27 research outputs found
Global variation in anastomosis and end colostomy formation following left-sided colorectal resection
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- Aahlin Ek
- Aamer A
- Aaniana K
- Ababneh A
- Abaliksta T
- Abantanga F
- Abantanga F
- Abbas A
- Abbas M
- Abbasy J
- Abbo O
- Abbo O
- Abbott T
- Abbouch M
- Abd-Elmawla M
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- Abdrabou Ak
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- Ahlonsou G
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- Al Bastawis F
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- Al-Bahrani A
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- Al-Faqawi M
- Al-Farram H
- Al-Hameedi Hii
- Al-Hasani Rkmj
- Al-Khatib A
- Al-Mallah A
- Al-Marakby D
- Al-Mousa M
- Al-Nahrawi S
- Al-Obaedi O
- Al-Saqqa S
- Al-Saqqa Sw
- Al-Shammari A
- Al-Slaibi I
- Al-Taher T
- Alaael-Dein S
- Alada M
- Alahmady O
- Alakaloko F
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- Alaloul E
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- Alimi Q
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- Aljiffry M
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- Alkammash A
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- Alkhabbaz D
- Alkhouri M
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- Almuallem S
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- Alqahtani E
- Alqahtani S
- Alrahawy M
- Alrajraji M
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- AlRowais M
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- Altamimi A
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- Altarayra M
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- Altwigry Am
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- Alyacoubi S
- Alyahya R
- Alyami R
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- Aruldas N
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- Asal M
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- Boijsen M
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- Bond-Smith G
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- Bowling K
- Bowman C
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- Bratu M
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- Chowdhury D
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- Ciubotaru C
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- Clegg-Lamptey Jn
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- Corbellino M
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- Costas-Chavarri A
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- Dervenis C
- Despotidis V
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- Dharamshi Ha
- Dhillon D
- Di Franco F
- Di Martino N
- Di Saverio S
- Di Saverio S
- Diab A
- Diaconescu B
- Diaconescu Ib
- Dias S
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- Diaz-Zorrilla C
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- Dickfos M
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- Dindyal S
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- El Ashal G
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- El Deen KN
- El Galeel AA
- El Gendy NH
- El Gendy A
- El Halawany M
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- El Hamid NA
- El Jamassi A
- El Kashash A
- El Kholy A
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- Elfeki H
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- Elkorashy Am
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- Elmasry M
- Elmelegy R
- Elmihy S
- Elnagar A
- Elnajjar Ma
- Elnemr Ae
- Elrasoul Ya
- Elrazek Aa
- Elsabbagh N
- Elsameea Aa
- Elsawahly Dme
- Elsawy A
- Elsayed M
- Elsayed M
- Elsayed N
- Elsayed Nar
- Elsayed Zm
- Elsebaaye Ao
- Elsehimy M
- Elsemelawy R
- Elshaar M
- Elshaer K
- Elshaer M
- Elshaer M
- Elshafay Ae
- Elshami M
- Elshanwany S
- Elsharkawy Aa
- Elsheikh S
- Elsherbiney S
- Elsherbiny As
- Elsherif Fa
- Elshobary M
- Elsiddig M
- Elsobky S
- Elsorogy Deaa
- Elwaey A
- Elwakil H
- Elwan A
- Elwan A
- Elwy E
- Elzahed N
- Elzayat I
- Elzayat M
- Elzayyat I
- Elzowawi F
- Emadeldin D
- Emadeldin H
- Emara E
- Emile S
- Eng C
- English W
- Esam A
- Escobar Eg.
