An endophytic Taxol-producing fungus BT2 isolated from Taxus chinensis var. mairei

BT2, a newly isolated endophytic fungus from Taxus chinensis var. mairei, was observed to produce Taxol. Besides Taxol, a potent anticancer drug, BT2 could also yield taxane baccatin III, which was an important intermediate for Taxol and semi-synthesis of Taxol in industry. The isolation of such a fungusmay provide a promising alterative approach to produce Taxol, and BT2 can serve as a potential material for fungus engineering to improve Taxol productio

3D U-Net Based Brain Tumor Segmentation and Survival Days Prediction

Past few years have witnessed the prevalence of deep learning in many application scenarios, among which is medical image processing. Diagnosis and treatment of brain tumors requires an accurate and reliable segmentation of brain tumors as a prerequisite. However, such work conventionally requires brain surgeons significant amount of time. Computer vision techniques could provide surgeons a relief from the tedious marking procedure. In this paper, a 3D U-net based deep learning model has been trained with the help of brain-wise normalization and patching strategies for the brain tumor segmentation task in the BraTS 2019 competition. Dice coefficients for enhancing tumor, tumor core, and the whole tumor are 0.737, 0.807 and 0.894 respectively on the validation dataset. These three values on the test dataset are 0.778, 0.798 and 0.852. Furthermore, numerical features including ratio of tumor size to brain size and the area of tumor surface as well as age of subjects are extracted from predicted tumor labels and have been used for the overall survival days prediction task. The accuracy could be 0.448 on the validation dataset, and 0.551 on the final test dataset.Comment: Third place award of the 2019 MICCAI BraTS challenge survival task [BraTS 2019](https://www.med.upenn.edu/cbica/brats2019.html

The disproportionality of ethnic minority teachers in England: trends, patterns, and problems

Data availability: Underlying data: All of the datasets used in this paper are freely and publicly available at the following sites. The School Workforce Census and School Census data from 2015 to 2021 is available here from the website of the Department of Education: https://explore-education-statistics.service.gov.uk/find-statistics/school-workforce-in-england. (DfE, 2023a) The data on applicants to teacher training is available from the UCAS website: https://www.ucas.com/data-and-analysis/ucas-teacher-training-releases/ucas-teacher-training-end-cycle-2021-data-resources. The data shows the number of applicants and the number accepted by ethnicity for 2014–2021, and broken down by ITT provider. The figures on the ethnicity of the resident population of England are available from the Office of National Statistics website here: https://www.ons.gov.uk/peoplepopulationandcommunity/culturalidentity/ethnicity/bulletins/ethnicgroupenglandandwales/census2021#ethnic-groups-in-england-and-wales The data on teaching in multi-cultural settings is available from TALIS 2018: https://stats.oecd.org/Index.aspx?QueryId=97205Copyright: © 2023 Gorard, S. et al. Background: England has an ethnically diverse population; reflected in the teacher workforce, and the student body in schools. However, it is not clear that these figures are in proportion to each other. This paper examines the ethnic profile of students and their teachers and considers their geographical distribution. Methods: This paper uses existing aggregated official publicly available datasets to describe the patterns and trends in the proportion of ethnic minority teachers compared to ethnic minority pupils in England 2015-2021. Data comes from the Department for Education (DfE), the University and Colleges Admissions Service (UCAS), the Organisation for Economic Co-operation and development (OECD/TALIS), and the Office for National Statistics (ONS). Results: We found that there are proportionately more White British teachers than in the student intakes to schools. This disproportion (where there are more White British teachers among teachers than there are White British pupils among pupils) is worse for promoted school leaders like deputies and headteachers than it is for classroom teachers. In London, due to the exceptional number of ethnic minority students, the disproportion (or mismatch) is worse in London than anywhere else. Areas with the fewest ethnic minority pupils (and teachers), like the North East, have the most proportionate workforce (in this limited sense). Conclusions: A student lacking any teachers of the same ethnic group might be treated differently at school, and there is some evidence that this might affect their attainment outcomes. The lack of ethnic diversity in some schools and areas, regardless of proportions, may impoverish the diversity of the whole school system. Several possible reasons for these patterns are noted in the paper, but it is clear that ethnic minority applicants to teacher training are less likely to be accepted, and less likely to obtain qualified teacher status or an eventual teaching post.The author(s) declared that no grants were involved in supporting this work

The disproportionality of ethnic minority teachers in England: trends, patterns, and problems

