Homomorphism to R of semidirect products: a dynamical construction

We define a modified version of Erschler and Karlsson construction of homomorphisms from random walks [A. Erschler and A. Karlsson, Ann. Inst. Fourier (Grenoble) 60 (2010), no. 6, 2095?2113]. We show that our definition is well adapted to semidirect products. The same construction is conjectured to work also for other classes of maps like quasi-morphisms.info:eu-repo/semantics/publishedVersio

On the stability of a quadratic functional equation over non-Archimedean spaces

Let G be an abelian group and suppose that X is a non-Archimedean Banach space. We study Hyers-Ulam-Rassias stability for the functional equation of quadratic type $$f (x + y + z) + f (x) + f (y) + f (z) = f (x + y) + f (y + z) + f (z + x)$$ where $f : G\to X$ is a map.info:eu-repo/semantics/publishedVersio

A note on the minimal displacement function

Let (X,d) be a metric space and Iso(X,d) the associated isometry group. We study the subadditivity of the minimal displacement function $f : Iso(X, d) \to R$ for different metric spaces. When (X,d) is ultrametric, we prove that the minimal displacement function is subadditive. We show, by a simple algebraic argument, that subadditivity does not hold for the direct isometry group of the hyperbolic plane. The same argument can be used for other metric spaces.info:eu-repo/semantics/publishedVersio

Transcriptome of the deep-sea black scabbardfish, Aphanopus carbo (Perciformes: Trichiuridae) : tissue-specific expression patterns and candidate genes associated to depth adaptation

Deep-sea fishes provide a unique opportunity to study the physiology and evolutionary adaptation to extreme environments. We carried out a high throughput sequencing analysis on a 454 GS-FLX titanium plate using unnormalized cDNA libraries from six tissues of A. carbo. Assemblage and annotations were performed by Newbler and InterPro/Pfam analyses, respectively. The assembly of 544,491 high quality reads provided 8,319 contigs, 55.6% of which retrieved blast hits against the NCBI nonredundant database or were annotated with ESTscan. Comparison of functional genes at both the protein sequences and protein stability levels, associated with adaptations to depth, revealed similarities between A. carbo and other bathypelagic fishes. A selection of putative genes was standardized to evaluate the correlation between number of contigs and their normalized expression, as determined by qPCR amplification. The screening of the libraries contributed to the identification of new EST simple-sequence repeats (SSRs) and to the design of primer pairs suitable for population genetic studies as well as for tagging and mapping of genes. The characterization of the deep-sea fish A. carbo first transcriptome is expected to provide abundant resources for genetic, evolutionary, and ecological studies of this species and the basis for further investigation of depth-related adaptation processes in fishes.Publisher PDFPeer reviewe

mRNA vaccines: a new opportunity for malaria, tuberculosis and HIV

The success of the first licensed mRNA-based vaccines against COVID-19 has created a widespread interest on mRNA technology for vaccinology. As expected, the number of mRNA vaccines in preclinical and clinical development increased exponentially since 2020, including numerous improvements in mRNA formulation design, delivery methods and manufacturing processes. However, the technology faces challenges such as the cost of raw materials, the lack of standardization, and delivery optimization. MRNA technology may provide a solution to some of the emerging infectious diseases as well as the deadliest hard-to-treat infectious diseases malaria, tuberculosis, and human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS), for which an effective vaccine, easily deployable to endemic areas is urgently needed. In this review, we discuss the functional structure, design, manufacturing processes and delivery methods of mRNA vaccines. We provide an up-to-date overview of the preclinical and clinical development of mRNA vaccines against infectious diseases, and discuss the immunogenicity, efficacy and correlates of protection of mRNA vaccines, with particular focus on research and development of mRNA vaccines against malaria, tuberculosis and HIV.info:eu-repo/semantics/publishedVersio

Agro de Nogueira, Melide, A Coruña : new data and new problematic

A propósito de uma data de AMS realizada para os restos de incineração da cista pequena de Agro de Nogueira os autores equacionam novas problemáticas sobre esta estação arqueológica e sobre a introdução do rito de incineração no Noroeste Peninsular.Based on a AMS date obtained from the burning remains of the small cist of Agro Nogueira the authors of this paper pose new hypotheses about this archaeological place and about the introduction of the rite of incineration in the Northwest of Iberian Peninsula

Microbial antigen identification and vaccine delivery systems

info:eu-repo/semantics/publishedVersio

Avaliação do desempenho do clone 3336 de Eucalyptus Urograndis na multiplicação e enraizamento in vitro.

Editores técnicos: Marcílio José Thomazini, Elenice Fritzsons, Patrícia Raquel Silva, Guilherme Schnell e Schuhli, Denise Jeton Cardoso, Luziane Franciscon. EVINCI. Resumos