- Espin-Basany E
- Espinoza F
- Espinoza Kt
- Espinoza Kt
- Essam A
- Essam Aa
- Essam M
- Essoun S
- Esteban E
- Estee Mm
- Estupinian S
- Etchill E
- Etchill E
- Etienne S
- Etman M
- Etwire V
- Evajelista Cv
- Evans D
- Evans E
- Eysa A
- Eyssartier E
- Ezzat E
- Ezzat T
- Faboya O
- Faccincani R
- Fadel A
- Fahiem A
- Fahim M
- Fahy C
- Fairfield C
- Fairfield C
- Fairfield C
- Fakher R
- Falaschi F
- Falco N
- Falzon M
- Farag A
- Farag S
- Farah A
- Farahat Mm
- Faraz A
- Fares M
- Farfan Esf
- Farhad M
- Farhan-Alanie Mmh
- Farhangmehr N
- Farinella E
- Farmakis K
- Farooq T
- Farouk Sam
- Farquharson A
- Farrugia A
- Farrugia A
- Faruq A
- Fathy Am
- Fattah Aa
- Fatuga A
- Faturoti O
- Faturoti O
- Faure A
- Fautz T
- Favero A
- Fawzy A
- Feidantsis T
- Felipe Co
- Fergany A
- Fergusson Sj
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- Fermani C
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- Fernandez-Bueno F
- Fernandez-Vega L
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- Ferrero E
- Fievet L
- Filatau A
- Findlay-Cooper K
- Firdouse M
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- Firwana A
- Fitsum A
- Fitzgerald Je
- Florez Ljg
- Foco M
- Fok Cyj
- Fontana T
- Foo Cc
- Forlin L
- Forno W
- Fouad A
- Fouad D
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- Fourcade L
- Fowler Aj
- Fozard T
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- Frade F
- Fraga Gp
- Franco H
- Francois P
- Francois-Coridon H
- Francone E
- Freitas Av
- Frey D
- Frisk B
- Fuentes-Rivera L
- Fujii F
- Furqan Mm
- Gü
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- Gaafar S
- Gaarder T
- Gad A
- Gad Mo
- Gadelkarim M
- Gadhvi V
- Gado A
- Gaiž
- Gaignard E
- Gaignard E
- Gala T
- Gala T
- Galiqi G
- Galleano R
- Gallo G
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- Galvez Cp
- Gamal D
- Gamal E
- Gamal H
- Gamal S
- Gamaly E
- Gamil D
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- Garaycochea O
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- Garcia-Marin Ja
- Garcia-Perez Jm
- Garland A
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- Gasteratos K
- Gaujoux S
- Gavagna L
- Gbessi Dg
- Gemeah M
- Gemenetzis G
- Gemenetzis G
- George R
- Germanos S
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- Gerosa A
- Gerosa A
- Geuoshy A
- Ghaben A
- Ghandora N
- Ghanem A
- Ghanem E
- Ghanem S
- Ghanem S
- Ghannam M
- Gharib A
- Gharib A
- Ghazy Aa
- Gheith A
- Ghetia M
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- Ghonaim Ma
- Ghoneem M
- Ghoneim O
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- Giardino Fr
- Giavarini L
- Giglio Mc
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- Giuriato Tf
- Gkiokas G
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- Goldin E
- Golding D
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- Grassi V
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- Grizhja B
- Grobler Dc
- Grosos C
- Grossart C
- Guasti Bpsj
- Gudal A
- Gudal A
- Gudal A
- Gudlaugsdottir K
- Guevara R
- Guglielmo V
- Gui D
- Gulbinas A
- Gulcicek Ob
- Gulielmi A
- Gultom Pa
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- Gunawan R
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- Gustafsson U
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- Hafiz S
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- Halhouli O
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- Halicioglu I
- Hall E
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- Hasanah A
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- Hashad E
- Hasheminia A
- Hashim A
- Hashish A
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- Haslegrave A
