The last defence? Surgical aspects of gouty arthritis of hand and wrist

OBJECTIVE: To review the epidemiology, pathophysiology, clinical manifestations, diagnosis, and treatment of gouty arthritis of the hand and wrist, with a focus on the surgical aspects. DATA SOURCES AND EXTRACTION: Electronic databases including MEDLINE, PubMed, and the Cochrane library were searched with the key words of 'gouty arthritis', 'hand', 'wrist', and 'surgical'. STUDY SELECTION: A total of 55 articles were selected for inclusion in this review. DATA SYNTHESIS: There is no existing study for the overall prevalence of gout in Asia, though one study showed that it was 3.1% in Taiwan. Its pathophysiology entails hyperuricaemia, trauma, lower temperatures, and previous diseases. Gouty arthritis of hand and wrist presents as acute wrist pain, subcutaneous or peritendinous tophi, tenosynovitis, entrapment neuropathy, tendon rupture, or even bone destruction. Demonstration of negatively birefringent crystals in the absence of organisms and a normal white cell count in synovial fluid confirm the diagnosis. Medical treatment including non-steroidal anti-inflammatory drugs, colchicines, allopurinol, uricosuric agents, and lifestyle modifications remain the mainstay of treatment. Surgical treatment options for tophaceous gout involve decompression by aspiration, incision and drainage, tenosynovectomy, shaving procedures, and complex surgical approach. CONCLUSION. While medical treatment remains the mainstay of treatment for gouty arthritis of the hand and wrist, 5% of patients may not respond. In this group, surgery is often performed in advanced stages, but yields less-than-satisfactory outcomes. Gouty arthritis is difficult to treat when it starts to cause stiffness and deformities. Although more studies are needed to evaluate the outcomes, the authors suggest that one possible solution is pre-emptive surgery.published_or_final_versio

Cases of Mycobaterium Marinum Tenosynovitis of the hand and wrist: clinical features. management and results

Selected paper for 2010 APOA-Pfizer Best Scientific Paper Award for Orthopaedic InfectionOpen Access JournaleCM XII: Implant Infection Conference Main Focus: Orthopedic and trauma related infectionsAsia Pacific Orthopaedic Association SessionINTRODUCTION: Mycobacterium marinum infections followed an unpredictable clinical course and delay in definitive diagnosis was frequently encountered. Chow et al. found that the average duration of infection before patients were seen by the Orthopaedics unit was 3.3-3.7 months.1 The initial diagnosis was commonly found to be mistaken for conditions such as rheumatoid arthritis and trigger finger which may lead to inappropriate management like steroid injections. The objective of this study was to review our experience with treatment of Mycobacterium marinum tenosynovitis of the hand and wrist and to assess for any clinical parameters that were associated with poor functional outcome and also suggest a treatment algorithm for these …published_or_final_versio

Current Management Of Acute Scaphoid Fractures: A Review

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Another light in the dark: review of new method for the arthroscopic repair of triangular fibrocartilage complex

The triangular fibrocartilage complex (TFCC) is an anatomically and biomechanically important structure. Repair of radial-sided TFCC tear has previously been challenging. We designed a new method of radial-sided TFCC tear repair and found that it was also applicable for ulnar-sided TFCC tear repair. From October 2006 to December 2010, 10 patients underwent this operation and were reviewed: 9 men and 1 woman, with a mean age of 33.9 years. Average postoperative follow-up was 8 months. We graded results according to the Mayo modified wrist score. We rated 2 of the 10 patients (20%) as 'excellent,' 3 (30%) as 'good,' and 5 (50%) as 'fair.' The 5 patients who were rated as 'fair' returned to regular jobs or had restricted employment. Based on this small sample, we recommend that this technique be considered an alternative method for TFCC repair.postprin

Lateral tibial condyle reconstruction by pedicled vascularized fibular head graft: Long-term result

