Causal Propagators for Algebraic Gauges

Applying the principle of analytic extension for generalized functions we derive causal propagators for algebraic non-covariant gauges. The so generated manifestly causal gluon propagator in the light-cone gauge is used to evaluate two one-loop Feynman integrals which appear in the computation of the three-gluon vertex correction. The result is in agreement with that obtained through the usual prescriptions.Comment: LaTex, 09 pages, no figure

Optimization of diarylazines as anti-HIV agents with dramatically

Non-nucleoside inhibitors of HIV-1 reverse transcriptase are reported that have ca. 100-fold greater solubility than the structurally related drugs etravirine and rilpivirine, while retaining high anti-viral activity. The solubility enhancements come from strategic placement of a morpholinylalkoxy substituent in the entrance channel of the NNRTI binding site. Compound 4d shows low-nanomolar activity similar to etravirine towards wild-type HIV-1 and key viral variants.Fil: Bollini, Mariela. University of Yale; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Cisneros, José A.. University of Yale; Estados UnidosFil: Spasov, Krasimir A.. University of Yale; Estados UnidosFil: Anderson, Karen S.. University of Yale; Estados UnidosFil: Jorgensen, William L.. University of Yale; Estados Unido

Small Extracellular Vesicles from Human Amniotic Fluid Samples as Promising Theranostics

Since the first evidence that stem cells can provide pro-resolving effects via paracrine secretion of soluble factors, growing interest has been addressed to define the most ideal cell source for clinical translation. Leftover or clinical waste samples of human amniotic fluid obtained following prenatal screening, clinical intervention, or during scheduled caesarean section (C-section) delivery at term have been recently considered an appealing source of mesenchymal progenitors with peculiar regenerative capacity. Human amniotic fluid stem cells (hAFSC) have been demonstrated to support tissue recovery in several preclinical models of disease by exerting paracrine proliferative, anti-inflammatory and regenerative influence. Small extracellular vesicles (EVs) concentrated from the hAFSC secretome (the total soluble trophic factors secreted in the cell-conditioned medium, hAFSC-CM) recapitulate most of the beneficial cell effects. Independent studies in preclinical models of either adult disorders or severe diseases in newborns have suggested a regenerative role of hAFSC-EVs. EVs can be eventually concentrated from amniotic fluid (hAF) to offer useful prenatal information, as recently suggested. In this review, we focus on the most significant aspects of EVs obtained from either hAFSC and hAF and consider the current challenges for their clinical translation, including isolation, characterization and quantification methods

Thirty Years of Precision Electroweak Physics

We discuss the development of the theory of electroweak radiative corrections and its role in testing the Standard Model, predicting the top quark mass, constraining the Higgs boson mass, and searching for deviations that may signal the presence of new physics.Comment: 19 pages, acknowledgments added, J.J.Sakurai Prize Talk, APS Meeting, Albuquerque, N.M., April 2002. To appear in a future issue of Journal of Physics

IRIS: Supporting & Managing the Research Life-cycle

IRIS is a new Current Research Information System (CRIS) developed by Cineca to upgrade and replace two previous solutions that have been used by Italian universities in the last 10 years. At the end of 2015, sixty-three Italian institutions are using IRIS. One of the main components of IRIS is DSpace-CRIS, an open source solution that can also be used as a standalone system, and as such is now installed in seven institutions outside Italy. The many solutions that IRIS provides include support for national research assessment exercises, institutional repositories (IR) and an expert finder. Both IRIS and DSpace-CRIS are compliant with the Common European Research Information Format (CERIF), allowing easy interchange and benchmarking with other CERIF compliant systems. New IRIS functionality includes Open Researcher and Contributor ID (ORCID) push / pull interoperability. IRIS has five different modules integrated together through standard protocols and interfaces.published_or_final_versio

An Algorithm to Construct Groebner Bases for Solving Integration by Parts Relations

This paper is a detailed description of an algorithm based on a generalized Buchberger algorithm for constructing Groebner-type bases associated with polynomials of shift operators. The algorithm is used for calculating Feynman integrals and has proven itself efficient in several complicated cases.Comment: LaTeX, 9 page

The Casimir energy of skyrmions in the 2+1-dimensional O(3)-model

One-loop quantum corrections to the classical vortices in 2+1 dimensional O(3)-models are evaluated. Skyrme and Zeeman potential terms are used to stabilize the size of topological solitons. Contributions from zero modes, bound-states and scattering phase-shifts are calculated for vortices with winding index n=1 and n=2. For both cases the S-matrix shows a pronounced series of resonances for magnon-vortex scattering in analogy to the well-established baryon resonances in hadron physics, while vortices with n>2 are already classically unstable against decay. The quantum corrections destabilize the classically bound n=2 configuration. Approximate independence of the results with respect to changes in the renormalization scale is demonstrated.Comment: 24 pages LaTeX, 14 figure

Antipsychotic drugs: is more worse? a meta-analysis of the published randomized control trials

Effectiveness and side-effects of high- versus low-dose neuroleptic treatment of chronic psychosis have been assessed through a meta-analysis of 22 published randomized control trials comparing different neuroleptic doses. No incremental clinical improvement was found at doses above 375 mg equivalent of chlorpromazine, while a significant increase in adverse reactions was observe

Action Principle for the Classical Dual Electrodynamics

The purpose of this paper is to formulate an action principle which allows for the construction of a classical lagrangean including both electric and magnetic currents. The lagrangean is non-local and shown to yield all the expected (local) equations for dual electrodynamics.Comment: latex, 8 pages, no figure

Systematic Implementation of Implicit Regularization for Multi-Loop Feynman Diagrams

Implicit Regularization (IReg) is a candidate to become an invariant framework in momentum space to perform Feynman diagram calculations to arbitrary loop order. In this work we present a systematic implementation of our method that automatically displays the terms to be subtracted by Bogoliubov's recursion formula. Therefore, we achieve a twofold objective: we show that the IReg program respects unitarity, locality and Lorentz invariance and we show that our method is consistent since we are able to display the divergent content of a multi-loop amplitude in a well defined set of basic divergent integrals in one loop momentum only which is the essence of IReg. Moreover, we conjecture that momentum routing invariance in the loops, which has been shown to be connected with gauge symmetry, is a fundamental symmetry of any Feynman diagram in a renormalizable quantum field theory