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- Hassaan A
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- Hassan A
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- Hassan A
- Hassan Ata
- Hassan I
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- Hassan Z
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- Hassanein Ab
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- Iacono C
- Iannone I
- Ibraheem Aa
- Ibraheem Hi
- Ibrahem Aa
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- Ibrahim A
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- Ibrahim A
- Ibrahim Am
- Ibrahim E
- Ibrahim Em
- Ibrahim I
- Ibrahim K
- Ibrahim M
- Ibrahim Mh
- Ibrahim Y
- Idress T
- Idris F
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- Iftekhar F
- Iftikhar Z
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- Ignatavicius P
- Ihediwa G
- Imoro O
- Ingabire Jca
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- Ioannidis O
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- Irwin G
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- Kasputyte S
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- Kiasat A
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- Kim My
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- Komolafe O
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- Kostov E
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- Kotecha D
- Koto Mz
- Kotobi H
- Koumpa F
- Kouraklis G
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- Kwizera S
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- Kyriazanos I
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- La Brocca A
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- Tarek A
- Tarek D
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- Tariq S
- Tata Md
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- Taylor F
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- Yildirim R
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- Zuber M
- Zuk G
- Zulkifli A
- Zumbü
- Publication venue
- 'Wiley'
- Publication date
- 27/11/2018
- Field of study
Background
End colostomy rates following colorectal resection vary across institutions in high-income settings, being influenced by patient, disease, surgeon and system factors. This study aimed to assess global variation in end colostomy rates after left-sided colorectal resection.
Methods
This study comprised an analysis of GlobalSurg-1 and -2 international, prospective, observational cohort studies (2014, 2016), including consecutive adult patients undergoing elective or emergency left-sided colorectal resection within discrete 2-week windows. Countries were grouped into high-, middle- and low-income tertiles according to the United Nations Human Development Index (HDI). Factors associated with colostomy formation versus primary anastomosis were explored using a multilevel, multivariable logistic regression model.
Results
In total, 1635 patients from 242 hospitals in 57 countries undergoing left-sided colorectal resection were included: 113 (6路9 per cent) from low-HDI, 254 (15路5 per cent) from middle-HDI and 1268 (77路6 per cent) from high-HDI countries. There was a higher proportion of patients with perforated disease (57路5, 40路9 and 35路4 per cent; P < 0路001) and subsequent use of end colostomy (52路2, 24路8 and 18路9 per cent; P < 0路001) in low- compared with middle- and high-HDI settings. The association with colostomy use in low-HDI settings persisted (odds ratio (OR) 3路20, 95 per cent c.i. 1路35 to 7路57; P = 0路008) after risk adjustment for malignant disease (OR 2路34, 1路65 to 3路32; P < 0路001), emergency surgery (OR 4路08, 2路73 to 6路10; P < 0路001), time to operation at least 48 h (OR 1路99, 1路28 to 3路09; P = 0路002) and disease perforation (OR 4路00, 2路81 to 5路69; P < 0路001).