Data availability: Underlying data: All of the datasets used in this paper are freely and publicly available at the following sites. The School Workforce Census and School Census data from 2015 to 2021 is available here from the website of the Department of Education: https://explore-education-statistics.service.gov.uk/find-statistics/school-workforce-in-england. (DfE, 2023a) The data on applicants to teacher training is available from the UCAS website: https://www.ucas.com/data-and-analysis/ucas-teacher-training-releases/ucas-teacher-training-end-cycle-2021-data-resources. The data shows the number of applicants and the number accepted by ethnicity for 2014–2021, and broken down by ITT provider. The figures on the ethnicity of the resident population of England are available from the Office of National Statistics website here: https://www.ons.gov.uk/peoplepopulationandcommunity/culturalidentity/ethnicity/bulletins/ethnicgroupenglandandwales/census2021#ethnic-groups-in-england-and-wales The data on teaching in multi-cultural settings is available from TALIS 2018: https://stats.oecd.org/Index.aspx?QueryId=97205Latest Version Published: 21 Apr 2023, 2:13 (https://doi.org/10.12688/routledgeopenres.17798.1) [version 1; peer review: awaiting peer review] This article is included in Education, Equity and Equality collectionCopyright 2023 The Author(s). Background: England has an ethnically diverse population; reflected in the teacher workforce, and the student body in schools. However, it is not clear that these figures are in proportion to each other. This paper examines the ethnic profile of students and their teachers and considers their geographical distribution. Methods: This paper uses existing aggregated official publicly available datasets to describe the patterns and trends in the proportion of ethnic minority teachers compared to ethnic minority pupils in England 2015-2021. Data comes from the Department for Education (DfE), the University and Colleges Admissions Service (UCAS), the Organisation for Economic Co-operation and development (OECD/TALIS), and the Office for National Statistics (ONS). Results: Compared to the student intakes to schools, we found that there are more White British teachers than expected. This disproportion (where there are more White British teachers among teachers than there are White British pupils among pupils) is worse for promoted school leaders like deputies and headteachers than it is for classroom teachers. In London, due to the exceptional number of ethnic minority students, the disproportion (or mismatch) is worse in London than anywhere else. Areas with the fewest ethnic minority pupils (and teachers), like the North East, have the most proportionate workforce (in this limited sense). Conclusions: A student lacking any teachers of the same ethnic group might be treated differently at school, and there is some evidence that this might affect their attainment outcomes. The lack of ethnic diversity in some schools and areas, regardless of proportions, may impoverish the diversity of the whole school system. Several possible reasons for these patterns are noted in the paper, but it is clear that ethnic minority applicants to teacher training are less likely to be accepted, and less likely to obtain qualified teacher status or an eventual teaching post.Economic & Social Research Council (Investigating Recruitment and Retention of Minority Ethnic Teachers)

A comparison of surgical outcomes between endoscopic and robotically assisted thyroidectomy: the authors’ initial experience

Background: The gasless, transaxillary endoscopic thyroidectomy (GTET) offers a distinct advantage over the conventional open operation by leaving no visible neck scar, and in an attempt to improve its ergonomics and surgical outcomes, the robotically assisted thyroidectomy (RAT) was introduced. The RAT uses the same endoscopic route as the GTET but with the assistance of the da Vinci S robotic system. Excellent results for RAT have been reported, but it remains unclear whether RAT offers any potential benefits over GTET. Methods: From June to December 2009, 46 patients underwent endoscopic thyroidectomy. Of these patients, 39 had surgery without the robot (GTET) and 7 had surgery with the robot (RAT). Demographics, surgical indications, operative findings, and postoperative outcomes were compared between the two groups. All the patients were followed up for at least 6 months after surgery. Results: Patient demographics, surgical indications, and extent of resection were similar between the two groups. The median total procedure time was significantly longer for RAT (149 min) than for GTET (100 min; p = 0.018), but the contralateral recurrent laryngeal nerve was more likely to identified in RAT (100%) than in GTET (42.9%; p = 0.070). On the average, GTET needed one more surgical assistant than RAT (1 vs. 0; ppublished_or_final_versionSpringer Open Choice, 21 Feb 201

Epidemiology and seasonality of respiratory viral infections in hospitalized children in Kuala Lumpur, Malaysia: a retrospective study of 27 years

