102 research outputs found
Project: Knowledge. A two-sided perspective on knowledge transfer & knowledge creation
Purpose: Our purpose is to describe and understand how a project-based, knowledge-intensive firm in the high-technology industry creates and transfers knowledge, seen from two perspectives. Methodology: Our qualitative case study has an explorative approach since earlier studies within our positioning are absent, thus we look at KM abductively. To gain more depth to our study, we mirror our findings from our case company with data collected from three additional organisations. Theoretical perspectives: We see a clear distinction between researchers, either seeing knowledge as an object or a process. Thus, we review theories from both sides, either focusing on the creation or transferring of knowledge. In addition, theories on KM in project organisations are accounted for. Empirical foundation: The study is based on the empirical foundation which consists of the data received through six interviews with employees at our main case company and, additionally, two interviews at each of our three mirror companies. Conclusion: The study found KM being seen from both perspectives in all four firms. Through this, we found implications for how our case company could proceed in the future
Konsten att balansera - om styrning i ett lÀkemedelsföretag
Syftet med denna uppsats Àr att studera och skapa förstÄelse för styrning av produktutveckling i ett stort lÀkemedelsföretag. Vi lÀgger fokus pÄ organisationsstruktur och omvÀrldsaspekten. VÄr ambition Àr att dÀrefter tillÀmpa den befintliga teorin för att om möjligt vidareutveckla denna. VÄr studie Àr en kvalitativ fallstudie med explorativ ansats. Vi har anvÀnt oss av en abduktiv metod och haft semistrukturerade intervjuer som bas för den empiriska datan. Den teori som vi anser Àr mest intressant för vÄr studie Àr situationsteorin gÀllande organisationsstrukturer. Vi tittar Àven pÄ matrisfunktionen som organisationsform, definitionen av kunskapsföretag och teorier kring effektiv portföljhantering, samt en modell för projektstyrning. VÄrt fallföretag Àr ett stort globalt lÀkemedelsföretag. Vi studerar deras inre processer och den miljö som Företaget verkar i och vi fokuserar pÄ Företagets styrmodell. Företaget befinner sig i en komplex och dynamisk miljö, vilket talar för en adhocratisk organisationsform. Dock har vi hittat vissa byrÄkratiska tendenser inom organisationen och vi har valt att kalla detta för selektiv byrÄkrati i och med att Företaget har valt att endast byrÄkratisera vissa specifika delar
Evolution of a physiological pH 6.8 bicarbonate buffer system: application to the dissolution testing of enteric coated products.
The use of compendial pH 6.8 phosphate buffer to assess dissolution of enteric coated products gives rise to poor in vitro-in vivo correlations because of the inadequacy of the buffer to resemble small intestinal fluids. A more representative and physiological medium, pH 6.8 bicarbonate buffer, was developed to evaluate the dissolution behaviour of enteric coatings. The bicarbonate system was evolved from pH7.4 Hanks balanced salt solution to produce a pH 6.8 bicarbonate buffer (modified Hanks buffer, mHanks), which resembles the ionic composition and buffer capacity of intestinal milieu. Prednisolone tablets were coated with a range of enteric polymers: hypromellose phthalate (HP-50 and HP-55), cellulose acetate phthalate (CAP), hypromellose acetate succinate (HPMCAS-LF and HPMCAS-MF), methacrylic acid copolymers (EUDRAGITÂź L100-55, EUDRAGITÂź L30D-55 and EUDRAGITÂź L100) and polyvinyl acetate phthalate (PVAP). Dissolution of coated tablets was carried out using USP-II apparatus in 0.1M HCl for 2h followed by pH 6.8 phosphate buffer or pH 6.8 mHanks bicarbonate buffer. In pH 6.8 phosphate buffer, the various enteric polymer coated products displayed rapid and comparable dissolution profiles. In pH 6.8 mHanks buffer, drug release was delayed and marked differences were observed between the various coated tablets, which is comparable to the delayed disintegration times reported in the literature for enteric coated products in the human small intestine. In summary, the use of pH 6.8 physiological bicarbonate buffer (mHanks) provides more realistic and discriminative in vitro release assessment of enteric coated formulations compared to compendial phosphate buffer
ChemInform Abstract: MEDIZINISCHE CHEMIE VON OXOCHINAZOLINEN 9. MITT. BASENKATALYSIERTE CYCLISIERUNGEN VON ACETYLENISCHEN OXOCHINAZOLINEN UND VERWANDTEN OFFENEN AMIDEN
ChemInform Abstract: SUBSTITUENT DEPENDENT MASS SPECTROMETRIC FRAGMENTATION OF MONOSUBSTITUTED PHENYL PROPARGYL ETHERS
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