Conclusion
Global differences existed in the proportion of patients receiving end stomas after left-sided colorectal resection based on income, which went beyond case mix alone
Surgical and anesthetic considerations of laryngeal saccular cyst: a case report
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Identifying the role of reactive oxygen species (ROSs) in Fusarium solani spores inactivation
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Convergent loss of PTEN leads to clinical resistance to a PI(3)Kalpha inhibitor
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2014
- Field of study
Broad and deep tumour genome sequencing has shed new light on tumour heterogeneity and provided important insights into the evolution of metastases arising from different clones. There is an additional layer of complexity, in that tumour evolution may be influenced by selective pressure provided by therapy, in a similar fashion to that occurring in infectious diseases. Here we studied tumour genomic evolution in a patient (index patient) with metastatic breast cancer bearing an activating PIK3CA (phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha, PI(3)Kalpha) mutation. The patient was treated with the PI(3)Kalpha inhibitor BYL719, which achieved a lasting clinical response, but the patient eventually became resistant to this drug (emergence of lung metastases) and died shortly thereafter. A rapid autopsy was performed and material from a total of 14 metastatic sites was collected and sequenced. All metastatic lesions, when compared to the pre-treatment tumour, had a copy loss of PTEN (phosphatase and tensin homolog) and those lesions that became refractory to BYL719 had additional and different PTEN genetic alterations, resulting in the loss of PTEN expression. To put these results in context, we examined six other patients also treated with BYL719. Acquired bi-allelic loss of PTEN was found in one of these patients, whereas in two others PIK3CA mutations present in the primary tumour were no longer detected at the time of progression. To characterize our findings functionally, we examined the effects of PTEN knockdown in several preclinical models (both in cell lines intrinsically sensitive to BYL719 and in PTEN-null xenografts derived from our index patient), which we found resulted in resistance to BYL719, whereas simultaneous PI(3)K p110beta blockade reverted this resistance phenotype. We conclude that parallel genetic evolution of separate metastatic sites with different PTEN genomic alterations leads to a convergent PTEN-null phenotype resistant to PI(3)Kalpha inhibitio
Psychiatric comorbidities in patients with inflammatory bowel disease
- Author
- A Mikocka-Walus
- A Sood
- AI Mendeloff
- Antonina A. Mikocka-Walus
- BJ Thabet
- BL Bonaz
- BR Filipovoc
- C Alexakis
- ES Brown
- FB Evertsz
- H Andrews
- J Cosnes
- JR Goodhand
- JR Walker
- Kurt Kroenke
- L Keefer
- L. Manea
- LG Marc
- LM Kurina
- LS Gaines
- M Zimmerman
- MC Kim
- Rasika Bhamre
- RE Tarter
- Rishika Sakaria
- RS Murthy
- S Besharat
- S Sahoo
- Sangeet Sawrav
- Shilpa Adarkar
- Shobna J Bhatia
- SN Khosla
- W Hauser
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Beyond Life and Limb: Exploring Incidental Mental Harm Under International Humanitarian Law
- Author
- A Barak
- A Eytan
- A Yaswi
- AA Thabet
- AL Peterson
- AP Schmid
- BJ Grey
- C Brain
- CG Addison
- D Luban
- D Richemond-Barak
- F Zatzick
- FJ Charlson
- G Blum
- G Blum
- HH Koh
- JD Ohlin
- JL Perilla
- JM Desmond
- K Ambos
- K Watkin
- KD Askin
- M Gelkopf