The technique of pedicled vascularized fibular graft for lateral tibial condyle reconstruction after en bloc resection of aggressive giant cell tumours was described by SP Chow et al. Early follow-up of two patients was presented in 1986. We present the 25 years follow-up of one patient with a literature review of alternative present day treatment options. The patient maintained community ambulant status despite developing late stage osteoarthritis. Although this procedure is performed rarely, it remains an alternative to the more sophisticated treatment options making it a useful method in centres with limited facilities and expertise. © 2011 The Author(s).published_or_final_versio

Epidemiology of occupational hand injury in Hong Kong

OBJECTIVES: To study the epidemiology of occupational hand injuries and associated social and industrial factors. DESIGN. For this retrospective case series of patients with occupational hand injuries, case records were retrieved to gather data. In addition, all the subjects were interviewed by a single interviewer using a predesigned questionnaire. SETTING: Division of Hand Surgery, Department of Orthopaedics and Traumatology, Queen Mary Hospital, Hong Kong. PATIENTS: A total of 250 patients with occupational hand injuries were treated during the period from 1999 to 2001. This period was chosen to obtain 10 years of follow-up data to assess return to work and any secondary injuries. MAIN OUTCOME MEASURES: Personal particulars (gender, age, marital status, education level, length of stay in Hong Kong, type of employment, wage system, personal habits, family size, number of breadwinners, income), type of industry and mode of injury, causes of injury according to the worker, work conditions, type of injury, and treatment given. RESULTS: Two groups of workers in our study had more occupational hand injuries, namely those with less than 1 year of experience on a new job and immigrants from China. Factors associated with a large proportion of occupational hand injuries were male gender with personal risk factors (smoking and regular consumption of alcohol, long working hours), and in the case of machine operators, inadequate training and use of safety devices. CONCLUSION: Occupational hand injuries lead to loss of working hours and compensation. For prevention, the workplace should be made into a safer and work-friendly environment. Workers should also have sufficient training.published_or_final_versio

Epidemiology of occupational hand injury in Hong Kong

OBJECTIVES: To study the epidemiology of occupational hand injuries and associated social and industrial factors. DESIGN. For this retrospective case series of patients with occupational hand injuries, case records were retrieved to gather data. In addition, all the subjects were interviewed by a single interviewer using a predesigned questionnaire. SETTING: Division of Hand Surgery, Department of Orthopaedics and Traumatology, Queen Mary Hospital, Hong Kong. PATIENTS: A total of 250 patients with occupational hand injuries were treated during the period from 1999 to 2001. This period was chosen to obtain 10 years of follow-up data to assess return to work and any secondary injuries. MAIN OUTCOME MEASURES: Personal particulars (gender, age, marital status, education level, length of stay in Hong Kong, type of employment, wage system, personal habits, family size, number of breadwinners, income), type of industry and mode of injury, causes of injury according to the worker, work conditions, type of injury, and treatment given. RESULTS: Two groups of workers in our study had more occupational hand injuries, namely those with less than 1 year of experience on a new job and immigrants from China. Factors associated with a large proportion of occupational hand injuries were male gender with personal risk factors (smoking and regular consumption of alcohol, long working hours), and in the case of machine operators, inadequate training and use of safety devices. CONCLUSION: Occupational hand injuries lead to loss of working hours and compensation. For prevention, the workplace should be made into a safer and work-friendly environment. Workers should also have sufficient training.published_or_final_versio

Biomechanical comparative study of the JuggerKnot™ soft anchor technique with other common mallet finger fracture fixation techniques

