modeling is presented. Roll control critieria are based on task margin, the excess of vehicle task performance capability over the pilot's task performance demand. Appropriate helicopter roll axis dynamic models are defined for use with analytic models for task performance. Both near-earth and up-and-away large-amplitude maneuvering phases are considered. The results of in-flight and moving-base simulation measurements are presented to support the roll control effectiveness criteria offered. This Volume contains the theoretical analysis, simulation results and criteria development

T-PHOT version 2.0: improved algorithms for background subtraction, local convolution, kernel registration, and new options

We present the new release v2.0 of T-PHOT, a publicly available software package developed to perform PSF-matched, prior-based, multiwavelength deconfusion photometry of extragalactic fields. New features included in the code are presented and discussed: background estimation, fitting using position dependent kernels, flux prioring, diagnostical statistics on the residual image, exclusion of selected sources from the model and residual images, individual registration of fitted objects. These new options improve on the performance of the code, allowing for more accurate results and providing useful aids for diagnostics.Comment: 7 pages, 8 figure

Amino acid sequence of retinal transducin at the site ADP-ribosylated by cholera toxin

Transducin was [32P]ADP-ribosylated by cholera toxin in bovine retinal rod outer segments and then partially purified on ω-amino octyl agarose to remove other ADP-ribosylated proteins. Trypsin digestion of the ADP-ribosylated transducin and further purification using boronate-polyacrylamide beads and high performance liquid chromatography yielded a single radiolabeled tetrapeptide, Ser-Arg-Val-Lys. The ADP-ribose is linked to the guanidinium group of arginine

Single-Crystal-to-Single-Crystal Transformation of a Novel 2-Fold Interpenetrated Cadmium-Organic Framework with Trimesate and 1,2-Bis(4-pyridyl)ethane into the Thermally Desolvated Form Which Exhibits Liquid and Gas Sorption Properties

A novel 2-fold interpenetrated pillared cadmium metal organic framework namely [Cd(HBTC)-BPE](n)center dot nDMF has been synthesized using 1,3,5-benzenetricarboxylic acid and 1,2-bis(4-pyridyl)ethane (BPE). This compound has been desolvated and subjected to various liquids and gases for sorption studies. Structures of the assynthesized (1) desolvated (2) and resolvated in benzene (3) have been determined by single-crystal X-ray diffraction analysis and further characterized by elemental analysis IR spectra, and thermogravimetric/differential scanning calorimetry analysis. Single crystal X-ray analysis revealed a 2-fold interpenetrated, three-dimensional (3D) framework which exhibits a 3,5-connected network with the Schlafli symbol of [(6(3))(6(9).8) and hms topology. Compound I exhibits a temperature-induced single-crystal-to-single-crystal (SC SC) transformation upon the release of N,N'-dimethylformamide molecules forming compound 2 (stable up to 300 C). SC SC transformation is also observed when it is immersed in benzene, chloroform, 1,4dioxane, and tetrahydrofuran. The uptake of different solvent molecules was analyzed, and desolvated samples selectively adsorb benzene, chloroform, 1,4-dioxane, and THF molecules over other selected polar solvents. Gas (N-2, CO2, and N2O) sorption experiments were also performed and the structure showed 2.5% N-2 4.5% CO2, and 3.4% N2O absorption by mass at room temperature and moderate gas pressures (similar to 10 bar)

Keeping Confidence: Responsibility and public health

Keeping Confidence: HIV and the criminal law from service provider perspectives Duration: June 2012 - March 2013 The Monument Trust generously funded Sigma Research at London School of Hygiene and Tropical Medicine and Birkbeck College to undertake a qualitative study on perceptions of criminal prosecutions for HIV transmission among HIV service providers. Five short reports outlining the key findings of the study focus on the main themes arising from our analysis of the focus group discussions. The findings and associated policy and practice recommendations will be of interest to: those who provide HIV health and social care and their professional bodies (for instance NHIVNA, CHIVA, BHIVA, BASHH, SSHA, BPS), police and others who play a role in criminal investigations and trials, and people with diagnosed HIV