- M Hakimi
- M Wertheimer
- MA Lumley
- MN Schmitt
- MN Schmitt
- MN Schmitt
- N Cahn
- N Lamp
- N Lubell
- Neria
- O Lepsius
- R Geiss
- R Mulheron
- R Ziegler
- RL Rabin
- S Gorove
- S Solomon
- T Meron
- T Meron
- TM Keane
- US Chairman of the Joint Chiefs of Staff
- W Hays-Parks
- WC Banks
- Y Tirosh
- Z Steel
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
AFPNA
- Author
- A Bakr
- A Bourquia
- A Bourquia
- A Bourquia
- A El-Husseini
- A Kaddah
- AI Olotu
- AM El-Refaey
- AO Asinobi
- AY Elzouki
- B Saeed
- B Strobele
- BJ Cremin
- C Scott
- CI Esezobor
- D Hahn
- D Ramsuran
- E Hamed
- E Muller
- FB Piel
- H Abu-Aisha
- I Anochie
- I Anochie
- IC Anochie
- IC Anochie
- IO Senbanjo
- K Maitland
- M Oneko
- M Thabet
- MB Abdelraheem
- MI McCulloch
- MI McCulloch
- MN Aloni
- MN Aloni
- MN Aloni
- NA Soliman
- OT Adedoyin
- OT Adedoyin
- PD Imani
- PJ Nourse
- PN Obiagwu
- R Bhimma
- R Bhimma
- R Bhimma
- R Bhimma
- R Raaijmakers
- RC Shroff
- TS Kunuanunua
- UK Kala
- WA Olowu
- WA Olowu
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Genome-Wide Identification of Differentially Expressed Genes Associated with the High Yielding of Oleoresin in Secondary Xylem of Masson Pine (Pinus massoniana Lamb) by Transcriptomic Analysis
- Author
- A Byun-McKay
- A Rodriguez-Garcia
- A Schmidt
- B Miller
- BG Harvey
- BJ Haas
- Bj枚rn Hamberger
- BL Strom
- BM Lange
- C Karanikas
- CF Higgin
- CI Keeling
- CL Steele
- Danyu Shen
- DM Martin
- DM Martin
- EM Davis
- F Bouvier
- F Supek
- HJ Lee
- HL Weng
- HW Guo
- I Thabet
- J Bohlmann
- J Bohlmann
- J Faldt
- JH Roberds
- JJW Coppen
- JW Westbrook
- KC da Silva Rodrigues-Correa
- KG Zulak
- KJ Livak
- M Jasinski
- MA Phillips
- MD Robinson
- N Nagy
- NJ Dafoe
- QH Liu
- Qinghua Liu
- S Trapp
- SAB Byun-McKay
- SG Li
- SG Ralph
- Shanping Hong
- T Uehara
- VM Kelkar
- W Tadesse
- WK Roberts
- XW Qin
- Y Gu
- Yongcheng Wei
- YR Liu
- ZH Wang
- Zhichun Zhou
- Zhongping Feng
- ZS Xu
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- Field of study
Paragangliomas of head and neck: a treatment option with CyberKnife radiosurgery
- Author
- A Nicolato
- Achille Bergantin
- AK Lalwani
- AL Jong de
- BE Baysal
- BJ Cummings
- CG Jackson
- D Fu
- DI Bojrab
- DM Kaylie
- F Raquet
- Giovanni Broggi
- HP Neumann
- Ida Milanesi
- J Pfeiffer
- J Sheehan
- JA Cece
- JA Jordan
- JC Flickinger
- JD Green Jr
- JH Lee
- JL Netterville
- JM Cole
- JM Larner
- JR Adler Jr
- JS Oghalai
- Laura Fariselli
- LD Watkins
- Livia C. Bianchi
- Lorenzo Brait
- M Gerosa
- M Gjuric
- M Gjuric
- M Lim
- M Lim
- M Sanna
- M Sanna
- Marcello Marchetti
- MH Thabet
- MR Hawthorne
- NM Young
- O Al-Mefty
- PB Chretien
- R Liscak
- RL Foote
- RW Hinerman
- S Eustacchio
- SC Springate
- SC Springate
- SD Chang
- SD Chang
- SJ Patel
- TP Murphy
- V Carrasco
- W Saringer
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Toxic Chemical Compounds of the Solanaceae
- Author
- Bombardelli E
- Bonte F
- Brailowsky S.
- Broekaert WF
- Cabrera AL
- Carrillo BJ
- Cham BE
- Chen Z
- Chiang HC
- Chortyk OT
- D'Arcy WG
- Dalvi RR
- Dewitt D
- Escohotado A.
- Falzoni EM
- Gonz谩lez MD
- Gottlieb OR
- G贸mez Fern谩ndez JR
- Krook L
- Lee MR
- Lee MR
- Lee MR
- Lee MR
- Leung AY
- Lorenti AS
- L贸pez T
- L贸pez TA
- L贸pez TA
- Mello JR
- Mello JR
- Mello JR
- Milanesi LM
- M眉ller J
- Nakajima M.
- Narula A
- Nikolic NC
- Ott J.
- Panter KE
- Pittarelli GW
- Pomilio AB
- Puche RC
- Ray AB
- Riet-Correa F
- Riet-Correa F
- Sangwan RS
- Schultes RE
- Soban D
- Soontrapa S
- Steffens JC
- Szallasi A.
- Thabet H
- Tomes CN
- Villoldo A.
- Vronen PJE
- Walters MR
- Publication venue
- 'SAGE Publications'
- Publication date
- Field of study