HKSSH Free Paper - Local Paper no. O126BACKGROUND: Bony mallet finger involves an avulsion fracture of the terminal extensor tendon insertion. Most do well with conservative treatment using splinting. Surgical fixation is indicated in open injuries, avulsion fracture involving at least one third of the articular surface and failed splinting treatment. Both treatment methods have limitations. Usual splinting protocol requires 6 weeks of full-time use and another 6 weeks for weaning. They are cumbersome, have compliance issues and most result in extension lag. Currently, there is no biomechanical sound repair that can allow mobilization after fixation and thus most result in loss of flexion range. This study was designed to compare the peak load resistance of the JuggerKnot™ (Biomet) soft anchor fixation to other fixation methods (Kirschner wire, pull-out wire, tension-band wiring) and to assess whether the suture anchor technique can allow early mobilization without protection. MATERIALS AND METHODS: Four different fixation techniques were assigned among twenty-four specimens (all fingers, no thumbs) from six cadaveric human hands in a randomized block fashion. Only one technique was performed on each finger. A downward load was applied to flex the distal phalanx and the maximum loading force was recorded. The load was tested at 30 degrees, 45 degrees and 60 degrees of flexion of the distal interphalangeal joint. Two separate data sets were performed for each finger before and after the osteotomy and fixation. The data underwent Shapiro-Wilk normality testing before analysis. The values of the mean peak load of the four groups were compared using the one-way analysis of variance test. RESULTS: All data points passed the Shapiro-Wilk test for normality. The mean peak load of the tension-band wiring group was 67.8N at 60 degrees of flexion which was significantly higher than the other three groups (p=0.008). The JuggerKnot™ fixation had mean peak loads of 13.35N (30°), 22.51N (45°) and 32.96N (60°) which were all above the required load for mobilization. No complications of implant failure or fragmentation of the dorsal fragment was noted. CONCLUSION: Tension-band wiring was the strongest fixation method but most technically demanding. The JuggerKnot™ soft anchor fixation was the most user-friendly, does not require trans-articular Kirschner wire fixation for protection and allows for safe immediate mobilization of the joint after fixation. Future studies are required to assess the fatigue strength of the fixation and the applicability in the clinical setting.postprin

Overprotection and the psychological states of cerebral palsy patients and their caretakers in Hong Kong: A preliminary report

Objective: To examine the relation between perceived overprotection and the psychological states of cerebral palsy patients and their primary caretakers in Hong Kong. Design: Cross-sectional survey, in which data of 14 pairs of cerebral palsy patients and their caretakers were analysed. Setting: Duchess of Kent Children's Hospital, Hong Kong. Participants: Cerebral palsy patients and their primary caretakers in Hong Kong. Main outcome measures: Perceived overprotection and psychological states. Results: Nearly two thirds of the 14 patients (mean age of 15 years) and 86% of the 14 primary caretakers (mean age of 47 years) perceived various levels of overprotection. For both patients and caretakers, perceived overprotection was positively associated with anxiety and unhappiness. The patients' and caretakers' psychological states and perception of overprotection were not related to the actual motor ability of the patients. Perceived overprotection of the patients was not related to that of the caretakers. Conclusion: Caretakers should be mindful that a well-meaning move may have undesirable consequences. More support and child-rearing education should be considered for caretakers.published_or_final_versio

Membrane interaction and structure of the transmembrane domain of influenza hemagglutinin and its fusion peptide complex

<p>Abstract</p> <p>Background</p> <p>To study the organization and interaction with the fusion domain (or fusion peptide, FP) of the transmembrane domain (TMD) of influenza virus envelope glycoprotein for its role in membrane fusion which is also essential in the cellular trafficking of biomolecules and sperm-egg fusion.</p> <p>Results</p> <p>The fluorescence and gel electrophoresis experiments revealed a tight self-assembly of TMD in the model membrane. A weak but non-random interaction between TMD and FP in the membrane was found. In the complex, the central TMD oligomer was packed by FP in an antiparallel fashion. FP insertion into the membrane was altered by binding to TMD. An infrared study exhibited an enhanced membrane perturbation by the complex formation. A model was built to illustrate the role of TMD in the late stages of influenza virus-mediated membrane fusion reaction.</p> <p>Conclusion</p> <p>The TMD oligomer anchors the fusion protein in the membrane with minimal destabilization to the membrane. Upon associating with FP, the complex exerts a synergistic effect on the membrane perturbation. This effect is likely to contribute to the complete membrane fusion during the late phase of fusion protein-induced fusion cascade. The results presented in the work characterize the nature of the interaction of TMD with the membrane and TMD in a complex with FP in the steps leading to pore initiation and dilation during virus-induced fusion. Our data and proposed fusion model highlight the key role of TMD-FP interaction and have implications on the fusion reaction mediated by other type I viral fusion proteins. Understanding the molecular mechanism of membrane fusion may assist in the design of anti-viral drugs.</p