<p>Abstract</p> <p>Background</p> <p>Viral respiratory tract infections (RTI) are relatively understudied in Southeast Asian tropical countries. In temperate countries, seasonal activity of respiratory viruses has been reported, particularly in association with temperature, while inconsistent correlation of respiratory viral activity with humidity and rain is found in tropical countries. A retrospective study was performed from 1982-2008 to investigate the viral etiology of children (≤ 5 years old) admitted with RTI in a tertiary hospital in Kuala Lumpur, Malaysia.</p> <p>Methods</p> <p>A total of 10269 respiratory samples from all children ≤ 5 years old received at the hospital's diagnostic virology laboratory between 1982-2008 were included in the study. Immunofluorescence staining (for respiratory syncytial virus (RSV), influenza A and B, parainfluenza types 1-3, and adenovirus) and virus isolation were performed. The yearly hospitalization rates and annual patterns of laboratory-confirmed viral RTIs were determined. Univariate ANOVA was used to analyse the demographic parameters of cases. Multiple regression and Spearman's rank correlation were used to analyse the correlation between RSV cases and meteorological parameters.</p> <p>Results</p> <p>A total of 2708 cases were laboratory-confirmed using immunofluorescence assays and viral cultures, with the most commonly detected being RSV (1913, 70.6%), parainfluenza viruses (357, 13.2%), influenza viruses (297, 11.0%), and adenovirus (141, 5.2%). Children infected with RSV were significantly younger, and children infected with influenza viruses were significantly older. The four main viruses caused disease throughout the year, with a seasonal peak observed for RSV in September-December. Monthly RSV cases were directly correlated with rain days, and inversely correlated with relative humidity and temperature.</p> <p>Conclusion</p> <p>Viral RTIs, particularly due to RSV, are commonly detected in respiratory samples from hospitalized children in Kuala Lumpur, Malaysia. As in temperate countries, RSV infection in tropical Malaysia also caused seasonal yearly epidemics, and this has implications for prophylaxis and vaccination programmes.</p

The ADAMTS (A Disintegrin and Metalloproteinase with Thrombospondin motifs) family

The ADAMTS (A Disintegrin and Metalloproteinase with Thrombospondin motifs) enzymes are secreted, multi-domain matrix-associated zinc metalloendopeptidases that have diverse roles in tissue morphogenesis and patho-physiological remodeling, in inflammation and in vascular biology. The human family includes 19 members that can be sub-grouped on the basis of their known substrates, namely the aggrecanases or proteoglycanases (ADAMTS1, 4, 5, 8, 9, 15 and 20), the procollagen N-propeptidases (ADAMTS2, 3 and 14), the cartilage oligomeric matrix protein-cleaving enzymes (ADAMTS7 and 12), the von-Willebrand Factor proteinase (ADAMTS13) and a group of orphan enzymes (ADAMTS6, 10, 16, 17, 18 and 19). Control of the structure and function of the extracellular matrix (ECM) is a central theme of the biology of the ADAMTS, as exemplified by the actions of the procollagen-N-propeptidases in collagen fibril assembly and of the aggrecanases in the cleavage or modification of ECM proteoglycans. Defects in certain family members give rise to inherited genetic disorders, while the aberrant expression or function of others is associated with arthritis, cancer and cardiovascular disease. In particular, ADAMTS4 and 5 have emerged as therapeutic targets in arthritis. Multiple ADAMTSs from different sub-groupings exert either positive or negative effects on tumorigenesis and metastasis, with both metalloproteinase-dependent and -independent actions known to occur. The basic ADAMTS structure comprises a metalloproteinase catalytic domain and a carboxy-terminal ancillary domain, the latter determining substrate specificity and the localization of the protease and its interaction partners; ancillary domains probably also have independent biological functions. Focusing primarily on the aggrecanases and proteoglycanases, this review provides a perspective on the evolution of the ADAMTS family, their links with developmental and disease mechanisms, and key questions for the future

Renal artery stenosis-when to screen, what to stent?

Renal artery stensosis (RAS) continues to be a problem for clinicians, with no clear consensus on how to investigate and assess the clinical significance of stenotic lesions and manage the findings. RAS caused by fibromuscular dysplasia is probably commoner than previously appreciated, should be actively looked for in younger hypertensive patients and can be managed successfully with angioplasty. Atheromatous RAS is associated with increased incidence of cardiovascular events and increased cardiovascular mortality, and is likely to be seen with increasing frequency. Evidence from large clinical trials has led clinicians away from recommending interventional revascularisation towards aggressive medical management. There is now interest in looking more closely at patient selection for intervention, with focus on intervening only in patients with the highest-risk presentations such as flash pulmonary oedema, rapidly declining renal function and severe resistant hypertension. The potential benefits in terms of improving hard cardiovascular outcomes may outweigh the risks of intervention in this group, and further research is needed