Keeping Confidence: Understanding the Law

Keeping Confidence: HIV and the criminal law from service provider perspectives Duration: June 2012 - March 2013 The Monument Trust generously funded Sigma Research at London School of Hygiene and Tropical Medicine and Birkbeck College to undertake a qualitative study on perceptions of criminal prosecutions for HIV transmission among HIV service providers. Five short reports outlining the key findings of the study focus on the main themes arising from our analysis of the focus group discussions. The findings and associated policy and practice recommendations will be of interest to: those who provide HIV health and social care and their professional bodies (for instance NHIVNA, CHIVA, BHIVA, BASHH, SSHA, BPS), police and others who play a role in criminal investigations and trials, and people with diagnosed HIV

Keeping Confidence: Practice and procedure

Keeping Confidence: HIV and the criminal law from service provider perspectives Duration: June 2012 - March 2013 The Monument Trust generously funded Sigma Research at London School of Hygiene and Tropical Medicine and Birkbeck College to undertake a qualitative study on perceptions of criminal prosecutions for HIV transmission among HIV service providers. Five short reports outlining the key findings of the study focus on the main themes arising from our analysis of the focus group discussions. The findings and associated policy and practice recommendations will be of interest to: those who provide HIV health and social care and their professional bodies (for instance NHIVNA, CHIVA, BHIVA, BASHH, SSHA, BPS), police and others who play a role in criminal investigations and trials, and people with diagnosed HIV

Keeping Confidence: Identifying resources

Keeping Confidence: HIV and the criminal law from service provider perspectives Duration: June 2012 - March 2013 The Monument Trust generously funded Sigma Research at London School of Hygiene and Tropical Medicine and Birkbeck College to undertake a qualitative study on perceptions of criminal prosecutions for HIV transmission among HIV service providers. Five short reports outlining the key findings of the study focus on the main themes arising from our analysis of the focus group discussions. The findings and associated policy and practice recommendations will be of interest to: those who provide HIV health and social care and their professional bodies (for instance NHIVNA, CHIVA, BHIVA, BASHH, SSHA, BPS), police and others who play a role in criminal investigations and trials, and people with diagnosed HIV. Catherine Dodds, Matthew Weait, Adam Bourne, Siri Egede, Kathie Jessup and Peter Weatherburn

Limited evolutionary rescue of locally adapted populations facing climate change

Peer reviewedPublisher PD

Variations in the management and survival of women under 50 years with breast cancer in the South East Thames region.

A retrospective, population-based study was undertaken to determine variations in the management of women aged less than 50 years with primary breast cancer in different hospital settings and the influence of these variations on survival. A total of 1757 women who were resident in the South East Thames Health Region aged less than 50 years at the time of diagnosis of breast cancer and who presented during a 5 year period (January 1984 to December 1988) were recorded by the Thames Cancer Registry. The hospitals at which primary surgery was undertaken were categorised as teaching or non-teaching hospitals. The non-teaching hospitals were grouped according to the mean number of patients treated annually during the study period (< or = 2, 3-9, > or = 10 each year). The following factors were compared between these groups: age, extent of disease, tumour morphology, extent of primary surgery (mastectomy vs less than mastectomy), use of axillary surgery (any vs none) and use of systemic adjuvant therapy. Survival rates for the different groups were compared. Registration rates did not differ significantly between health districts. A total of 1485 (85%) women underwent surgery in over 90 different hospitals. In 1324 (86%) of these cases the surgery was undertaken in a total of 42 NHS hospitals within SE Thames Health Region or in seven teaching hospitals in adjacent regions. Mastectomy rates decreased from 52% in 1984 to 28% in 1988 (P<0.0001), but were consistently higher in teaching hospitals (P=0.01). The use of any form of axillary surgery decreased from 49% to 36% over the 5 year period (P=0.003), with significantly lower rates of axillary surgery being performed in non-teaching hospitals (P<0.0001). The proportion of cases recorded as having non-specific morphology was higher in nonteaching than in teaching hospitals (P<0.0001). On multivariate analysis survival was significantly (P<0.001) influenced by stage and tumour histology. Among patients who underwent surgery, the type of hospital in which this was undertaken did not appear to influence survival significantly. This analysis of routine cancer registry data indicates that patients were widely dispersed in a large number of different hospitals and that there were marked variations in practice according to the type of hospital to which patients presented. The treatments provided were frequently at variance with those recommended at a consensus conference held during the study period, particularly in relation to the use of axillary surgery and adjuvant systemic therapy. The way in which services are currently provided may hamper the delivery of appropriate management and comprehensive support. These data thus have implications for the purchasing and provision of services for this common condition