44 research outputs found
Recommended from our members
Author Correction: Expanded encyclopaedias of DNA elements in the human and mouse genomes
Online Correction for: https://doi.org/10.1038/s41586-020-2493-4 | Erratum for https://bura.brunel.ac.uk/handle/2438/21299In the version of this article initially published, two members of the ENCODE Project Consortium were missing from the author list. Rizi Ai (Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA, USA) and Shantao Li (Program in Computational Biology and Bioinformatics, Yale University, New Haven, CT, USA) are now included in the author list. These errors have been corrected in the online version of the article : 'Expanded encyclopaedias of DNA elements in the human and mouse genomes'.https://www.nature.com/articles/s41586-021-04226-3https://www.nature.com/articles/s41586-021-04226-
Recommended from our members
Perspectives on ENCODE
Supplementary information is available for this paper at https://doi.org/10.1038/s41586-020- 2449-8.© 2020, The Author(s). The Encylopedia of DNA Elements (ENCODE) Project launched in 2003 with the long-term goal of developing a comprehensive map of functional elements in the human genome. These included genes, biochemical regions associated with gene regulation (for example, transcription factor binding sites, open chromatin, and histone marks) and transcript isoforms. The marks serve as sites for candidate cis-regulatory elements (cCREs) that may serve functional roles in regulating gene expression1. The project has been extended to model organisms, particularly the mouse. In the third phase of ENCODE, nearly a million and more than 300,000 cCRE annotations have been generated for human and mouse, respectively, and these have provided a valuable resource for the scientific community.NIH grants: U01HG007019, U01HG007033, U01HG007036, U01HG007037, U41HG006992, U41HG006993, U41HG006994, U41HG006995, U41HG006996, U41HG006997, U41HG006998, U41HG006999, U41HG007000, U41HG007001, U41HG007002, U41HG007003, U41HG007234, U54HG006991, U54HG006997, U54HG006998, U54HG007004, U54HG007005, U54HG007010 and UM1HG009442
A Review of Validation Studies of Dental Bitewing Radiographs for Forensic Identification
A review of the methodological aspects of aminoacid racemisation for use in forensic sciences
Accurate age determination of adult cadavers and human remains is a key requirement in
forensic practice. The current morphological methods lack accuracy and precision, require
specialist training and are costly. The use of aspartic acid racemization (AAR) in human dentine
provides a simple, cost-effective solution and the method can achieve accuracies of 63 years at
best. Currently, there are differences in AAR methodology between laboratories which produce
different results on the rate of racemization in teeth. These inconsistencies must be resolved if the
technique is to be successfully applied to age determinations in forensic cases. This paper reviews
the differences in protocol which have been used, discusses how each method will affect the
results obtained from AAR analysis and gives recommendations for optimization of the
methological protocol as a \ufb01rst step towards international standardization